Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Titin homolog

Gene

ttn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase (PubMed:18390597, PubMed:20346955). Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity).By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15963ATPPROSITE-ProRule annotation1
Active sitei16055Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15940 – 15948ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • actin filament binding Source: CAFA
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • myosin binding Source: CAFA
  • protein serine/threonine kinase activity Source: UniProtKB-KW

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiG4SLH0

Names & Taxonomyi

Protein namesi
Recommended name:
Titin homolog1 Publication (EC:2.7.11.12 Publications)
Gene namesi
Name:ttn-1Imported
ORF Names:W06H8.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiW06H8.8a ; CE52437 ; WBGene00006436 ; ttn-1
W06H8.8b ; CE52423 ; WBGene00006436 ; ttn-1
W06H8.8c ; CE36723 ; WBGene00006436 ; ttn-1
W06H8.8d ; CE52449 ; WBGene00006436 ; ttn-1
W06H8.8e ; CE52441 ; WBGene00006436 ; ttn-1
W06H8.8f ; CE52428 ; WBGene00006436 ; ttn-1
W06H8.8g ; CE52417 ; WBGene00006436 ; ttn-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004353701 – 18562Titin homologCuratedAdd BLAST18562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi842 ↔ 897PROSITE-ProRule annotation
Disulfide bondi1700 ↔ 1751PROSITE-ProRule annotation
Disulfide bondi3919 ↔ 3969PROSITE-ProRule annotation
Disulfide bondi4059 ↔ 4109PROSITE-ProRule annotation
Disulfide bondi14568 ↔ 14618PROSITE-ProRule annotation
Disulfide bondi16290 ↔ 16342PROSITE-ProRule annotation
Disulfide bondi16508 ↔ 16571PROSITE-ProRule annotation
Disulfide bondi16627 ↔ 16677PROSITE-ProRule annotation
Disulfide bondi16726 ↔ 16778PROSITE-ProRule annotation
Disulfide bondi17379 ↔ 17431PROSITE-ProRule annotation
Disulfide bondi17478 ↔ 17530PROSITE-ProRule annotation
Disulfide bondi17697 ↔ 17754PROSITE-ProRule annotation
Disulfide bondi18143 ↔ 18195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiG4SLH0
PaxDbiG4SLH0
PeptideAtlasiG4SLH0

Expressioni

Tissue specificityi

Expression is restricted to body wall, enteric and vulval muscles.3 Publications

Developmental stagei

Expression begins at 2.5-fold stage and continues throughout adulthood.1 Publication

Gene expression databases

BgeeiWBGene00006436 Expressed in 4 organ(s), highest expression level in material anatomical entity

Interactioni

Subunit structurei

Interacts (via C-terminus) with myosin. Interacts with actin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiG4SLH0, 1 interactor
STRINGi6239.W06H8.8g

Structurei

3D structure databases

DisProtiDP01090
ProteinModelPortaliG4SLH0
SMRiG4SLH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 176Ig-like 1PROSITE-ProRule annotationAdd BLAST87
Domaini406 – 493Ig-like 2PROSITE-ProRule annotationAdd BLAST88
Domaini821 – 913Ig-like 3PROSITE-ProRule annotationAdd BLAST93
Domaini943 – 1038Ig-like 4PROSITE-ProRule annotationAdd BLAST96
Domaini1135 – 1225Ig-like 5PROSITE-ProRule annotationAdd BLAST91
Domaini1679 – 1762Ig-like 6PROSITE-ProRule annotationAdd BLAST84
Domaini3095 – 3177Ig-like 7PROSITE-ProRule annotationAdd BLAST83
Domaini3179 – 3264Ig-like 8PROSITE-ProRule annotationAdd BLAST86
Domaini3789 – 3878Ig-like 9PROSITE-ProRule annotationAdd BLAST90
Domaini3897 – 3985Ig-like 10PROSITE-ProRule annotationAdd BLAST89
Domaini4038 – 4125Ig-like 11PROSITE-ProRule annotationAdd BLAST88
Repeati4599 – 4626PVET 11 PublicationAdd BLAST28
Repeati4627 – 4665PVET 21 PublicationAdd BLAST39
Repeati4666 – 4704PVET 31 PublicationAdd BLAST39
Repeati4755 – 4787PVET 41 PublicationAdd BLAST33
Repeati4788 – 4826PVET 51 PublicationAdd BLAST39
Repeati4827 – 4865PVET 61 PublicationAdd BLAST39
Repeati4917 – 4948PVET 71 PublicationAdd BLAST32
Repeati4949 – 4987PVET 81 PublicationAdd BLAST39
Repeati4988 – 5026PVET 91 PublicationAdd BLAST39
Repeati5027 – 5065PVET 101 PublicationAdd BLAST39
Repeati5066 – 5104PVET 111 PublicationAdd BLAST39
Repeati5105 – 5143PVET 121 PublicationAdd BLAST39
Repeati5144 – 5182PVET 131 PublicationAdd BLAST39
Repeati5183 – 5221PVET 141 PublicationAdd BLAST39
Repeati5273 – 5304PVET 151 PublicationAdd BLAST32
Repeati5305 – 5343PVET 161 PublicationAdd BLAST39
Repeati5344 – 5382PVET 171 PublicationAdd BLAST39
Repeati5434 – 5465PVET 181 PublicationAdd BLAST32
Repeati5466 – 5504PVET 191 PublicationAdd BLAST39
Repeati5505 – 5543PVET 201 PublicationAdd BLAST39
Repeati5544 – 5582PVET 211 PublicationAdd BLAST39
Repeati5583 – 5621PVET 221 PublicationAdd BLAST39
Repeati5622 – 5660PVET 231 PublicationAdd BLAST39
Repeati5661 – 5699PVET 241 PublicationAdd BLAST39
Repeati5700 – 5738PVET 251 PublicationAdd BLAST39
Repeati5739 – 5777PVET 261 PublicationAdd BLAST39
Repeati5778 – 5816PVET 271 PublicationAdd BLAST39
Repeati5817 – 5855PVET 281 PublicationAdd BLAST39
Repeati5856 – 5894PVET 291 PublicationAdd BLAST39
Repeati5895 – 5933PVET 301 PublicationAdd BLAST39
Repeati5934 – 5972PVET 311 PublicationAdd BLAST39
Repeati5973 – 6011PVET 321 PublicationAdd BLAST39
Repeati6012 – 6050PVET 331 PublicationAdd BLAST39
Repeati6051 – 6089PVET 341 PublicationAdd BLAST39
Repeati6090 – 6128PVET 351 PublicationAdd BLAST39
Repeati6129 – 6167PVET 361 PublicationAdd BLAST39
Repeati6219 – 6250PVET 371 PublicationAdd BLAST32
Repeati6251 – 6289PVET 381 PublicationAdd BLAST39
Repeati6290 – 6328PVET 391 PublicationAdd BLAST39
Repeati6329 – 6367PVET 401 PublicationAdd BLAST39
Repeati6368 – 6406PVET 411 PublicationAdd BLAST39
Repeati6407 – 6445PVET 421 PublicationAdd BLAST39
Repeati6446 – 6484PVET 431 PublicationAdd BLAST39
Repeati6485 – 6523PVET 441 PublicationAdd BLAST39
Repeati6524 – 6562PVET 451 PublicationAdd BLAST39
Repeati6563 – 6601PVET 461 PublicationAdd BLAST39
Repeati6602 – 6640PVET 471 PublicationAdd BLAST39
Repeati6641 – 6679PVET 481 PublicationAdd BLAST39
Repeati6680 – 6718PVET 491 PublicationAdd BLAST39
Repeati6719 – 6757PVET 501 PublicationAdd BLAST39
Repeati6758 – 6796PVET 511 PublicationAdd BLAST39
Repeati6797 – 6835PVET 521 PublicationAdd BLAST39
Repeati6836 – 6874PVET 531 PublicationAdd BLAST39
Repeati6875 – 6913PVET 541 PublicationAdd BLAST39
Repeati6914 – 6952PVET 551 PublicationAdd BLAST39
Repeati6953 – 6991PVET 561 PublicationAdd BLAST39
Repeati6992 – 6996BLUE 11 Publication5
Repeati6997 – 7012BLUE 21 PublicationAdd BLAST16
Repeati7013 – 7028BLUE 31 PublicationAdd BLAST16
Repeati7029 – 7044BLUE 41 PublicationAdd BLAST16
Repeati7045 – 7060BLUE 51 PublicationAdd BLAST16
Repeati7061 – 7076BLUE 61 PublicationAdd BLAST16
Repeati7077 – 7092BLUE 71 PublicationAdd BLAST16
Repeati7093 – 7108BLUE 81 PublicationAdd BLAST16
Repeati7109 – 7124BLUE 91 PublicationAdd BLAST16
Repeati7125 – 7140BLUE 101 PublicationAdd BLAST16
Repeati7141 – 7156BLUE 111 PublicationAdd BLAST16
Repeati7157 – 7172BLUE 121 PublicationAdd BLAST16
Repeati7173 – 7188BLUE 131 PublicationAdd BLAST16
Repeati7189 – 7204BLUE 141 PublicationAdd BLAST16
Repeati7205 – 7220BLUE 151 PublicationAdd BLAST16
Repeati7221 – 7236BLUE 161 PublicationAdd BLAST16
Repeati7237 – 7252BLUE 171 PublicationAdd BLAST16
Repeati7253 – 7268BLUE 181 PublicationAdd BLAST16
Repeati7269 – 7284BLUE 191 PublicationAdd BLAST16
Repeati7285 – 7300BLUE 201 PublicationAdd BLAST16
Repeati7301 – 7316BLUE 211 PublicationAdd BLAST16
Repeati7317 – 7332BLUE 221 PublicationAdd BLAST16
Repeati7333 – 7348BLUE 231 PublicationAdd BLAST16
Repeati7349 – 7364BLUE 241 PublicationAdd BLAST16
Repeati7365 – 7380BLUE 251 PublicationAdd BLAST16
Repeati7381 – 7396BLUE 261 PublicationAdd BLAST16
Repeati7397 – 7412BLUE 271 PublicationAdd BLAST16
Repeati7413 – 7428BLUE 281 PublicationAdd BLAST16
Repeati7429 – 7444BLUE 291 PublicationAdd BLAST16
Repeati7445 – 7460BLUE 301 PublicationAdd BLAST16
Repeati7461 – 7476BLUE 311 PublicationAdd BLAST16
Repeati7477 – 7492BLUE 321 PublicationAdd BLAST16
Repeati7493 – 7508BLUE 331 PublicationAdd BLAST16
Repeati7509 – 7524BLUE 341 PublicationAdd BLAST16
Repeati7525 – 7540BLUE 351 PublicationAdd BLAST16
Repeati7541 – 7556BLUE 361 PublicationAdd BLAST16
Repeati7557 – 7572BLUE 371 PublicationAdd BLAST16
Repeati7573 – 7588BLUE 381 PublicationAdd BLAST16
Repeati7589 – 7604BLUE 391 PublicationAdd BLAST16
Repeati7605 – 7620BLUE 401 PublicationAdd BLAST16
Repeati7621 – 7628BLUE 411 Publication8
Repeati7629 – 7644BLUE 421 PublicationAdd BLAST16
Repeati7645 – 7652BLUE 431 Publication8
Repeati7653 – 7668BLUE 441 PublicationAdd BLAST16
Repeati7669 – 7684BLUE 451 PublicationAdd BLAST16
Repeati7685 – 7700BLUE 461 PublicationAdd BLAST16
Repeati7701 – 7716BLUE 471 PublicationAdd BLAST16
Repeati7717 – 7732BLUE 481 PublicationAdd BLAST16
Repeati7733 – 7748BLUE 491 PublicationAdd BLAST16
Repeati7749 – 7764BLUE 501 PublicationAdd BLAST16
Repeati7765 – 7772BLUE 511 Publication8
Repeati7773 – 7788BLUE 521 PublicationAdd BLAST16
Repeati7789 – 7804BLUE 531 PublicationAdd BLAST16
Repeati7805 – 7820BLUE 541 PublicationAdd BLAST16
Repeati7821 – 7836BLUE 551 PublicationAdd BLAST16
Repeati7837 – 7852BLUE 561 PublicationAdd BLAST16
Repeati7853 – 7868BLUE 571 PublicationAdd BLAST16
Repeati7869 – 7884BLUE 581 PublicationAdd BLAST16
Repeati7885 – 7900BLUE 591 PublicationAdd BLAST16
Repeati7901 – 7916BLUE 601 PublicationAdd BLAST16
Repeati7917 – 7932BLUE 611 PublicationAdd BLAST16
Repeati7933 – 7948BLUE 621 PublicationAdd BLAST16
Repeati7949 – 7964BLUE 631 PublicationAdd BLAST16
Repeati7965 – 7980BLUE 641 PublicationAdd BLAST16
Repeati7981 – 7996BLUE 651 PublicationAdd BLAST16
Repeati7997 – 8012BLUE 661 PublicationAdd BLAST16
Repeati8013 – 8028BLUE 671 PublicationAdd BLAST16
Repeati8029 – 8044BLUE 681 PublicationAdd BLAST16
Repeati8045 – 8060BLUE 691 PublicationAdd BLAST16
Repeati8061 – 8076BLUE 701 PublicationAdd BLAST16
Repeati8077 – 8084BLUE 711 Publication8
Repeati8085 – 8100BLUE 721 PublicationAdd BLAST16
Repeati8101 – 8116BLUE 731 PublicationAdd BLAST16
Repeati8117 – 8132BLUE 741 PublicationAdd BLAST16
Repeati8133 – 8148BLUE 751 PublicationAdd BLAST16
Repeati8149 – 8164BLUE 761 PublicationAdd BLAST16
Repeati8165 – 8180BLUE 771 PublicationAdd BLAST16
Repeati8181 – 8196BLUE 781 PublicationAdd BLAST16
Repeati8197 – 8212BLUE 791 PublicationAdd BLAST16
Repeati8213 – 8228BLUE 801 PublicationAdd BLAST16
Repeati8229 – 8244BLUE 811 PublicationAdd BLAST16
Repeati8245 – 8260BLUE 821 PublicationAdd BLAST16
Repeati8261 – 8276BLUE 831 PublicationAdd BLAST16
Repeati8277 – 8292BLUE 841 PublicationAdd BLAST16
Repeati8293 – 8308BLUE 851 PublicationAdd BLAST16
Repeati8309 – 8324BLUE 861 PublicationAdd BLAST16
Repeati8325 – 8340BLUE 871 PublicationAdd BLAST16
Repeati8341 – 8356BLUE 881 PublicationAdd BLAST16
Repeati8357 – 8371BLUE 891 PublicationAdd BLAST15
Repeati8373 – 8388BLUE 901 PublicationAdd BLAST16
Repeati8389 – 8404BLUE 911 PublicationAdd BLAST16
Repeati8405 – 8420BLUE 921 PublicationAdd BLAST16
Repeati8421 – 8436BLUE 931 PublicationAdd BLAST16
Repeati8437 – 8452BLUE 941 PublicationAdd BLAST16
Repeati8453 – 8468BLUE 951 PublicationAdd BLAST16
Repeati8469 – 8484BLUE 961 PublicationAdd BLAST16
Domaini8950 – 9041Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST92
Domaini10461 – 10553Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini12432 – 12547Ig-like 12PROSITE-ProRule annotationAdd BLAST116
Domaini13963 – 14036Ig-like 13PROSITE-ProRule annotationAdd BLAST74
Domaini14153 – 14247Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini14253 – 14348Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini14350 – 14448Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST99
Domaini14451 – 14542Ig-like 14PROSITE-ProRule annotationAdd BLAST92
Domaini14550 – 14634Ig-like 15PROSITE-ProRule annotationAdd BLAST85
Domaini14638 – 14727Ig-like 16PROSITE-ProRule annotationAdd BLAST90
Domaini14826 – 14920Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST95
Domaini14937 – 15027Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST91
Domaini15180 – 15274Ig-like 17PROSITE-ProRule annotationAdd BLAST95
Domaini15283 – 15371Ig-like 18PROSITE-ProRule annotationAdd BLAST89
Domaini15383 – 15475Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST93
Domaini15503 – 15596Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST94
Domaini15599 – 15687Ig-like 19PROSITE-ProRule annotationAdd BLAST89
Domaini15692 – 15786Ig-like 20PROSITE-ProRule annotationAdd BLAST95
Domaini15791 – 15883Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST93
Domaini15934 – 16189Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini16268 – 16358Ig-like 21PROSITE-ProRule annotationAdd BLAST91
Domaini16500 – 16575Ig-like 22PROSITE-ProRule annotationAdd BLAST76
Domaini16605 – 16692Ig-like 23PROSITE-ProRule annotationAdd BLAST88
Domaini16705 – 16789Ig-like 24PROSITE-ProRule annotationAdd BLAST85
Domaini16829 – 16918Ig-like 25PROSITE-ProRule annotationAdd BLAST90
Domaini16932 – 17025Ig-like 26PROSITE-ProRule annotationAdd BLAST94
Domaini17037 – 17126Ig-like 27PROSITE-ProRule annotationAdd BLAST90
Domaini17154 – 17245Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST92
Domaini17249 – 17336Ig-like 28PROSITE-ProRule annotationAdd BLAST88
Domaini17358 – 17447Ig-like 29PROSITE-ProRule annotationAdd BLAST90
Domaini17457 – 17548Ig-like 30PROSITE-ProRule annotationAdd BLAST92
Domaini17570 – 17661Ig-like 31PROSITE-ProRule annotationAdd BLAST92
Domaini17676 – 17765Ig-like 32PROSITE-ProRule annotationAdd BLAST90
Domaini17782 – 17873Ig-like 33PROSITE-ProRule annotationAdd BLAST92
Domaini18008 – 18097Ig-like 34PROSITE-ProRule annotationAdd BLAST90
Domaini18121 – 18213Ig-like 35PROSITE-ProRule annotationAdd BLAST93
Domaini18224 – 18316Ig-like 36PROSITE-ProRule annotationAdd BLAST93
Domaini18329 – 18417Ig-like 37PROSITE-ProRule annotationAdd BLAST89
Domaini18429 – 18519Ig-like 38PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16206 – 16264Autoinhibitory domain1 PublicationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1766 – 1786Sequence analysisAdd BLAST21
Coiled coili2011 – 2038Sequence analysisAdd BLAST28
Coiled coili2065 – 2085Sequence analysisAdd BLAST21
Coiled coili2205 – 2231Sequence analysisAdd BLAST27
Coiled coili2606 – 2630Sequence analysisAdd BLAST25
Coiled coili5212 – 5235Sequence analysisAdd BLAST24
Coiled coili6984 – 7812Sequence analysisAdd BLAST829
Coiled coili7876 – 8273Sequence analysisAdd BLAST398
Coiled coili8316 – 8490Sequence analysisAdd BLAST175
Coiled coili9371 – 9510Sequence analysisAdd BLAST140
Coiled coili9577 – 9749Sequence analysisAdd BLAST173
Coiled coili9822 – 9995Sequence analysisAdd BLAST174
Coiled coili10046 – 10129Sequence analysisAdd BLAST84
Coiled coili11018 – 11064Sequence analysisAdd BLAST47
Coiled coili12408 – 12428Sequence analysisAdd BLAST21
Coiled coili12797 – 12828Sequence analysisAdd BLAST32
Coiled coili12980 – 13103Sequence analysisAdd BLAST124
Coiled coili13237 – 13380Sequence analysisAdd BLAST144
Coiled coili13455 – 13628Sequence analysisAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4503 – 6982Glu-richPROSITE-ProRule annotationAdd BLAST2480

Domaini

The PEVK region may serve as an entropic spring to bear the passive tension of the sarcomere.1 Publication
The BLUE region may serve as a force and thermal sensors.1 Publication
The autoinhibitory domain may interact with the kinase catalytic core thereby preventing its activation.1 Publication

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00860000133679
InParanoidiG4SLH0
OMAiETTYMEA
OrthoDBiEOG091G005W

Family and domain databases

CDDicd00063 FN3, 11 hits
Gene3Di2.60.40.10, 63 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 10 hits
PF07679 I-set, 37 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 11 hits
SM00409 IG, 50 hits
SM00408 IGc2, 37 hits
SM00406 IGv, 4 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 50 hits
SSF49265 SSF49265, 6 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 11 hits
PS50835 IG_LIKE, 38 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (9+)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform gImported (identifier: G4SLH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGNEKKGGG LPPTQQRHLN IDTTVGGSIS QPVSPSMSYS TDRETVMRSA
60 70 80 90 100
SGHATVAETH LIRSIGSQSQ SYTEEHWSSE ITSFVALAPP KFIQVIKAYR
110 120 130 140 150
VHSTDTISLV VEVASDPPAI FEWFYNEKSV LQDRDRFQVG HGINISRLKV
160 170 180 190 200
SRPEQGVYKC VTRNPAGVST SYGYITVNAD REHLSSSKED MRLQRQHSVT
210 220 230 240 250
YHQAPRFLTQ VPNLFVTAGS NVIIDVEVDA NPPARFSWFV NGKEYRDSIH
260 270 280 290 300
GVEMFSPDVN RSVVRFSIPV AGEYKVVASN VHGSAMSCGH VDIQKVIELE
310 320 330 340 350
ESTLTTSTTA FDPMTTSMRA LGNNGRNSRQ AVNMFELNYT QRSSSVPRGV
360 370 380 390 400
RHLESHIEVS NMTGEEKKTQ QQTRTDAASI VESRFHPQPP KPPRAGTSRR
410 420 430 440 450
FLPEPPKFVT TLPSVITVNA EEKLVLSVDV QAIPAAEFAW HVNGFEVKKS
460 470 480 490 500
QSVVLLDEHN KSTLVLHPPV KQGKYKVTAR NDVGSDSVTT QVTRIGEVKD
510 520 530 540 550
GAGSEPPDIV ESAVTVTCSH EEDVGSHSSL QTVRRIQEMQ EEDEVDPIKP
560 570 580 590 600
FIEATSPKVK ESVEHPFANI LNPKKREERL SPSGKGKHLL FAPRITAHPS
610 620 630 640 650
ESVFKILDGS PLKLRVMASS LPPATFLWML NNFELRSNQN VTIRNDEENS
660 670 680 690 700
SEIEFQKAPN GNVTVSAKNH LGEDRWTGKV ILQYESPPPG QKITTIEKVT
710 720 730 740 750
ESWTLEEAVI TQVVPTAADP GDRIVIIVRF DENKTSNCQF NWTINGVNIE
760 770 780 790 800
KLEENLVAVE STEFESSLIV EKLEEQLCGE VVCVVKNQHG EVFSSSAHLR
810 820 830 840 850
IRDDDSSFEI VPPNLPEECA PKIVEPLHSA SFLDGQAMSL RCKITANPSA
860 870 880 890 900
AVVWSKDDVN VEDWVLNKDV TTTVLDGGVC ELLNPECFAE DAGLYKCTAT
910 920 930 940 950
NPHGTAETAA FINVEGAEYI KDHEEAEISE SVLTDDVHII LPPKFIETLT
960 970 980 990 1000
AETDNFQQLG YVRMVATVRS VAPITVSWQK DGMDIYENEK YEVMQFADGA
1010 1020 1030 1040 1050
QILTIRAPTN LDSGVYTCTA ESEHGVSNSS CQVELTISAE SSPESFEKVE
1060 1070 1080 1090 1100
ITPPEEVKET GIDDDIEVIL KEEVSGTAQI EKREEEFKLL VKVADQVAST
1110 1120 1130 1140 1150
LVANVFLEAV HEAVKKIVET EDEEEDNQIE ATQEPRFETS TDEYHVKENG
1160 1170 1180 1190 1200
TIKMAATISG HPTPFLEWYF GEEKLQVSQN VSMYYEAGTS AIILKNVQKR
1210 1220 1230 1240 1250
QGGNYFLRAH NCHGESILPM KLTVDPIEAV THVLETSIPK VVVEQDAKEE
1260 1270 1280 1290 1300
EVRRAAEIIS EQFAQLWVQD AQTEAVSAQA HQTPVVAEQA SEEPTLPEVV
1310 1320 1330 1340 1350
AALQEQKPSV EKAPQPQFEV LETEDQDVVE QMQKQLPPVQ KSMSVQEEKA
1360 1370 1380 1390 1400
SSQRTPSPMN YEDKVKTIQS NLLRVNSHEA MEPIEATNLL LNTALQLKNE
1410 1420 1430 1440 1450
HVCDETTTVI VTQQPQKYDQ LVTVVESNIE YHALRLSTSS SSPLKFIDLE
1460 1470 1480 1490 1500
TIIQKPSTSC ESIDRMFVEK SKRTANAQHR IVVLQGMSNT FHNAITWSLK
1510 1520 1530 1540 1550
KVKKLVGDAE AKAYADVEVV KQDETNEQVM TIIDNDTIVP QLLQVAAAAN
1560 1570 1580 1590 1600
KLKLENVSVA LIKEGDRAHQ ELVIEYESSI DEPMFEPVHN TSHLTFHQQQ
1610 1620 1630 1640 1650
PTGPDQHVWS RRSKFEEDEA HVVAVFVEVD ANCPDQSVEI VATVNAAYEG
1660 1670 1680 1690 1700
DNRQGIEDEP FTEVSQSLAT ESSAAPQAPK FLRKLVNCFG RIGEPVQLKC
1710 1720 1730 1740 1750
LIAGMPQPEI EWTVDGDPIV PNDEYSIVYE DGVCILRIES TLIEDEGEYC
1760 1770 1780 1790 1800
CTASNVAGTT FSKCYLKLSE ADDDAVDLLR QLSEIKIIDP TLSTGYPMSM
1810 1820 1830 1840 1850
ISDEENTSHQ LLSNVLLTDK EVPITATYNE DLSRAESFRR FFESAETTVK
1860 1870 1880 1890 1900
VTELYQGESV EAQFQQPEKR EQVSTSNTDV MFVNQKVDVM ESTVSTVGNA
1910 1920 1930 1940 1950
VRQSVSSSTN SWDYMFNDPF PESQEINVIE NELYEPRVPL LPQKLSYKGQ
1960 1970 1980 1990 2000
EIFANTNTVE RNSKAGAKAK GEVENLKKCV ETLLLFDAEM DMKDIKESSP
2010 2020 2030 2040 2050
KKEIISKKDQ QSLDDQIKVT QQILKDVERD LNKMERTSPG KSLSPNKRTF
2060 2070 2080 2090 2100
APKDVEDIEA AIFSISDQLA DRQSSEEALR EALQEMILSN SSPMKELSRN
2110 2120 2130 2140 2150
NETSKPEVLK SEIQKIPEVE TKISEVYPIV KLKQAISAIE NSLLEDTEVT
2160 2170 2180 2190 2200
EIMKRKGSDK DKRKATRIKR VPSAHSARIT PITSNLRDRL NQLHQLTVSE
2210 2220 2230 2240 2250
DSGSLKQNEE AKEIQELFVK IEKEINTIAE LCKEKMTKKG ADTVTHVLNS
2260 2270 2280 2290 2300
VLQHVASIIN VILVAQDHQP IEVHAETTKT AEVSVWYSFD VHPESEDIIG
2310 2320 2330 2340 2350
IVDEEPTNRR PSSTPRGSTR SSNLTTSQDS QATTKMTVSS EDTIEAPIAP
2360 2370 2380 2390 2400
PRKGRSLSRD AERLLEIQPR APPRRSRQSG DTLSPEPTPV LTLVKSDETP
2410 2420 2430 2440 2450
APVRPPRSRS RHSGDELAET SPEAQPIRPP RSHSRHSGDE LEEVQPVRPP
2460 2470 2480 2490 2500
RSKSKTADAN CLQIESMDES QYSLSCIHIQ KTNFAFTNST HETSNASVVV
2510 2520 2530 2540 2550
DLRNMAQLEC TVQSLDDLAS IQMLCEESDY PSDTDRSLLL AGTVRYFNRA
2560 2570 2580 2590 2600
SPSLHEVSPS LNMESVSMDL KPETEPEEIV QDVYVNVELH SVPSLSSLVE
2610 2620 2630 2640 2650
VNPNTLMQTL ASEKSSLKAA EEDEKEGEEE GEEEVTADVS FIGRSVLSTE
2660 2670 2680 2690 2700
TLDVVLEEKD MSQMNSTLPL DYERAFSSNT IRETDILSDE SITVDSSYHK
2710 2720 2730 2740 2750
SPEPTVDFAR SQVKSEEVTE NFSLIHKPAR RRVTGIVVNS LIYTIAANIA
2760 2770 2780 2790 2800
EDNTFDVDVV QEPQRYNISI KVIEDIVDFT SLTIMSDCED DPPADVLVLK
2810 2820 2830 2840 2850
QDTSKLQALS YDDISVATTR TGITVSIVAR SLNDGIYASL EEIAWGEVEM
2860 2870 2880 2890 2900
TVPDIMQMST EEKSSLQFNV TVSESNLEEA KSLKSQVSFR SSQNSVSEMD
2910 2920 2930 2940 2950
NTISSTATIS IPSYVVKLES TATITCELNN YLPKNCTIDW YCGKTKIIID
2960 2970 2980 2990 3000
HEQFDRISHD LLEVLIIRSV EAINGNLYSL KINEDLFPVA YLIVENTNLT
3010 3020 3030 3040 3050
TSANILTRPE TQFVMEGQPT VITVELDDPN VIVNWLKDRR PLHENERIRL
3060 3070 3080 3090 3100
ETDGQGNHRV IIPNTCVGDQ GTYLALTSSE SVAITLVVEE RIEEKEVMVI
3110 3120 3130 3140 3150
ASGTESEEDD VQEYLVPPGS TATIACELEE CELKRSIRWL RDGKDIRFEQ
3160 3170 3180 3190 3200
GKTEHVQNGL KHYLVVHDAT SLDSGLYKTE RSEEQCEETI IPRGVVATIQ
3210 3220 3230 3240 3250
CQTSEPQESI QWSKDGNIIP SDISRFEFRS LDNNQSHEMV ISNISWSDAG
3260 3270 3280 3290 3300
VYSVLINGKS SFVSKIVVVE SELITQSVEE EPEAEPEIDV SLHIVESEQI
3310 3320 3330 3340 3350
IELNVPQSPK LGASHETLVP IGQDDIEVID KQEAAPVVES IEETSSIGSE
3360 3370 3380 3390 3400
EFEIIEKFTE EEVPKVAEPS EPTQADVPKI AAPLEQSQIQ QEVPTVAAPS
3410 3420 3430 3440 3450
EPTQADVPKE AAPSEPSQAD VPKVAAPLEQ TQIQQEVPMV AAPLEPTQAD
3460 3470 3480 3490 3500
VPKVAAPLEQ SQIQQEVPTV AAPSEPTQAD VPKEAAPSEP SQADVPKVAA
3510 3520 3530 3540 3550
PLEQTQIQQE VPMVAAPLEP IQEEVPKEAA PSEPTQEDVP KGAAPLEPTQ
3560 3570 3580 3590 3600
EDVPKEAAPS GPTQEDVPKE EAPSEPTQED VPKEAAPSEP TQENVPKEAA
3610 3620 3630 3640 3650
PSEPTKDVPK EAAPSEPIQE EVPKEATLSE PTQEQSEVSK RSEPVEPTQI
3660 3670 3680 3690 3700
QQAASEEETP LEETNETVVQ TNEDVKEAEV PENAEAQKVV DSSDLQVAAS
3710 3720 3730 3740 3750
EIAHLAIDEA VLETSNQPSQ FDSLQEQKPS VVHENEHVRS VCVDLTFSRD
3760 3770 3780 3790 3800
SEQIVSDVIV AEVGYDEDEC STIADTITSL SSSPLYTAPV FTERLPSSAC
3810 3820 3830 3840 3850
FANSKLTLEV MFSGVPQPTI SWLIDDHELV SDGERISIKC ENGVSAIRFF
3860 3870 3880 3890 3900
NVDRNAGGFL KCRATNCAGQ VETSCEIVAA DEISVISDSS ITSSTRPHFV
3910 3920 3930 3940 3950
VPLPERVTHT VNDHITIKCK FSGQPLPAAM WEKDGVLLDL QKYQVTTEDG
3960 3970 3980 3990 4000
TSILKIESAS LDDKAVYTCT IANEAGCEST SCTIDVVDDH LGLQQTGLHV
4010 4020 4030 4040 4050
MCERDQNDVE LDILVQSPNH LGVTFNFPPV NRTLARQPPY FLLPLSDKVV
4060 4070 4080 4090 4100
IDEKCTLKCV VMGIPLVIVK WIVDGVVVTE DDNHEIHFED GIALLRMKNI
4110 4120 4130 4140 4150
KKDKSVVQCE AINCKGKVTT SCVLTKCGVE ESEAGDLQKP SFVLSLKDTC
4160 4170 4180 4190 4200
TTTDHATLKC IVVGTPLPDV SCSFNGVTDN SKIRSEDGIV LIQVNDVTEE
4210 4220 4230 4240 4250
GIVVECTISN ETGSSTSNCV VKIIKQEEKN YQRPIIVFNQ AGSVNNEREL
4260 4270 4280 4290 4300
SVKVGVIASP EPTLFWKHNG KSIEEGGDYY LIFEDGIGIL KVFNIQDGSH
4310 4320 4330 4340 4350
EFTCIAKNEY GQTTVEIPVE IGLKTENKLT LVKTLNDIAV VDDIVQLKIV
4360 4370 4380 4390 4400
AEGDLPIEFK WFEDGQILED DSSHKITVDK CISTLQLKLE ETGTRIITCE
4410 4420 4430 4440 4450
VSNSSSKVNA SCNVERVHNT VSDFVMTNDN STRFLAVGRK CTRERNNTIL
4460 4470 4480 4490 4500
KAVVVARENI GDICEIDGEK IPDAYIEGNS LSIKVDTLSK KLSNVSFKVS
4510 4520 4530 4540 4550
ASEGKVFETR KIEIAQEDTD EENFEINYSL RIDEQSGNTT YTFENSELYQ
4560 4570 4580 4590 4600
GNQSRELDNT ERNFTVNKEK DESKKPSEVQ PAEIVEQKDV PVQETSAPTV
4610 4620 4630 4640 4650
EKLAPVESKE TPEVQAAEIV EQKDVPVPET RAPTVEPTVE KHTPVDSKET
4660 4670 4680 4690 4700
SEVEPAEIVE QKDVPVPETS APTVEPTVEK HTPVESKEKS EVQPAEIVEQ
4710 4720 4730 4740 4750
KDVTCEEEIK ELLTEVEVEL FFSQAEVFSG LELDLLMECS EYVTTSIQKG
4760 4770 4780 4790 4800
STAAPAQEPT VEKLAPVESK ETSEVEPAEI VEQKDVPVPE TSAPSVEPTV
4810 4820 4830 4840 4850
EKLAPVESKE TSEVQQAEIV EQKDVPVPET SAPSVEPTVE KLAPAESKET
4860 4870 4880 4890 4900
SEVQPAEIVE QKDVTCEEEI KELLTEVEVE LFFSQAEVFS GLELDLLMEC
4910 4920 4930 4940 4950
SEYVTTSIQK GSTAAPAQEP TVEKLAPVES KETSEVQQAE IIEQKDVPVP
4960 4970 4980 4990 5000
ETSAPTVEPT VEKLKPVESK ETSEVQQVEI IEQKDVPVPE TSAPTVEPTV
5010 5020 5030 5040 5050
EKLAPVESKE TSEVQQAEII EQKDVPVPET SAPTVEPTVE KLKPVESKET
5060 5070 5080 5090 5100
SEVQQVEIIE QKDVPVPETS APTVEPTVEK LAPVESKETS EVQQAEIIEQ
5110 5120 5130 5140 5150
KDVPVPETSA PTVEPTVEKL KPVESKETSE VQQVEIIEQK DVPVPETSAP
5160 5170 5180 5190 5200
TVEPTVEKHA PVESKETSEV QPAEIVEQKV VPVPETSAPT VEPTVEKLAP
5210 5220 5230 5240 5250
VESKETPEVQ PAEILEQKDV TCEEEIKELL TEVEVELFFS KAEVFSGLEL
5260 5270 5280 5290 5300
DLLMECSEYV TTSIQKGSTA APAQEPTVEK LAPVESKETS EVEPAEIVEQ
5310 5320 5330 5340 5350
KDVPVPETSA PTVEPTVEKL KSVESKETSE VQQAEIIEQK DVPVPETSAP
5360 5370 5380 5390 5400
TVEPTVEKLA PVDSKETSEV EPAEIVEQKD VTCEEEIKEL LTEVEVELLF
5410 5420 5430 5440 5450
SQAEVFSGLE LDLLMECSEY VTTSIQKGST AAPAQEPTVE KLAPVESKET
5460 5470 5480 5490 5500
SEVEPAEIVE QKDVPVPETS APTVEPTVEK LKSVESKETS EVQQAEIIEQ
5510 5520 5530 5540 5550
KDVPVPETSA PTVEPTVEKH APVESKETSE VQPAEIVEQK VVPVPETSAP
5560 5570 5580 5590 5600
TVEPTVEKLA PVESKETSEV EPAEIVEQKD VPVPETSAPT VEPTVEKLAP
5610 5620 5630 5640 5650
VESKETSEVE PAEIVEQKDV PVPETSAPTV EPTIEKLAPV ESKETSEVEP
5660 5670 5680 5690 5700
AEIVEQKDVS VPETSAPTVE PTIEKLAPVE SKETSEVEPA EIVEQKDVSV
5710 5720 5730 5740 5750
PETSAPTVEP TVEKLAPVES KETSEVEPAE IVEQKDVPVP ETSAPTVEPT
5760 5770 5780 5790 5800
VEKLAPVESK ETSEVQPAEI VEHKDVQVPE TSSPTVEPTV EKLAPVESKE
5810 5820 5830 5840 5850
TSEVEPAEIV EQKDVPVPET SAPTVEPTVE KLAPVESKET SEVEPAEIVE
5860 5870 5880 5890 5900
QKDVPVPETS APTVEPTVEK LAPVESKETS EVQPAEIVEQ KDVSVPETSA
5910 5920 5930 5940 5950
PTVEPTVEKL APVESKETSE VQPAEIVEQK DVPVPETSAP TVEPTVEKLA
5960 5970 5980 5990 6000
PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE
6010 6020 6030 6040 6050
PAEIVEQKDV PVPETSAPTV EPTVEKLAPV ESKETSEVQP AEIVEHKDVQ
6060 6070 6080 6090 6100
VPETSAPTVE PTIEKLAPVE SKETSEVEPA EIVEQKDVSV PETSAPTVEP
6110 6120 6130 6140 6150
TIEKLAPVES KETSEVQPAE IVEHKDVQVP ETSSPTVEPT VEKLAPVESK
6160 6170 6180 6190 6200
ETSEVQPAEI VEQKDVTCEE EIKELLTEVE VELFFSQAEV FSGLELDLLM
6210 6220 6230 6240 6250
ECSEYVTTSI QKGSTAAPAH EPTVEKLAPV ESKETSEVEP AEIVEQKDVP
6260 6270 6280 6290 6300
VPETSAPTVE PTVEKLAPVE SKETSEVEPA EIVEQKDLPV PETSAPTVEP
6310 6320 6330 6340 6350
TVEKLAPVES KKTSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK
6360 6370 6380 6390 6400
ETSEVEPAEI VEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVEPAEIV
6410 6420 6430 6440 6450
EQKDVPVPET SAPTVEPTIE KLAPVESKET SEVEPAEIVE QKDVSVPETS
6460 6470 6480 6490 6500
APTVEPTIEK LAPVESKETS EVEPAEIVEQ KDVSVPETSA PTVEPTVEKL
6510 6520 6530 6540 6550
APVESKETSE VEPAEIVEQK DVPVPETSAP TVEPTVEKLA PVESKETSEV
6560 6570 6580 6590 6600
QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV
6610 6620 6630 6640 6650
PVPETSAPTV EPTVEKLAPV ESKETSEVEP AEIVEQKDVP VPETSAPTVE
6660 6670 6680 6690 6700
PTVEKLAPVE SKETSEVQPA EIVEHKDVQV PETTATTFEP TKEKLAPVDS
6710 6720 6730 6740 6750
KETSEVQTAE IVEQKDVPVP ETSATTVEPT KEKLAPGESK ETSEVQQAAI
6760 6770 6780 6790 6800
VEQKDVAVPE TSATTVEPTK EKLAPVESKE TSEIQTAEIV EQKDVPVPET
6810 6820 6830 6840 6850
STSYVEPTKE KLAPGESKET SEVQQAAIVE QKDVPVPETS ATTVEPTKEK
6860 6870 6880 6890 6900
LAPVESKETS EIQQAAVVEQ KDVPVPETSA TTVEPTKEKL APVESKETSE
6910 6920 6930 6940 6950
VQQAAIVEQK DVPVPEANAP TFEPTVEKLA PVESKETSEV QQAAIVEQKD
6960 6970 6980 6990 7000
VPVPEANAPT VEPTVEKLAP VESKETSVES KETQADAKLK KEKDDKHKQE
7010 7020 7030 7040 7050
ADAKLQKEND DKLKQEADAK LKKENDDKLK QEADAKLKKE NDDKLKQEAD
7060 7070 7080 7090 7100
AKLKKENDDK LKQEAAAKLK KENDDKLKQE ADAKLKKEND DKLKQEADAK
7110 7120 7130 7140 7150
LQKENDDKLK QEADAKLQKE NDDKLKQEAD AKLQKENDDK LKQEADAKLQ
7160 7170 7180 7190 7200
KENDDKLKQE ADAKLQKEND DKLKQEADAK LKKENDDKLK QEADAKLKKE
7210 7220 7230 7240 7250
KHDKLKQEAD AKLQKENDDK LKQEADAKLQ KENDDKLKQE ADAKLQKEKD
7260 7270 7280 7290 7300
DKLKQEADAK LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK
7310 7320 7330 7340 7350
LKHEADAKLQ KEKDDKLKQE ADAKLKKEKD DRLKKDADAK LQKEKDDKLK
7360 7370 7380 7390 7400
QEADAKLKKE KDDKLKHEAD AKLQKEKDDK LKQEADAKLK KEKDDKLKQE
7410 7420 7430 7440 7450
ADAKLQKEKD DKLKQEADAK LKKEKDDKLK QEADAKLQKE KDDKLKQEAD
7460 7470 7480 7490 7500
AKLKKEKDDK LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK
7510 7520 7530 7540 7550
LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLK
7560 7570 7580 7590 7600
KEKDDKLKQE ADAKLKKEKD DKLKQDADAK LKKEKDDKLK HEADAKLQKE
7610 7620 7630 7640 7650
KDDNFKQEAN AKLQKEKDDK LKQEKDDNFK QEANAKLQKE KDDKLKQEKD
7660 7670 7680 7690 7700
DKLKQEADAK LKKEKDDKLK QEADAKLKKE KDDKLKQEAD AKLKKDKDDK
7710 7720 7730 7740 7750
LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK LKKDKDDKLK
7760 7770 7780 7790 7800
QEADAKLKKE KDDKLKQEKN DKLKQEADAK LKKEKDDKLK QEADAKLKKE
7810 7820 7830 7840 7850
KDDKLKQETD AKLKKDKDDK LKQEADAKLK KDKDDKLKQE ADAKLKKDKD
7860 7870 7880 7890 7900
DKLKQEADGK LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK
7910 7920 7930 7940 7950
LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK LKKEKDDKLK
7960 7970 7980 7990 8000
QEADAKLKKD KDDKLKQEAN AKLQKEKDDK LKQEADAKLQ KEKDDKLKQE
8010 8020 8030 8040 8050
ADAKLKKEKD DKLKQEADAK LQKEKDDKLK QEADAKLKKE KDDKLKQEAD
8060 8070 8080 8090 8100
AKLQKEKDDN FKQEANAKLQ KEKDDKLKQE KDDKLKQEAD AKLKKEKDDK
8110 8120 8130 8140 8150
LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK
8160 8170 8180 8190 8200
QEADAKLKKD KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE
8210 8220 8230 8240 8250
TDAKLKKDKD DKLKQEADAK LKKEKDDKLK QEADAKLKKE KDDKLKQEAD
8260 8270 8280 8290 8300
AKLKKEKDDK LKQEADAKLK KDKDDKLKQE ADAKLKKDKD DKLKQEADGK
8310 8320 8330 8340 8350
LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK LKQEADAKLK
8360 8370 8380 8390 8400
KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD
8410 8420 8430 8440 8450
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD
8460 8470 8480 8490 8500
DKLKQEADAK LKKDKDDKLK QEADAKLKKE KGDKLKLEDQ TNQSRIFEET
8510 8520 8530 8540 8550
SIEVTSLLKC KQQAIIVSKS FALCERVVLN AEEPFTLEVF CNAVFVKQRT
8560 8570 8580 8590 8600
DKIGIGIIFE RSGASKKDES RPDRLDDNCV LTDVTDGLSI LSPPPKAKKH
8610 8620 8630 8640 8650
LKKKKKHHKK EKIAVKETEQ DEKTVSHLKP EISGMERKRS NSGSSDIFVD
8660 8670 8680 8690 8700
VDIEAGEESI HTDALVDLNF YDYDQMELSI FEDYDSDDDS ASIDCDVSLS
8710 8720 8730 8740 8750
NVAADDGIDV FPSDGDTQEV EQKVTLPKKH QSDEDVISKE EENLETSVSY
8760 8770 8780 8790 8800
GSIEETVSFT IGTGQSIIEH PKSHAVGQMN SEVIIKCKTS QPISDAKWFC
8810 8820 8830 8840 8850
NGMVLLPDEQ VNMTVTGCEA VLRLVKFLPQ NKGNYHVLID GSIGSQPAIL
8860 8870 8880 8890 8900
SGPVPPVILN KLTKPITHQA GKSFTYKFNF MGAPAPRLRV LSNGEPVSFD
8910 8920 8930 8940 8950
VKYEIYDNIA SLYIPKMSKR DGGEYTVVLE NKYGKDESDL HITMVDTPLK
8960 8970 8980 8990 9000
PRKAQLVALT DTSATFKWLP PHTGESDILH YIVMRRSTES RRWRNIGHVQ
9010 9020 9030 9040 9050
EKTFTAIELV PNEFYAFRIV AVNGFGEGAP SEIIEVNTLD YDQEESFDFA
9060 9070 9080 9090 9100
GEEELKLDDV QVNNEVVTEI TIEESEVTIE EHRKLKKKSK KSKKTTDEPE
9110 9120 9130 9140 9150
LDSEIALEVS SDITSSLEIT TESTIPDTAP ESQETLNVEI AVTETTVQKI
9160 9170 9180 9190 9200
TNPSDESAKK DVNEDTAVSS IVKKDDKDVN KKSLPESGLT TKKEIQGKPE
9210 9220 9230 9240 9250
KKIMKKKTEK ADSSISETSE TLTKDLTQTK QSEPEPAKRT TETSVQDEVK
9260 9270 9280 9290 9300
RKTETTSKSK QTTEEHPQPG GKSDSSISST SDASEVKQVQ QSESEAQKVT
9310 9320 9330 9340 9350
EKPETAKLES KSKMTEDTTK ESDNKETVDE KPKKKVLKKK TEKSDSTISE
9360 9370 9380 9390 9400
TSETSAVESA GPSESETQNV AAVDKEKKQK ETDEKQKLEA EIAGKKSTEQ
9410 9420 9430 9440 9450
KSKLEAEAKL KRAAEEDAAK KQKEKTEAAS KKAAAEKLEL EKQAQINKAA
9460 9470 9480 9490 9500
EADAVKKQNE LDEQNKLEAT KKLAAEKLKL EEQSAAKSKQ AAEEQAKLDA
9510 9520 9530 9540 9550
QTKAKAAEKQ TGLEKDEKSN KDSGSNETVE EKPKKKVLKK KTEKSDSSIS
9560 9570 9580 9590 9600
QKSDTSKTVA ESAGSSESET QKVADATSKQ KETDKKQKLE AEITAKKSAD
9610 9620 9630 9640 9650
EKSKLETESK LIKAAEDAAK KQKEKEDKLK LEADVASKKA AAEKLELEKQ
9660 9670 9680 9690 9700
AQIKKAAEAD AVKKQKELAE KQKLESEAAT KKAAAEKLKL EEQAQINKAA
9710 9720 9730 9740 9750
EADAVKKQKE LDEKNKLEAN KKSAAEKLKL EEESAAKSKQ TVEEQAKLDA
9760 9770 9780 9790 9800
QTKEKTAEKQ TGLEKDDKST KDSESKETVD EKPKKKVLKK KTEKSDSSIS
9810 9820 9830 9840 9850
QKSVTSKTVV ESGGPSESET QKVADAARKQ KETDEKQKLE AEITAKKSAD
9860 9870 9880 9890 9900
EKSKLEAESK LKKAAEVEAA KKQKEKDEQL KLDTEAASKK AAAEKLELEK
9910 9920 9930 9940 9950
QAQIKKAAEA DAVKKEKELA EKQKLESEAA TKKAAAEKLK LEEQKKKDAE
9960 9970 9980 9990 10000
TASIEKQKEQ EKLAQEQSKL EVDAKKSAEK QKLESETKSK KTEEAPKESV
10010 10020 10030 10040 10050
DEKPKKKVLK KKTEKSDSSI SQKSDTAKTV AESAGQSDSE TQKVSEADKA
10060 10070 10080 10090 10100
HKQKESDEKQ KLESEIAAKK SAEQKSKLET EAKTKKVIED ESAKKQKEQE
10110 10120 10130 10140 10150
DKKKGDDSAK KQKDQKEKQK LESEATSKKP TSEKQKDEKT PQEKAKSENE
10160 10170 10180 10190 10200
TVMTTEPQQL EVKSEPKKSD KTETVEKEVA SSTEKSDDSK TKEPKEKKKI
10210 10220 10230 10240 10250
IKKKKDTTKP QEASKELSSD ESRIDLESDI SLSLDTVTES DDLSTASTIK
10260 10270 10280 10290 10300
LQKESDESGI DSRMGQTSEA EDSPFISQPV SATVTEMAGE AKFTVKFSRK
10310 10320 10330 10340 10350
PIYVKWMRDD REIRVAYGKA SVETTDDSSV LVIKNIDGKD VGNIYAVFDS
10360 10370 10380 10390 10400
EYRSAMARLD LRVPCKITLE SSSNAPEIVA GKNLDLSFKI SGYPLPTNIE
10410 10420 10430 10440 10450
LLHNNENLRT RSDVTDFDDS ISIRMKRLKL EDSGEIKIIG KNDSSEDQLR
10460 10470 10480 10490 10500
IPINVIEVTS KPTSLQVTST ERETVTLTWS LPTELNGSNV NEYLVERKTV
10510 10520 10530 10540 10550
DGGRWRHACT VTDSRAVVDG LFSGTEYVFR VVAVNGAGQS APSDTIEATT
10560 10570 10580 10590 10600
QAEEEIDETV PTSPVEKVKE PVSKKPENTK ESEGHKKRDR KESEDHDENN
10610 10620 10630 10640 10650
LGKSGKDEFA TSGESGTSNQ NEESAQLNTS FTSTEQHGQT EKQVRKGTRK
10660 10670 10680 10690 10700
SLTRSLNIRE SDIDADVVEV EYDEQGDDIP SDPTTSGTYA FDKIEEEPAR
10710 10720 10730 10740 10750
TSGEMAMAEK DSDAMEVRGL NKKLSKKGGK EGTSTEKSSS KTKKQEKSAL
10760 10770 10780 10790 10800
SVQEMNKSLK KKGEKGEAET AASDFIENAD QTGMSIQDLN KSMKKKVESG
10810 10820 10830 10840 10850
EATGQINDAS NNKDADELSI QDSQQSLKKK SENESVTGEQ LDKSQEVEDD
10860 10870 10880 10890 10900
KMTIQSLKKS IKKKPESREV SGGKSEKSKE KESDEMSIQQ LNKSVKKKPE
10910 10920 10930 10940 10950
NEAVTQGKSG KSQEQESDKM SIQALNKSMK KKDGVDGVEG NINIGRSDGD
10960 10970 10980 10990 11000
QLSVNDIDAE LSTSEQVENA SQNLGATADS DGDSLSLQTL KKRISKKGIH
11010 11020 11030 11040 11050
GEAESKLGEK QSGSDSFTLQ DLYEELKAKE DAVEAGAETS NADQSAEKTS
11060 11070 11080 11090 11100
LEVRDMKKKM KKKQVSGTAE NLIGESNRDE TSMEIRDLNT QHSNQTGEDE
11110 11120 11130 11140 11150
SSTFNFGQKD QEQYSMVMKD VSKKLARQNA EEIQSGKLIP TTNEEKTGLA
11160 11170 11180 11190 11200
LTGKNKNLKK GEENEKTKFE AKHLGSSSAS DSLAESTLRS KKTKKGEVEK
11210 11220 11230 11240 11250
SELSIDMKNQ DKTTLATTLL EDDLAKTTSA EESEAEHLVA LQNKEKTSLA
11260 11270 11280 11290 11300
MRRKRVSFDS STKSESIEDV IPDKNRDSDK MSITGIKKKM SQKSESAEAQ
11310 11320 11330 11340 11350
KNESPEVKEI SSFEEKTLKS KKKSKADRNQ GTEANLGDKT IDKDYLSVTD
