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Protein
Submitted name:

MCG1618, isoform CRA_c

Gene

Nsmce4a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • DNA repair Source: GO_Central
  • positive regulation of response to DNA damage stimulus Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyi

Protein namesi
Submitted name:
MCG1618, isoform CRA_cImported
Submitted name:
NSE4 homolog A, SMC5-SMC6 complex componentImported
Gene namesi
Name:Nsmce4aImported
ORF Names:mCG_1618Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915122 Nsmce4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000040331 Expressed in 293 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125300

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 182Nse4-Nse3_bdgInterPro annotationAdd BLAST53
Domaini283 – 371Nse4_CInterPro annotationAdd BLAST89

Phylogenomic databases

eggNOGiKOG2866 Eukaryota
COG5125 LUCA
GeneTreeiENSGT00390000011476
KOiK22825
OMAiKMEESHQ
OrthoDBiEOG091G0GO8
TreeFamiTF313999

Family and domain databases

InterProiView protein in InterPro
IPR027786 Nse4/EID
IPR014854 Nse4_C
IPR029225 Nse4_Nse3-bd
PANTHERiPTHR16140 PTHR16140, 1 hit
PfamiView protein in Pfam
PF15412 Nse4-Nse3_bdg, 1 hit
PF08743 Nse4_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3XA30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDSSGRRS EGRGRGRDPH RDRTRSRSRS RSPLARRGAA PERREAAERP
60 70 80 90 100
SLEDSDLSDS GDELMDPACL EAEYDQGLCR QIRHQYRALI NSVQQNREDI
110 120 130 140 150
LNAGDKLTEV LEEANTLFNE VSRAREAVLD AQFLVLASDL GKEKAKQLRS
160 170 180 190 200
DLSSFDMLRY VETLLTHMGV NPLEAQEVIR DEDRADIELI VYDSWKISGK
210 220 230 240 250
TAENTFNKTH TFHFLLGSIH GEFPVPKPRS DRPRQPRMIE EQRAMPAQLK
260 270 280 290 300
CMEESHQEAT EKEVERILGL LQTYFREDPD TPMSFFDFVV DPHSFPRTVE
310 320 330 340 350
NIFHVSFIIR DGFARIRLDQ DRLPIIEPVI NEESEGIDHN IQIRSQGIIA
360 370 380
LSYHDWEEIV KTFEISEPVI PLSQSQQRLS A
Length:381
Mass (Da):43,753
Last modified:November 16, 2011 - v1
Checksum:i230F03EFA73A26BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UGP0F6UGP0_MOUSE
NSE4 homolog A, SMC5-SMC6 complex c...
Nsmce4a
71Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC175034 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL17677.1
RefSeqiNP_001156327.1, NM_001162855.1
UniGeneiMm.21714
Mm.411879

Genome annotation databases

EnsembliENSMUST00000160289; ENSMUSP00000125300; ENSMUSG00000040331
GeneIDi67872
KEGGimmu:67872
UCSCiuc009kad.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC175034 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL17677.1
RefSeqiNP_001156327.1, NM_001162855.1
UniGeneiMm.21714
Mm.411879

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125300

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160289; ENSMUSP00000125300; ENSMUSG00000040331
GeneIDi67872
KEGGimmu:67872
UCSCiuc009kad.2 mouse

Organism-specific databases

CTDi54780
MGIiMGI:1915122 Nsmce4a

Phylogenomic databases

eggNOGiKOG2866 Eukaryota
COG5125 LUCA
GeneTreeiENSGT00390000011476
KOiK22825
OMAiKMEESHQ
OrthoDBiEOG091G0GO8
TreeFamiTF313999

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040331 Expressed in 293 organ(s), highest expression level in embryo

Family and domain databases

InterProiView protein in InterPro
IPR027786 Nse4/EID
IPR014854 Nse4_C
IPR029225 Nse4_Nse3-bd
PANTHERiPTHR16140 PTHR16140, 1 hit
PfamiView protein in Pfam
PF15412 Nse4-Nse3_bdg, 1 hit
PF08743 Nse4_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3XA30_MOUSE
AccessioniPrimary (citable) accession number: G3XA30
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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