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Entry version 46 (08 May 2019)
Sequence version 1 (14 Dec 2011)
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Protein

UvrABC system protein A

Gene

CTO_0361

Organism
Chlamydia trachomatis serovar A (strain A2497)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.SAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi625 – 632ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingSAAS annotation, Excision nucleaseSAAS annotation
Biological processDNA damage, DNA excisionSAAS annotation, DNA repair
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CTRA580047:G1H0C-364-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UvrABC system protein ASAAS annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CTO_0361Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydia trachomatis serovar A (strain A2497)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri580047 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009287 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.

SAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini314 – 580ABC transporterInterPro annotationAdd BLAST267
Domaini590 – 913ABC transporterInterPro annotationAdd BLAST324

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K03701

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKHGWCP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003439 ABC_transporter-like
IPR013815 ATP_grasp_subdomain_1
IPR027417 P-loop_NTPase
IPR004602 UvrA
IPR041552 UvrA_DNA-bd
IPR041102 UvrA_inter

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17755 UvrA_DNA-bind, 1 hit
PF17760 UvrA_inter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00630 uvra, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G4NMI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSIVRLSGI TVRNLKNITV EFCPREIVLF TGVSGSGKSS LAFNTIYAAG
60 70 80 90 100
RKRYLATLPS FFATKLDSLP DPSVKKIEGL SPTVAVKQNF FEQHIHATVG
110 120 130 140 150
STTEINSYLA LLFSLEGQAY DPVTLHPLTL YSKEKILSEI AAIPDGTQLT
160 170 180 190 200
LLAPLPARDV LTVRECLRQG FTKVLIDEEV VPIHKFLTTG IPVPGQLIVD
210 220 230 240 250
TLIKNTSNTP RLKVSLFTTL DIGHGECSLH FDNQKRVFST QATLPETQQT
260 270 280 290 300
YAPLSPDLFS SHSHKDRCPQ CQGSGIFISI DDPCIIQQTL SIEDNCCPFA
310 320 330 340 350
GNCSTFLYRT IYQSLADSLG FSLSTPWQNL SPEIQHIFLY GKEGLSIPVK
360 370 380 390 400
LFDGTLGKKT QTHKQWKGVL NEIGEKIRFS NKPARYLPKG TSYTVCPRCN
410 420 430 440 450
KTGLSDYANA TRWHGKSFAD FQQMSLQELF IFLNQLPEKE LAIEEVIQGF
460 470 480 490 500
KSRLTILIDL GLPYLSPERA IDTLSGGERE RTALAKHLGA ELIGVMYILD
510 520 530 540 550
EPSIGLHPQD THKLMNVIRR LRDQGNTVLL VEHDEQMISL ADRVIDIGPG
560 570 580 590 600
AGIFGGEVVF NGSPREFLAK SDSLTAQYLR QEQHISVPAK RTNSLGTITL
610 620 630 640 650
SKANKHNLKD LTVSIPLGQM TVVTGVSGSG KSSLINDTLV PCVEEFIEQG
660 670 680 690 700
FCSTLSIQGA LSRLVHINRD LPGRSQRSIP LTYIKAFDEV RQLFAEQPRC
710 720 730 740 750
KTLGLTKSHF SFNTPLGACA ECGGLGSITT TDNRDSITCP SCLGKRFLPQ
760 770 780 790 800
VLEVRYKNKT IADILEMTAY EAKNFFLDEP SIHQKIETLC TLGLQYLPLG
810 820 830 840 850
RPLYSLSGGE IQRLKLAYEL LAPVKHPTLY VLDEPTTGLH THDVKQLIYV
860 870 880 890 900
VQSLIHQGHS VIIIEHNMHV VKVADYILEL GPEGGNKGGY LIASCSPEEL
910 920 930 940 950
IHKHTPTAIA LRPFLSSPQE LPYLPDPSPK PPVPAAITIA NAHQHNLKHI
960 970 980 990 1000
DLSIPRYALT AVTGPSASGK HSLVFDILHA AGNIAYAELF PPYIRQALIK
1010 1020 1030 1040 1050
KTPLPAVDKV TGLSPVIAIE KTSASRNSNH SVASALEISE MLESLFTRIG
1060 1070 1080 1090 1100
HPYSPISGDA LRTISPETIA EELLTHYTKG YVTITVPFPK EEEFFSYTQE
1110 1120 1130 1140 1150
MLQEGFLKLY ANEQFYDLDG PFPTSLENPA LVIHHVKILE KNLPSLLASL
1160 1170 1180 1190 1200
TLAFSKASSV CLHIEYAGTS LSKTYRQGLQ DASRNLFPNI ETPSILNHES
1210 1220 1230 1240 1250
YLCPLCHGKG FLSTCSILPH KKRFAQHTPI SLFTSLFPNQ DPSPIYPLLN
1260 1270 1280 1290 1300
ELGIPSIALF QEIDVLSFES LCLGTQQHLG LNALCTKAML MESEEDFPPD
1310 1320 1330 1340 1350
LISKTPCNQC QGLGVYTYKH CTRIHSISLS EIYQSNVAFL KKLLLSVEEE
1360 1370 1380 1390 1400
PSLVQDILSR LDLLDRVGLG YVILGQEQQS LSDGEHYRLL LAKAFSSGLT
1410 1420 1430 1440 1450
DVIYLLEDPL AGIHPEDAPC LLAVIKKLVT NHNTVIVTDR EGSLAEHADY
1460 1470 1480 1490 1500
LLHLGPEPGP NGGYLLSTSA LKQSQPVLCN TRSSEETPQL SVSVSTSTIQ
1510 1520 1530 1540 1550
IENLAFPLQR LSTISGVSGS GKTTLLNSIY EHGCAILEKD PSVFSEIIFL
1560 1570 1580 1590 1600
DSYPQIASSR SDISTYFDIA PSLRNFYASL TQAKALNISV SMFSPNTKQG
1610 1620 1630 1640 1650
QCSDCWGLGY QWIDRAFYAM EKRPCPTCGG FRVQPLIQEV VYEGKHFGQL
1660 1670 1680 1690 1700
LQASLNEVAE TFSFLKKIQK PLHTLITNGL GYLSLGQNMA SLSLSEKIAI
1710 1720 1730 1740 1750
KLTKYLFLPP KHPTLFLLDE IATSLDNQQQ SALLVQLNTL ASLGHTVVII
1760 1770 1780
ENHPAFSQQA DFWIQMGRKT DNHILFAGPN PNLSFT
Length:1,786
Mass (Da):196,944
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i192EA83E6163A0D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002401 Genomic DNA Translation: AEP35177.1

NCBI Reference Sequences

More...
RefSeqi
WP_012728108.1, NC_017437.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEP35177; AEP35177; CTO_0361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cra:CTO_0361
cty:CTR_3301

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|580047.4.peg.367

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002401 Genomic DNA Translation: AEP35177.1
RefSeqiWP_012728108.1, NC_017437.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAEP35177; AEP35177; CTO_0361
KEGGicra:CTO_0361
cty:CTR_3301
PATRICifig|580047.4.peg.367

Phylogenomic databases

KOiK03701
OMAiSKHGWCP

Enzyme and pathway databases

BioCyciCTRA580047:G1H0C-364-MONOMER

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR013815 ATP_grasp_subdomain_1
IPR027417 P-loop_NTPase
IPR004602 UvrA
IPR041552 UvrA_DNA-bd
IPR041102 UvrA_inter
PfamiView protein in Pfam
PF17755 UvrA_DNA-bind, 1 hit
PF17760 UvrA_inter, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG4NMI3_CHLT4
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G4NMI3
Secondary accession number(s): H1ZQQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 8, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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