11360 11370 11380 11390 11400
KNQSLEKSEA SGQAEKSIKA PNKSKVTTSF ADESLTSELD RLMADEEMAE
11410 11420 11430 11440 11450
MMFAEEEKAA DLLNVMNKNK GLNKSEQEES QEISLKSQSK VKDSDSLSST
11460 11470 11480 11490 11500
DKKIGLKKSD KDQKLGTSKI FGSKDQESVG YEEKTSNFSK QRRGVSDLGS
11510 11520 11530 11540 11550
DAMTDQKNVQ ESQYAEISAD DHMSKTGADG EISATRTIVD GSDAAQGSEY
11560 11570 11580 11590 11600
AEISKKRKFK RAEQIGEAET SLCDSRENTH DSLSISDVNP ELRRSNVEIS
11610 11620 11630 11640 11650
AFGQIDLTAE EVTSLTDINK DAQLTKKQDE NDAKKSVSKN LKAGAKKDSD
11660 11670 11680 11690 11700
TLSITSKKDK FGKRQDSREA SATVEQQGEE KVTKNLKGSR GKKEKLGDAG
11710 11720 11730 11740 11750
IDVNFENQEE FASTTGDIES IVSEKGHDTY SEKTVKSSKK KSPQTAGAEY
11760 11770 11780 11790 11800
GGSESLNASS ALSTTDVDAQ LKNQEKDGVA ESSIGKSNQK DSYSEQELNV
11810 11820 11830 11840 11850
NKKKKQAVGA AMNQGSGSTK ESDNLAVASV ESNLAKDSAN QEASLHGLVD
11860 11870 11880 11890 11900
NDATSLSQLD SEHRLKKRDD ELSAHTKLGK HTQSENIALT ETDDSLVKGD
11910 11920 11930 11940 11950
SEESAELNIK QQGETAEDKY VESRKKTTLK KKPEQKQVTD TLSAVDGRHD
11960 11970 11980 11990 12000
TTSLSVADSG ISFDKSMENE LAGSGDGTAS ASVSAKVRGA DGNAKTNLIS
12010 12020 12030 12040 12050
SFEKPGQESK TSKTLSGKQK KQEKSSFAEK NAGFDLSMGE GKNDESVESS
12060 12070 12080 12090 12100
LQKNRDADSL ALQGTDLAFS KPSDSSANAH LDMPQRELTL RICQAETVDW
12110 12120 12130 12140 12150
SDDSEVEEGT RTSAPGEVKK KKKFIISAIS QDGEFSDAES ITFDENGVRV
12160 12170 12180 12190 12200
EKRRRKKRDP KEYMGAGELA MRIPAFAKKM QYIGCIEGDV VVFTIKVVSD
12210 12220 12230 12240 12250
DVPLIRMYRN DFPVANFDKM AFEGFTKGSE HSFNVTINDI RKLDGGKLVF
12260 12270 12280 12290 12300
EAKNDYGVDK CTILLDVRDS GSFIEDYSEI HRSAEIQNSV GDVQVKEGET
12310 12320 12330 12340 12350
AKLTGRVDGF PLPELIWIKN GKEIDMMVPS TKYQLDYHSD GEFEARIANC
12360 12370 12380 12390 12400
TFEDDDDYSL LVENLAGVDS CNFQVFVDCN EYPDDEHFNR RRRLQRGRRV
12410 12420 12430 12440 12450
MEASSDSELD DAKKRKKRRI KRVVERRNPN APRLTQLIPP RFDKILSDHD
12460 12470 12480 12490 12500
AIEGENVVMM VETLGEPEPQ VRFYRDGKLI DDGSGDRMEV RHEDEMRKHW
12510 12520 12530 12540 12550
LILKDICKDE EAEYACQAIN VAGEAWCFSD VVVHMSEESR DDDKSVDEVD
12560 12570 12580 12590 12600
DSTVLEEKKD DGDDKSKPKT KKKIIKKKET PESEQVTAAE PEQQKISEVD
12610 12620 12630 12640 12650
VQSVAETEVG AKKKPDAEKP TDLSKAKKDS KSKKSDEPEA STEEKSTTEK
12660 12670 12680 12690 12700
PTNDKTSKKS AEKKTVKPKK EVTGKPLEAK KPVEDKKDAS QPSSSKESSP
12710 12720 12730 12740 12750
PTDGKKKKQI PKALFIPDEI SSRFGDPSTM HSETNITTTI RGREGSADAK
12760 12770 12780 12790 12800
TPLVEPLSAS VSMKVESAKE KAEFSFKRRS ETPDDKSRKK EGLPPAKKSE
12810 12820 12830 12840 12850
KKDEVTAEKQ STEALIESKK KEVDESKISE QQPSDKNKSE VVGVPEKAAG
12860 12870 12880 12890 12900
PETKKDVSEI EEVPKKKTIK KKTEKSDSSI SQKSNVLKPA DDDKSKSDDV
12910 12920 12930 12940 12950
TDKSKKTTED QTKVATDSKL EKAADTTKQI ETETVVDDKS KKKVLKKKTE
12960 12970 12980 12990 13000
KSDSFISQKS ETPPVVEPTK PAESEAQKIA EVNKAKKQKE VDDNLKREAE
13010 13020 13030 13040 13050
VAAKKIADEK LKIEAEANIK KTAEVEAAKK QKEKDEQLKL ETEVVSKKSA
13060 13070 13080 13090 13100
AEKLELEKQA QIKKAAEADA VKKQKELNEK NKLEAAKKSA ADKLKLEEES
13110 13120 13130 13140 13150
AAKSKKVSEE SVKFGEEKKT KAGEKTVQVE SEPTSKKTID TKDVGATEPA
13160 13170 13180 13190 13200
DETPKKKIIK KKTEKSDSSI SQKSATDSEK VSKQKEQDEP TKPAVSETQM
13210 13220 13230 13240 13250
VTEADKSKKQ KETDEKLKLD AEIAAKTKQE ADEKSKLDAQ EKIKKVSEDD
13260 13270 13280 13290 13300
AARKEKELND KLKLESEIAT KKASADKLKL EEQAQAKKAA EVEAAKKQKE
13310 13320 13330 13340 13350
KDEQLKLDTE AASKKAAAEK LELEKQAQIK KAAGADAVKK QKELDEKNKL
13360 13370 13380 13390 13400
EANKKSAAGK LKIEEESAAK SKQTVEEQAK LDAQTKAKTA EKQTKLEKDE
13410 13420 13430 13440 13450
KSTKESESKE TVDEKPKKKV LKKKTEKSDS SISQKSETSK TVVESAGPSE
13460 13470 13480 13490 13500
SETQKVADAA RKQKETDEKQ KLEAEITAKK SADEKSKLEA ESKLKKAAEV
13510 13520 13530 13540 13550
EAAKKQKEKD EQLKLDTEAA SKKAAAEKLE LEKQSHIKKA AEVDAVKKQK
13560 13570 13580 13590 13600
ELEEKQRLES EAATKKADAE KLKLEEQKKK AAEIALIEIQ KEQEKLAQEQ
13610 13620 13630 13640 13650
SRLEDEAKKS AEKQKLESET KSKQTEEAPK ESVDEKPKKK VLKKKTEKSD
13660 13670 13680 13690 13700
SSISQKSKSA KSTVDAAETL ESDFNLVEKK TVQKVEQSPD ESTSATIKRD
13710 13720 13730 13740 13750
PAQKTEEISK QDDGDEKKTT TDGKPPKPED SEATPKKRVV KKKTQKSDSV
13760 13770 13780 13790 13800
ASDASLADVS KLSDDVEEKP KKKVLKKKTE KSDSVISETS SVDTIKPESV
13810 13820 13830 13840 13850
EIPTEKAEQM ILHNRFSTDS AVESEPKNAH KDDTEKTTDD MMTRRKSSAI
13860 13870 13880 13890 13900
FSDDEQSISS KTSSEGRRRR RRTGFASKFA SDTLALRGDN VEIEAELLAE
13910 13920 13930 13940 13950
DDTVTWKVNG KDADLNSRCH EMSHTFFRTL IIDEVEPTDS GMEITATCGT
13960 13970 13980 13990 14000
ESHTTILKVE ELPVDFVKYL PRKTSGKEGQ EVTISVTLNH PIDISKVVWL
14010 14020 14030 14040 14050
KDGKPLEINK DYSIDTVGCS VSLTLRRAKY EDSGKYKVVC DGVDCSTHLS
14060 14070 14080 14090 14100
IQGKPVLKNV SETKPVITVD KDDQFSLLVA YDSNPEASFS MTVDGKDLEF
14110 14120 14130 14140 14150
DGRSRIDVVD DGLKLTKRGV SKTDAGEYEV KLKNEFGEVA QKFDVKVNDT
14160 14170 14180 14190 14200
PSAPGDVSVV KAESDCLHIE WTAPTEDNGA EVTSYVIEKK ESGRRKFHKV
14210 14220 14230 14240 14250
ATVNGKKTSY VVDDLEIETP YIVRIAAVNK FGTGEFIETK PVQTGSPFQV
14260 14270 14280 14290 14300
PTVEFPPTID NVTSTSCSLS WPKPIEDGGS PVYGYDVYKR ENEGEWQKMN
14310 14320 14330 14340 14350
GEELVFTESF NVRALSSGKE YEFKIEACNE AGLRSNSNVV SKKLTVEGLV
14360 14370 14380 14390 14400
PEIILDMPMV KVLDNDKVEV TWKSDGEKEF VVQYKSDGSS IWASVDIGGP
14410 14420 14430 14440 14450
RSESAATSKC IIDGLREGIP YVFRVAARNQ HGTGEFSEPT IPVVVLADDA
14460 14470 14480 14490 14500
PRVLKAIKPV KIPKKGELRL ECHAAGHPAP EYIWYKDGKE IIPTDENTEI
14510 14520 14530 14540 14550
VNEGSMSALI IHELAGEDVG LYKVLVENIH GTAESEAEVG ISDVRAHFNS
14560 14570 14580 14590 14600
SFSELTEIEE GHDIELTCEV SDEEAVVNWY KDGKKLVASD RVQFYAMARK
14610 14620 14630 14640 14650
RTLRIKGSTD ADSGVYKCET TDGRSRTEGE VIVNEQEPHI LVGPQDAIVK
14660 14670 14680 14690 14700
DFGETMVLFC ETSKPVRKVK WFKNGVEIWP QMNKAIMEND GKRATLEIKN
14710 14720 14730 14740 14750
FDKHDIGAYT ASVSEKETSA PAKLVFEVAP NLIIPTEIRD GVTVHAGNEF
14760 14770 14780 14790 14800
DFAVEFSGFP IPTIHLTNNG TPLKAIAVVT EYDDSVSVRM KDVTLDNSGT
14810 14820 14830 14840 14850
VRVIAESPLG QCIKEIPLKI IDKPSAPCDL QFKEVTEDSV FLSWQPPLET
14860 14870 14880 14890 14900
NGAPLTGYVI ERKAVDNNRW RPCGQVKPTK LTFVAEDLFC NQVYGFRILA
14910 14920 14930 14940 14950
VNEVGESEPC DTVDVLTLES SEPVSESSEL FVPKIAILRT PQVTVAVDET
14960 14970 14980 14990 15000
KVTLRWEECP ETSLYKVERK KVGDSDWLEI ANTDRNKFKD RSLTESGEYV
15010 15020 15030 15040 15050
YQVTATGIHA VSSPSEETNP VKILVPGSEM PASKTEKKTD AAKSESEQKS
