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Protein
Submitted name:

Cholinergic receptor, nicotinic, alpha polypeptide 9

Gene

Chrna9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • acetylcholine-gated cation-selective channel activity Source: MGI
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor, nicotinic, alpha polypeptide 9Imported
Submitted name:
MCG5735Imported
Gene namesi
Name:Chrna9Imported
ORF Names:mCG_5735Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1202403 Chrna9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei239 – 262HelicalSequence analysisAdd BLAST24
Transmembranei269 – 290HelicalSequence analysisAdd BLAST22
Transmembranei302 – 321HelicalSequence analysisAdd BLAST20
Transmembranei458 – 476HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501509180823 – 479Sequence analysisAdd BLAST457

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000029205 Expressed in 56 organ(s), highest expression level in thymus

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-223 Neuronal nicotinic acetylcholine receptor complex, alpha9-alpha10
CPX-227 Neuronal nicotinic acetylcholine receptor complex, alpha9
STRINGi10090.ENSMUSP00000031108

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 236Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini244 – 474Neur_chan_membInterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
KOiK04810
OMAiVEDVEWE
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3X8Z7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRPHPCISF CWMYFAASGI KAVETANGKY AQKLFSDLFE DYSNALRPVE
60 70 80 90 100
DTDAVLNVTL QVTLSQIKDM DERNQILTAY LWIRQTWHDA YLTWDRDQYD
110 120 130 140 150
GLDSIRIPSD LVWRPDIVLY NKADDESSEP VNTNVVLRYD GLITWDSPAI
160 170 180 190 200
TKSSCVVDVT YFPFDSQQCN LTFGSWTYNG NQVDIFNALD SGDLSDFIED
210 220 230 240 250
VEWEVQGMPA VKNVISYGCC SEPYPDVTFT LLLKRRSSFY IVNLLIPCVL
260 270 280 290 300
ISFLAPLSFY LPAASGEKVS LGVTILLAMT VFQLMVAEIM PASENVPLIG
310 320 330 340 350
KYYIATMALI TASTALTIMV MNIHFCGAEA RPVPHWAKVV ILKYMSRILF
360 370 380 390 400
VYDVGESCLS PRHSQEPEQI TKVYGKLPGS NLKASRNKDL SRKKELRKLL
410 420 430 440 450
KNDLGYQGGI PQNTDSYCAR YEALTKNIEY IAKCLKDHKA TNSKGSEWKK
460 470
VAKVIDRFFM WIFFAMVFVM TVLIIARAD
Length:479
Mass (Da):54,323
Last modified:November 16, 2011 - v1
Checksum:i2F639CEF6A456BCE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUW0A0A0J9YUW0_MOUSE
Cholinergic receptor, nicotinic, al...
Chrna9
258Annotation score:
D3Z2J9D3Z2J9_MOUSE
Cholinergic receptor, nicotinic, al...
Chrna9
16Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115293 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37758.1
RefSeqiNP_001074573.1, NM_001081104.1
UniGeneiMm.140015
Mm.486671

Genome annotation databases

EnsembliENSMUST00000031108; ENSMUSP00000031108; ENSMUSG00000029205
GeneIDi231252
KEGGimmu:231252
UCSCiuc008xog.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115293 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37758.1
RefSeqiNP_001074573.1, NM_001081104.1
UniGeneiMm.140015
Mm.486671

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-223 Neuronal nicotinic acetylcholine receptor complex, alpha9-alpha10
CPX-227 Neuronal nicotinic acetylcholine receptor complex, alpha9
STRINGi10090.ENSMUSP00000031108

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031108; ENSMUSP00000031108; ENSMUSG00000029205
GeneIDi231252
KEGGimmu:231252
UCSCiuc008xog.1 mouse

Organism-specific databases

CTDi55584
MGIiMGI:1202403 Chrna9

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
KOiK04810
OMAiVEDVEWE
OrthoDBiEOG091G0R20
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Miscellaneous databases

ChiTaRSiChrna9 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029205 Expressed in 56 organ(s), highest expression level in thymus

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3X8Z7_MOUSE
AccessioniPrimary (citable) accession number: G3X8Z7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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