UniProtKB - G3X952 (G3X952_MOUSE)

BLAST

>tr|G3X952|G3X952_MOUSE MCG20985, isoform CRA_a OS=Mus musculus OX=10090 GN=Zkscan2 PE=1 SV=1
MATVMNPQIDVEVEECLIMKVEKDSEWVSEPILERSGSTECESFRKCFRQFCYEDVTGPH
EAFSKLWELCCRWLKPEMRSKEQILEQLVIEQFLTILPEKIQTWAQKQCPESGEEAVALV
VHLEKETRRLRKQVSSPLPSEKQAPPRTVWEVADFEPEQLETQHRVVSLEEAGSLHSGHQ
EQLNQKREHRPLPKNAHSSVWVPVPSDEWNALDEEVTTQEPIRDVHTERSFSYKKSVQQV
PAHRGLYHEIRKESAGSMVSLGDSVSAPNKIAQLEQKKEPWSVGLHSSNKRNSVLQSNYI
KEKSVHAVQIPARNAGKVWREQQQWGLEDEKIAGVHWSYEETKTFLAILKESRFYETLQA
CPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHMLEPCAFFEDMDALL
NPAAHTSSTERPKVVISLPLKRTAISAKEQVSLVEEEEGAEDSDGDEVGIEFIRKSEIRA
APVLFQNLSGVHWGYEETKTFLDILQETRFYEALQACHRKSKLYGVVAEQLRECGFLRTP
EQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDALVNCRPSSLSTNTSEEVPSLSRQERG
HIEVEPREPTTWEPVETPQEAVLEDSGSERLSEEEMIEEPELEGPSGLLQSPAGFEIGTI
IKEDPTQVMFKDTEPHRVLMEKPKRLVSQNTNPSKYCKREYFSGRHCENLQGVRQGKLMS
QPRDTGKAVVHQRPCVGRRPYRLLKYGENFGRSARLVCRMTHQKENPFKCGVCGKCFGRS
RSLIRHQRIHTGEKPFKCPDCGKSFNDSSNFGAHQRVHTGEKPYRCRECGKCFSQSSSLI
IHQRTHTGEKPYQCEECGKSFTNSSHFSAHRRIHTEENPYKCGDCEKSFNNCARFREHQR
IHNGEKPYTCAQCGKHFNKSSFLTKHREVHMREKLLPYSPSVYSPENLLKGKSAELRKTF

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History
Entry version 60 (10 Oct 2018)
Sequence version 1 (16 Nov 2011)
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Protein

Submitted name:

MCG20985, isoform CRA_a

Gene

Zkscan2

Organism

Mus musculus (Mouse)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: MCG20985, isoform CRA_aImported Submitted name: Zinc finger with KRAB and SCAN domains 2Imported
Gene namesⁱ	Name:Zkscan2Imported ORF Names:mCG_20985Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2444060 Zkscan2

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030757 Expressed in 144 organ(s), highest expression level in head

Bgeeⁱ

ENSMUSG00000030757 Expressed in 144 organ(s), highest expression level in head

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000041821

STRINGⁱ

10090.ENSMUSP00000041821

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 126	SCAN boxInterPro annotationAdd BLAST	82
Domainⁱ	222 – 293	KRABInterPro annotationAdd BLAST	72
Domainⁱ	768 – 795	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	796 – 823	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	824 – 851	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	852 – 879	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	880 – 907	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	908 – 935	C2H2-typeInterPro annotationAdd BLAST	28

Keywords - Domainⁱ

RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063287
KEGG Orthology (KO) More...KOⁱ	K09229
OMAⁱ	KIQAWAQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
TreeFamⁱ	TF336839

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

G3X952-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MATVMNPQID VEVEECLIMK VEKDSEWVSE PILERSGSTE CESFRKCFRQ 
        60         70         80         90        100
FCYEDVTGPH EAFSKLWELC CRWLKPEMRS KEQILEQLVI EQFLTILPEK 
       110        120        130        140        150
IQTWAQKQCP ESGEEAVALV VHLEKETRRL RKQVSSPLPS EKQAPPRTVW 
       160        170        180        190        200
EVADFEPEQL ETQHRVVSLE EAGSLHSGHQ EQLNQKREHR PLPKNAHSSV 
       210        220        230        240        250
WVPVPSDEWN ALDEEVTTQE PIRDVHTERS FSYKKSVQQV PAHRGLYHEI 
       260        270        280        290        300
RKESAGSMVS LGDSVSAPNK IAQLEQKKEP WSVGLHSSNK RNSVLQSNYI 
       310        320        330        340        350
KEKSVHAVQI PARNAGKVWR EQQQWGLEDE KIAGVHWSYE ETKTFLAILK 
       360        370        380        390        400
ESRFYETLQA CPRNSQVYGA VAEWLRECGF LRTPEQCRTK FKSLQKSYRK 
       410        420        430        440        450
VRNGHMLEPC AFFEDMDALL NPAAHTSSTE RPKVVISLPL KRTAISAKEQ 
       460        470        480        490        500
VSLVEEEEGA EDSDGDEVGI EFIRKSEIRA APVLFQNLSG VHWGYEETKT 
       510        520        530        540        550
FLDILQETRF YEALQACHRK SKLYGVVAEQ LRECGFLRTP EQCRTKFKSL 
       560        570        580        590        600
QKSYRKVKNG HVLESCAFYK EMDALVNCRP SSLSTNTSEE VPSLSRQERG 
       610        620        630        640        650
HIEVEPREPT TWEPVETPQE AVLEDSGSER LSEEEMIEEP ELEGPSGLLQ 
       660        670        680        690        700
SPAGFEIGTI IKEDPTQVMF KDTEPHRVLM EKPKRLVSQN TNPSKYCKRE 
       710        720        730        740        750
YFSGRHCENL QGVRQGKLMS QPRDTGKAVV HQRPCVGRRP YRLLKYGENF 
       760        770        780        790        800
GRSARLVCRM THQKENPFKC GVCGKCFGRS RSLIRHQRIH TGEKPFKCPD 
       810        820        830        840        850
CGKSFNDSSN FGAHQRVHTG EKPYRCRECG KCFSQSSSLI IHQRTHTGEK 
       860        870        880        890        900
PYQCEECGKS FTNSSHFSAH RRIHTEENPY KCGDCEKSFN NCARFREHQR 
       910        920        930        940        950
IHNGEKPYTC AQCGKHFNKS SFLTKHREVH MREKLLPYSP SVYSPENLLK 
       960
GKSAELRKTF

Length:960

Mass (Da):110,492

Last modified:November 16, 2011 - v1

Checksum:ⁱD2D91ADA85F180B9

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3UZ80	G3UZ80_MOUSE	MCG20985, isoform CRA_b MCG20985, isoform CRA_b (Zinc finger with KRAB and SCAN domains 2)	Zkscan2 mCG_20985	271	Annotation score:
F7BPE8	F7BPE8_MOUSE	Zinc finger with KRAB and SCAN doma... Zinc finger with KRAB and SCAN domains 2	Zkscan2	42	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC117184 Genomic DNA No translation available. CH466531 Genomic DNA Translation: EDL17312.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001074798.1, NM_001081329.1
UniGeneⁱ	Mm.135397

Genome annotation databases

Ensemblⁱ	ENSMUST00000042470; ENSMUSP00000041821; ENSMUSG00000030757
GeneIDⁱ	210162
KEGGⁱ	mmu:210162
UCSC genome browser More...UCSCⁱ	uc009jps.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
G3X952	Zkscan2 protein		MOUSE		292	UniRef100_G3X952

Protein	Similar proteins		Species	Score	Length	Source
G3X952	Zinc finger with KRAB and SCAN domains 2		RAT		960	UniRef90_D3ZXU0
Zkscan2 protein		MOUSE		292
UPI000A315C60		MUSCR		966
UPI000A307CC6		MUSPA		965
Zkscan2 protein (Fragment)		RAT		369
+3

Protein	Similar proteins		Species	Score	Length	Source
G3X952	Zinc finger protein with KRAB and SCAN domains 2		HUMAN		967	UniRef50_Q63HK3
Uncharacterized protein		CHLSB		968
Uncharacterized protein		MACMU		967
ZKSCAN2 isoform 1		PONAB		967
Uncharacterized protein		MACNE		967
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC117184 Genomic DNA No translation available. CH466531 Genomic DNA Translation: EDL17312.1
RefSeqⁱ	NP_001074798.1, NM_001081329.1
UniGeneⁱ	Mm.135397

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000041821

STRINGⁱ

10090.ENSMUSP00000041821

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042470; ENSMUSP00000041821; ENSMUSG00000030757
GeneIDⁱ	210162
KEGGⁱ	mmu:210162
UCSCⁱ	uc009jps.2 mouse

Organism-specific databases

CTDⁱ	342357
MGIⁱ	MGI:2444060 Zkscan2

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063287
KOⁱ	K09229
OMAⁱ	KIQAWAQ
OrthoDBⁱ	EOG091G02KC
TreeFamⁱ	TF336839

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030757 Expressed in 144 organ(s), highest expression level in head

Bgeeⁱ

ENSMUSG00000030757 Expressed in 144 organ(s), highest expression level in head

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3X952_MOUSE
Accessionⁱ	G3X952Primary (citable) accession number: G3X952
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	October 10, 2018
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3X952 (G3X952_MOUSE)

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MCG20985, isoform CRA_a

Zkscan2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