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Protein
Submitted name:

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-209968 Thyroxine biosynthesis
R-MMU-428643 Organic anion transporters

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium/iodide cotransporterImported
Submitted name:
Solute carrier family 5 (Sodium iodide symporter), member 5Imported
Gene namesi
Name:Slc5a5Imported
ORF Names:mCG_14796Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2149330 Slc5a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 36HelicalSequence analysisAdd BLAST20
Transmembranei56 – 75HelicalSequence analysisAdd BLAST20
Transmembranei87 – 110HelicalSequence analysisAdd BLAST24
Transmembranei131 – 156HelicalSequence analysisAdd BLAST26
Transmembranei162 – 180HelicalSequence analysisAdd BLAST19
Transmembranei192 – 211HelicalSequence analysisAdd BLAST20
Transmembranei242 – 261HelicalSequence analysisAdd BLAST20
Transmembranei282 – 307HelicalSequence analysisAdd BLAST26
Transmembranei342 – 371HelicalSequence analysisAdd BLAST30
Transmembranei392 – 413HelicalSequence analysisAdd BLAST22
Transmembranei419 – 437HelicalSequence analysisAdd BLAST19
Transmembranei444 – 466HelicalSequence analysisAdd BLAST23
Transmembranei523 – 544HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000000792 Expressed in 86 organ(s), highest expression level in epithelium of stomach

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955
KOiK14385
OMAiATFGAWD
OrthoDBiEOG091G07OC
TreeFamiTF316728

Family and domain databases

CDDicd11503 SLC5sbd_NIS, 1 hit
Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
IPR035689 SLC5A5
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3X8P5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL
110 120 130 140 150
TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG
260 270 280 290 300
GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR
510 520 530 540 550
GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR
610
PEAETHPLYL GHDAETNL
Length:618
Mass (Da):65,540
Last modified:November 16, 2011 - v1
Checksum:i448AC5FE85A5118E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99PN0SC5A5_MOUSE
Sodium/iodide cotransporter
Slc5a5 Nis
618Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019302 Genomic DNA No translation available.
CH466569 Genomic DNA Translation: EDL28884.1
RefSeqiNP_444478.2, NM_053248.2
UniGeneiMm.172923

Genome annotation databases

EnsembliENSMUST00000000809; ENSMUSP00000000809; ENSMUSG00000000792
GeneIDi114479
KEGGimmu:114479
UCSCiuc009mbz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019302 Genomic DNA No translation available.
CH466569 Genomic DNA Translation: EDL28884.1
RefSeqiNP_444478.2, NM_053248.2
UniGeneiMm.172923

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000809; ENSMUSP00000000809; ENSMUSG00000000792
GeneIDi114479
KEGGimmu:114479
UCSCiuc009mbz.2 mouse

Organism-specific databases

CTDi6528
MGIiMGI:2149330 Slc5a5

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955
KOiK14385
OMAiATFGAWD
OrthoDBiEOG091G07OC
TreeFamiTF316728

Enzyme and pathway databases

ReactomeiR-MMU-209968 Thyroxine biosynthesis
R-MMU-428643 Organic anion transporters

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000792 Expressed in 86 organ(s), highest expression level in epithelium of stomach

Family and domain databases

CDDicd11503 SLC5sbd_NIS, 1 hit
Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
IPR035689 SLC5A5
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3X8P5_MOUSE
AccessioniPrimary (citable) accession number: G3X8P5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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