UniProtKB - G3XAG5 (G3XAG5_HUMAN)
Protein
Chloride channel protein
Gene
CLCN4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- voltage-gated chloride channel activity Source: UniProtKB-UniRule
Keywordsi
Biological process | Ion transportUniRule annotation, Transport |
Ligand | ChlorideUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Chloride channel proteinUniRule annotation |
Gene namesi | Name:CLCN4Imported ORF Names:hCG_401215Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000073464.11 |
HGNCi | HGNC:2022, CLCN4 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 88 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 153 – 178 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 199 – 221 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 227 – 243 | HelicalUniRule annotationAdd BLAST | 17 | |
Transmembranei | 255 – 279 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 291 – 308 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 337 – 354 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 410 – 430 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 437 – 456 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 484 – 509 | HelicalUniRule annotationAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000073464, Expressed in Brodmann (1909) area 46 and 215 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 569 – 635 | CBSInterPro annotationAdd BLAST | 67 | |
Domaini | 666 – 724 | CBSInterPro annotationAdd BLAST | 59 |
Sequence similaritiesi
Keywords - Domaini
CBS domainPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158265 |
Family and domain databases
Gene3Di | 1.10.3080.10, 1 hit |
InterProi | View protein in InterPro IPR000644, CBS_dom IPR014743, Cl-channel_core IPR001807, Cl-channel_volt-gated IPR002246, Cl_channel-4 |
PANTHERi | PTHR45711:SF2, PTHR45711:SF2, 2 hits |
Pfami | View protein in Pfam PF00571, CBS, 2 hits PF00654, Voltage_CLC, 2 hits |
PRINTSi | PR00762, CLCHANNEL PR01115, CLCHANNEL4 |
SMARTi | View protein in SMART SM00116, CBS, 2 hits |
SUPFAMi | SSF81340, SSF81340, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
G3XAG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT
60 70 80 90 100
SKSKESIWEF IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE
110 120 130 140 150
GVCLSAFWYS HEQCCWTSNE TTFEDRDKCP LWQKWSELLV NQSEGASAYI
160 170 180 190 200
LNYLMYILWA LLFAFLAVSL VRVFAPYACG SGIPEIKTIL SGFIIRGYLG
210 220 230 240 250
KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS LFSKYSKNEG
260 270 280 290 300
KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV
310 320 330 340 350
AAFTLRSINP FGNSRLVLFY VEYHTPWRRK TTRLGKYPVL EVIVVTAITA
360 370 380 390 400
IIAYPNPYTR QSTSELISEL FNDCGALESS QLCDYINDPN MTRPVDDIPD
410 420 430 440 450
RPAGVGVYTA MWQLALALIF KIVVTIFTFG MKIPSGLFIP SMAVGAIAGR
460 470 480 490 500
MVGIGVEQLA YHHHDWIIFR NWCRPGADCV TPGLYAMVGA AACLGGVTRM
510 520 530 540 550
TVSLVVIMFE LTGGLEYIVP LMAAAVTSKW VADAFGKEGI YEAHIHLNGY
560 570 580 590 600
PFLDVKDEFT HRTLATDVMR PRRGEPPLSV LTQDSMTVED VETLIKETDY
610 620 630 640 650
NGFPVVVSRD SERLIGFAQR RELILAIKNA RQRQEGIVSN SIMYFTEEPP
660 670 680 690 700
ELPANSPHPL KLRRILNLSP FTVTDHTPME TVVDIFRKLG LRQCLVTRSG
710 720
RLLGIITKKD VLRHMAQMAN QDPESIMFN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP51793 | CLCN4_HUMAN | H(+)/Cl(-) exchange transporter 4 | CLCN4 | 760 | Annotation score: | ||
E9PFB5 | E9PFB5_HUMAN | H(+)/Cl(-) exchange transporter 4 | CLCN4 | 152 | Annotation score: | ||
A0A6Q8PF24 | A0A6Q8PF24_HUMAN | H(+)/Cl(-) exchange transporter 4 | CLCN4 | 103 | Annotation score: | ||
A0A6Q8PG54 | A0A6Q8PG54_HUMAN | H(+)/Cl(-) exchange transporter 4 | CLCN4 | 735 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC003666 Genomic DNA No translation available. AC121345 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98777.1 |
Genome annotation databases
Ensembli | ENST00000380829; ENSP00000370209; ENSG00000073464 |
UCSCi | uc064xyj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC003666 Genomic DNA No translation available. AC121345 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98777.1 |
3D structure databases
SMRi | G3XAG5 |
ModBasei | Search... |
Proteomic databases
MaxQBi | G3XAG5 |
PRIDEi | G3XAG5 |
ProteomicsDBi | 33742 |
Protocols and materials databases
Antibodypediai | 23690, 166 antibodies |
Genome annotation databases
Ensembli | ENST00000380829; ENSP00000370209; ENSG00000073464 |
UCSCi | uc064xyj.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000073464.11 |
HGNCi | HGNC:2022, CLCN4 |
OpenTargetsi | ENSG00000073464 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158265 |
Miscellaneous databases
ChiTaRSi | CLCN4, human |
Gene expression databases
Bgeei | ENSG00000073464, Expressed in Brodmann (1909) area 46 and 215 other tissues |
Family and domain databases
Gene3Di | 1.10.3080.10, 1 hit |
InterProi | View protein in InterPro IPR000644, CBS_dom IPR014743, Cl-channel_core IPR001807, Cl-channel_volt-gated IPR002246, Cl_channel-4 |
PANTHERi | PTHR45711:SF2, PTHR45711:SF2, 2 hits |
Pfami | View protein in Pfam PF00571, CBS, 2 hits PF00654, Voltage_CLC, 2 hits |
PRINTSi | PR00762, CLCHANNEL PR01115, CLCHANNEL4 |
SMARTi | View protein in SMART SM00116, CBS, 2 hits |
SUPFAMi | SSF81340, SSF81340, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3XAG5_HUMAN | |
Accessioni | G3XAG5Primary (citable) accession number: G3XAG5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |