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Entry version 77 (02 Jun 2021)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Myocardin-related transcription factor B

Gene

Mrtfb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myocardin-related transcription factor BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MrtfbImported
Synonyms:Mkl2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3050795, Mrtfb

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
G3X8R8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
G3X8R8

PRoteomics IDEntifications database

More...
PRIDEi
G3X8R8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
341126

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009569, Expressed in brain and 273 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G3X8R8, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3X8R8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Coiled coilARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182979

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEQQPYS

Database of Orthologous Groups

More...
OrthoDBi
190145at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326024

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043451, Myocardin-like
IPR004018, RPEL_repeat
IPR003034, SAP_dom
IPR036361, SAP_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22793, PTHR22793, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02755, RPEL, 2 hits
PF02037, SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00707, RPEL, 3 hits
SM00513, SAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF68906, SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51073, RPEL, 3 hits
PS50800, SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3X8R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHTGAIDTE EELGPLAHLA PSPQSESVAH EFQELSLQSS QHLPTLNERK
60 70 80 90 100
NVLQLRLQQR RTREQLVDQG IMPPLKSPAA FHEQIKSLER ARTENFLKHK
110 120 130 140 150
IRSRPDRSEL VRMHILEETF AEPSLQATQM KLKRARLADD LNEKIAQRPG
160 170 180 190 200
PMELVEKNIL PVDSSVKEAI IGVVKEDYPH THGEFSFDED SSDALSPDQP
210 220 230 240 250
ASQESQGSAA SPSEPKVSAS PPPVTASTPA QFTSVSPAVP EFLKTPLTAD
260 270 280 290 300
QPPTRSTAPV LPTNTVSSAK SGPMLVKQSH PKNPNDKHRS KKCKDPKPRV
310 320 330 340 350
KKLKYHQYIP PNQKGEKSEP QMDSNYARLL QQQQLFLQLQ ILSQQQQQQQ
360 370 380 390 400
QQHYNYQTIL PAPIKTDKNS SSGSNSGSSS SMPARRPGPL PSSLDDLKVS
410 420 430 440 450
ELKTELKLRG LPVSGTKPDL IERLKPYQEV TSSNLATGSI VAVSSATIVT
460 470 480 490 500
SNPEVTVALP VTTLHNAVTS SVSTFKADLA LPATSSVPHV ENAHSPLPIS
510 520 530 540 550
PSPSEQSSLS TDDTNMTDTF TEIMTMMSPS QLLCSSPLRV VSHDDSLSPS
560 570 580 590 600
SSTLSTLELD AAEKDRKLQE KEKQIEELKR KLEQEQKLVE VLKMQLEVEK
610 620 630 640 650
RGQQRPPDPQ PSDPPHPFNT SDPKHGSVGS SIKDEASLPD CSSPQQPITV
660 670 680 690 700
PGHSVGQPIS TGSQTLVAKK TVVVKQEVPM AQAEQQNVVS QFYLSSQGQP
710 720 730 740 750
PALVAQPQAL LTTQTTQLLL PVSIQGSNVT SVQLPVGSLQ LQTPAQGRVQ
760 770 780 790 800
AQPHVAAATQ VPAAALPSAL TSALPQKQEA FPQHVLGQPQ PVRKVFTNSA
810 820 830 840 850
PNTVLQYQRQ PGPTNQQPFV SKTSNPALQS RTAPLAPLQN GPSLASKPSS
860 870 880 890 900
PPPPQQFVVQ HSLFATPITK TKDPPRYEEA IKQARSTQPA LPEVSSVHSQ
910 920 930 940 950
QMDDLFDILI KSGEISFPIK EEPSPISKMK PVTASITTMP VNTVVSRPPP
960 970 980 990 1000
QVQIAPPVSL EPVNSLSASL ENQLEAFLDG TLPSATDTGP LQNSSEDRES
1010 1020 1030 1040 1050
FSLIEDLQND LLSHSSMLYQ SHSPMETSEA QLVSGTPCLS LDLSDSNLDN
1060 1070 1080 1090
MEWLDITMPT TSSGLTPLST TAPSMFSADF LDPQDLPLPW D
Length:1,091
Mass (Da):118,550
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7739BB410204D1CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P59759MRTFB_MOUSE
Myocardin-related transcription fac...
Mrtfb Mkl2
1,080Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5DTZ3Q5DTZ3_MOUSE
MKIAA1243 protein
Mrtfb mKIAA1243, Mkl2
1,080Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8R2L3Q8R2L3_MOUSE
MKL/myocardin-like 2
Mrtfb Mkl2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001116139.1, NM_001122667.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000009713; ENSMUSP00000009713; ENSMUSG00000009569

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
239719

UCSC genome browser

More...
UCSCi
uc007yfy.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001116139.1, NM_001122667.2

3D structure databases

SMRiG3X8R8
ModBaseiSearch...

Proteomic databases

jPOSTiG3X8R8
MaxQBiG3X8R8
PRIDEiG3X8R8
ProteomicsDBi341126

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1832, 114 antibodies

The DNASU plasmid repository

More...
DNASUi
239719

Genome annotation databases

EnsembliENSMUST00000009713; ENSMUSP00000009713; ENSMUSG00000009569
GeneIDi239719
UCSCiuc007yfy.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57496
MGIiMGI:3050795, Mrtfb

Phylogenomic databases

GeneTreeiENSGT00950000182979
OMAiMEQQPYS
OrthoDBi190145at2759
TreeFamiTF326024

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
239719, 0 hits in 50 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mrtfb, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000009569, Expressed in brain and 273 other tissues
ExpressionAtlasiG3X8R8, baseline and differential

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR043451, Myocardin-like
IPR004018, RPEL_repeat
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
PANTHERiPTHR22793, PTHR22793, 1 hit
PfamiView protein in Pfam
PF02755, RPEL, 2 hits
PF02037, SAP, 1 hit
SMARTiView protein in SMART
SM00707, RPEL, 3 hits
SM00513, SAP, 1 hit
SUPFAMiSSF68906, SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51073, RPEL, 3 hits
PS50800, SAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3X8R8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X8R8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 2, 2021
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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