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Protein
Submitted name:

Protein lifeguard 4

Gene

TMBIM4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Submitted name:
Protein lifeguard 4Imported
Submitted name:
Transmembrane BAX inhibitor motif containing 4, isoform CRA_aImported
Gene namesi
Name:TMBIM4Imported
ORF Names:hCG_16706Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000155957.17
HGNCiHGNC:24257 TMBIM4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 106HelicalUniRule annotationAdd BLAST22
Transmembranei118 – 136HelicalUniRule annotationAdd BLAST19
Transmembranei143 – 163HelicalUniRule annotationAdd BLAST21
Transmembranei169 – 190HelicalUniRule annotationAdd BLAST22
Transmembranei202 – 221HelicalUniRule annotationAdd BLAST20
Transmembranei227 – 245HelicalUniRule annotationAdd BLAST19
Transmembranei257 – 279HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155957

PTM / Processingi

Proteomic databases

PRIDEiG3XAA5

Expressioni

Gene expression databases

BgeeiENSG00000155957 Expressed in 111 organ(s), highest expression level in testis

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00500000044791
OMAiSHNAYAE
OrthoDBiEOG091G0JRK

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

G3XAA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPDPRYPR SSIEDDFNYG SSVASATVHI RMVLQRDCTF SKQYMRIPSA
60 70 80 90 100
PSATLNIIRF FHLRQSGRSG MVNIFYKGPT FLRKVYSILS LQVLLTTVTS
110 120 130 140 150
TVFLYFESVR TFVHESPALI LLFALGSLGL IFALILNRHK YPLNLYLLFG
160 170 180 190 200
FTLLEALTVA VVVTFYDVYI ILQAFILTTT VFFGLTVYTL QSKKDFSKFG
210 220 230 240 250
AGLFALLWIL CLSGFLKFFF YSEIMELVLA AAGALLFCGF IIYDTHSLMH
260 270 280
KLSPEEYVLA AISLYLDIIN LFLHLLRFLE AVNKK
Length:285
Mass (Da):32,416
Last modified:February 17, 2016 - v3
Checksum:i2A1481E240167C31
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9HC24LFG4_HUMAN
Protein lifeguard 4
TMBIM4 GAAP, LFG4, CGI-119
238Annotation score:
G3V1M2G3V1M2_HUMAN
Protein lifeguard 4
TMBIM4
162Annotation score:
G3V1R8G3V1R8_HUMAN
Protein lifeguard 4
TMBIM4 hCG_16706
61Annotation score:
L7MUG5L7MUG5_HUMAN
Protein lifeguard 4
TMBIM4
162Annotation score:
E7EWY5E7EWY5_HUMAN
Protein lifeguard 4
TMBIM4
161Annotation score:
A0A087WXH1A0A087WXH1_HUMAN
Protein lifeguard 4
TMBIM4
210Annotation score:
Q7Z782Q7Z782_HUMAN
Protein lifeguard 4
TMBIM4
46Annotation score:
F5H1S4F5H1S4_HUMAN
Protein lifeguard 4
TMBIM4
47Annotation score:
F5GXT9F5GXT9_HUMAN
Protein lifeguard 4
TMBIM4
43Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078927 Genomic DNA No translation available.
KF455663 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97158.1
RefSeqiNP_001269535.1, NM_001282606.1
UniGeneiHs.505934

Genome annotation databases

EnsembliENST00000286424; ENSP00000286424; ENSG00000155957
GeneIDi51643
UCSCiuc009zqr.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078927 Genomic DNA No translation available.
KF455663 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97158.1
RefSeqiNP_001269535.1, NM_001282606.1
UniGeneiHs.505934

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiG3XAA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286424; ENSP00000286424; ENSG00000155957
GeneIDi51643
UCSCiuc009zqr.5 human

Organism-specific databases

CTDi51643
EuPathDBiHostDB:ENSG00000155957.17
HGNCiHGNC:24257 TMBIM4
OpenTargetsiENSG00000155957
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00500000044791
OMAiSHNAYAE
OrthoDBiEOG091G0JRK

Miscellaneous databases

ChiTaRSiTMBIM4 human

Gene expression databases

BgeeiENSG00000155957 Expressed in 111 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3XAA5_HUMAN
AccessioniPrimary (citable) accession number: G3XAA5
Secondary accession number(s): A0A0J9YXA5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 17, 2016
Last modified: November 7, 2018
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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