UniProtKB - G4XXL9 (G4XXL9_HUMAN)
Protein
Cytochrome c
Gene
CYCS
Organism
Homo sapiens (Human)
Status
Functioni
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.UniRule annotation
GO - Molecular functioni
- electron transfer activity Source: InterPro
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | ApoptosisARBA annotation, Electron transport, Respiratory chainUniRule annotationARBA annotation, Transport |
Ligand | HemePROSITE-ProRule annotationARBA annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome cARBA annotation |
Gene namesi | Name:CYCSImported ORF Names:hCG_2009955Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172115.8 |
Subcellular locationi
Mitochondrion
- Mitochondrion intermembrane space ARBA annotation
Mitochondrion
- mitochondrial intermembrane space Source: UniProtKB-SubCell
Other locations
- respirasome Source: UniProtKB-KW
Keywords - Cellular componenti
MitochondrionUniRule annotationARBA annotationPTM / Processingi
Post-translational modificationi
Binds 1 heme group per subunit.UniRule annotation
Keywords - PTMi
AcetylationARBA annotationProteomic databases
PRIDEi | G4XXL9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172115, Expressed in heart and 212 other tissues |
ExpressionAtlasi | G4XXL9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 103 | Cytochrome cInterPro annotationAdd BLAST | 102 |
Sequence similaritiesi
Phylogenomic databases
OMAi | AQCHTIN |
OrthoDBi | 1533604at2759 |
Family and domain databases
Gene3Di | 1.10.760.10, 1 hit |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR002327, Cyt_c_1A/1B |
PANTHERi | PTHR11961, PTHR11961, 1 hit |
Pfami | View protein in Pfam PF00034, Cytochrom_C, 1 hit |
PRINTSi | PR00604, CYTCHRMECIAB |
SUPFAMi | SSF46626, SSF46626, 1 hit |
PROSITEi | View protein in PROSITE PS51007, CYTC, 1 hit |
i Sequence
Sequence statusi: Complete.
G4XXL9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDVEKGKKI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGYSYT
60 70 80 90 100
AANKNKGIIW GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK
KATNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JF919224 Genomic DNA Translation: AEP27189.1 CH471073 Genomic DNA Translation: EAW93823.1 CH471073 Genomic DNA Translation: EAW93824.1 |
RefSeqi | NP_061820.1, NM_018947.5 |
Genome annotation databases
GeneIDi | 54205 |
KEGGi | hsa:54205 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JF919224 Genomic DNA Translation: AEP27189.1 CH471073 Genomic DNA Translation: EAW93823.1 CH471073 Genomic DNA Translation: EAW93824.1 |
RefSeqi | NP_061820.1, NM_018947.5 |
3D structure databases
SMRi | G4XXL9 |
ModBasei | Search... |
Proteomic databases
PRIDEi | G4XXL9 |
Protocols and materials databases
Antibodypediai | 3917, 1366 antibodies |
Genome annotation databases
GeneIDi | 54205 |
KEGGi | hsa:54205 |
Organism-specific databases
CTDi | 54205 |
EuPathDBi | HostDB:ENSG00000172115.8 |
Phylogenomic databases
OMAi | AQCHTIN |
OrthoDBi | 1533604at2759 |
Miscellaneous databases
BioGRID-ORCSi | 54205, 490 hits in 824 CRISPR screens |
ChiTaRSi | CYCS, human |
GenomeRNAii | 54205 |
Gene expression databases
Bgeei | ENSG00000172115, Expressed in heart and 212 other tissues |
ExpressionAtlasi | G4XXL9, baseline and differential |
Family and domain databases
Gene3Di | 1.10.760.10, 1 hit |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR002327, Cyt_c_1A/1B |
PANTHERi | PTHR11961, PTHR11961, 1 hit |
Pfami | View protein in Pfam PF00034, Cytochrom_C, 1 hit |
PRINTSi | PR00604, CYTCHRMECIAB |
SUPFAMi | SSF46626, SSF46626, 1 hit |
PROSITEi | View protein in PROSITE PS51007, CYTC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G4XXL9_HUMAN | |
Accessioni | G4XXL9Primary (citable) accession number: G4XXL9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |