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Entry version 58 (02 Jun 2021)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

HMG box domain-containing 3

Gene

Hmgxb3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi41 – 99HMG boxPROSITE-ProRule annotationAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HMG box domain-containing 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hmgxb3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2441817, Hmgxb3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G3X9M3

PRoteomics IDEntifications database

More...
PRIDEi
G3X9M3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
335239

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024622, Expressed in cardiac ventricle and 294 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G3X9M3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000089498

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QZFJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006983

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006879_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CWLVHPP

TreeFam database of animal gene trees

More...
TreeFami
TF330893

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR039598, HMGXB3
IPR040648, HMGXB3_CxC4

The PANTHER Classification System

More...
PANTHERi
PTHR17609, PTHR17609, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18717, CxC4, 1 hit
PF09011, HMG_box_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3X9M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPYDGAEV TVLMEEIEEA YYTSPGPPKK KKKYKIHGEK AKKPRSAYLL
60 70 80 90 100
YYYDIYLKVQ QELPHLPQSE INKKISESWR LLSVAERSYY LEKAKLEKEG
110 120 130 140 150
LDPNSKLSAL TAVVPDIPGF RKILPRSEYI IIPKSTLQED RSCPQLELCV
160 170 180 190 200
AQNQMSPKGS TLMSNASPDV VASHAGMAEQ CLAVEALAEE VGALPQPGTV
210 220 230 240 250
QEIATSEILS HDMLLEEASL EVGESHQPYQ TSLVIEETLV NGSSDLPTGS
260 270 280 290 300
LAVPHSQVGE SLSVVTVMRD SSESSPSAPA TQFIMLPLPA YSVVENPSSI
310 320 330 340 350
KLTTTYTRRG HGTCTSPGCS FTYVTRHKPP KCPTCGNFLG GKWIPKEKPA
360 370 380 390 400
KVKVELASGV SSKGSVIKRN QQSVTTEQNP SKENASKLTL ENSEAEVPGN
410 420 430 440 450
RGTAVTKMPV VKSGAQAEIS LGTTENDSPG PDILPSAEGT SSSSLLQAHK
460 470 480 490 500
KSPGVDLFTT GPKAPELKGR ARGKPSLLAA ARPMRAILPA PTSVGRGSGV
510 520 530 540 550
GLPRARQAFP LDKTPSVRTC GLKPSTLKQL GQPIQQPPST GEVKLSNCAS
560 570 580 590 600
SRTPQLKIVE VKPDLFPPYK YSCTVTLDLG LATSRGRGKC KNPSCSYVYT
610 620 630 640 650
NRHKPRICPS CGFNLAKDRT EKTPKAIEAS SPHPDVPSTT EALNPTQREV
660 670 680 690 700
QRQSTLQLLR KVLQIPENES ELAEVFALIH ELNSSRLILS NVSEETVTIE
710 720 730 740 750
QTSWSNYYES PSTQCLLCSS PLFKGGHNSL AGPQECWLLT ANRLQVVTAQ
760 770 780 790 800
VKMCLNPHCL ALHSFTDIYT GLFNVGNKLL VSLDLLFAIR NQIKLGEDPR
810 820 830 840 850
VSVGVVLKSV QEQTEKTLTS EELSQLQELL CNGYWAFECL TVRDYNDMIC
860 870 880 890 900
GICGVAPKVE MAQRNEENVL ALKSVEFTWP EFLGSSEVNV EDFWTTMETE
910 920 930 940 950
VIEQVAFPAS IPITKFDASV IAPFFPPLMR GAVVVNTEKD KTQDMQPVPG
960 970 980 990 1000
NGSALVRLLQ EGTCKLEELG SYSGEELQYL LEQCDIPFSP EDSRDQLCFS
1010 1020 1030 1040 1050
LLALYESVQN GARARPPPAH FTGGKIYKVC PHQVVCGSKY LVRGESARDH
1060 1070 1080 1090 1100
VDLLASSRHW PPVYVVDMAT PVALCADLCY PELTSQMWGK NQGCFSNPTE
1110 1120 1130 1140 1150
PVVSVSCPEL LDQHYSVDVT EAENSVQHPV TKSATRRIVH ANTKPDPSDP
1160 1170 1180 1190 1200
SAGHRSLSLC PELAPYASTT DSKLSSVRQR PIAFDNATHY YLYNRLMDFL
1210 1220 1230 1240 1250
TSREIVNRQI HDIVQSCQPG EVVIRDTLYR LGVAQIKTEA QEEGEEEEVA

SVVE
Length:1,254
Mass (Da):137,275
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65ADA07521637B84
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6AXF8Q6AXF8_MOUSE
HMG box domain-containing 3
Hmgxb3
1,286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B973A0A494B973_MOUSE
HMG box domain-containing 3
Hmgxb3
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9M0A0A494B9M0_MOUSE
HMG box domain-containing 3
Hmgxb3
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_598895.2, NM_134134.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091884; ENSMUSP00000089498; ENSMUSG00000024622

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:106894

UCSC genome browser

More...
UCSCi
uc008fbq.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_598895.2, NM_134134.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089498

Proteomic databases

EPDiG3X9M3
PRIDEiG3X9M3
ProteomicsDBi335239

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1181, 93 antibodies

The DNASU plasmid repository

More...
DNASUi
106894

Genome annotation databases

EnsembliENSMUST00000091884; ENSMUSP00000089498; ENSMUSG00000024622
GeneIDi106894
KEGGimmu:106894
UCSCiuc008fbq.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22993
MGIiMGI:2441817, Hmgxb3

Phylogenomic databases

eggNOGiENOG502QZFJ, Eukaryota
GeneTreeiENSGT00390000006983
HOGENOMiCLU_006879_0_0_1
OMAiCWLVHPP
TreeFamiTF330893

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
106894, 4 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hmgxb3, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024622, Expressed in cardiac ventricle and 294 other tissues
ExpressionAtlasiG3X9M3, baseline and differential

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR039598, HMGXB3
IPR040648, HMGXB3_CxC4
PANTHERiPTHR17609, PTHR17609, 1 hit
PfamiView protein in Pfam
PF18717, CxC4, 1 hit
PF09011, HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3X9M3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X9M3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 2, 2021
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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