UniProtKB - G3XA98 (G3XA98_HUMAN)

BLAST

>tr|G3XA98|G3XA98_HUMAN Fibulin 5, isoform CRA_a OS=Homo sapiens OX=9606 GN=FBLN5 PE=1 SV=1
MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDGVSLSSPRLECNGAISAH
CNLCLPGSSDSSASASQVAGITDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGP
YSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCN
PTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLN
EDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQ
HECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIR
CEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYY
IFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRL
RIYVSQYPF

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History
Entry version 76 (07 Nov 2018)
Sequence version 1 (16 Nov 2011)
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Protein

Submitted name:

Fibulin 5, isoform CRA_a

Gene

FBLN5

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

elastic fiber assembly Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	CalciumSAAS annotation

Ligand

CalciumSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Fibulin 5, isoform CRA_aImported Submitted name: Fibulin-5Imported
Gene namesⁱ	Name:FBLN5Imported ORF Names:hCG_21251Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140092.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3602 FBLN5

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000140092

OpenTargetsⁱ

ENSG00000140092

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_5015091878	24 – 489	Sequence analysisAdd BLAST		466

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	252 ↔ 262	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRIDEⁱ	G3XA98

PRIDEⁱ

G3XA98

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000140092 Expressed in 199 organ(s), highest expression level in thoracic aorta

Bgeeⁱ

ENSG00000140092 Expressed in 199 organ(s), highest expression level in thoracic aorta

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	83 – 123	EGF-likeInterPro annotationAdd BLAST	41
Domainⁱ	168 – 208	EGF-likeInterPro annotationAdd BLAST	41
Domainⁱ	209 – 247	EGF-likeInterPro annotationAdd BLAST	39
Domainⁱ	248 – 287	EGF-likeInterPro annotationAdd BLAST	40
Domainⁱ	288 – 328	EGF-likeInterPro annotationAdd BLAST	41

Keywords - Domainⁱ

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118806
OMAⁱ	DDGVHCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04QP

Family and domain databases

InterProⁱ	View protein in InterPro IPR026823 cEGF IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR037288 Fibulin-5 IPR037287 Fibulin_3/4/5 IPR009030 Growth_fac_rcpt_cys_sf
PANTHERⁱ	PTHR44074 PTHR44074, 1 hit PTHR44074:SF4 PTHR44074:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12662 cEGF, 3 hits PF07645 EGF_CA, 2 hits
SMARTⁱ	View protein in SMART SM00181 EGF, 5 hits SM00179 EGF_CA, 6 hits
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 4 hits PS01186 EGF_2, 4 hits PS50026 EGF_3, 5 hits PS01187 EGF_CA, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

G3XA98-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPGIKRILTV TILALCLPSP GNAQAQCTNG FDLDRQSGQC LDGVSLSSPR 
        60         70         80         90        100
LECNGAISAH CNLCLPGSSD SSASASQVAG ITDIDECRTI PEACRGDMMC 
       110        120        130        140        150
VNQNGGYLCI PRTNPVYRGP YSNPYSTPYS GPYPAAAPPL SAPNYPTISR 
       160        170        180        190        200
PLICRFGYQM DESNQCVDVD ECATDSHQCN PTQICINTEG GYTCSCTDGY 
       210        220        230        240        250
WLLEGQCLDI DECRYGYCQQ LCANVPGSYS CTCNPGFTLN EDGRSCQDVN 
       260        270        280        290        300
ECATENPCVQ TCVNTYGSFI CRCDPGYELE EDGVHCSDMD ECSFSEFLCQ 
       310        320        330        340        350
HECVNQPGTY FCSCPPGYIL LDDNRSCQDI NECEHRNHTC NLQQTCYNLQ 
       360        370        380        390        400
GGFKCIDPIR CEEPYLRISD NRCMCPAENP GCRDQPFTIL YRDMDVVSGR 
       410        420        430        440        450
SVPADIFQMQ ATTRYPGAYY IFQIKSGNEG REFYMRQTGP ISATLVMTRP 
       460        470        480 
IKGPREIQLD LEMITVNTVI NFRGSSVIRL RIYVSQYPF

Length:489

Mass (Da):54,126

Last modified:November 16, 2011 - v1

Checksum:ⁱ66CD7175BCC607E5

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9UBX5	FBLN5_HUMAN	Fibulin-5 Fibulin-5, FIBL-5 (Developmental arteries and neural crest EGF-like protein, Dance) (Urine p50 protein, UP50)	FBLN5 DANCE, UNQ184/PRO210	448	Annotation score:
G3V4U0	G3V4U0_HUMAN	Fibulin-5 Fibulin-5	FBLN5	453	Annotation score:
G3V3Y2	G3V3Y2_HUMAN	Fibulin-5 Fibulin-5	FBLN5	91	Annotation score:
G3V329	G3V329_HUMAN	Fibulin-5 Fibulin-5	FBLN5	44	Annotation score:
G3V2P8	G3V2P8_HUMAN	Fibulin-5 Fibulin-5	FBLN5	35	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL049872 Genomic DNA No translation available. AL590328 Genomic DNA No translation available. KF455988 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81465.1
UniGeneⁱ	Hs.332708

Genome annotation databases

Ensemblⁱ	ENST00000267620; ENSP00000267620; ENSG00000140092
UCSC genome browser More...UCSCⁱ	uc010aue.4 human

Protein	Similar proteins		Species	Score	Length	Source
G3XA98	Full-length cDNA clone CS0DI085YI08 of Placenta of Homo sapiens (human) (Fragment)		HUMAN		545	UniRef100_G3XA98
UPI0001880462		HUMAN		392

Protein	Similar proteins		Species	Score	Length	Source
G3XA98	Fibulin-5		HUMAN		448	UniRef90_Q9UBX5
Fibulin-5		PONAB		448
Fibulin-5		BOVIN		448
FBLN5 isoform 3		PANTR		448
Uncharacterized protein		PANPA		448
+98

Protein	Similar proteins		Species	Score	Length	Source
G3XA98	Fibulin-5		HUMAN		448	UniRef50_Q9UBX5
Fibulin-5		PONAB		448
Fibulin-5		BOVIN		448
Fibulin-5		RAT		448
Fibulin-5		MOUSE		448
+353

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL049872 Genomic DNA No translation available. AL590328 Genomic DNA No translation available. KF455988 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81465.1
UniGeneⁱ	Hs.332708

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	G3XA98

PRIDEⁱ

G3XA98

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000267620; ENSP00000267620; ENSG00000140092
UCSCⁱ	uc010aue.4 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140092.14
HGNCⁱ	HGNC:3602 FBLN5
OpenTargetsⁱ	ENSG00000140092
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000118806
OMAⁱ	DDGVHCS
OrthoDBⁱ	EOG091G04QP

Gene expression databases

Bgeeⁱ	ENSG00000140092 Expressed in 199 organ(s), highest expression level in thoracic aorta

Bgeeⁱ

ENSG00000140092 Expressed in 199 organ(s), highest expression level in thoracic aorta

Family and domain databases

InterProⁱ	View protein in InterPro IPR026823 cEGF IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR037288 Fibulin-5 IPR037287 Fibulin_3/4/5 IPR009030 Growth_fac_rcpt_cys_sf
PANTHERⁱ	PTHR44074 PTHR44074, 1 hit PTHR44074:SF4 PTHR44074:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF12662 cEGF, 3 hits PF07645 EGF_CA, 2 hits
SMARTⁱ	View protein in SMART SM00181 EGF, 5 hits SM00179 EGF_CA, 6 hits
SUPFAMⁱ	SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 4 hits PS01186 EGF_2, 4 hits PS50026 EGF_3, 5 hits PS01187 EGF_CA, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3XA98_HUMAN
Accessionⁱ	G3XA98Primary (citable) accession number: G3XA98
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	November 7, 2018
	This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3XA98 (G3XA98_HUMAN)

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Fibulin 5, isoform CRA_a

FBLN5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