UniProtKB - G4WFQ2 (SCXND_MESEU)
Protein
Sodium channel neurotoxin MeuNaTxalpha-13
Gene
N/A
Organism
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Status
Functioni
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.By similarity
GO - Molecular functioni
- sodium channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response Source: InterPro
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel neurotoxin MeuNaTxalpha-131 Publication |
Organismi | Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)Imported |
Taxonomic identifieri | 34648 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | ‹1 – 5 | Curated | ›5 | |
ChainiPRO_0000447459 | 6 – 71 | Sodium channel neurotoxin MeuNaTxalpha-131 PublicationAdd BLAST | 66 | |
PropeptideiPRO_0000447460 | 72 – 73 | Removed by a carboxypeptidaseCurated | 2 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 17 ↔ 70 | By similarity | ||
Disulfide bondi | 21 ↔ 43 | By similarity | ||
Disulfide bondi | 29 ↔ 53 | By similarity | ||
Disulfide bondi | 33 ↔ 55 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 71 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 65 |
Domaini
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).Curated
Sequence similaritiesi
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00107, Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR003614, Scorpion_toxin-like IPR036574, Scorpion_toxin-like_sf IPR018218, Scorpion_toxinL IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
PRINTSi | PR00285, SCORPNTOXIN |
SMARTi | View protein in SMART SM00505, Knot1, 1 hit |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863, LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
G4WFQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
TGVESARDAY IAKPHNCVYE CFDAFSSYCN DLCTENGAKS GYCQIAGKYG
60 70
NGCWCIELPD NVPIRIPGKC HRR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ332129 Genomic DNA Translation: ADW41694.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HQ332129 Genomic DNA Translation: ADW41694.1 |
3D structure databases
SMRi | G4WFQ2 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00107, Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR003614, Scorpion_toxin-like IPR036574, Scorpion_toxin-like_sf IPR018218, Scorpion_toxinL IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
PRINTSi | PR00285, SCORPNTOXIN |
SMARTi | View protein in SMART SM00505, Knot1, 1 hit |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863, LCN_CSAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCXND_MESEU | |
Accessioni | G4WFQ2Primary (citable) accession number: G4WFQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 3, 2019 |
Last sequence update: | December 14, 2011 | |
Last modified: | December 2, 2020 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |