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Entry version 60 (16 Jan 2019)
Sequence version 1 (16 Nov 2011)
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Protein

Sodium/hydrogen exchanger 3

Gene

Slc9a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.By similarity

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • potassium:proton antiporter activity Source: GO_Central
  • sodium:proton antiporter activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-425986 Sodium/Proton exchangers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc9a3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:105064 Slc9a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicCuratedAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei12 – 23Name=A/M1Sequence analysisAdd BLAST12
Topological domaini24 – 49CytoplasmicCuratedAdd BLAST26
Intramembranei50 – 68Name=B/M2Sequence analysisAdd BLAST19
Topological domaini69 – 74CytoplasmicCurated6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei75 – 94Helical; Name=C/M3Sequence analysisAdd BLAST20
Topological domaini95 – 107ExtracellularCuratedAdd BLAST13
Transmembranei108 – 128Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini129 – 134CytoplasmicCurated6
Transmembranei135 – 155Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini156 – 175ExtracellularCuratedAdd BLAST20
Transmembranei176 – 197Helical; Name=F/M5ASequence analysisAdd BLAST22
Topological domaini198 – 205CytoplasmicCurated8
Transmembranei206 – 227Helical; Name=G/M5BSequence analysisAdd BLAST22
Topological domaini228 – 247ExtracellularCuratedAdd BLAST20
Transmembranei248 – 269Helical; Name=H/M6Sequence analysisAdd BLAST22
Topological domaini270 – 285CytoplasmicCuratedAdd BLAST16
Transmembranei286 – 304Helical; Name=I/M7Sequence analysisAdd BLAST19
Topological domaini305 – 335ExtracellularCuratedAdd BLAST31
Transmembranei336 – 357Helical; Name=J/M8Sequence analysisAdd BLAST22
Topological domaini358 – 364CytoplasmicCurated7
Transmembranei365 – 385Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini386 – 400ExtracellularCuratedAdd BLAST15
Intramembranei401 – 421Name=LSequence analysisAdd BLAST21
Topological domaini422 – 430ExtracellularCurated9
Transmembranei431 – 451Helical; Name=M/M10Sequence analysisAdd BLAST21
Topological domaini452 – 829CytoplasmicCuratedAdd BLAST378

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004333551 – 829Sodium/hydrogen exchanger 3Add BLAST829

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei550PhosphoserineBy similarity1
Modified residuei558PhosphoserineBy similarity1
Modified residuei588PhosphoserineCombined sources1
Modified residuei603PhosphoserineBy similarity1
Modified residuei659Phosphoserine; by SGK1By similarity1
Modified residuei805PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-659 by SGK1 is associated with increased abundance at the cell membrane.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
G3X939

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G3X939

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G3X939

PeptideAtlas

More...
PeptideAtlasi
G3X939

PRoteomics IDEntifications database

More...
PRIDEi
G3X939

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G3X939

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
G3X939

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036123 Expressed in 24 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G3X939 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Interacts with AHCYL1; the interaction is required for SLC9A3 activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038142

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
G3X939

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3X939

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni586 – 663Interaction with PDZD3By similarityAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966 Eukaryota
COG0025 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158616

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247044

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3X939

KEGG Orthology (KO)

More...
KOi
K12040

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKILMRR

Database of Orthologous Groups

More...
OrthoDBi
389547at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018410 Na/H_exchanger_3/5
IPR004709 NaH_exchanger
IPR011256 Reg_factor_effector_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10110 PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999 Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084 NAHEXCHNGR
PR01087 NAHEXCHNGR3