15060 15070 15080 15090 15100
AEEIVAEKQV DQSQASESTT EAVEEKKTKK VVKKKVAENK GEETLQEVKE
15110 15120 15130 15140 15150
KLKKGKAVEK VQDESRRGSL QASSDNESVT TTSEKRSEAE LEKNSEKSAE
15160 15170 15180 15190 15200
KKSTSADLEA ADKAETEKSE TGKETTEKKK KVVKKVAKKG LVKADKSKIE
15210 15220 15230 15240 15250
LTAGKEGEIS AQVAETGVSV EWKKDGKALD ASYTVTSTGG VSTVKIPIVD
15260 15270 15280 15290 15300
VNTSGVFTCK VKSSEGDEEE VSIAVTVKLP EVPKVEAEQS IVEVKVGDVA
15310 15320 15330 15340 15350
KLSAKISEPA SSVNWTKDDK PIKEDGNVKA QLSPDGTAQL TISKTDSAHS
15360 15370 15380 15390 15400
GIYKLNVEND AGKGKVEIAL RIKGAAKGAP GIPTGPIVFD DVTESSAEFS
15410 15420 15430 15440 15450
WKAPENNGGC EITGYNVERK ESKNKGWKQC GKTKELKFKA DGLEEGTDYD
15460 15470 15480 15490 15500
VKVSAVNTMG TGSALEGKIT TLKKKEETGK QKSEKSESDE KKSESDKVSE
15510 15520 15530 15540 15550
LKQIGKPEYV SSTATSIALK WTSDNDEVTY TVQMKEANSK RPWAVVAKEI
15560 15570 15580 15590 15600
SECSATIAQL KEGTSYLFRV IAQNKTGQTV TSEQSESIEC KDTTESKKPA
15610 15620 15630 15640 15650
FTNAPTDLTA VKNGKTKITA EFTGHPAPEI HWFKNKKEIF SGKRQWIENI
15660 15670 15680 15690 15700
AGATSLTIGE MREDDEGEYK IVVKNTAGSV EHSCKLTMDQ LPEINRVDRY
15710 15720 15730 15740 15750
ASTLVFDKGE TVKLRLSFSG RPQPEVIWID NNGKVIEESR KMKIEKTVLN
15760 15770 15780 15790 15800
TVLTINSIDS QDQGEFALKI KNRCGEDKYA IGIQVTDRPA APGKPAVEDQ
15810 15820 15830 15840 15850
NVDSVRLRWA APTNDGGSPV RNYTVEMCTE KGKTWTKAEV TKQAFITLFN
15860 15870 15880 15890 15900
LVPGESYRFR VRADNTFGQS EPSDESELVV VKNVSRVVEE PKKKEVKVKE
15910 15920 15930 15940 15950
QESVDYERVA KDSEPSEYKT IDIHRLPNDL QAKYIIHEEL GKGAYGTVYR
15960 15970 15980 15990 16000
ATEKATGKTW AAKMVQVRPG VKKENVIHEI SMMNQLHHEK LLNLHEAFDM
16010 16020 16030 16040 16050
GNEMWLIEEF VSGGELFEKI LEDDSLMSEE EVRDYMHQIL LGVSHMHKNQ
16060 16070 16080 16090 16100
IVHLDLKPEN ILLKAKNSNE LKIIDFGLAR KLDPKKSVKL LFGTPEFCAP
16110 16120 16130 16140 16150
EVVNYQPVGL STDMWTVGVI SYVLLSGLSP FLGDSDEDTL ANVSASDWDF
16160 16170 16180 16190 16200
DDPSWDDVSD LAKDFICRLM IKDKRKRMSV QDALRHPWIT GPLLSAFNDL
16210 16220 16230 16240 16250
SEYVKKMQPK LDKSGVPARQ KRNFLSLKRW SDDLLPIGRL AKRGAIFRRL
16260 16270 16280 16290 16300
TMDGVFERNI AFDTDAAPSV KKQLEDIVAN VGDLIATLSC DVDGVPSPKV
16310 16320 16330 16340 16350
QWYKDDKELT VPSMKYDSFY NEGLAELTVK NIVESDAGKY TCRATNDLGS
16360 16370 16380 16390 16400
IMTHAKLSVK ADEKKKKKSK TSPAVIEKKK DRKTSKVVVI EEMIDMPPNF
16410 16420 16430 16440 16450
HHLLQDDEAK IGEPKILVVT NTTLPEPTVD WYHNGEHISI NDSNYLRKHD
16460 16470 16480 16490 16500
KGRYELHILS VDSTDEGKWK AVGKNAFGEC ESEAKLTVVI PDGQYAPSFG
16510 16520 16530 16540 16550
KQLSDVKCSE SDILKLEVNI QANPAPEINW FRNESEIEHS QHHRLQFDDG
16560 16570 16580 16590 16600
SGNYSLTIID AYAEDSGEYK CVAKNKIGKA HTVCCVRIEE LLSKRSKKID
16610 16620 16630 16640 16650
GSKAPRFRMQ LPTPREVPQG ADLTLVCSVS GTPHPNIKWT KDDKPIDMSN
16660 16670 16680 16690 16700
KQVRHENGVC TLHIIGARDD DQGRYVCEAE NIHGVAQSFS VVEIKEAVDK
16710 16720 16730 16740 16750
DHVRPKFLEP LVNCSTCEGN EMVLECCVTG KPIPTITWYK DGLKLIIENR
16760 16770 16780 16790 16800
MLQYTDRKGV SRLNIMNVVM NDDGEYTCEA VNSLGKDFTH CTVKVVDMGL
16810 16820 16830 16840 16850
SKTRLTPVRS RSRSRSRSPS VVGGEIQRPP VVTRPLADAT VTEGNRELLE
16860 16870 16880 16890 16900
VEVDGFPTPT IEWYHDGKLV AESRTLRTYF DGRVAFLKIY EAHEEHNGQY
16910 16920 16930 16940 16950
VCKVSNKLGA VETRAIVVVE APDAAEHVTQ MPTFVKKLQD VVLKTAGETA
16960 16970 16980 16990 17000
TFTCQSYANP AAQVVWLHNG KALQQTKSNY KTRLFDDNTA TLVIENVTDE
17010 17020 17030 17040 17050
LCGTYTAVAN NQFGDVHTSA QLTISGSEAK KIAASLPYFI IELKPKINVV
17060 17070 17080 17090 17100
EGATLSIQAD LNGSPIPEVV WLKDNSELVE SDRIQMKCDG VNYQLLVRDV
17110 17120 17130 17140 17150
GLEDEGTYTI TAENEKGKIR QNTEVSVTKS KEVKEKKEKK KVEKKDEGKK
17160 17170 17180 17190 17200
KPGRPGLPRP SGASKTEQVT MAFDAPSEGP ADSYEVERRC PDQREWVSCG
17210 17220 17230 17240 17250
STKSLELEIK GLTPNTEYIF RVAGKNKQGL GEWSEMTSTL KTASVGQAPQ
17260 17270 17280 17290 17300
FTISPQSKII ANRDDEFEIA VEFSGTPTPS VKWYKENLQI VPDEKIDVAT
17310 17320 17330 17340 17350
TSTSSILNLK SQEENGTFNC LIENELGQAS ASCQVTIFNK PASLQSTPDH
17360 17370 17380 17390 17400
SLERNLVPTL QKALNNESAQ AGQQIMLTCR ISSRSESTVA WFKDDERIES
17410 17420 17430 17440 17450
AGRYELSSDK KSNHKLVCHA VQSQDTGKYR CVVTNKYGYA ESECNVAVED
17460 17470 17480 17490 17500
VTKFIAPSFS ATLSDSTAIL GHNITLECKV EGSPAPEVSW TKDGERISTT
17510 17520 17530 17540 17550
RRIRQTQDEN GNCKLSISKA ESDDMGVYVC SATSVAGVDS TSSMVMIAKT
17560 17570 17580 17590 17600
TGTDSHLVIA QTADEKHEKP RFTRAPPSLI EVNESGQFTL IAKAVGEPKP
17610 17620 17630 17640 17650
TVTWLKDGRE ILRTNRIYHH FVTGDGESHL IAECVVSKTS GIFSCKAENP
17660 17670 17680 17690 17700
NGTVIAETQV IVQRMKPANQ LANVAPKFTI PLTDMGIVNG HPTTLSCNVT
17710 17720 17730 17740 17750
GSPEPTLEWI YIDDSGHKIN LTSSTTDWTE CRFGKVAELK SERVLREQRG
17760 17770 17780 17790 17800
TYQCIATNSS GQATTQCYLL VGELSDEPAG PPRFVKCLQD TWTPLKESIE
17810 17820 17830 17840 17850
FSVELAGFPT PDLTWYHNEK KINEGKDVKI TFPSDTTSVL SIKNVSLASL
17860 17870 17880 17890 17900
GMYFVEASNI HGVLRTAGRL NVSDERRKAE PPQFKHVLEP VLAVQPKVAF
17910 17920 17930 17940 17950
SEEHPRASSS AATARVKKGA APMFLQGLED MDLKAGASAA VAGKLGRKLR
17960 17970 17980 17990 18000
PHRSTTNDAD KLAKALAQSL RLDEPRASID SRPESAANAA LDEVRAAINS
18010 18020 18030 18040 18050
RNKRVCRPKF MVKPKPRKVL EEYKSLRLKT AISGNPMPQV HWDKEGIILE
18060 18070 18080 18090 18100
TGNKYSIYND GDFYYLEVHH VSTFDKGFYN CTAANNEGII TCTSEIDVLP
18110 18120 18130 18140 18150
NKEDSAAQVA KRKSRKEAKA PNFIEVLPGR SQANLNESLC VECSVSAYPC
18160 18170 18180 18190 18200
ASIIWTRNSV RLLPQADRYT MSYDGECASL KFISVTPGDE GTYACEAVNE
18210 18220 18230 18240 18250
LGSAVTNMNL QVSGVDPNAA EGIPPLFRFE KIKSVRKVVD GSRVELAAEL
18260 18270 18280 18290 18300
VQASEPLQIR WLRNKVTIVD SPSFSYSRSE NMVFLTIADV FPEDGGEYTV
18310 18320 18330 18340 18350
EAKNQSGIAR CTMQLDVRNN ERSVADEAPR VFDFEPTTRS DPGVSVELRA
18360 18370 18380 18390 18400
KVIGHPDPVI SWTKAGQKLN NEEKYMMRNE GDKFILRIAN VTRADAGKYE
18410 18420 18430 18440 18450
LTAINPSGQA NAELELTVVQ STKTVGAKPK FNESPISVQT CEKNRAELRA
18460 18470 18480 18490 18500
SFSGTPAPAC RWFYNGNELI DGLDGYTITS SDTNSSLLIN SVDKKHFGEY
18510 18520 18530 18540 18550
LCTIRNQNGE ELANAMILSE VLSMFYSSLF LVVFVDIVAQ CHVARLLHFL
18560
NEERFVGRNI FA
Note: No experimental confirmation available.Curated
Length:18,562
Mass (Da):2,056,723
Last modified:January 25, 2012 - v2
Checksum:iB0E1A953AE6231FB
GO
Isoform eImported (identifier: G4SLH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18521-18534: VLSMFYSSLFLVVF → GSSAALPQRRTIRR
     18535-18562: Missing.

