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Protein

Rab11 family-interacting protein 2

Gene

Rab11fip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein homodimerization activity Source: MGI
  • protein kinase binding Source: MGI
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 2
Short name:
Rab11-FIP2
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1922248 Rab11fip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004240631 – 512Rab11 family-interacting protein 2Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei227Phosphoserine; by MARK2By similarity1
Modified residuei277PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiG3XA57
PaxDbiG3XA57
PeptideAtlasiG3XA57
PRIDEiG3XA57

PTM databases

iPTMnetiG3XA57
PhosphoSitePlusiG3XA57

Expressioni

Gene expression databases

BgeeiENSMUSG00000040022 Expressed in 237 organ(s), highest expression level in indifferent gonad
ExpressionAtlasiG3XA57 baseline and differential
GenevisibleiG3XA57 MM

Interactioni

Subunit structurei

Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217140, 2 interactors
IntActiG3XA57, 1 interactor
STRINGi10090.ENSMUSP00000059978

Structurei

3D structure databases

ProteinModelPortaliG3XA57
SMRiG3XA57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 102C2PROSITE-ProRule annotationAdd BLAST102
Domaini437 – 499FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 102Necessary for its cellular translocation to the plasma membraneBy similarityAdd BLAST88
Regioni465 – 512Necessary for interaction with AP2A1, RAB11A, subcellular location, endocytosis activity and homooligomerizationBy similarityAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi323 – 325NPF 1By similarity3
Motifi406 – 408NPF 2By similarity3
Motifi440 – 442NPF 2By similarity3

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEZZ Eukaryota
ENOG410Z26C LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG054920
KOiK12484
OMAiHMNPTSN
OrthoDBiEOG091G09IV
TreeFamiTF326172

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: G3XA57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLSEQAQKW FPTHVQVTVL QAKDLKPKGK SGTNDTYTII QLGKEKYSTS
60 70 80 90 100
VAEKTLEPVW KEEASFELPG LLMQGSPEKY ILFLIVMHRS LVGLDKFLGQ
110 120 130 140 150
VAINLNDIFE DKQRRKTEWF RLESKQGKRI KNRGEIKVNI QFMRNNMTAS
160 170 180 190 200
MFDLSMKDKT RSPFAKLKDK MKGRKSDGVF SDTSSAIVPS THMPDANPEF
210 220 230 240 250
SSGEMQMKSK PKKPFLLGPQ RLSSAHSMSD LTGSHLSSEK LKSSTVGPTH
260 270 280 290 300
LLSRQIDSFG VVPESGSLKS PHRRTLSFDT SKLNQPGSIV DEGEHSFGRQ
310 320 330 340 350
SDPFTNVTAS LPQKFATLPR KKNPFEESSE PWDSSMNLFS KPIEVRKESK
360 370 380 390 400
REKREKVSLF ERVTGKRDSR RPDKLNNGGS DSPCDLKSPS AFSENRQDYF
410 420 430 440 450
EYESTNPFTA KFRASTIMPS SSFHVNPTSS EDLRKIPDNN PFDATAGYRS
460 470 480 490 500
LTYEEVLQEL VKHKELLRRK DTHIRELEDY IDNLLVRVME ETPSILRVPY
510
EPSRKAGKFT NS
Length:512
Mass (Da):58,207
Last modified:November 16, 2011 - v1
Checksum:i5A6622C5E0B96728
GO
Isoform 2 (identifier: G3XA57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     507-512: GKFTNS → VYTQDHLSPGPPHLCGEATSTHS

Show »
Length:529
Mass (Da):59,989
Checksum:iB323D6B7E10F0DA0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UW57G3UW57_MOUSE
RAB11 family interacting protein 2 ...
Rab11fip2 mCG_21156
370Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053310507 – 512GKFTNS → VYTQDHLSPGPPHLCGEATS THS in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105061 Genomic DNA No translation available.
AC162855 Genomic DNA No translation available.
CH466585 Genomic DNA Translation: EDL01829.1
BC089010 mRNA Translation: AAH89010.1
BC139380 mRNA Translation: AAI39381.1
BC139419 mRNA Translation: AAI39420.1
CCDSiCCDS38033.1 [G3XA57-2]
RefSeqiNP_001028344.2, NM_001033172.3 [G3XA57-2]
NP_001157839.1, NM_001164367.1
UniGeneiMm.24167

Genome annotation databases

EnsembliENSMUST00000051996; ENSMUSP00000059978; ENSMUSG00000040022 [G3XA57-2]
ENSMUST00000170819; ENSMUSP00000133151; ENSMUSG00000040022 [G3XA57-1]
GeneIDi74998
KEGGimmu:74998
UCSCiuc008ibm.1 mouse [G3XA57-1]
uc008ibn.2 mouse [G3XA57-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105061 Genomic DNA No translation available.
AC162855 Genomic DNA No translation available.
CH466585 Genomic DNA Translation: EDL01829.1
BC089010 mRNA Translation: AAH89010.1
BC139380 mRNA Translation: AAI39381.1
BC139419 mRNA Translation: AAI39420.1
CCDSiCCDS38033.1 [G3XA57-2]
RefSeqiNP_001028344.2, NM_001033172.3 [G3XA57-2]
NP_001157839.1, NM_001164367.1
UniGeneiMm.24167

3D structure databases

ProteinModelPortaliG3XA57
SMRiG3XA57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217140, 2 interactors
IntActiG3XA57, 1 interactor
STRINGi10090.ENSMUSP00000059978

PTM databases

iPTMnetiG3XA57
PhosphoSitePlusiG3XA57

Proteomic databases

MaxQBiG3XA57
PaxDbiG3XA57
PeptideAtlasiG3XA57
PRIDEiG3XA57

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051996; ENSMUSP00000059978; ENSMUSG00000040022 [G3XA57-2]
ENSMUST00000170819; ENSMUSP00000133151; ENSMUSG00000040022 [G3XA57-1]
GeneIDi74998
KEGGimmu:74998
UCSCiuc008ibm.1 mouse [G3XA57-1]
uc008ibn.2 mouse [G3XA57-2]

Organism-specific databases

CTDi22841
MGIiMGI:1922248 Rab11fip2

Phylogenomic databases

eggNOGiENOG410IEZZ Eukaryota
ENOG410Z26C LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG054920
KOiK12484
OMAiHMNPTSN
OrthoDBiEOG091G09IV
TreeFamiTF326172

Enzyme and pathway databases

ReactomeiR-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins

Miscellaneous databases

ChiTaRSiRab11fip2 mouse
PROiPR:G3XA57
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040022 Expressed in 237 organ(s), highest expression level in indifferent gonad
ExpressionAtlasiG3XA57 baseline and differential
GenevisibleiG3XA57 MM

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFIP2_MOUSE
AccessioniPrimary (citable) accession number: G3XA57
Secondary accession number(s): B9EID4, Q5HZI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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