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Protein

RNA polymerase II transcription factor B subunit 2

Gene

MGG_00397

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:MGG_00397Imported
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)Imported
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
Proteomesi
  • UP000009058 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:MGG_00397

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi318829.MGG_00397T0

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

InParanoidiG4NCE6
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

G4NCE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQPVITLS DHLEKQNGAT FKKLYQQPAT AFAIFRRMLP PLAKTFVMSL
60 70 80 90 100
LYMPQPLPLT ALDSWVKPEA KKNKDQALSI LRSMHITTIT PVTKEKPVQE
110 120 130 140 150
MSLTPNFKKS LRLALEGGGS HNSFGVPSSL PIPPQVDVAF LDKWARSRWD
160 170 180 190 200
AILHYVVNSV EETDSMEPSK KYNFGGSKLQ DTVKTLLVQG GLVQRRSSER
210 220 230 240 250
ISITKTGFTF LLQEANAQVW TLLLQWLHSV NEDNTNRAVD MLSFLFMLGT
260 270 280 290 300
LELGQAYDTG ALSEERRNML PDLNDFGLVY IPPSNPDQYF PTRLATTLTS
310 320 330 340 350
GSSALRSVSS GVAAATAEAG ENNTKGAIIL ETNFRIYAYT STPLQIAILA
360 370 380 390 400
LFANLKMRFA GMVTGQLSRH SIKRAISHGI TADQIIEYLA SHAHEQMHRI
410 420 430 440 450
AAIRNKPVLP PTVVDQIRLW QLETERMQVQ RGYLFKDFES QAEFKAIADY
460 470 480 490
ADEVGVLIWR SDARQLFFAS KTAEIANFIK SEKHRKKLAA
Length:490
Mass (Da):54,873
Last modified:December 14, 2011 - v1
Checksum:i9EE7110EC189ACAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA Translation: EHA49095.1
RefSeqiXP_003718679.1, XM_003718631.1

Genome annotation databases

EnsemblFungiiMGG_00397T0; MGG_00397T0; MGG_00397
GeneIDi2674140
KEGGimgr:MGG_00397

Similar proteinsi

Entry informationi

Entry nameiG4NCE6_MAGO7
AccessioniPrimary (citable) accession number: G4NCE6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: May 23, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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