UniProtKB - G4XH65 (G4XH65_HUMAN)
Protein
Estrogen receptor
Gene
ESR1
Organism
Homo sapiens (Human)
Status
Functioni
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation
GO - Molecular functioni
- chromatin binding Source: Ensembl
- estrogen receptor activity Source: InterPro
- nuclear receptor activity Source: Ensembl
- sequence-specific DNA binding Source: Ensembl
- steroid binding Source: UniProtKB-KW
- transcription factor binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- androgen metabolic process Source: Ensembl
- antral ovarian follicle growth Source: Ensembl
- cellular response to estradiol stimulus Source: Ensembl
- cellular response to estrogen stimulus Source: Ensembl
- epithelial cell development Source: Ensembl
- epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
- male gonad development Source: Ensembl
- mammary gland alveolus development Source: Ensembl
- mammary gland branching involved in pregnancy Source: Ensembl
- positive regulation of fibroblast proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
- prostate epithelial cord elongation Source: Ensembl
- regulation of apoptotic process Source: Ensembl
- regulation of branching involved in prostate gland morphogenesis Source: Ensembl
- regulation of inflammatory response Source: Ensembl
- regulation of toll-like receptor signaling pathway Source: Ensembl
- stem cell differentiation Source: Ensembl
- uterus development Source: Ensembl
- vagina development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Lipid-binding, Metal-binding, Steroid-bindingUniRule annotationARBA annotation, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen receptorUniRule annotationShort name: ERUniRule annotation Alternative name(s): ER-alphaUniRule annotation Estradiol receptorUniRule annotation Nuclear receptor subfamily 3 group A member 1UniRule annotation |
Gene namesi | Name:ESR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000091831.21 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | G4XH65, baseline and differential |
Genevisiblei | G4XH65, HS |
Interactioni
Subunit structurei
Binds DNA as a homodimer.
UniRule annotationGO - Molecular functioni
- transcription factor binding Source: Ensembl
Chemistry databases
BindingDBi | G4XH65 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 182 – 257 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 311 – 547 | NR LBDInterPro annotationAdd BLAST | 237 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 174 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 259 – 282 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 553 – 573 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 558 – 573 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
OMAi | LHAPANF |
PhylomeDBi | G4XH65 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G4XH65-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80 90 100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL
110 120 130 140 150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY
160 170 180 190 200
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW
210 220 230 240 250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM
260 270 280 290 300
MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR
310 320 330 340 350
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA
360 370 380 390 400
DRELVHMINW AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG
410 420 430 440 450
KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS
460 470 480 490 500
IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ
510 520 530 540 550
HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL LEMLDAHRLH
560 570 580 590
APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JF810888 mRNA Translation: AEP43755.1 |
RefSeqi | NP_000116.2, NM_000125.3 NP_001116212.1, NM_001122740.1 NP_001116213.1, NM_001122741.1 NP_001116214.1, NM_001122742.1 XP_011533845.1, XM_011535543.2 XP_011533846.1, XM_011535544.2 XP_011533847.1, XM_011535545.2 XP_016865865.1, XM_017010376.1 XP_016865866.1, XM_017010377.1 XP_016865867.1, XM_017010378.1 XP_016865868.1, XM_017010379.1 XP_016865869.1, XM_017010380.1 XP_016865870.1, XM_017010381.1 |
Genome annotation databases
GeneIDi | 2099 |
KEGGi | hsa:2099 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JF810888 mRNA Translation: AEP43755.1 |
RefSeqi | NP_000116.2, NM_000125.3 NP_001116212.1, NM_001122740.1 NP_001116213.1, NM_001122741.1 NP_001116214.1, NM_001122742.1 XP_011533845.1, XM_011535543.2 XP_011533846.1, XM_011535544.2 XP_011533847.1, XM_011535545.2 XP_016865865.1, XM_017010376.1 XP_016865866.1, XM_017010377.1 XP_016865867.1, XM_017010378.1 XP_016865868.1, XM_017010379.1 XP_016865869.1, XM_017010380.1 XP_016865870.1, XM_017010381.1 |
3D structure databases
SMRi | G4XH65 |
ModBasei | Search... |
Chemistry databases
BindingDBi | G4XH65 |
Protocols and materials databases
Antibodypediai | 739, 4045 antibodies |
DNASUi | 2099 |
Genome annotation databases
GeneIDi | 2099 |
KEGGi | hsa:2099 |
Organism-specific databases
CTDi | 2099 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
Phylogenomic databases
OMAi | LHAPANF |
PhylomeDBi | G4XH65 |
Miscellaneous databases
BioGRID-ORCSi | 2099, 23 hits in 1010 CRISPR screens |
ChiTaRSi | ESR1, human |
GenomeRNAii | 2099 |
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | G4XH65, baseline and differential |
Genevisiblei | G4XH65, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024178, Oest_rcpt/oest-rel_rcp IPR001292, Oestr_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G4XH65_HUMAN | |
Accessioni | G4XH65Primary (citable) accession number: G4XH65 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 14, 2011 |
Last sequence update: | December 14, 2011 | |
Last modified: | April 7, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |