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Entry version 63 (29 Sep 2021)
Sequence version 2 (07 Apr 2021)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor 12

Gene

ARHGEF12

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 136PDZInterPro annotationAdd BLAST65
Domaini787 – 977DHInterPro annotationAdd BLAST191
Domaini1019 – 1132PHInterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 63DisorderedSequence analysisAdd BLAST63
Regioni267 – 315DisorderedSequence analysisAdd BLAST49
Regioni579 – 717DisorderedSequence analysisAdd BLAST139
Regioni1138 – 1199DisorderedSequence analysisAdd BLAST62
Regioni1366 – 1406DisorderedSequence analysisAdd BLAST41
Regioni1475 – 1494DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili206 – 226Sequence analysisAdd BLAST21
Coiled coili232 – 259Sequence analysisAdd BLAST28
Coiled coili519 – 539Sequence analysisAdd BLAST21
Coiled coili1204 – 1224Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 60Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi579 – 596Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi628 – 650Polar residuesSequence analysisAdd BLAST23
Compositional biasi664 – 683Polar residuesSequence analysisAdd BLAST20
Compositional biasi693 – 707Polar residuesSequence analysisAdd BLAST15
Compositional biasi1154 – 1168Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1169 – 1199Polar residuesSequence analysisAdd BLAST31
Compositional biasi1375 – 1406Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1477 – 1494Polar residuesSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157662

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003962_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFCQHQQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13390, PH_LARG, 1 hit
cd08754, RGS_LARG, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037801, ARHGEF12_PH
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR037884, LARG_RGS
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3X0I7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTQPTITD RFPLKKPIRH ASILTRESPT DKKQKVERST SHDFDPTDSS
60 70 80 90 100
SKKTKSSSEE SRSETYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED
110 120 130 140 150
GAAMRAGVQT GDRIIKVNGT LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG
160 170 180 190 200
SPQIPLADSE VEPAAFGHMS PIMTSPHSPG TSGNTERITS PVLMGEENNV
210 220 230 240 250
VHNQKVEILR KMLQQEQERL QFLQEDYSRT PAQRLLKEIQ EAKKHIPQLQ
260 270 280 290 300
EQLSKATGST QDGAVVLSSK TSGDSLPLSE VEADSGDGLG RIDYSSGDGS
310 320 330 340 350
RPNSDIADSP RSGLKERIYL EESPEKSEMI PDNDTQSNIG SPLIRTAPQI
360 370 380 390 400
IGAEDDDFGT EHEQINGQCS CFQSIELLRS RPAHLAAFLH HVVSQFDPAT
410 420 430 440 450
LLCYLYSDLY KQTNSKETRR IFLEFHQFFL DRAAHLKVSV PDEISLDLEK
460 470 480 490 500
RRPELIPEDL HRHYVQTMQD KVYPEVQKHL EDFRQKRSMG LTLAESELTK
510 520 530 540 550
LDAERDRDRV ILEKERACAE QIITKIEELL MTAQAVEEDK SSTMQYVILM
560 570 580 590 600
YMKHLGVRVK EPRNLEHKRG RIGFLPKIKQ SIKKDREGEE KVKRRGFPSI
610 620 630 640 650
LGPPRRPSRH DSSAIGRAME LQKQRHPKHL STPSSVSPEP QDSAKLRQSG
660 670 680 690 700
ISSDAADVMY MPPNPMSSLT SGTSASQDGG KENEMGSKQI GEGPASGDST
710 720 730 740 750
DGTPRTPNTV FDFPAPPLDQ LQEEEGEIER FPEHGTPKSF RKLDSIAFGE
760 770 780 790 800
SQSEDEQFEN DLETDPPNWQ QLVSREVLLG LKPCEIKRQE VINELFYTER
810 820 830 840 850
AHVRTLKVLD QVFYQRVSRE GILSSSELRR IFSNLEEILQ LHIGLNEQMK
860 870 880 890 900
AVRKRNETSV IDEIGEDLLI WFSGSGEEKL KHAAATFCSN QPFALEMIKS
910 920 930 940 950
RQKKDSRFQT FVQDAESNPL CRRLQLKDII PTQMQRLTKY PLLLDNIAKY
960 970 980 990 1000
TERPKEREKV KKAADHCRQI LNYVNQAVKE AENKQRLEDY QRRLDTSNLK
1010 1020 1030 1040 1050
LSEYPNVEEL RNLDLTKRKM IHEGPLVWKV NRDKTIDLYT LLLEDILVLL
1060 1070 1080 1090 1100
QKQDDRLVLR CHSKILASTA DSKHTFSPVI KLNTVLVRQV ATDNKALFVI
1110 1120 1130 1140 1150
SMSDNGAQIY ELVAQTVSEK AVWQDLIGRM ALTVKEQSTK PIPLPESPPC
1160 1170 1180 1190 1200
EGEREEEEAS KLKEESHDVS TSSLQSPEKQ MGAETSLMSK PQSPSSVISG
1210 1220 1230 1240 1250
KSEISDLLAE RQFEKEQMEE TSKESGMDFQ STIPEPHLPV CEERWALDAL
1260 1270 1280 1290 1300
RNLGLLKQLL VQQLGLTEKR TPEDWPHFSR FRTSSQGVQV ESPGVSQNVL
1310 1320 1330 1340 1350
DHSENNKTSQ FGEGHTSLQT RTGQIACYSP RTSIESPVPQ DYMELASQDS
1360 1370 1380 1390 1400
RASNLLVMDH MIMTPEPSSA ELEGGPDDSG EHFFDAREAH SDDNPSESDG
1410 1420 1430 1440 1450
TERKEEEALQ LRISGNVLIL DGFETVQESS TEEEGVSNLP SVGWAHQQQS
1460 1470 1480 1490 1500
VLNPRSDGGG SPFTPEFLVQ QRWRPGEESG FSAQSPSSSA DSHSQIMQYI
1510 1520 1530
RKIEADLEHL KKVEESYMTL CQRLAGSALT EEHSDKS
Length:1,537
Mass (Da):172,868
Last modified:April 7, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7D3EA80DF57DB10
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSHAT00000021362; ENSSHAP00000021192; ENSSHAG00000017964

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSHAT00000021362; ENSSHAP00000021192; ENSSHAG00000017964

Phylogenomic databases

GeneTreeiENSGT00940000157662
HOGENOMiCLU_003962_1_0_1
OMAiTFCQHQQ

Family and domain databases

CDDicd13390, PH_LARG, 1 hit
cd08754, RGS_LARG, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037801, ARHGEF12_PH
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR037884, LARG_RGS
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3X0I7_SARHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3X0I7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: April 7, 2021
Last modified: September 29, 2021
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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