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Entry version 59 (16 Oct 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

DNA segment, Chr 15, Wayne State University 169, expressed, isoform CRA_a

Gene

Arhgap39

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA segment, Chr 15, Wayne State University 169, expressed, isoform CRA_aImported
Submitted name:
Rho GTPase-activating protein 39Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap39Imported
Synonyms:D15Wsu169eImported
ORF Names:mCG_134448Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107858 Arhgap39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033697 Expressed in 270 organ(s), highest expression level in CA1 field of hippocampus

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 99WWInterPro annotationAdd BLAST35
Domaini717 – 869MyTH4InterPro annotationAdd BLAST153
Domaini916 – 1104Rho-GAPInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni113 – 175DisorderedSequence analysisAdd BLAST63
Regioni220 – 269DisorderedSequence analysisAdd BLAST50
Regioni284 – 313DisorderedSequence analysisAdd BLAST30
Regioni328 – 372DisorderedSequence analysisAdd BLAST45
Regioni406 – 431DisorderedSequence analysisAdd BLAST26
Regioni443 – 531DisorderedSequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi113 – 137PolarSequence analysisAdd BLAST25
Compositional biasi152 – 170PolarSequence analysisAdd BLAST19
Compositional biasi240 – 258PolarSequence analysisAdd BLAST19
Compositional biasi287 – 302PolarSequence analysisAdd BLAST16
Compositional biasi333 – 371PolarSequence analysisAdd BLAST39
Compositional biasi464 – 488PolarSequence analysisAdd BLAST25
Compositional biasi498 – 512PolarSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG4K Eukaryota
ENOG410XQ23 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003161

KEGG Orthology (KO)

More...
KOi
K20649

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGTCAQF

Database of Orthologous Groups

More...
OrthoDBi
1123653at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.25.40.530, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00784 MyTH4, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00139 MyTH4, 1 hit
SM00324 RhoGAP, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51016 MYTH4, 1 hit
PS50238 RHOGAP, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

G3X932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMSQAQDYE CRSHHVDEQE PRIPGSSTRL EWVEIIEPRT RERMYANLVT
60 70 80 90 100
GECVWDPPAG VRIKRTSEDQ WWELFDPNTS RFYYYSAASQ RTVWHRPQNC
110 120 130 140 150
DIIPLAKLQT LKQNTESPRA SADNSPGRGS RDGSTGSSLE PELEERTQEL
160 170 180 190 200
PVRSGRATTL VTSKEDTSSC SPPGVLLEKD YEVYRDYSAD GQLLHYRTSS
210 220 230 240 250
LRWNSGNKER MLIKVADREP SFLTPQGNGY PADNQPGGHH RRPSGSQHSP
260 270 280 290 300
NLQTFVPDTD GTVFFPERRP SPFLRRAELS GNCSPLLIQP RKPSSDSQPS
310 320 330 340 350
SPRYGYEPPL YEEPPVEYQA PIYDEPPMDV QFEANSPYQT GSPQRSPGRK
360 370 380 390 400
PHPFLQTTKQ TPTSPCQQLM RTKQKCPERF LSLEYSPVGK EYVRQLVYVE
410 420 430 440 450
QAGSSPKLRA GPRHKYAPNP GGGTYSLQPS PCLLRDQRLG VRSGDYSTME
460 470 480 490 500
GPESRPSQPP TPLPQAQEDA MSWSSQQDTM SSTGYSPGTR KRKNRKPSLC
510 520 530 540 550
QVPSTSSTDG AGGLLGEQPL TEERSPCRAS LTPVKAEADL VRGTPEPFLA
560 570 580 590 600
QARLAWEAQQ AHFHMKQRGS WDSQQDGSGY ESDGAVPLPM PGPVVRAFSE
610 620 630 640 650
DEALAQQDSK HWKRSTFDKL GFPQILLEKS VSVQTNLASP EPHLHPSQSE
660 670 680 690 700
DLGACAQFES SRQNRSAMPS SSCVFPTFTL RKPSSETDIE NWASKHFNKH
710 720 730 740 750
TQGLFRRKVS IANMLAWSSE SIKKPMIVTS DRHVKKEACE IFKLIQMYMG
760 770 780 790 800
DRRAKADPLH VALEIATKGW SAQGLRDELY IQLCRQTTEN FRLESLARGW
810 820 830 840 850
ELMAICLAFF PPTPKFHSYL EGYIYRHMDP VNDTKVTQHI KELLERNSKK
860 870 880 890 900
KSKLRKKPKP YVEEPDGVAI STYAKYCYHK LQKAALTGAK KGLKKPNVEE
910 920 930 940 950
IRHAKNAVFS PSMFGSALQE VMSMQKERYP DRQLPWVQTR LSEEVLALNG
960 970 980 990 1000
DQTEGIFRVP GDIDEVNALK LQVDQWKVPT GLEDPHVPAS LLKLWYRELE
1010 1020 1030 1040 1050
EPLIPHEFYE QCIAHYESPE AAVAVVHALP RINRMVLCYL IRFLQVFVQP
1060 1070 1080 1090 1100
ANVAITKMDV SNLAMVMAPN CLRCQSDDPR VIFENTRKEM SFLRVLIQHL

DTSFMEGVL
Length:1,109
Mass (Da):125,409
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC54466265B69A611
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P59281RHG39_MOUSE
Rho GTPase-activating protein 39
Arhgap39 D15Wsu169e, Kiaa1688
1,107Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX46H7BX46_MOUSE
Rho GTPase-activating protein 39
Arhgap39
1,078Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJM3H3BJM3_MOUSE
Rho GTPase-activating protein 39
Arhgap39
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLS4H3BLS4_MOUSE
Rho GTPase-activating protein 39
Arhgap39
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKC8H3BKC8_MOUSE
Rho GTPase-activating protein 39
Arhgap39
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJU8H3BJU8_MOUSE
Rho GTPase-activating protein 39
Arhgap39
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJW7H3BJW7_MOUSE
Rho GTPase-activating protein 39
Arhgap39
11Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC156550 Genomic DNA No translation available.
CH466545 Genomic DNA Translation: EDL29616.1

NCBI Reference Sequences

More...
RefSeqi
NP_001161760.1, NM_001168288.1
XP_006520857.1, XM_006520794.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000036176; ENSMUSP00000036697; ENSMUSG00000033697

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
223666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:223666

UCSC genome browser

More...
UCSCi
uc007wmh.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156550 Genomic DNA No translation available.
CH466545 Genomic DNA Translation: EDL29616.1
RefSeqiNP_001161760.1, NM_001168288.1
XP_006520857.1, XM_006520794.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000036176; ENSMUSP00000036697; ENSMUSG00000033697
GeneIDi223666
KEGGimmu:223666
UCSCiuc007wmh.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80728
MGIiMGI:107858 Arhgap39

Phylogenomic databases

eggNOGiENOG410IG4K Eukaryota
ENOG410XQ23 LUCA
GeneTreeiENSGT00390000003161
KOiK20649
OMAiLGTCAQF
OrthoDBi1123653at2759
TreeFamiTF323577

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Arhgap39 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033697 Expressed in 270 organ(s), highest expression level in CA1 field of hippocampus

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.25.40.530, 1 hit
InterProiView protein in InterPro
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00784 MyTH4, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00139 MyTH4, 1 hit
SM00324 RhoGAP, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF48350 SSF48350, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51016 MYTH4, 1 hit
PS50238 RHOGAP, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3X932_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X932
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 16, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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