Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Luteinizing hormone beta

Gene

Lhb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-193048 Androgen biosynthesis
R-MMU-193993 Mineralocorticoid biosynthesis
R-MMU-209822 Glycoprotein hormones
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Names & Taxonomyi

Protein namesi
Submitted name:
Luteinizing hormone betaImported
Submitted name:
Luteinizing hormone beta subunitImported
Submitted name:
Lutropin subunit betaImported
Gene namesi
Name:LhbImported
ORF Names:mCG_23164Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96782 Lhb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501509182521 – 141Sequence analysisAdd BLAST121

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000100916 Expressed in 31 organ(s), highest expression level in pituitary gland

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 130Cys_knotInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
KOiK08521
OMAiTTTICAG
OrthoDBiEOG091G0XFH
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3X9G6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELRFASVRLP GCPPGVDPIV
110 120 130 140
SFPVALSCRC GPCRLSSSDC GGPRTQPMAC DLPHLPGLLL L
Length:141
Mass (Da):15,113
Last modified:November 16, 2011 - v1
Checksum:i5E996FB8F32E83BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O09108LSHB_MOUSE
Lutropin subunit beta
Lhb
141Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151602 Genomic DNA No translation available.
HF564719 Genomic DNA Translation: CCP37924.1
CH466603 Genomic DNA Translation: EDL22853.1
RefSeqiNP_032523.2, NM_008497.2
XP_011249112.1, XM_011250810.2
UniGeneiMm.57061

Genome annotation databases

EnsembliENSMUST00000072453; ENSMUSP00000072276; ENSMUSG00000100916
GeneIDi16866
KEGGimmu:16866
UCSCiuc009gvb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151602 Genomic DNA No translation available.
HF564719 Genomic DNA Translation: CCP37924.1
CH466603 Genomic DNA Translation: EDL22853.1
RefSeqiNP_032523.2, NM_008497.2
XP_011249112.1, XM_011250810.2
UniGeneiMm.57061

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072453; ENSMUSP00000072276; ENSMUSG00000100916
GeneIDi16866
KEGGimmu:16866
UCSCiuc009gvb.1 mouse

Organism-specific databases

CTDi3972
MGIiMGI:96782 Lhb

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
KOiK08521
OMAiTTTICAG
OrthoDBiEOG091G0XFH
TreeFamiTF332940

Enzyme and pathway databases

ReactomeiR-MMU-193048 Androgen biosynthesis
R-MMU-193993 Mineralocorticoid biosynthesis
R-MMU-209822 Glycoprotein hormones
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000100916 Expressed in 31 organ(s), highest expression level in pituitary gland

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3X9G6_MOUSE
AccessioniPrimary (citable) accession number: G3X9G6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again