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Entry version 56 (18 Sep 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Putative multidrug resistance protein 1 (ATP-binding cassette C1)

Gene

Smp_171740

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi883 – 890ATPPROSITE-ProRule annotation8
Nucleotide bindingi1455 – 1462ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative multidrug resistance protein 1 (ATP-binding cassette C1)Imported (EC:3.6.3.44Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Smp_171740Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchistosoma mansoni (Blood fluke)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6183 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 33HelicalSequence analysisAdd BLAST22
Transmembranei40 – 62HelicalSequence analysisAdd BLAST23
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei135 – 153HelicalSequence analysisAdd BLAST19
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Transmembranei574 – 597HelicalSequence analysisAdd BLAST24
Transmembranei644 – 669HelicalSequence analysisAdd BLAST26
Transmembranei675 – 694HelicalSequence analysisAdd BLAST20
Transmembranei760 – 780HelicalSequence analysisAdd BLAST21
Transmembranei800 – 822HelicalSequence analysisAdd BLAST23
Transmembranei1156 – 1177HelicalSequence analysisAdd BLAST22
Transmembranei1229 – 1250HelicalSequence analysisAdd BLAST22
Transmembranei1315 – 1342HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6183.Smp_171740.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini535 – 817ABC transmembrane type-1InterPro annotationAdd BLAST283
Domaini850 – 1074ABC transporterInterPro annotationAdd BLAST225
Domaini1180 – 1381ABC transmembrane type-1InterPro annotationAdd BLAST202
Domaini1421 – 1661ABC transporterInterPro annotationAdd BLAST241

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G4VJ79

KEGG Orthology (KO)

More...
KOi
K05665

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G4VJ79

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G4VJ79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLMDYVCP YSGEGLVCIS LLLNTVGILY VVLKMKEFAL YTFARPAFVS
60 70 80 90 100
ISLVSFIIVM HYERKRNTPN SGVCFYYLLL LNFVWICCCW NHIVHYIKNS
110 120 130 140 150
KNSMALFTTI NNTSIIPNRN TTLPLYSMIQ NKEDFYEILD YINLLISLII
160 170 180 190 200
FILNCNSERR QCLETNKIIN ITKKCPNVIT DVLNNPIDEN DDKDLSEHLT
210 220 230 240 250
NETTLNYNDV NVEIQNLQHF TPSNLSSVIN CHTTCVDQKR IYLIIKGFRK
260 270 280 290 300
PVEFKDIWRL DSQHCSENVS KIFLNNLDKY LIPNKSTNNY LEKRRASMGN
310 320 330 340 350
STHHVNNDSS DSEFRRRSAQ SILGFGIPQH NKHLYKSGLT NTYPDDINIR
360 370 380 390 400
RASEGIALLN NDKTSPQHNN NDTITTANNN KNIHSETNSI NLKPHQNEST
410 420 430 440 450
DLQMDSTNHD LPSNTIIGFS KDQSTRRSVR IHVDTKPEYI PGLSEINTDS
460 470 480 490 500
SEVFLKDLDS KSTINEHIDN HLIHKVKSVT TDDELNKSIE INDITTTTTM
510 520 530 540 550
ESSSNLCHCF SIICIHQTKF SLLYALLKTY GKTLLWSAFL KLLYDILVFV
560 570 580 590 600
NPLLLKLLLN FLQNIQSEPI WHGYLYAIAI FIDTTVQSLI LQSYFHIVFK
610 620 630 640 650
LGMNIKTAIT AAVYRKSLRL SNKARYQSTT GQIMNLMSSD AQQFVQLMPF
660 670 680 690 700
INILWSGPFQ ITIAMILLWR ELGPSVLAGV GVLLLLLPVN VLIARRSKVF
710 720 730 740 750
QEKKSSCADS RIKFINELMN GIRVLKLYAW EPSFMKEIGL IRDKEVKYLR
760 770 780 790 800
RFTYFQSLSF LWHCTPFFVA ISSFGVYILT SNKNILDAQK AFVSLSLFNI
810 820 830 840 850
LRFPLFMFPM IISNLAQCYV SIGRLTKFLA HTELDMESYS KEDTPGIAAV
860 870 880 890 900
VERGVFGWDP DEEPTLTNIS IQFPEGQLTT IMGSVGSGKS SLLHALLGDM
910 920 930 940 950
ENFNGRVNVK GTVAYVPQQP WIFNATLRDN ILFHHSYEPI KYQHVLHACN
960 970 980 990 1000
LIPDLEILPN GDMTEIGDKG INLSGGQKQR VSLARACYAD ADVYLLDDPL
1010 1020 1030 1040 1050
SAVDPHVGLH LLKYVLSRST GLLASKTCIL TTHSPKALPF SDRIGLMSDG
1060 1070 1080 1090 1100
QIIELGNYRQ LIHSHTSRLS AFLITAIRAE SEVQSNSSKE RVDCSPENLK
1110 1120 1130 1140 1150
KVLTRQDTLS FGLSVKGSGS RLVGPVFESH SRVRDRGCAL LRSPIIGRNG
1160 1170 1180 1190 1200
VNFRVFFIYI KNIGLLYSLL VLLFYPINHL LSLGTNLWLA DWSNDFKQNQ
1210 1220 1230 1240 1250
YNDSYSNLSL LNISNIQVEQ YYSQRNYRLS IYGIIGILQV LFAMLSIYTL
1260 1270 1280 1290 1300
SMGHLGCVIR LHSRLLSYVL HAPATFFDLV PHGRIVNRFS QDIATLDNPV
1310 1320 1330 1340 1350
LVSLNSTLNC VLTCFLTLCL ACTLNVYMII PICLLTIIYL YIQNLYVTTS
1360 1370 1380 1390 1400
RQLKRLESIS LSPIFSHFSE TLSGVDSIRA YKLIEIYKTI SSIRQDLNNS
1410 1420 1430 1440 1450
AVYASIISQS FLPNNWPEGK IEFINYGTKY RPELNLALKS INFKVEKGEK
1460 1470 1480 1490 1500
LGIVGRTGSG KSSLVLGLFR MLEAAEGKIL IDGFDISKIG LHDLRNRLTL
1510 1520 1530 1540 1550
IPQDPVLFSG TLRFNLDPFN HYTDDAIWHA LELANLKSFI KDANNNNDVN
1560 1570 1580 1590 1600
FGLDMNISEG GSNISLGQRQ LVCLARALLR HTSILVLDEA TAAIDMQTDN
1610 1620 1630 1640 1650
LIQETIRREF SSSTVITIAH RINTVLDYDR ILVLEDGQMK ELDSPKKLLQ
1660
NKNSTFYSLA KDAHIVD
Length:1,667
Mass (Da):188,894
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i414C7CC40ABE6E6C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HE601627 Genomic DNA Translation: CCD79480.1

NCBI Reference Sequences

More...
RefSeqi
XP_018652084.1, XM_018796999.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Smp_171740.1; Smp_171740.1:pep; Smp_171740

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Smp_171740.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8354785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
smm:Smp_171740

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601627 Genomic DNA Translation: CCD79480.1
RefSeqiXP_018652084.1, XM_018796999.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6183.Smp_171740.1

Genome annotation databases

EnsemblMetazoaiSmp_171740.1; Smp_171740.1:pep; Smp_171740
GeneDBiSmp_171740.1:pep
GeneIDi8354785
KEGGismm:Smp_171740

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8354785

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiG4VJ79
KOiK05665
OrthoDBi138195at2759
PhylomeDBiG4VJ79

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG4VJ79_SCHMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G4VJ79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 18, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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