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UniProtKB - G3X952 (G3X952_MOUSE)
Protein
Submitted name:
Zinc finger with KRAB and SCAN domains 2
Gene
Zkscan2
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
ARBA annotationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger with KRAB and SCAN domains 2Imported |
Gene namesi | Name:Zkscan2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444060, Zkscan2 |
VEuPathDBi | HostDB:ENSMUSG00000030757 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationPTM / Processingi
Proteomic databases
EPDi | G3X952 |
jPOSTi | G3X952 |
PeptideAtlasi | G3X952 |
PTM databases
iPTMneti | G3X952 |
PhosphoSitePlusi | G3X952 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030757, Expressed in head and 177 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 126 | SCAN boxInterPro annotationAdd BLAST | 82 | |
Domaini | 222 – 293 | KRABInterPro annotationAdd BLAST | 72 | |
Domaini | 768 – 795 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 796 – 823 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 824 – 851 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 852 – 879 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 880 – 907 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 908 – 935 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 582 – 631 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 594 – 610 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161884 |
HOGENOMi | CLU_002678_88_0_1 |
OMAi | NGHMLEP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | G3X952 |
TreeFami | TF336839 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR044822, Myb_DNA-bind_4 IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 2 hits PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G3X952-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATVMNPQID VEVEECLIMK VEKDSEWVSE PILERSGSTE CESFRKCFRQ
60 70 80 90 100
FCYEDVTGPH EAFSKLWELC CRWLKPEMRS KEQILEQLVI EQFLTILPEK
110 120 130 140 150
IQTWAQKQCP ESGEEAVALV VHLEKETRRL RKQVSSPLPS EKQAPPRTVW
160 170 180 190 200
EVADFEPEQL ETQHRVVSLE EAGSLHSGHQ EQLNQKREHR PLPKNAHSSV
210 220 230 240 250
WVPVPSDEWN ALDEEVTTQE PIRDVHTERS FSYKKSVQQV PAHRGLYHEI
260 270 280 290 300
RKESAGSMVS LGDSVSAPNK IAQLEQKKEP WSVGLHSSNK RNSVLQSNYI
310 320 330 340 350
KEKSVHAVQI PARNAGKVWR EQQQWGLEDE KIAGVHWSYE ETKTFLAILK
360 370 380 390 400
ESRFYETLQA CPRNSQVYGA VAEWLRECGF LRTPEQCRTK FKSLQKSYRK
410 420 430 440 450
VRNGHMLEPC AFFEDMDALL NPAAHTSSTE RPKVVISLPL KRTAISAKEQ
460 470 480 490 500
VSLVEEEEGA EDSDGDEVGI EFIRKSEIRA APVLFQNLSG VHWGYEETKT
510 520 530 540 550
FLDILQETRF YEALQACHRK SKLYGVVAEQ LRECGFLRTP EQCRTKFKSL
560 570 580 590 600
QKSYRKVKNG HVLESCAFYK EMDALVNCRP SSLSTNTSEE VPSLSRQERG
610 620 630 640 650
HIEVEPREPT TWEPVETPQE AVLEDSGSER LSEEEMIEEP ELEGPSGLLQ
660 670 680 690 700
SPAGFEIGTI IKEDPTQVMF KDTEPHRVLM EKPKRLVSQN TNPSKYCKRE
710 720 730 740 750
YFSGRHCENL QGVRQGKLMS QPRDTGKAVV HQRPCVGRRP YRLLKYGENF
760 770 780 790 800
GRSARLVCRM THQKENPFKC GVCGKCFGRS RSLIRHQRIH TGEKPFKCPD
810 820 830 840 850
CGKSFNDSSN FGAHQRVHTG EKPYRCRECG KCFSQSSSLI IHQRTHTGEK
860 870 880 890 900
PYQCEECGKS FTNSSHFSAH RRIHTEENPY KCGDCEKSFN NCARFREHQR
910 920 930 940 950
IHNGEKPYTC AQCGKHFNKS SFLTKHREVH MREKLLPYSP SVYSPENLLK
960
GKSAELRKTF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UZ80 | G3UZ80_MOUSE | Zinc finger with KRAB and SCAN doma... | Zkscan2 | 271 | Annotation score: | ||
F7BPE8 | F7BPE8_MOUSE | Zinc finger with KRAB and SCAN doma... | Zkscan2 | 42 | Annotation score: |
Sequence databases
RefSeqi | NP_001074798.1, NM_001081329.1 |
Genome annotation databases
Ensembli | ENSMUST00000042470; ENSMUSP00000041821; ENSMUSG00000030757 |
GeneIDi | 210162 |
KEGGi | mmu:210162 |
UCSCi | uc009jps.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001074798.1, NM_001081329.1 |
3D structure databases
SMRi | G3X952 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000041821 |
PTM databases
iPTMneti | G3X952 |
PhosphoSitePlusi | G3X952 |
Proteomic databases
EPDi | G3X952 |
jPOSTi | G3X952 |
PeptideAtlasi | G3X952 |
Protocols and materials databases
Antibodypediai | 59128, 55 antibodies from 12 providers |
DNASUi | 210162 |
Genome annotation databases
Ensembli | ENSMUST00000042470; ENSMUSP00000041821; ENSMUSG00000030757 |
GeneIDi | 210162 |
KEGGi | mmu:210162 |
UCSCi | uc009jps.2, mouse |
Organism-specific databases
CTDi | 342357 |
MGIi | MGI:2444060, Zkscan2 |
VEuPathDBi | HostDB:ENSMUSG00000030757 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161884 |
HOGENOMi | CLU_002678_88_0_1 |
OMAi | NGHMLEP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | G3X952 |
TreeFami | TF336839 |
Miscellaneous databases
BioGRID-ORCSi | 210162, 0 hits in 65 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030757, Expressed in head and 177 other tissues |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR044822, Myb_DNA-bind_4 IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 2 hits PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | G3X952_MOUSE | |
Accessioni | G3X952Primary (citable) accession number: G3X952 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | January 19, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |