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Protein
Submitted name:

HEAT repeat-containing 1

Gene

Heatr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • snoRNA binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HEAT repeat-containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Heatr1Imported
ORF Names:mCG_119362Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442524 Heatr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050244 Expressed in 260 organ(s), highest expression level in epiblast (generic)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000054084

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1856 – 2009BP28CTInterPro annotationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2110 – 2130Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1837 Eukaryota
ENOG410XNQQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015845

KEGG Orthology (KO)

More...
KOi
K14550

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYPKQLI

Database of Orthologous Groups

More...
OrthoDBi
524830at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314593

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012954 BP28_C_dom
IPR022125 U3snoRNP10_N
IPR040191 UTP10

The PANTHER Classification System

More...
PANTHERi
PTHR13457 PTHR13457, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08146 BP28CT, 1 hit
PF12397 U3snoRNP10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01036 BP28CT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3X9B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLAQQLQR LALPQTDPSL LSRREVASLL FDPKEAATID RDTAFAIGCT
60 70 80 90 100
GLEELLGIDP AFEQFEAPLF SQLAKGLERS VQTKAVNKQL DENISSFLLH
110 120 130 140 150
LSPYFLLKPA QKCLEWLIHR FHIHLYNADS LIACVLPYHE TRVFVRVIQL
160 170 180 190 200
LKISNPKHKW FWLSPVKHSG VPLARGTLVT HCYKDLGFMD FICSLVTRSV
210 220 230 240 250
KAFAEDPGSS TRLRVLLAFY ASTIVSALVA AENLSDNVVA KLFPYIQKGL
260 270 280 290 300
KSSLPDYRAA TYMIICQISV KVTMEDTFVK SLASQLIKTL TKVPSQVNDG
310 320 330 340 350
LGCLIILLQR QKPENLGEKP FLHLCGVPDL IGLLHGISES YDVSPLLRCM
360 370 380 390 400
LPHLVASVVQ HIAGEEAEGI DGQIYKNHLE EILIKIPLTN NLDHLLASHL
410 420 430 440 450
FEEYISYSSQ EETQANGVAL LNEQFLPLIR LLESKYPRAL DAVLEEHLKE
460 470 480 490 500
ITGLKKQELF HQFISLSTSG GKYQFLEDSD TSLMLSLNHP LAPVRLLAVN
510 520 530 540 550
HLKTFMKTSK EGIDETFIKE AILTRLGDDN VDVVLATLSA FEIFQQHFGV
560 570 580 590 600
EETVSSLLNL FQRADLSKNE GWFRVLELAA NILIKEEILS KNDQLANQVV
610 620 630 640 650
VQLLPFMVIT SNDIESPDMK IAIHLSKSGI CSLHPLLRGW KEALENVIKS
660 670 680 690 700
RKSREIIGVG NQKMVQLLGS NLSLGERSTV LKLVEDLVCA GEKESYSLKQ
710 720 730 740 750
KVAFHVTVSV LISCCSSFQE TCFPFALRVF SLLQKKIRKL KSVITAVEIP
760 770 780 790 800
SEWHLELMLN RGLPEELWVR YVQELHGAQR VVMEDAILLV FSMKCFIFAM
810 820 830 840 850
KAPKSFPTGA MWWNPEQLDE DSRHYLHLLI GIFEMLLEVS DAMHFRVLIR
860 870 880 890 900
LIMKVHLQDV LQLFKFFCVL WTYGSSLSNP LNCTVKSELQ TQALYIGSAM
910 920 930 940 950
LSSQNTQYKQ KLASTASPVV MSLLLNLGSH IKEVRRAAVQ CLQALRGVPS
960 970 980 990 1000
KFELVIDHLI PKAEEITSDA TYVLQDLATL FDELQNEEKQ KSHQKLSETL
1010 1020 1030 1040 1050
RSLLHCVYGC PSYIAKGLMK VLQGVNSEMV LAQLLPMVEQ LLEKVEKEPT
1060 1070 1080 1090 1100
AVLKDEAVVL HLTLGKYNEY SASLLQKDPK SLDLFIKAMH TTKELHPGMP
1110 1120 1130 1140 1150
TVRITALEKI TKPFFAAVSD GQVQQKLLCV LFDLLVNCKD AHCVQTVGSV
1160 1170 1180 1190 1200
FKGISVDAEQ IRIELEPRDK AKSLGTIQQT RRQKMQQKKS QDVESVQEVE
1210 1220 1230 1240 1250
GPYWQRVTLI LELLQHKKKL KCPQILIPPL FNLLSRCLEP LSSEQGNMEY
1260 1270 1280 1290 1300
TKQLILSCLL NICQKLSPDG GRIPKDVVDE EKFNVELIVQ CIRLSEMPQT
1310 1320 1330 1340 1350
HHHALLLLGT VAGIFPDKVL HNIMSIFTFM GANVMRLDDA YSFQVISKTV
1360 1370 1380 1390 1400
KMVIPALIQS DTGDSVEVTR NVEQIVVKII GVFVDALPHV PEHRRLPILV
1410 1420 1430 1440 1450
QLVTTLSAKK FLWILLVLLF EQYVTKTVLV AAYGEKDAIL EADTEFWISV
1460 1470 1480 1490 1500
CCEFSVQHQV QSLMHILHYL EKLPEEKEEA TSKTVSTKSE VQDEMLPVFK
1510 1520 1530 1540 1550
VDAHTSKQLR HFKYLSVSFM SQLLASNHFL KKVVGSGGPK SLHGLEQGLL
1560 1570 1580 1590 1600
ETVLSYINTV AQSMEKNADK LTGKFWRALL SKAYDMLDKV NALLPTETFI
1610 1620 1630 1640 1650
SVIRGLVGNP LPSVRRKALD LLNNKLQQHT FWRKKMVHRF LKLVPVLLAI
1660 1670 1680 1690 1700
VQHKKREAED EQAINRQTAL YTLKLLCKNF GAQNREPFIP VLSTAVKLIE
1710 1720 1730 1740 1750
PEKKEEKNVL GSALLCIAEV TSTLEALAIP QLPSLMPSLL TAMKSTSELV
1760 1770 1780 1790 1800
HSEVCLLSAL AALHKVVETL PHFISPYLEG LLTQVIHLEK ITREMGSASQ
1810 1820 1830 1840 1850
ANIRLTALKK TLATELSPRV LLPAISKTFK QIQKNWKNHM GPFMSILQEH
1860 1870 1880 1890 1900
IGVMKKEELL SHQSQLTTFF LEALDFRAQH SEDDLEEVGK TEGWIIDCLV
1910 1920 1930 1940 1950
AMVVKLSEVT FRPLFFKLFD WAKTEDAPKD RLLTFYNLAD CIAEKLKGLF
1960 1970 1980 1990 2000
TLFAGHLVKP FADTLNQVNI SKTDEAFFDS ERDPEKCCLL LQFILNCLYK
2010 2020 2030 2040 2050
VFLFDTQNFM SRERAEALMM PLVDQLENRL GGEERFQERV TKYLVPCIAQ
2060 2070 2080 2090 2100
FSVAMADDSM WKPLNYQILL KTRDSSPKVR FAALITVLAL AEKLRENYIV
2110 2120 2130 2140
LLPESIPFLA ELMEDECEEV EHQCQKTIQQ LEAVLGEPLQ SYF
Length:2,143
Mass (Da):242,072
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78A2B46C199F8BB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VNI1A0A1Y7VNI1_MOUSE
HEAT repeat-containing 1
Heatr1
744Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VNG8A0A1Y7VNG8_MOUSE
HEAT repeat-containing 1
Heatr1
344Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC154221 Genomic DNA No translation available.
CH466588 Genomic DNA Translation: EDL32306.1

NCBI Reference Sequences

More...
RefSeqi
NP_659084.3, NM_144835.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.171186

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000059270; ENSMUSP00000054084; ENSMUSG00000050244

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217995

UCSC genome browser

More...
UCSCi
uc007plk.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154221 Genomic DNA No translation available.
CH466588 Genomic DNA Translation: EDL32306.1
RefSeqiNP_659084.3, NM_144835.4
UniGeneiMm.171186

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059270; ENSMUSP00000054084; ENSMUSG00000050244
GeneIDi217995
KEGGimmu:217995
UCSCiuc007plk.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55127
MGIiMGI:2442524 Heatr1

Phylogenomic databases

eggNOGiKOG1837 Eukaryota
ENOG410XNQQ LUCA
GeneTreeiENSGT00390000015845
KOiK14550
OMAiEYPKQLI
OrthoDBi524830at2759
TreeFamiTF314593

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Heatr1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050244 Expressed in 260 organ(s), highest expression level in epiblast (generic)

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012954 BP28_C_dom
IPR022125 U3snoRNP10_N
IPR040191 UTP10
PANTHERiPTHR13457 PTHR13457, 1 hit
PfamiView protein in Pfam
PF08146 BP28CT, 1 hit
PF12397 U3snoRNP10, 1 hit
SMARTiView protein in SMART
SM01036 BP28CT, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3X9B1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X9B1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: January 16, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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