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Entry version 68 (07 Apr 2021)
Sequence version 1 (14 Dec 2011)
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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi95 – 102ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseImported, Hydrolase
Biological processProtein transport, TranslocationUniRule annotationARBA annotation, Transport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secAUniRule annotation
ORF Names:Tmari_1586Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243274 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000013901 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, CytoplasmUniRule annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G4FFW6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 615SECA_MOTOR_DEADInterPro annotationAdd BLAST615

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecA family.UniRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVHYDVQ

Database of Orthologous Groups

More...
OrthoDBi
212453at2

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01382, SecA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000185, SecA
IPR020937, SecA_CS
IPR011115, SecA_DEAD
IPR014018, SecA_motor_DEAD
IPR011130, SecA_preprotein_X-link_dom
IPR011116, SecA_Wing/Scaffold
IPR036266, SecA_Wing/Scaffold_sf
IPR036670, SecA_X-link_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30612, PTHR30612, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF07517, SecA_DEAD, 1 hit
PF01043, SecA_PP_bind, 1 hit
PF07516, SecA_SW, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00906, SECA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00957, SecA_DEAD, 1 hit
SM00958, SecA_PP_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF81767, SSF81767, 1 hit
SSF81886, SSF81886, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01312, SECA, 1 hit
PS51196, SECA_MOTOR_DEAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G4FFW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILFDKNKRI LKKYAKMVSK INQIESDLRS KKNSELIRLS MVLKEKVNSF
60 70 80 90 100
EDADEHLFEA FALVREAARR TLGMRPFDVQ VMGGIALHEG KVAEMKTGEG
110 120 130 140 150
KTLAATMPIY LNALIGKGVH LVTVNDYLAR RDALWMGPVY LFLGLRVGVI
160 170 180 190 200
NSLGKSYEVV WKNPDLARKA IEENWSVWPD GFNGEVLKEE SMNKEAVEAF
210 220 230 240 250
QVELKEITRK EAYLCDVTYG TNNEFGFDYL RDNLVLDYND KVQRGHFYAI
260 270 280 290 300
VDEADSVLID EARTPLIISG PSKESPSVYR RFAQIAKKFV KDKDFTVDEK
310 320 330 340 350
ARTIILTEEG VAKAEKIIGV ENLYDPGNVS LLYHLINALK ALHLFKKDVD
360 370 380 390 400
YVVMNGEVII VDEFTGRLLP GRRYSGGLHQ AIEAKEGVPI KEESITYATI
410 420 430 440 450
TFQNYFRMYE KLAGMTGTAK TEESEFVQVY GMEVVVIPTH KPMIRKDHDD
460 470 480 490 500
LVFRTQKEKY EKIVEEIEKR YKKGQPVLVG TTSIEKSELL SSMLKKKGIP
510 520 530 540 550
HQVLNAKYHE KEAEIVAKAG QKGMVTIATN MAGRGTDIKL GPGVAELGGL
560 570 580 590 600
CIIGTERHES RRIDNQLRGR AGRQGDPGES IFFLSLEDDL LRIFGSEQIG
610 620 630 640 650
KVMNILKIEE GQPIQHPMLS KLIENIQKKV EGINFSIRKT LMEMDDVLDK
660 670 680 690 700
QRRAVYSLRD QILLEKDYDE YLKDIFEDVV STRVEEFCSG KNWDIESLKN
710 720 730 740 750
SLSFFPAGLF DLDEKQFSSS EELHDYLFNR LWEEYQRKKQ EIGEDYRKVI
760 770 780 790 800
RFLMLRIIDD HWRRYLEEVE HVKEAVQLRS YGQKDPIVEF KKETYYMFDE
810 820 830 840 850
MMRRINDTIA NYVLRVVKVS EKDEKEAKEE LGKIRLVHEE FNLVNRAMRR
860 870
ATEKKKKKDG LHSFGRIRVK R
Length:871
Mass (Da):100,486
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24F661A1799AC89C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP004077 Genomic DNA Translation: AGL50510.1

NCBI Reference Sequences

More...
RefSeqi
NP_229378.1, NC_000853.1
WP_004082002.1, NZ_CP011107.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AGL50510; AGL50510; Tmari_1586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tma:TM1578
tmm:Tmari_1586
tmw:THMA_1613

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243274.17.peg.1586

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004077 Genomic DNA Translation: AGL50510.1
RefSeqiNP_229378.1, NC_000853.1
WP_004082002.1, NZ_CP011107.1

3D structure databases

SMRiG4FFW6
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiAGL50510; AGL50510; Tmari_1586
KEGGitma:TM1578
tmm:Tmari_1586
tmw:THMA_1613
PATRICifig|243274.17.peg.1586

Phylogenomic databases

OMAiMVHYDVQ
OrthoDBi212453at2

Family and domain databases

HAMAPiMF_01382, SecA, 1 hit
InterProiView protein in InterPro
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000185, SecA
IPR020937, SecA_CS
IPR011115, SecA_DEAD
IPR014018, SecA_motor_DEAD
IPR011130, SecA_preprotein_X-link_dom
IPR011116, SecA_Wing/Scaffold
IPR036266, SecA_Wing/Scaffold_sf
IPR036670, SecA_X-link_sf
PANTHERiPTHR30612, PTHR30612, 1 hit
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF07517, SecA_DEAD, 1 hit
PF01043, SecA_PP_bind, 1 hit
PF07516, SecA_SW, 1 hit
PRINTSiPR00906, SECA
SMARTiView protein in SMART
SM00957, SecA_DEAD, 1 hit
SM00958, SecA_PP_bind, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF81767, SSF81767, 1 hit
SSF81886, SSF81886, 1 hit
PROSITEiView protein in PROSITE
PS01312, SECA, 1 hit
PS51196, SECA_MOTOR_DEAD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG4FFW6_THEMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G4FFW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 7, 2021
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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