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Protein
Submitted name:

ATP binding cassette subfamily C member 11

Gene

ABCC11

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi547 – 554ATPPROSITE-ProRule annotation8
Nucleotide bindingi1178 – 1185ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP binding cassette subfamily C member 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei161 – 187HelicalSequence analysisAdd BLAST27
Transmembranei199 – 224HelicalSequence analysisAdd BLAST26
Transmembranei274 – 295HelicalSequence analysisAdd BLAST22
Transmembranei301 – 323HelicalSequence analysisAdd BLAST23
Transmembranei377 – 402HelicalSequence analysisAdd BLAST26
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei802 – 826HelicalSequence analysisAdd BLAST25
Transmembranei861 – 884HelicalSequence analysisAdd BLAST24
Transmembranei941 – 958HelicalSequence analysisAdd BLAST18
Transmembranei964 – 980HelicalSequence analysisAdd BLAST17
Transmembranei1052 – 1072HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9305.ENSSHAP00000018086

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 441ABC transmembrane type-1InterPro annotationAdd BLAST277
Domaini511 – 735ABC transporterInterPro annotationAdd BLAST225
Domaini806 – 1103ABC transmembrane type-1InterPro annotationAdd BLAST298
Domaini1144 – 1378ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162968

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3WRN1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEGVYYG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01TC

TreeFam database of animal gene trees

More...
TreeFami
TF352085

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF168 PTHR24223:SF168, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3WRN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRRKDWGP SPTGGSVNLG MDLEDSMVYG LTYKKFTFGD NYWSPGPHNK
60 70 80 90 100
PEEQKTLSDG KNHAAWKTMI PIRPKSKSSM EHPVDGAGLI SYLTNSWLTP
110 120 130 140 150
LMIQGFQKRL NEHTVPPLSI YDSSEKNSER LRYLWEEEVA RYGYEKASVT
160 170 180 190 200
RVLFRFQRTR FCFDILASIF FSIMSVLGPV LLVPKILENS IDVSKNLSYS
210 220 230 240 250
IGLCFALFFT ECLKSFSLCA CWTINHRTGA RLRTAACSLA FEKLMEFRSL
260 270 280 290 300
THISVGETIS FFTSDINHLF EGACFGPLII ITLATIVTAS ASTYVTLGPT
310 320 330 340 350
AFLGIVCYLL TFPLQAVLTK IIVRLQNKTA EVSDKRIRIT TEILTCIKLI
360 370 380 390 400
KMYSWEKPFS AIIKALRNKE QKLSEKCGFL QSLNTSVLFV APTVATVVMF
410 420 430 440 450
LVHTGLKLEL TTSVAFTAVA TLSTLKLSVF FVPFSIKGFT NSESAAQRLK
460 470 480 490 500
KFFLKECPAF YVQELKGSAA LVFDNATLSW EWNDSGICNG AMEMNGKGDC
510 520 530 540 550
ADKPAVVSSQ VKNQRLSQLG EKKTNLGPVL HNINIVVPKG KILGICGNTG
560 570 580 590 600
SGKSCLLSAI LGEMNLHSGS VGVNGSLAYV PQQPWIFSGT VRSNILMGEK
610 620 630 640 650
YDQARYHHVI HSCSLKRDLE ILPYGDMSEI GERGLNLSGG QRQRISLARA
660 670 680 690 700
VYADRDIYLL DDPLSAVDAH VGKHIFEECI KKALSGKTMV LVTHQLQYLE
710 720 730 740 750
FCDYIILLKD GKISESGTHD ELLQKKGQYA QLIQKICGET AQNVTDGAKN
760 770 780 790 800
IGEKTEVDLY SQEGFFNENP VLETQLTEKE EMEEGSLSWK VYHYYIQGAG
810 820 830 840 850
GYIITFLTFF IMMVNVSLTT FSFWWLSHWL HQGSGASNST RINGTKYMGP
860 870 880 890 900
GSLLDNPQFH IYQIVYGVSA LALIFTGVMS SGFFTRTTRK SATVLHNTLF
910 920 930 940 950
MKILHCPMSF FDTTPNGRFL NCFSGDLNEL DQMLPMVAEE FLLLLFVVVS
960 970 980 990 1000
ILIIVVILSP YFLIVGSIVG IIFLILFQAF KKTINVIKRL ENYSRSPLYS
1010 1020 1030 1040 1050
HIITSLNGLS SIHVYGTAND YIQEFRRLTD NHCNYVFLFL STTRWTSLRL
1060 1070 1080 1090 1100
ELLTNLITLA VALFVVLSPS SISYSYKAMA ISYVLQLATN FQACARLGSE
1110 1120 1130 1140 1150
TEARFTSAER ILQYMKKIKL SVPESSLHIK GVSCPPDWPQ QGQIVFKDYQ
1160 1170 1180 1190 1200
MKYRDNTPIV LNDINLTFYS QEVVGIVGRT GSGKSSLAVA LFRLVEPAAG
1210 1220 1230 1240 1250
SIFIDNIDIC SLGLEDLRSK LSIIPQDPVL LSGTIRFNLD PFESYTDEQI
1260 1270 1280 1290 1300
WQALERTCLT KTISKLPEKL LAEVVENGGN FSVGEKQLLC IARALLRNSK
1310 1320 1330 1340 1350
IILIDEATAS IDVDTDALIQ HTIREAFHGC TVLIIAHRIT TVLDCDRILV
1360 1370 1380
MDNGKVLEYD KPEVLQQRPN SAFSALLAAA HKNIK
Length:1,385
Mass (Da):154,678
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2C0848C142412F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEFK01021334 Genomic DNA No translation available.
AEFK01021335 Genomic DNA No translation available.
AEFK01021336 Genomic DNA No translation available.
AEFK01021337 Genomic DNA No translation available.
AEFK01021338 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSHAT00000018235; ENSSHAP00000018086; ENSSHAG00000015355

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01021334 Genomic DNA No translation available.
AEFK01021335 Genomic DNA No translation available.
AEFK01021336 Genomic DNA No translation available.
AEFK01021337 Genomic DNA No translation available.
AEFK01021338 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000018086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSHAT00000018235; ENSSHAP00000018086; ENSSHAG00000015355

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000162968
InParanoidiG3WRN1
OMAiFEGVYYG
OrthoDBiEOG091G01TC
TreeFamiTF352085

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF168 PTHR24223:SF168, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3WRN1_SARHA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3WRN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: December 5, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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