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Protein
Submitted name:

HEAT repeat-containing 1

Gene

Heatr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Submitted name:
HEAT repeat-containing 1Imported
Gene namesi
Name:Heatr1Imported
ORF Names:mCG_119362Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442524 Heatr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000050244 Expressed in 260 organ(s), highest expression level in epiblast (generic)

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054084

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1856 – 2009BP28CTInterPro annotationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2110 – 2130Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1837 Eukaryota
ENOG410XNQQ LUCA
GeneTreeiENSGT00390000015845
KOiK14550
OMAiMEDTFVN
OrthoDBiEOG091G0OMO
TreeFamiTF314593

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012954 BP28_C_dom
IPR022125 U3snoRNP10_N
PfamiView protein in Pfam
PF08146 BP28CT, 1 hit
PF12397 U3snoRNP10, 1 hit
SMARTiView protein in SMART
SM01036 BP28CT, 1 hit
SUPFAMiSSF48371 SSF48371, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3X9B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLAQQLQR LALPQTDPSL LSRREVASLL FDPKEAATID RDTAFAIGCT
60 70 80 90 100
GLEELLGIDP AFEQFEAPLF SQLAKGLERS VQTKAVNKQL DENISSFLLH
110 120 130 140 150
LSPYFLLKPA QKCLEWLIHR FHIHLYNADS LIACVLPYHE TRVFVRVIQL
160 170 180 190 200
LKISNPKHKW FWLSPVKHSG VPLARGTLVT HCYKDLGFMD FICSLVTRSV
210 220 230 240 250
KAFAEDPGSS TRLRVLLAFY ASTIVSALVA AENLSDNVVA KLFPYIQKGL
260 270 280 290 300
KSSLPDYRAA TYMIICQISV KVTMEDTFVK SLASQLIKTL TKVPSQVNDG
310 320 330 340 350
LGCLIILLQR QKPENLGEKP FLHLCGVPDL IGLLHGISES YDVSPLLRCM
360 370 380 390 400
LPHLVASVVQ HIAGEEAEGI DGQIYKNHLE EILIKIPLTN NLDHLLASHL
410 420 430 440 450
FEEYISYSSQ EETQANGVAL LNEQFLPLIR LLESKYPRAL DAVLEEHLKE
460 470 480 490 500
ITGLKKQELF HQFISLSTSG GKYQFLEDSD TSLMLSLNHP LAPVRLLAVN
510 520 530 540 550
HLKTFMKTSK EGIDETFIKE AILTRLGDDN VDVVLATLSA FEIFQQHFGV
560 570 580 590 600
EETVSSLLNL FQRADLSKNE GWFRVLELAA NILIKEEILS KNDQLANQVV
610 620 630 640 650
VQLLPFMVIT SNDIESPDMK IAIHLSKSGI CSLHPLLRGW KEALENVIKS
660 670 680 690 700
RKSREIIGVG NQKMVQLLGS NLSLGERSTV LKLVEDLVCA GEKESYSLKQ
710 720 730 740 750
KVAFHVTVSV LISCCSSFQE TCFPFALRVF SLLQKKIRKL KSVITAVEIP
760 770 780 790 800
SEWHLELMLN RGLPEELWVR YVQELHGAQR VVMEDAILLV FSMKCFIFAM
810 820 830 840 850
KAPKSFPTGA MWWNPEQLDE DSRHYLHLLI GIFEMLLEVS DAMHFRVLIR
860 870 880 890 900
LIMKVHLQDV LQLFKFFCVL WTYGSSLSNP LNCTVKSELQ TQALYIGSAM
910 920 930 940 950
LSSQNTQYKQ KLASTASPVV MSLLLNLGSH IKEVRRAAVQ CLQALRGVPS
960 970 980 990 1000
KFELVIDHLI PKAEEITSDA TYVLQDLATL FDELQNEEKQ KSHQKLSETL
1010 1020 1030 1040 1050
RSLLHCVYGC PSYIAKGLMK VLQGVNSEMV LAQLLPMVEQ LLEKVEKEPT
1060 1070 1080 1090 1100
AVLKDEAVVL HLTLGKYNEY SASLLQKDPK SLDLFIKAMH TTKELHPGMP
1110 1120 1130 1140 1150
TVRITALEKI TKPFFAAVSD GQVQQKLLCV LFDLLVNCKD AHCVQTVGSV
1160 1170 1180 1190 1200
FKGISVDAEQ IRIELEPRDK AKSLGTIQQT RRQKMQQKKS QDVESVQEVE
1210 1220 1230 1240 1250
GPYWQRVTLI LELLQHKKKL KCPQILIPPL FNLLSRCLEP LSSEQGNMEY
1260 1270 1280 1290 1300
TKQLILSCLL NICQKLSPDG GRIPKDVVDE EKFNVELIVQ CIRLSEMPQT
1310 1320 1330 1340 1350
HHHALLLLGT VAGIFPDKVL HNIMSIFTFM GANVMRLDDA YSFQVISKTV
1360 1370 1380 1390 1400
KMVIPALIQS DTGDSVEVTR NVEQIVVKII GVFVDALPHV PEHRRLPILV
1410 1420 1430 1440 1450
QLVTTLSAKK FLWILLVLLF EQYVTKTVLV AAYGEKDAIL EADTEFWISV
1460 1470 1480 1490 1500
CCEFSVQHQV QSLMHILHYL EKLPEEKEEA TSKTVSTKSE VQDEMLPVFK
1510 1520 1530 1540 1550
VDAHTSKQLR HFKYLSVSFM SQLLASNHFL KKVVGSGGPK SLHGLEQGLL
1560 1570 1580 1590 1600
ETVLSYINTV AQSMEKNADK LTGKFWRALL SKAYDMLDKV NALLPTETFI
1610 1620 1630 1640 1650
SVIRGLVGNP LPSVRRKALD LLNNKLQQHT FWRKKMVHRF LKLVPVLLAI
1660 1670 1680 1690 1700
VQHKKREAED EQAINRQTAL YTLKLLCKNF GAQNREPFIP VLSTAVKLIE
1710 1720 1730 1740 1750
PEKKEEKNVL GSALLCIAEV TSTLEALAIP QLPSLMPSLL TAMKSTSELV
1760 1770 1780 1790 1800
HSEVCLLSAL AALHKVVETL PHFISPYLEG LLTQVIHLEK ITREMGSASQ
1810 1820 1830 1840 1850
ANIRLTALKK TLATELSPRV LLPAISKTFK QIQKNWKNHM GPFMSILQEH
1860 1870 1880 1890 1900
IGVMKKEELL SHQSQLTTFF LEALDFRAQH SEDDLEEVGK TEGWIIDCLV
1910 1920 1930 1940 1950
AMVVKLSEVT FRPLFFKLFD WAKTEDAPKD RLLTFYNLAD CIAEKLKGLF
1960 1970 1980 1990 2000
TLFAGHLVKP FADTLNQVNI SKTDEAFFDS ERDPEKCCLL LQFILNCLYK
2010 2020 2030 2040 2050
VFLFDTQNFM SRERAEALMM PLVDQLENRL GGEERFQERV TKYLVPCIAQ
2060 2070 2080 2090 2100
FSVAMADDSM WKPLNYQILL KTRDSSPKVR FAALITVLAL AEKLRENYIV
2110 2120 2130 2140
LLPESIPFLA ELMEDECEEV EHQCQKTIQQ LEAVLGEPLQ SYF
Length:2,143
Mass (Da):242,072
Last modified:November 16, 2011 - v1
Checksum:i78A2B46C199F8BB3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VNI1A0A1Y7VNI1_MOUSE
HEAT repeat-containing 1
Heatr1
744Annotation score:
A0A1Y7VNG8A0A1Y7VNG8_MOUSE
HEAT repeat-containing 1
Heatr1
344Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154221 Genomic DNA No translation available.
CH466588 Genomic DNA Translation: EDL32306.1
RefSeqiNP_659084.3, NM_144835.4
UniGeneiMm.171186

Genome annotation databases

EnsembliENSMUST00000059270; ENSMUSP00000054084; ENSMUSG00000050244
GeneIDi217995
KEGGimmu:217995
UCSCiuc007plk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154221 Genomic DNA No translation available.
CH466588 Genomic DNA Translation: EDL32306.1
RefSeqiNP_659084.3, NM_144835.4
UniGeneiMm.171186

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059270; ENSMUSP00000054084; ENSMUSG00000050244
GeneIDi217995
KEGGimmu:217995
UCSCiuc007plk.1 mouse

Organism-specific databases

CTDi55127
MGIiMGI:2442524 Heatr1

Phylogenomic databases

eggNOGiKOG1837 Eukaryota
ENOG410XNQQ LUCA
GeneTreeiENSGT00390000015845
KOiK14550
OMAiMEDTFVN
OrthoDBiEOG091G0OMO
TreeFamiTF314593

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiHeatr1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050244 Expressed in 260 organ(s), highest expression level in epiblast (generic)

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012954 BP28_C_dom
IPR022125 U3snoRNP10_N
PfamiView protein in Pfam
PF08146 BP28CT, 1 hit
PF12397 U3snoRNP10, 1 hit
SMARTiView protein in SMART
SM01036 BP28CT, 1 hit
SUPFAMiSSF48371 SSF48371, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiG3X9B1_MOUSE
AccessioniPrimary (citable) accession number: G3X9B1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 10, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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