UniProtKB - G3XA98 (G3XA98_HUMAN)
Protein
Fibulin-5
Gene
FBLN5
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- integrin binding Source: Ensembl
GO - Biological processi
- elastic fiber assembly Source: Ensembl
- intramembranous bone growth Source: Ensembl
- negative regulation of angiogenesis Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of osteoblast proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein localization to cell surface Source: Ensembl
- regulation of cell growth Source: Ensembl
- regulation of removal of superoxide radicals Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Fibulin-5ARBA annotation |
Gene namesi | Name:FBLN5Imported ORF Names:hCG_21251Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3602, FBLN5 |
VEuPathDBi | HostDB:ENSG00000140092.14 |
Subcellular locationi
Extracellular region or secreted
- collagen-containing extracellular matrix Source: Ensembl
- elastic fiber Source: Ensembl
- extracellular space Source: Ensembl
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5015091878 | 24 – 489 | Fibulin-5Sequence analysisAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 252 ↔ 262 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
PRIDEi | G3XA98 |
ProteomicsDBi | 33689 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140092, Expressed in thoracic aorta and 213 other tissues |
ExpressionAtlasi | G3XA98, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 123 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 168 – 208 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 209 – 247 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 248 – 287 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 288 – 328 | EGF-likeInterPro annotationAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the fibulin family.ARBA annotation
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158774 |
OMAi | ACRGDMV |
Family and domain databases
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR037288, Fibulin-5 IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24050:SF21, PTHR24050:SF21, 1 hit |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 2 hits |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 5 hits PS01187, EGF_CA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
G3XA98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGIKRILTV TILALCLPSP GNAQAQCTNG FDLDRQSGQC LDGVSLSSPR
60 70 80 90 100
LECNGAISAH CNLCLPGSSD SSASASQVAG ITDIDECRTI PEACRGDMMC
110 120 130 140 150
VNQNGGYLCI PRTNPVYRGP YSNPYSTPYS GPYPAAAPPL SAPNYPTISR
160 170 180 190 200
PLICRFGYQM DESNQCVDVD ECATDSHQCN PTQICINTEG GYTCSCTDGY
210 220 230 240 250
WLLEGQCLDI DECRYGYCQQ LCANVPGSYS CTCNPGFTLN EDGRSCQDVN
260 270 280 290 300
ECATENPCVQ TCVNTYGSFI CRCDPGYELE EDGVHCSDMD ECSFSEFLCQ
310 320 330 340 350
HECVNQPGTY FCSCPPGYIL LDDNRSCQDI NECEHRNHTC NLQQTCYNLQ
360 370 380 390 400
GGFKCIDPIR CEEPYLRISD NRCMCPAENP GCRDQPFTIL YRDMDVVSGR
410 420 430 440 450
SVPADIFQMQ ATTRYPGAYY IFQIKSGNEG REFYMRQTGP ISATLVMTRP
460 470 480
IKGPREIQLD LEMITVNTVI NFRGSSVIRL RIYVSQYPF
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UBX5 | FBLN5_HUMAN | Fibulin-5 | FBLN5 DANCE, UNQ184/PRO210 | 448 | Annotation score: | ||
G3V4U0 | G3V4U0_HUMAN | Fibulin-5 | FBLN5 | 453 | Annotation score: | ||
G3V3Y2 | G3V3Y2_HUMAN | Fibulin-5 | FBLN5 | 91 | Annotation score: | ||
G3V329 | G3V329_HUMAN | Fibulin-5 | FBLN5 | 44 | Annotation score: | ||
G3V2P8 | G3V2P8_HUMAN | Fibulin-5 | FBLN5 | 35 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049872 Genomic DNA No translation available. AL590328 Genomic DNA No translation available. KF455988 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81465.1 |
Genome annotation databases
Ensembli | ENST00000267620; ENSP00000267620; ENSG00000140092 |
UCSCi | uc010aue.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049872 Genomic DNA No translation available. AL590328 Genomic DNA No translation available. KF455988 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81465.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | G3XA98 |
ProteomicsDBi | 33689 |
Protocols and materials databases
Antibodypediai | 72, 431 antibodies |
Genome annotation databases
Ensembli | ENST00000267620; ENSP00000267620; ENSG00000140092 |
UCSCi | uc010aue.4, human |
Organism-specific databases
HGNCi | HGNC:3602, FBLN5 |
OpenTargetsi | ENSG00000140092 |
VEuPathDBi | HostDB:ENSG00000140092.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158774 |
OMAi | ACRGDMV |
Miscellaneous databases
ChiTaRSi | FBLN5, human |
Gene expression databases
Bgeei | ENSG00000140092, Expressed in thoracic aorta and 213 other tissues |
ExpressionAtlasi | G3XA98, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR037288, Fibulin-5 IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24050:SF21, PTHR24050:SF21, 1 hit |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 2 hits |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 5 hits PS01187, EGF_CA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3XA98_HUMAN | |
Accessioni | G3XA98Primary (citable) accession number: G3XA98 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |