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Protein

Histone acetyltransferase

Gene

Kat6a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei679Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferaseUniRule annotation (EC:2.3.1.48UniRule annotation)
Gene namesi
Name:Kat6aImported
Synonyms:Myst3Imported
ORF Names:mCG_13090Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442415 Kat6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000031540 Expressed in 276 organ(s), highest expression level in ganglionic eminence

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 171H15InterPro annotationAdd BLAST77
Domaini206 – 265PHD-typeInterPro annotationAdd BLAST60
Domaini262 – 313PHD-typeInterPro annotationAdd BLAST52
Domaini503 – 777MYST-type HATInterPro annotationAdd BLAST275

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1204 – 1224Sequence analysisAdd BLAST21
Coiled coili1277 – 1297Sequence analysisAdd BLAST21
Coiled coili1387 – 1407Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00920000148999
KOiK11305
OMAiCDPPLTR
OrthoDBiEOG091G00D2
TreeFamiTF106483

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR031280 KAT6A
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10615:SF26 PTHR10615:SF26, 2 hits
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55729 SSF55729, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51726 MYST_HAT, 1 hit
PS50016 ZF_PHD_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3X940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRRTVLEQ
60 70 80 90 100
LELSVKDGTI LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDTKQSVDWN
110 120 130 140 150
KLLKRAFEGL AETGGSTLKS IERFLKSQKD VSAACGGSAA PGFHQQLRLA
160 170 180 190 200
IKRAVGHGRL LKDGPLYRLN TKAASAEGKE GCESLSCLPP VSLLPHEKDK
210 220 230 240 250
PVAEPIPICS FCLGTKEQNR EKQPEELVSC ADCGNSGHPS CLKFSPELTV
260 270 280 290 300
RVKALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM
310 320 330 340 350
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YANPIGRPKN RLKKQNTVSK
360 370 380 390 400
GPFSKVRTGP GRGRKRKITV SSQSASSSEE GYLERIDGLD FCRDSNAPLK
410 420 430 440 450
FNKKTKGLID GLTKFFTPSP DGRKARGEVV DYSEQYRIRK KGNRKSSTSD
460 470 480 490 500
WPTDNQDGWE SKQENEERLF GSQEIMTERD MELFRDIQEQ ALQKVGVTGP
510 520 530 540 550
PDPQVRCPSV IEFGKYEIHT WYSSPYPQEY SRLPKLYLCE FCLKYMKSRT
560 570 580 590 600
ILQQHMKKCG WFHPPANEIY RKNNISVFEV DGNVSTIYCQ NLCLLAKLFL
610 620 630 640 650
DHKTLYYDVE PFLFYVLTQN DVKGCHLVGY FSKEKHCQQK YNVSCIMILP
660 670 680 690 700
QYQRKGYGRF LIDFSYLLSK REGQAGSPEK PLSDLGRLSY MAYWKSVILE
710 720 730 740 750
CLYHQNDKQI SIKKLSKLTG VCPQDITSTL HHLRMLDFRS DQFVIIRREK
760 770 780 790 800
LIQDHMAKLQ LNLRPVDVDP ECLRWTPVIV SNSVVSEDED EEADEGEKEE
810 820 830 840 850
PQGQERELET RVKVGKSVSR EKKDQESSSL IETDKKPEVK ELASSSRLSK
860 870 880 890 900
QALPRDSLPA NSQPPRRGRC GRKNRKTQER FGDKDSKMLV DETLSASQEQ
910 920 930 940 950
YGDCEEKSET SQERFTEMEE QLAAPQVQAD GKPDIPKGRF SESVELWRGQ
960 970 980 990 1000
LKKSPETLKC RLPEGNDRLP CCYTDGDRAV FRGFSESSEE EEEPESPRSN
1010 1020 1030 1040 1050
SPPILTKPTL KRKKPILHRR RRVRKRKHHN SSVVTETISE TTEVLDEPFE
1060 1070 1080 1090 1100
DSDSERPMPR LEPTFEMEEE EEEEEEESEL FPRGYFHCLS SQDILRCQSS
1110 1120 1130 1140 1150
SKRPSKEEEE EEEESDDADD TPVLKPVSLL RKCDVNSASL EPDTSTPMKK
1160 1170 1180 1190 1200
KKGWPKGKSR KPIHWKKRPG RKPGFKLNQE IIAASAQECI VEPVVPIKPG
1210 1220 1230 1240 1250
RKPRTQENEE IVEVKEDLLE ERKEEMHTEP DEEAEEEEDT TSSDIRAMSP
1260 1270 1280 1290 1300
LDSSNSPEAE PKEPEPEEED EKPSDDQRQS EEEPQELEEQ EQEEEDEVTT
1310 1320 1330 1340 1350
EANQNEDHDA DDEDEGHLDS LKTKEPEEQP AREDDKEEPG IQGSFLAANM
1360 1370 1380 1390 1400
QDSRENTKDK DEAEPDSEED QPSHEASVVS ETMPGSEEDH EEDSNTKEEL
1410 1420 1430 1440 1450
IELKEEEEIP HSELDLETVQ AVQSLTQEES SEHEGAYQDC EETLAACQTL
1460 1470 1480 1490 1500
QSYTHTDEDP QMSMVEDCHA SEHNSPISSI PSHPSQSVRS VNSPSMPALE
1510 1520 1530 1540 1550
SGYTQISPEQ GSLSAPSMQN METSPMMDVP SVSDHSQQVV DSGFSDLGSI
1560 1570 1580 1590 1600
ESTTENYENP SSYDSTMGSS ICGNNSSQSS CSYGGLSSSS SLTQNSCVVT
1610 1620 1630 1640 1650
QQMANMGNSC SMLQQNTVQP AANCNIKSPQ TCVVERPPSN QQPPPPPPPP
1660 1670 1680 1690 1700
PPPQQPQPPP QQQAAPQPPP PQPQQQQQQQ QQPPPPQQQP QPPPPQQQPP
1710 1720 1730 1740 1750
LSQCSMNNSF TAAPMIMEIP ESGSTGNISI YERIPGDFGA GSYSQPSATF
1760 1770 1780 1790 1800
SLAKLQQLTN TIMDPHAMPY SHSPAVTSYA TSVSLSNTGL AQLAPSHPLA
1810 1820 1830 1840 1850
GTPQAQATMT PPPNLASTTM NLTSPLLQCN MSATNIGIPH TQRLQGQMPV
1860 1870 1880 1890 1900
KGHISIRSKS APLPSATAHQ QQLYGRSPPA VAMQAGPRAL AVQRGMNMGV
1910 1920 1930 1940 1950
NLMPTPAYNV NSMNMNTLNA MNSYRMTQPM MNSSYHSNPA YMNQTAQYPM
1960 1970 1980 1990 2000
QMQMGMMGSQ AYTQQPMQPN PHGNMMYTGP SHHSYMNAAG VPKQSLNGPY

MRR
Length:2,003
Mass (Da):224,871
Last modified:November 16, 2011 - v1
Checksum:iE2660A9CA1621B30
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BZ21KAT6A_MOUSE
Histone acetyltransferase KAT6A
Kat6a Moz, Myst3
2,003Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115361 Genomic DNA No translation available.
AC142414 Genomic DNA No translation available.
CH466580 Genomic DNA Translation: EDL32873.1
RefSeqiNP_001074618.1, NM_001081149.1
XP_006509175.1, XM_006509112.2
UniGeneiMm.182776

Genome annotation databases

EnsembliENSMUST00000044331; ENSMUSP00000038181; ENSMUSG00000031540
ENSMUST00000110696; ENSMUSP00000106324; ENSMUSG00000031540
GeneIDi244349
KEGGimmu:244349
UCSCiuc009lec.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115361 Genomic DNA No translation available.
AC142414 Genomic DNA No translation available.
CH466580 Genomic DNA Translation: EDL32873.1
RefSeqiNP_001074618.1, NM_001081149.1
XP_006509175.1, XM_006509112.2
UniGeneiMm.182776

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044331; ENSMUSP00000038181; ENSMUSG00000031540
ENSMUST00000110696; ENSMUSP00000106324; ENSMUSG00000031540
GeneIDi244349
KEGGimmu:244349
UCSCiuc009lec.1 mouse

Organism-specific databases

CTDi7994
MGIiMGI:2442415 Kat6a

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00920000148999
KOiK11305
OMAiCDPPLTR
OrthoDBiEOG091G00D2
TreeFamiTF106483

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRSiKat6a mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031540 Expressed in 276 organ(s), highest expression level in ganglionic eminence

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR031280 KAT6A
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10615:SF26 PTHR10615:SF26, 2 hits
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55729 SSF55729, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51726 MYST_HAT, 1 hit
PS50016 ZF_PHD_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiG3X940_MOUSE
AccessioniPrimary (citable) accession number: G3X940
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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