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UniProtKB - G3XA89 (G3XA89_HUMAN)
Protein
E3 ubiquitin-protein ligase Mdm2
Gene
MDM2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
GO - Molecular functioni
- identical protein binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: InterPro
GO - Biological processi
- negative regulation of apoptotic process Source: InterPro
- negative regulation of transcription by RNA polymerase II Source: InterPro
- regulation of biological quality Source: UniProt
- regulation of cell cycle Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase Mdm2ARBA annotation (EC:2.3.2.27ARBA annotation)Alternative name(s): Double minute 2 proteinARBA annotation RING-type E3 ubiquitin transferase Mdm2ARBA annotation p53-binding protein Mdm2ARBA annotation |
Gene namesi | Name:MDM2Imported ORF Names:hCG_2014981Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6973, MDM2 |
VEuPathDBi | HostDB:ENSG00000135679 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Nucleus
- nucleolus ARBA annotation
- nucleoplasm ARBA annotation
Nucleus
- nucleoplasm Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000135679, Expressed in oviduct epithelium and 219 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 115 | SWIB/MDM2InterPro annotationAdd BLAST | 84 | |
Domaini | 250 – 279 | RanBP2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 389 – 430 | RING-typeInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 186 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 203 – 225 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 322 – 378 | DisorderedSequence analysisAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 116 – 136 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 176 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 331 – 359 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 360 – 376 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the MDM2/MDM4 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00530000063539 |
HOGENOMi | CLU_043544_0_0_1 |
Family and domain databases
CDDi | cd16783, mRING-HC-C2H2C4_MDM2, 1 hit |
Gene3Di | 1.10.245.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028340, Mdm2 IPR015459, MDM2_E3_ligase IPR044080, MDM2_mRING-HC-C2H2C4 IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf IPR003121, SWIB_MDM2_domain IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 2 hits |
Pfami | View protein in Pfam PF02201, SWIB, 1 hit PF00641, zf-RanBP, 1 hit |
PIRSFi | PIRSF500700, MDM2, 2 hits PIRSF006748, p53_MDM_2/4, 2 hits |
SUPFAMi | SSF47592, SSF47592, 2 hits SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS51925, SWIB_MDM2, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
G3XA89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRSRQMCNT NMSVPTDGAV TTSQIPASEQ ETLVRPKPLL LKLLKSVGAQ
60 70 80 90 100
KDTYTMKEVL FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK
110 120 130 140 150
EHRKIYTMIY RNLVVVNQQE ENSDELSGER QRKRHKSDSI SLSFDESLAL
160 170 180 190 200
CVIREICCER SSSSESTGTP SNPDLDAGVS EHSGDWLDQD SVSDQFSVEF
210 220 230 240 250
EVESLDSEDY SLSEEGQELS DEDDEVYQVT VYQAGESDTD SFEEDPEISL
260 270 280 290 300
ADYWKCTSCN EMNPPLPSHC NRCWALRENW LPEDKGKDKG EISEKAKLEN
310 320 330 340 350
STQAEEGFDV PDCKKTIVND SRESCVEEND DKITQASQSQ ESEDYSQPST
360 370 380 390 400
SSSIIYSSQE DVKEFEREET QDKEESVESS LPLNAIEPCV ICQGRPKNGC
410 420 430 440
IVHGKTGHLM ACFTCAKKLK KRNKPCPVCR QPIQMIVLTY FP
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ00987 | MDM2_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 491 | Annotation score: | ||
E7EPE2 | E7EPE2_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 522 | Annotation score: | ||
J3KN53 | J3KN53_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 466 | Annotation score: | ||
F5GWH7 | F5GWH7_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 455 | Annotation score: | ||
Q9H4C5 | Q9H4C5_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 243 | Annotation score: | ||
A0A0C4DFR5 | A0A0C4DFR5_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 266 | Annotation score: | ||
A7UKX8 | A7UKX8_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 mdm2 | 256 | Annotation score: | ||
F5H4Q8 | F5H4Q8_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 170 | Annotation score: | ||
A0A1B0GXJ6 | A0A1B0GXJ6_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 117 | Annotation score: | ||
A0A0A8KB88 | A0A0A8KB88_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 185 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025423 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97207.1 |
RefSeqi | NP_001138811.1, NM_001145339.2 |
Genome annotation databases
Ensembli | ENST00000258148.11; ENSP00000258148.7; ENSG00000135679.27 |
GeneIDi | 4193 |
UCSCi | uc009zqx.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025423 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97207.1 |
RefSeqi | NP_001138811.1, NM_001145339.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 33681 |
Protocols and materials databases
Antibodypediai | 3664, 1789 antibodies from 47 providers |
DNASUi | 4193 |
Genome annotation databases
Ensembli | ENST00000258148.11; ENSP00000258148.7; ENSG00000135679.27 |
GeneIDi | 4193 |
UCSCi | uc009zqx.6, human |
Organism-specific databases
CTDi | 4193 |
HGNCi | HGNC:6973, MDM2 |
OpenTargetsi | ENSG00000135679 |
VEuPathDBi | HostDB:ENSG00000135679 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063539 |
HOGENOMi | CLU_043544_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 4193, 210 hits in 1135 CRISPR screens |
ChiTaRSi | MDM2, human |
GenomeRNAii | 4193 |
Gene expression databases
Bgeei | ENSG00000135679, Expressed in oviduct epithelium and 219 other tissues |
Family and domain databases
CDDi | cd16783, mRING-HC-C2H2C4_MDM2, 1 hit |
Gene3Di | 1.10.245.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028340, Mdm2 IPR015459, MDM2_E3_ligase IPR044080, MDM2_mRING-HC-C2H2C4 IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf IPR003121, SWIB_MDM2_domain IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 2 hits |
Pfami | View protein in Pfam PF02201, SWIB, 1 hit PF00641, zf-RanBP, 1 hit |
PIRSFi | PIRSF500700, MDM2, 2 hits PIRSF006748, p53_MDM_2/4, 2 hits |
SUPFAMi | SSF47592, SSF47592, 2 hits SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS51925, SWIB_MDM2, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3XA89_HUMAN | |
Accessioni | G3XA89Primary (citable) accession number: G3XA89 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |