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Entry version 73 (29 Sep 2021)
Sequence version 1 (16 Nov 2011)
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Protein

Signal-induced proliferation-associated 1-like protein 3

Gene

Sipa1l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 3
Short name:
SIPA1-like protein 3
Alternative name(s):
SPA-1-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sipa1l3
Synonyms:Spal3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921456, Sipa1l3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000030583

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice at 4 weeks postnatal age show reduced lens size and microphthalmia (PubMed:26231217).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004354761 – 1776Signal-induced proliferation-associated 1-like protein 3Add BLAST1776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei394PhosphoserineBy similarity1
Modified residuei1358PhosphoserineCombined sources1
Modified residuei1381PhosphothreonineCombined sources1
Modified residuei1442N6-acetyllysineBy similarity1
Modified residuei1538PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1617PhosphoserineCombined sources1
Modified residuei1672PhosphoserineCombined sources1
Modified residuei1694PhosphothreonineBy similarity1
Modified residuei1698PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G3X9J0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
G3X9J0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G3X9J0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G3X9J0

PeptideAtlas

More...
PeptideAtlasi
G3X9J0

PRoteomics IDEntifications database

More...
PRIDEi
G3X9J0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
261228

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G3X9J0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
G3X9J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing lens.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030583, Expressed in intestine and 265 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G3X9J0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000082965

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
G3X9J0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3X9J0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini605 – 822Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini960 – 1024PDZPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 157DisorderedSequence analysisAdd BLAST117
Regioni240 – 325DisorderedSequence analysisAdd BLAST86
Regioni438 – 461DisorderedSequence analysisAdd BLAST24
Regioni1040 – 1104DisorderedSequence analysisAdd BLAST65
Regioni1117 – 1164DisorderedSequence analysisAdd BLAST48
Regioni1184 – 1632DisorderedSequence analysisAdd BLAST449
Regioni1678 – 1705DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1715 – 1769Sequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 65Polar residuesSequence analysisAdd BLAST20
Compositional biasi89 – 130Polar residuesSequence analysisAdd BLAST42
Compositional biasi251 – 266Polar residuesSequence analysisAdd BLAST16
Compositional biasi267 – 284Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi295 – 320Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1052 – 1068Polar residuesSequence analysisAdd BLAST17
Compositional biasi1076 – 1104Polar residuesSequence analysisAdd BLAST29
Compositional biasi1192 – 1210Polar residuesSequence analysisAdd BLAST19
Compositional biasi1254 – 1278Polar residuesSequence analysisAdd BLAST25
Compositional biasi1296 – 1319Polar residuesSequence analysisAdd BLAST24
Compositional biasi1407 – 1447Polar residuesSequence analysisAdd BLAST41
Compositional biasi1490 – 1517Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1521 – 1540Polar residuesSequence analysisAdd BLAST20
Compositional biasi1563 – 1582Polar residuesSequence analysisAdd BLAST20
Compositional biasi1589 – 1603Polar residuesSequence analysisAdd BLAST15
Compositional biasi1691 – 1705Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159183

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002127_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3X9J0

Identification of Orthologs from Complete Genome Data

More...
OMAi
WVQNGSM

Database of Orthologous Groups

More...
OrthoDBi
28453at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G3X9J0

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap/Ran_GAP_dom
IPR031204, SIPA1L3
IPR021818, SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF15, PTHR15711:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145, Rap_GAP, 1 hit
PF11881, SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G3X9J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTYRPLPND GVDLAASCGA RSTDILPGPH PGDYTPMGFW AQNGSMPQPL
60 70 80 90 100
GESPAATTTR PSPTTPAMPK MGVRARVADW PPKRDALREQ SNPSPSQDTD
110 120 130 140 150
GVKTTKVAHS MRNLQNGQLP SSTPASSGSR AFHRLSRRRS KDVEFQDGWP
160 170 180 190 200
RSPGRAFLPL RHRSSSEITL SECDVEEPGD PRGTRHPGVL PLFREYGSTS
210 220 230 240 250
SIDVQGVPEQ SFFDILNEFR SEQPEARGSQ NLRELLQVDP GALSGGSCGT
260 270 280 290 300
KGDPRNGQPT KDSLQSLQPL KEKEKSRKKP VRGLGSGDTV DSSIFRKLRS
310 320 330 340 350
SKPEGEVGRP LGETEESRSP PEASRPWVCQ KSFAHFDVQS MLFDLNEAAA
360 370 380 390 400
NRVSVAQRRN TTTGASAASA ASAMVTLTAS RAHSLGTLDP AFTSTEDLNC
410 420 430 440 450
KENLEQDLGD DNSNDLLLSC PHFRNEIGGE RERNVSFSRA SVGSPGGSSE
460 470 480 490 500
AHMAEPTLST HRTNASISVL EVPKEQQRTQ SRPRQYSIEH VDLGARYYQD
510 520 530 540 550
YFVGKEHANY FGVDEKLGPV AVSIKREKLE DHKDHGPQYQ YRIIFRTREL
560 570 580 590 600
ITLRGSILED ATPTATKHGT GRGLPLKDAL EYVIPELNIH CLRLALNTPK
610 620 630 640 650
VTEQLLKLDE QGLCRKHKVG ILYCKAGQSS EEEMYNNEEA GPAFEEFLDL
660 670 680 690 700
LGDKVCLKGF TKYAAQLDVK TDSTGTHSLY TTYQDYEIMF HVSTLLPYTP
710 720 730 740 750
NNRQQLLRKR HIGNDIVTII FQEPGALPFT PKNIRSHFQH VFIIVRVHNP
760 770 780 790 800
CTENVCYSMA VTRSKDAPPF GPPIPNGTTF RKSDVFRDFL LAKVINAENA
810 820 830 840 850
AHKSDKFHTM ATRTRQEYLK DLAENCVSNT PIDSSGKFNL ISLTSKKKEK
860 870 880 890 900
TKARAGAEQH SAGAIAWRVA AQDYAQGSEI DCILGISNEF VVLLDLRTKE
910 920 930 940 950
VVFNCYCGDV IGWTPDSSTI KIFYGRGDHI FLQAAEGSVE DIRDIVQRLK
960 970 980 990 1000
VMTNGWETVD MTLRRNGLGQ LGFHVKYDGT VAEVEDYGFA WQAGLRQGSR
1010 1020 1030 1040 1050
LVEICKVAVV TLSHDQMIDL LRTSVTVKVV IIPPFEDGTP RRGWPETYDM
1060 1070 1080 1090 1100
NASEPKTESE TTTPGGRPPY RSNAPWQWSG PASHNSLPAT KWTTPATPGH
1110 1120 1130 1140 1150
AQSLSRLPKQ TPVVPFRESQ PLHSKRPVSF PETPFAASPA GADRVPPYRQ
1160 1170 1180 1190 1200
PSGSFSTPGS ATYARYKPSP ERYAAAPHPL LSFDPHFMHD GMSSGDSSSG
1210 1220 1230 1240 1250
GLTSQESTME RPKPEPLWHV PAQARLSAMT GSIGSKHPSR QDAAGKDSPN
1260 1270 1280 1290 1300
RHSKGEPQYS SHSSSNTLSS NASSSHSDDR WFDPLDPLEP EQDPFSKGGS
1310 1320 1330 1340 1350
SDSGIDTTLY TSSPSCMSLA KAPRPTKPHK PPGNIGLCGG GRESAGRPHP
1360 1370 1380 1390 1400
VDRRREVSPA PVVAGQNKGY RPKLYSSGSC TPPGLVGGSR DPPRQPSDMG
1410 1420 1430 1440 1450
SRAGYPTQVY KTASAETPRP SQLSQCSPFQ LSTSVPKSFF SKQPAHNKHS
1460 1470 1480 1490 1500
TGWKRTDEPP PRPLPFTDSK KQVDTNAKNV FGQPRLRASL RDLRSPRKNY
1510 1520 1530 1540 1550
KSTIEDDLKK LIVMDNLGPE QERDTGQSPQ KSLQRTLSDE SLCSGRREPS
1560 1570 1580 1590 1600
FASPASLEPG LPSDVLFTST CTFPSSTLPA RRQHQHAHPP SGAPSTTPAT
1610 1620 1630 1640 1650
GNGFPEKKSA ISASELSLAD GRDRPLRRLD PGMMPLPDTA AGLEWSSLVN
1660 1670 1680 1690 1700
AAKAYEVQRA VSLFSLNDPA LSPEIPPAHS PVHSHLSLER GPQTPRATPT
1710 1720 1730 1740 1750
MSEESPLDLT GKVYQLEVML KQLHTDLQKE KQDKVVLQSE VASLRQNNQR
1760 1770
LQEESQAASE QLRKFAELFS REKKEL
Length:1,776
Mass (Da):195,063
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD19E1C84BA720CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1S0S4R1S0_MOUSE
Signal-induced proliferation-associ...
Sipa1l3
849Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2N4S4R2N4_MOUSE
Signal-induced proliferation-associ...
Sipa1l3
726Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1P8S4R1P8_MOUSE
Signal-induced proliferation-associ...
Sipa1l3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1U8S4R1U8_MOUSE
Signal-induced proliferation-associ...
Sipa1l3
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2C7S4R2C7_MOUSE
Signal-induced proliferation-associ...
Sipa1l3
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC164640 Genomic DNA No translation available.
AC166079 Genomic DNA No translation available.
CH466593 Genomic DNA Translation: EDL24066.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39871.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074497.1, NM_001081028.1
XP_011249034.1, XM_011250732.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000085809; ENSMUSP00000082965; ENSMUSG00000030583
ENSMUST00000183096; ENSMUSP00000138171; ENSMUSG00000030583

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74206

UCSC genome browser

More...
UCSCi
uc009gbs.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164640 Genomic DNA No translation available.
AC166079 Genomic DNA No translation available.
CH466593 Genomic DNA Translation: EDL24066.1
CCDSiCCDS39871.1
RefSeqiNP_001074497.1, NM_001081028.1
XP_011249034.1, XM_011250732.2

3D structure databases

SMRiG3X9J0
ModBaseiSearch...

Protein-protein interaction databases

IntActiG3X9J0, 1 interactor
STRINGi10090.ENSMUSP00000082965

PTM databases

iPTMnetiG3X9J0
PhosphoSitePlusiG3X9J0

Proteomic databases

EPDiG3X9J0
jPOSTiG3X9J0
MaxQBiG3X9J0
PaxDbiG3X9J0
PeptideAtlasiG3X9J0
PRIDEiG3X9J0
ProteomicsDBi261228

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
59222, 64 antibodies

The DNASU plasmid repository

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DNASUi
74206

Genome annotation databases

EnsembliENSMUST00000085809; ENSMUSP00000082965; ENSMUSG00000030583
ENSMUST00000183096; ENSMUSP00000138171; ENSMUSG00000030583
GeneIDi74206
KEGGimmu:74206
UCSCiuc009gbs.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23094
MGIiMGI:1921456, Sipa1l3
VEuPathDBiHostDB:ENSMUSG00000030583

Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00940000159183
HOGENOMiCLU_002127_0_0_1
InParanoidiG3X9J0
OMAiWVQNGSM
OrthoDBi28453at2759
PhylomeDBiG3X9J0
TreeFamiTF318626

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
74206, 2 hits in 62 CRISPR screens

Protein Ontology

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PROi
PR:G3X9J0
RNActiG3X9J0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030583, Expressed in intestine and 265 other tissues

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap/Ran_GAP_dom
IPR031204, SIPA1L3
IPR021818, SIPA1L_C
PANTHERiPTHR15711:SF15, PTHR15711:SF15, 1 hit
PfamiView protein in Pfam
PF02145, Rap_GAP, 1 hit
PF11881, SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSI1L3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X9J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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