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Entry version 42 (18 Sep 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

Ribonuclease III, putative

Gene

Smp_033600

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ribonuclease III, putativeImported (EC:3.1.26.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Smp_033600Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchistosoma mansoni (Blood fluke)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6183 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6183.Smp_033600.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini546 – 659RNase IIIInterPro annotationAdd BLAST114
Domaini731 – 883RNase IIIInterPro annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 50DisorderedSequence analysisAdd BLAST26

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G4LVA9

KEGG Orthology (KO)

More...
KOi
K11592

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G4LVA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWIPPVSDNP TPFNIERELL PTVISEPSSK TSSLSSTTGT LDRDSLKENC
60 70 80 90 100
PQYTPQNVRY QHYPVPKVRC LSFPYQTLPS CGSAVYLYTW SLPRSDIMTQ
110 120 130 140 150
LCSLAAACFQ DTSTTVGLLF SKPISKKGYV CRIPLYLTRG MARSRVRLTG
160 170 180 190 200
KFTLSEKELK CVESAHHVIA ELITNIAHMS HVGYKPSDPL LRAHFDRQNA
210 220 230 240 250
STNIPESLRV VLFDRFGDLS FNPEKANILS LVTLIRLPDY TVDYEALGAL
260 270 280 290 300
LEWSLCRDKG ISTADDNFPT HVKPVHGIVP KWRIRLSQIP QDNWVGLVVK
310 320 330 340 350
PNHLPDSDPG MFSISKVSSE TASSPVPETL ASKLGDIQNV KGASPLTYSD
360 370 380 390 400
YYRIKYQQMK TISFTIDPSL PLFECLRITR HQNSTQVNAG LRKNKASIKP
410 420 430 440 450
SLFLSDACLV HPLSSWIWFQ VSLVPTILYQ MSRALLASQL FTELNYELKS
460 470 480 490 500
PQPFSQIRIN SLTISNDSLS HTTILVPDRL SVPVFLNGEP MEQNIFDFEV
510 520 530 540 550
DRATSEIDKE LDNKAHSESL EKSTICPHPN NLIEPTTLLG ARDAVDLERL
560 570 580 590 600
EFYGDSFLHF IATLCVYGTN PQDADEGCLS SKRGSLVSNA HLCDIACDLK
610 620 630 640 650
WYEYCTGQTF SPPEHFLPPC YSVASEACKY DPRLYTRLTD KSLADMVEAL
660 670 680 690 700
IGCFLLRSGL SAAFNLLHYF QICPVSWSTL KNDKHYKVEA PWHFFLQPKL
710 720 730 740 750
YSELNCGNAL NASCRSLHIS KEIILELNQR FFQLQEKLGY YFKGIELLAE
760 770 780 790 800
AMTHQSSINK QYWGNYQRLE FLGDSILGHI ISNYLFQKCP NSSPGALTTA
810 820 830 840 850
RSTVVSNINL ANVVVEHDIY PFIDFGNCSL KACIDDIKSI HRQTDSHFER
860 870 880 890 900
IELITKKVSS GLNVKVLADV FESILGAIFV DSNGNHQVAS SIIHRFLGKT
910 920
MTTQLLCHQS YMKIFMIRLH RLMVSAYV
Length:928
Mass (Da):104,579
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4325B1535FC925E3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABG01000013 Genomic DNA Translation: CCD58848.1

NCBI Reference Sequences

More...
RefSeqi
XP_018645207.1, XM_018791597.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Smp_033600.1; Smp_033600.1:pep; Smp_033600

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Smp_033600.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8353934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
smm:Smp_033600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABG01000013 Genomic DNA Translation: CCD58848.1
RefSeqiXP_018645207.1, XM_018791597.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6183.Smp_033600.1

Genome annotation databases

EnsemblMetazoaiSmp_033600.1; Smp_033600.1:pep; Smp_033600
GeneDBiSmp_033600.1:pep
GeneIDi8353934
KEGGismm:Smp_033600

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8353934

Phylogenomic databases

InParanoidiG4LVA9
KOiK11592
OrthoDBi1337630at2759

Family and domain databases

CDDicd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
InterProiView protein in InterPro
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00535 RIBOc, 2 hits
SUPFAMiSSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG4LVA9_SCHMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G4LVA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 18, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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