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Protein
Submitted name:

Fibulin 5, isoform CRA_a

Gene

FBLN5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Fibulin 5, isoform CRA_aImported
Submitted name:
Fibulin-5Imported
Gene namesi
Name:FBLN5Imported
ORF Names:hCG_21251Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140092.14
HGNCiHGNC:3602 FBLN5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501509187824 – 489Sequence analysisAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi252 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRIDEiG3XA98

Expressioni

Gene expression databases

BgeeiENSG00000140092 Expressed in 199 organ(s), highest expression level in thoracic aorta

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 123EGF-likeInterPro annotationAdd BLAST41
Domaini168 – 208EGF-likeInterPro annotationAdd BLAST41
Domaini209 – 247EGF-likeInterPro annotationAdd BLAST39
Domaini248 – 287EGF-likeInterPro annotationAdd BLAST40
Domaini288 – 328EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118806
OMAiDDGVHCS
OrthoDBiEOG091G04QP

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037288 Fibulin-5
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF4 PTHR44074:SF4, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 3 hits
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G3XA98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGIKRILTV TILALCLPSP GNAQAQCTNG FDLDRQSGQC LDGVSLSSPR
60 70 80 90 100
LECNGAISAH CNLCLPGSSD SSASASQVAG ITDIDECRTI PEACRGDMMC
110 120 130 140 150
VNQNGGYLCI PRTNPVYRGP YSNPYSTPYS GPYPAAAPPL SAPNYPTISR
160 170 180 190 200
PLICRFGYQM DESNQCVDVD ECATDSHQCN PTQICINTEG GYTCSCTDGY
210 220 230 240 250
WLLEGQCLDI DECRYGYCQQ LCANVPGSYS CTCNPGFTLN EDGRSCQDVN
260 270 280 290 300
ECATENPCVQ TCVNTYGSFI CRCDPGYELE EDGVHCSDMD ECSFSEFLCQ
310 320 330 340 350
HECVNQPGTY FCSCPPGYIL LDDNRSCQDI NECEHRNHTC NLQQTCYNLQ
360 370 380 390 400
GGFKCIDPIR CEEPYLRISD NRCMCPAENP GCRDQPFTIL YRDMDVVSGR
410 420 430 440 450
SVPADIFQMQ ATTRYPGAYY IFQIKSGNEG REFYMRQTGP ISATLVMTRP
460 470 480
IKGPREIQLD LEMITVNTVI NFRGSSVIRL RIYVSQYPF
Length:489
Mass (Da):54,126
Last modified:November 16, 2011 - v1
Checksum:i66CD7175BCC607E5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UBX5FBLN5_HUMAN
Fibulin-5
FBLN5 DANCE, UNQ184/PRO210
448Annotation score:
G3V4U0G3V4U0_HUMAN
Fibulin-5
FBLN5
453Annotation score:
G3V3Y2G3V3Y2_HUMAN
Fibulin-5
FBLN5
91Annotation score:
G3V329G3V329_HUMAN
Fibulin-5
FBLN5
44Annotation score:
G3V2P8G3V2P8_HUMAN
Fibulin-5
FBLN5
35Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049872 Genomic DNA No translation available.
AL590328 Genomic DNA No translation available.
KF455988 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81465.1
UniGeneiHs.332708

Genome annotation databases

EnsembliENST00000267620; ENSP00000267620; ENSG00000140092
UCSCiuc010aue.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049872 Genomic DNA No translation available.
AL590328 Genomic DNA No translation available.
KF455988 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81465.1
UniGeneiHs.332708

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiG3XA98

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267620; ENSP00000267620; ENSG00000140092
UCSCiuc010aue.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000140092.14
HGNCiHGNC:3602 FBLN5
OpenTargetsiENSG00000140092
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118806
OMAiDDGVHCS
OrthoDBiEOG091G04QP

Gene expression databases

BgeeiENSG00000140092 Expressed in 199 organ(s), highest expression level in thoracic aorta

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037288 Fibulin-5
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF4 PTHR44074:SF4, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 3 hits
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiG3XA98_HUMAN
AccessioniPrimary (citable) accession number: G3XA98
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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