ESR1

Functionⁱ

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

UniRule annotation

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
estrogen receptor activity Source: InterPro
nuclear receptor activity Source: Ensembl
sequence-specific DNA binding Source: Ensembl
steroid binding Source: UniProtKB-KW
transcription factor binding Source: Ensembl
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen metabolic process Source: Ensembl
antral ovarian follicle growth Source: Ensembl
cellular response to estradiol stimulus Source: Ensembl
cellular response to estrogen stimulus Source: Ensembl
epithelial cell development Source: Ensembl
epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
male gonad development Source: Ensembl
mammary gland alveolus development Source: Ensembl
mammary gland branching involved in pregnancy Source: Ensembl
positive regulation of fibroblast proliferation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
prostate epithelial cord elongation Source: Ensembl
regulation of apoptotic process Source: Ensembl
regulation of branching involved in prostate gland morphogenesis Source: Ensembl
regulation of inflammatory response Source: Ensembl
regulation of toll-like receptor signaling pathway Source: Ensembl
stem cell differentiation Source: Ensembl
uterus development Source: Ensembl
vagina development Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation
Ligand	Lipid-binding, Metal-binding, Steroid-bindingUniRule annotationARBA annotation, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Estrogen receptorUniRule annotation Short name: ERUniRule annotation Alternative name(s): ER-alphaUniRule annotation Estradiol receptorUniRule annotation Nuclear receptor subfamily 3 group A member 1UniRule annotation
Gene namesⁱ	Name:ESR1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

VEuPathDBⁱ	HostDB:ENSG00000091831.21

VEuPathDBⁱ

HostDB:ENSG00000091831.21

Keywords - Cellular componentⁱ

NucleusUniRule annotationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000091831, Expressed in endometrium and 168 other tissues
ExpressionAtlasⁱ	G4XH65, baseline and differential
Genevisibleⁱ	G4XH65, HS

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer.

UniRule annotation

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	G4XH65

BindingDBⁱ

G4XH65

Structureⁱ

3D structure databases

SMRⁱ	G4XH65
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	182 – 257	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	311 – 547	NR LBDInterPro annotationAdd BLAST		237

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	147 – 174	DisorderedSequence analysisAdd BLAST	28
Regionⁱ	259 – 282	DisorderedSequence analysisAdd BLAST	24
Regionⁱ	553 – 573	DisorderedSequence analysisAdd BLAST	21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	558 – 573	Polar residuesSequence analysisAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotationARBA annotation

Keywords - Domainⁱ

Zinc-fingerARBA annotation

Phylogenomic databases

OMAⁱ	LHAPANF
PhylomeDBⁱ	G4XH65

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit
PIRSFⁱ	PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit
PRINTSⁱ	PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

G4XH65-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA 
        60         70         80         90        100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL 
       110        120        130        140        150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY 
       160        170        180        190        200
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW 
       210        220        230        240        250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM 
       260        270        280        290        300
MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR 
       310        320        330        340        350
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA 
       360        370        380        390        400
DRELVHMINW AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG 
       410        420        430        440        450
KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS 
       460        470        480        490        500
IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ 
       510        520        530        540        550
HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL LEMLDAHRLH 
       560        570        580        590 
APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV

Length:595

Mass (Da):66,216

Last modified:December 14, 2011 - v1

Checksum:ⁱ5455C57AB0CCCAA7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JF810888 mRNA Translation: AEP43755.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000116.2, NM_000125.3 NP_001116212.1, NM_001122740.1 NP_001116213.1, NM_001122741.1 NP_001116214.1, NM_001122742.1 XP_011533845.1, XM_011535543.2 XP_011533846.1, XM_011535544.2 XP_011533847.1, XM_011535545.2 XP_016865865.1, XM_017010376.1 XP_016865866.1, XM_017010377.1 XP_016865867.1, XM_017010378.1 XP_016865868.1, XM_017010379.1 XP_016865869.1, XM_017010380.1 XP_016865870.1, XM_017010381.1

Genome annotation databases

GeneIDⁱ	2099
KEGGⁱ	hsa:2099

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
G4XH65	Estrogen receptor	)	HUMAN		595	UniRef100_P03372
Isoform 3 of Estrogen receptor		HUMAN		422

Protein	Similar proteins		Species	Score	Length	Source
G4XH65	Estrogen receptor	)	HUMAN		595	UniRef90_P03372
Estrogen receptor		PROCO		599
Estrogen receptor		OTOGA		598
Estrogen receptor		COLAP		595
Estrogen receptor		MANLE		595
+61

Protein	Similar proteins		Species	Score	Length	Source
G4XH65	Estrogen receptor	)	HUMAN		595	UniRef50_P03372
Estrogen receptor (Fragment)		MICUN		525
Estrogen receptor		ICTPU		617
Estrogen receptor		PAGMA		581
Estrogen receptor		SPAAU		581
+367

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JF810888 mRNA Translation: AEP43755.1
RefSeqⁱ	NP_000116.2, NM_000125.3 NP_001116212.1, NM_001122740.1 NP_001116213.1, NM_001122741.1 NP_001116214.1, NM_001122742.1 XP_011533845.1, XM_011535543.2 XP_011533846.1, XM_011535544.2 XP_011533847.1, XM_011535545.2 XP_016865865.1, XM_017010376.1 XP_016865866.1, XM_017010377.1 XP_016865867.1, XM_017010378.1 XP_016865868.1, XM_017010379.1 XP_016865869.1, XM_017010380.1 XP_016865870.1, XM_017010381.1

3D structure databases

SMRⁱ	G4XH65
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	G4XH65

BindingDBⁱ

G4XH65

Protocols and materials databases

Antibodypediaⁱ	739, 4055 antibodies
The DNASU plasmid repository More...DNASUⁱ	2099

Genome annotation databases

GeneIDⁱ	2099
KEGGⁱ	hsa:2099

Organism-specific databases

CTDⁱ	2099
VEuPathDBⁱ	HostDB:ENSG00000091831.21

Phylogenomic databases

OMAⁱ	LHAPANF
PhylomeDBⁱ	G4XH65

Miscellaneous databases

BioGRID-ORCSⁱ	2099, 23 hits in 1010 CRISPR screens
ChiTaRSⁱ	ESR1, human
GenomeRNAiⁱ	2099

Gene expression databases

Bgeeⁱ	ENSG00000091831, Expressed in endometrium and 168 other tissues
ExpressionAtlasⁱ	G4XH65, baseline and differential
Genevisibleⁱ	G4XH65, HS

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit
PIRSFⁱ	PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit
PRINTSⁱ	PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G4XH65_HUMAN
Accessionⁱ	G4XH65Primary (citable) accession number: G4XH65
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 14, 2011
	Last sequence update:	December 14, 2011
	Last modified:	June 2, 2021
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - G4XH65 (G4XH65_HUMAN)

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Estrogen receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