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Protein

Peptide deformylase

Gene

def3

Organism
Rickettsia japonica (strain ATCC VR-1363 / YH)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotationSAAS annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi142IronUniRule annotation1
Metal bindingi184IronUniRule annotation1
Active sitei185UniRule annotation1
Metal bindingi188IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotationSAAS annotation (EC:3.5.1.88UniRule annotationSAAS annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:def3Imported
Synonyms:defUniRule annotation
Ordered Locus Names:RJP_0052Imported
OrganismiRickettsia japonica (strain ATCC VR-1363 / YH)Imported
Taxonomic identifieri652620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000002659 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01462
OMAiHREYSSV

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit

Sequencei

Sequence statusi: Complete.

G4KLW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLKTALLL TAIIFITGCK SNMKNENNIS LPQYVTLNIQ TLNSSEDKTI
60 70 80 90 100
RIKAKTLNFP LSSEDLRDIS ILEKKYDQEE NCAGLAAPQI GISKCIIIFA
110 120 130 140 150
VHEDAELKKW RPDLKDTMPK TIWINPSYKP IGIDKHEDYE GCFSVENATG
160 170 180 190 200
PVARFKKIHY HAYDINGNQI QGIAEGFLAR VIQHEIDHLN GKVFLDYVAP
210 220
KKIMTKEEYL EMRKKAMEQE NIKS
Length:224
Mass (Da):25,559
Last modified:December 14, 2011 - v1
Checksum:i64E69BBBAACD4ED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011533 Genomic DNA Translation: BAK96277.1
RefSeqiWP_014120468.1, NZ_AMRT02000007.1

Genome annotation databases

EnsemblBacteriaiBAK96277; BAK96277; RJP_0052
GeneIDi34514982
KEGGirja:RJP_0052

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011533 Genomic DNA Translation: BAK96277.1
RefSeqiWP_014120468.1, NZ_AMRT02000007.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK96277; BAK96277; RJP_0052
GeneIDi34514982
KEGGirja:RJP_0052

Phylogenomic databases

KOiK01462
OMAiHREYSSV

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG4KLW9_RICJY
AccessioniPrimary (citable) accession number: G4KLW9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: December 20, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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