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55136 SSF55136, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840 b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3X939-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWHRALGPGW KLLLALALTS LQGARGAEEE PSSDGSFQVV TFKWHHVQDP
60 70 80 90 100
YIIALWILVA SLAKIVFHLS HKVTSIVPES ALLIVLGLVL GGIVWAADHI
110 120 130 140 150
ASFTLTPTLF FFYLLPPIVL DAGYFMPNRL FFGNLGTILL YAVIGTIWNA
160 170 180 190 200
ATTGLSLYGV FLSGLMGELK IGLLDFLLFG SLIAAVDPVA VLAVFEEVHV
210 220 230 240 250
NEVLFIIVFG ESLLNDAVTV VLYNVFESFV TLGGDAVTGV DCVKGIVSFF
260 270 280 290 300
VVSLGGTLVG VIFAFLLSLV TRFTKHVRII EPGFVFVISY LSYLTSEMLS
310 320 330 340 350
LSSILAITFC GICCQKYVKA NISEQSATTV RYTMKMLASG AETIIFMFLG
360 370 380 390 400
ISAVNPDIWT WNTAFVLLTL VFISVYRAIG VVLQTWILNR YRMVQLETID
410 420 430 440 450
QVVMSYGGLR GAVAYALVVL LDEKKVKEKN LFVSTTLIVV FFTVIFQGLT
460 470 480 490 500
IKPLVQWLKV KRSEHREPKL NEKLHGRAFD HILSAIEDIS GQIGHNYLRD
510 520 530 540 550
KWSNFDRKFL SKVLMRRSAQ KSRDRILNVF HELNLKDAIS YVAEGERRGS
560 570 580 590 600
LAFIRSPSTD NMVNVDFNTP RPSTVEASVS YFLRENVSAV CLDMQSLEQR
610 620 630 640 650
RRSIRDTEDM VTHHTLQQYL YKPRQEYKHL YSRHELTPNE DEKQDKEIFH
660 670 680 690 700
RTMRKRLESF KSAKLGINQN KKAAKLYKRE RAQKRRNSSI PNGKLPMENL
710 720 730 740 750
AHNYTIKEKD LELSEHEEAT NYEEISGGIE FLASVTQDVA SDSGAGIDNP
760 770 780 790 800
VFSPDEDLDP SILSRVPPWL SPGETVVPSQ RARVQIPNSP SNFRRLTPFR
810 820
LSNKSVDSFL QADGHEEQLQ PAAPESTHM
Length:829
Mass (Da):93,104
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2458CAE3F11B357
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YD40A0A286YD40_MOUSE
Sodium/hydrogen exchanger
Slc9a3
862Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK033564 mRNA Translation: BAC28362.1
AC154839 Genomic DNA No translation available.
CH466563 Genomic DNA Translation: EDL37085.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36731.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074529.1, NM_001081060.1
XP_006517085.1, XM_006517022.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.261564

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000036208; ENSMUSP00000038142; ENSMUSG00000036123
ENSMUST00000221703; ENSMUSP00000152682; ENSMUSG00000036123

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:105243

UCSC genome browser

More...
UCSCi
uc007res.2 mouse
uc007ret.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033564 mRNA Translation: BAC28362.1
AC154839 Genomic DNA No translation available.
CH466563 Genomic DNA Translation: EDL37085.1
CCDSiCCDS36731.1
RefSeqiNP_001074529.1, NM_001081060.1
XP_006517085.1, XM_006517022.3
UniGeneiMm.261564

3D structure databases

ProteinModelPortaliG3X939
SMRiG3X939
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038142

PTM databases

iPTMnetiG3X939
PhosphoSitePlusiG3X939

Proteomic databases

jPOSTiG3X939
MaxQBiG3X939
PaxDbiG3X939
PeptideAtlasiG3X939
PRIDEiG3X939

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036208; ENSMUSP00000038142; ENSMUSG00000036123
ENSMUST00000221703; ENSMUSP00000152682; ENSMUSG00000036123
GeneIDi105243
KEGGimmu:105243
UCSCiuc007res.2 mouse
uc007ret.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6550
MGIiMGI:105064 Slc9a3

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00940000158616
HOGENOMiHOG000247044
InParanoidiG3X939
KOiK12040
OMAiSKILMRR
OrthoDBi389547at2759
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G3X939

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036123 Expressed in 24 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiG3X939 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018410 Na/H_exchanger_3/5
IPR004709 NaH_exchanger
IPR011256 Reg_factor_effector_dom_sf
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01087 NAHEXCHNGR3
SUPFAMiSSF55136 SSF55136, 1 hit
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X939
Secondary accession number(s): Q8BZU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: November 16, 2011
Last modified: January 16, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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