Note: Produced by alternative splicing of isoform g.Curated
Show »
Length:18,534
Mass (Da):2,053,390
Checksum:iBC8A682B943C8C0A
GO
Isoform fImported (identifier: G4SLH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16191-16205: Missing.
     18521-18534: VLSMFYSSLFLVVF → GSSAALPQRRTIRR
     18535-18562: Missing.

Note: Produced by alternative splicing of isoform g.Curated
Show »
Length:18,519
Mass (Da):2,051,755
Checksum:i6A8441C5D0BA7729
GO
Isoform dImported (identifier: G4SLH0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5409-5428: Missing.
     10572-10598: VSKKPENTKESEGHKKRDRKESEDHDE → GKFRRNWKVTVNHRSLNLINVACCVIA
     10599-18562: Missing.

Note: Produced by alternative splicing of isoform g.Curated
Show »
Length:10,578
Mass (Da):1,174,304
Checksum:i71BF50C502FB4F16
GO
Isoform cImported (identifier: G4SLH0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3178-3215: KTERSEEQCE...PQESIQWSKD → SVCISNVEFR...KRISNNSLHN
     3216-18562: Missing.

Note: Produced by alternative splicing of isoform g. No experimental confirmation available.Curated
Show »
Length:3,215
Mass (Da):358,130
Checksum:iCDD9F3DDB22813FF
GO
Isoform aImported (identifier: G4SLH0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-296: V → ERRTDGKLEKFQIEFKKKLVQI
     376-802: DAASIVESRF...FSSSAHLRIR → G
     1123-1129: EEEDNQI → VSLRLKI
     1130-18562: Missing.

Note: Produced by alternative splicing of isoform g. No experimental confirmation available.Curated
Show »
Length:724
Mass (Da):80,209
Checksum:iB0398B1F70E84273
GO
Isoform bImported (identifier: G4SLH0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-802: DAASIVESRF...FSSSAHLRIR → G
     1123-1129: EEEDNQI → VSLRLKI
     1130-18562: Missing.

Note: Produced by alternative splicing of isoform g. No experimental confirmation available.Curated
Show »
Length:703
Mass (Da):77,592
Checksum:i0633F9F513DF2435
GO
Isoform hImported (identifier: G4SLH0-8) [UniParc]FASTAAdd to basket
Also known as: 301kDa_11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-15826: Missing.
     18521-18534: VLSMFYSSLFLVVF → GSSAALPQRRTIRR
     18535-18562: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:2,708
Mass (Da):300,731
Checksum:i2BBEEBE856FA4571
GO
Isoform iImported (identifier: G4SLH0-9) [UniParc]FASTAAdd to basket
Also known as: 301kDa_11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-15826: Missing.
     16191-16205: Missing.
     18521-18534: VLSMFYSSLFLVVF → GSSAALPQRRTIRR
     18535-18562: Missing.

Note: Produced by alternative promoter usage and alternative splicing of isoform 301kDa_1.Curated
Show »
Length:2,693
Mass (Da):299,097
Checksum:i1CE4AD2011E8391A
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2LDW1A0A2I2LDW1_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
7,858Annotation score:
A0A2I2LDX0A0A2I2LDX0_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
7,815Annotation score:
A0A2I2LDV8A0A2I2LDV8_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
7,843Annotation score:
A0A2I2LG61A0A2I2LG61_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
7,830Annotation score:
A0A2I2LDV7A0A2I2LDV7_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
15,173Annotation score:
A0A2I2LG13A0A2I2LG13_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
14,747Annotation score:
A0A2I2LDV4A0A2I2LDV4_CAEEL
Titin homolog
ttn-1 CELE_W06H8.8, W06H8.8
2,789Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0580451 – 15826Missing in isoform h and isoform i. CuratedAdd BLAST15826
Alternative sequenceiVSP_058046296V → ERRTDGKLEKFQIEFKKKLV QI in isoform a. Curated1
Alternative sequenceiVSP_058047376 – 802DAASI…HLRIR → G in isoform a and isoform b. CuratedAdd BLAST427
Alternative sequenceiVSP_0580481123 – 1129EEEDNQI → VSLRLKI in isoform a and isoform b. Curated7
Alternative sequenceiVSP_0580491130 – 18562Missing in isoform a and isoform b. CuratedAdd BLAST17433
Alternative sequenceiVSP_0580503178 – 3215KTERS…QWSKD → SVCISNVEFRVAHLCVNSLT STLHALKRKRISNNSLHN in isoform c. CuratedAdd BLAST38
Alternative sequenceiVSP_0580513216 – 18562Missing in isoform c. CuratedAdd BLAST15347
Alternative sequenceiVSP_0580525409 – 5428Missing in isoform d. CuratedAdd BLAST20
Alternative sequenceiVSP_05805310572 – 10598VSKKP…EDHDE → GKFRRNWKVTVNHRSLNLIN VACCVIA in isoform d. CuratedAdd BLAST27
Alternative sequenceiVSP_05805410599 – 18562Missing in isoform d. CuratedAdd BLAST7964
Alternative sequenceiVSP_05805516191 – 16205Missing in isoform f and isoform i. CuratedAdd BLAST15
Alternative sequenceiVSP_05805618521 – 18534VLSMF…FLVVF → GSSAALPQRRTIRR in isoform e, isoform f, isoform h and isoform i. CuratedAdd BLAST14
Alternative sequenceiVSP_05805718535 – 18562Missing in isoform e, isoform f, isoform h and isoform i. CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130758 Genomic DNA Translation: AAN61517.1
AY130758 Genomic DNA Translation: AAN61518.1
AY130758 Genomic DNA Translation: AAN61519.1
AY130758 Genomic DNA Translation: AAN61520.1
AY130758 Genomic DNA Translation: AAN61521.1
BX284605 Genomic DNA Translation: CCD72168.1
BX284605 Genomic DNA Translation: CCD72169.1
BX284605 Genomic DNA Translation: CCD72170.1
BX284605 Genomic DNA Translation: CCD72171.1
BX284605 Genomic DNA Translation: CCD72172.1
BX284605 Genomic DNA Translation: CCD72173.1
BX284605 Genomic DNA Translation: CCD72174.1
PIRiE89066
T33247
RefSeqiNP_001024198.1, NM_001029027.3
NP_001024199.1, NM_001029028.3
NP_001024200.1, NM_001029029.3 [G4SLH0-5]
NP_001024201.1, NM_001029030.3
NP_001024202.1, NM_001029031.4
NP_001024203.1, NM_001029032.3
NP_001024204.1, NM_001029033.3
UniGeneiCel.20750

Genome annotation databases

EnsemblMetazoaiW06H8.8a; W06H8.8a; WBGene00006436 [G4SLH0-6]
W06H8.8b; W06H8.8b; WBGene00006436 [G4SLH0-7]
W06H8.8c; W06H8.8c; WBGene00006436 [G4SLH0-5]
W06H8.8d; W06H8.8d; WBGene00006436 [G4SLH0-4]
W06H8.8e.1; W06H8.8e.1; WBGene00006436 [G4SLH0-2]
W06H8.8e.2; W06H8.8e.2; WBGene00006436 [G4SLH0-2]
W06H8.8f.1; W06H8.8f.1; WBGene00006436 [G4SLH0-3]
W06H8.8f.2; W06H8.8f.2; WBGene00006436 [G4SLH0-3]
W06H8.8g; W06H8.8g; WBGene00006436 [G4SLH0-1]
GeneIDi266969
UCSCiW06H8.8e.2 c. elegans

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130758 Genomic DNA Translation: AAN61517.1
AY130758 Genomic DNA Translation: AAN61518.1
AY130758 Genomic DNA Translation: AAN61519.1
AY130758 Genomic DNA Translation: AAN61520.1
AY130758 Genomic DNA Translation: AAN61521.1
BX284605 Genomic DNA Translation: CCD72168.1
BX284605 Genomic DNA Translation: CCD72169.1
BX284605 Genomic DNA Translation: CCD72170.1
BX284605 Genomic DNA Translation: CCD72171.1
BX284605 Genomic DNA Translation: CCD72172.1
BX284605 Genomic DNA Translation: CCD72173.1
BX284605 Genomic DNA Translation: CCD72174.1
PIRiE89066
T33247
RefSeqiNP_001024198.1, NM_001029027.3
NP_001024199.1, NM_001029028.3
NP_001024200.1, NM_001029029.3 [G4SLH0-5]
NP_001024201.1, NM_001029030.3
NP_001024202.1, NM_001029031.4
NP_001024203.1, NM_001029032.3
NP_001024204.1, NM_001029033.3
UniGeneiCel.20750

3D structure databases

DisProtiDP01090
ProteinModelPortaliG4SLH0
SMRiG4SLH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiG4SLH0, 1 interactor
STRINGi6239.W06H8.8g

Proteomic databases

EPDiG4SLH0
PaxDbiG4SLH0
PeptideAtlasiG4SLH0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW06H8.8a; W06H8.8a; WBGene00006436 [G4SLH0-6]
W06H8.8b; W06H8.8b; WBGene00006436 [G4SLH0-7]
W06H8.8c; W06H8.8c; WBGene00006436 [G4SLH0-5]
W06H8.8d; W06H8.8d; WBGene00006436 [G4SLH0-4]
W06H8.8e.1; W06H8.8e.1; WBGene00006436 [G4SLH0-2]
W06H8.8e.2; W06H8.8e.2; WBGene00006436 [G4SLH0-2]
W06H8.8f.1; W06H8.8f.1; WBGene00006436 [G4SLH0-3]
W06H8.8f.2; W06H8.8f.2; WBGene00006436 [G4SLH0-3]
W06H8.8g; W06H8.8g; WBGene00006436 [G4SLH0-1]
GeneIDi266969
UCSCiW06H8.8e.2 c. elegans

Organism-specific databases

CTDi266969
WormBaseiW06H8.8a ; CE52437 ; WBGene00006436 ; ttn-1
W06H8.8b ; CE52423 ; WBGene00006436 ; ttn-1
W06H8.8c ; CE36723 ; WBGene00006436 ; ttn-1
W06H8.8d ; CE52449 ; WBGene00006436 ; ttn-1
W06H8.8e ; CE52441 ; WBGene00006436 ; ttn-1
W06H8.8f ; CE52428 ; WBGene00006436 ; ttn-1
W06H8.8g ; CE52417 ; WBGene00006436 ; ttn-1

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00860000133679
InParanoidiG4SLH0
OMAiETTYMEA
OrthoDBiEOG091G005W

Enzyme and pathway databases

SignaLinkiG4SLH0

Miscellaneous databases

PROiPR:G4SLH0

Gene expression databases

BgeeiWBGene00006436 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd00063 FN3, 11 hits
Gene3Di2.60.40.10, 63 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 10 hits
PF07679 I-set, 37 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 11 hits
SM00409 IG, 50 hits
SM00408 IGc2, 37 hits
SM00406 IGv, 4 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 50 hits
SSF49265 SSF49265, 6 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 11 hits
PS50835 IG_LIKE, 38 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTN1_CAEEL
AccessioniPrimary (citable) accession number: G4SLH0
Secondary accession number(s): A7DT28
, G4SLD6, G5EDP1, G5EDT5, G5EF69, G5EFF0, Q65XY2, Q8ISF3, Q8ISF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: January 25, 2012
Last modified: November 7, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again