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Entry version 49 (02 Jun 2021)
Sequence version 2 (07 Apr 2021)
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Protein
Submitted name:

Mannose receptor C-type 1

Gene

MRC1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation
LigandLectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mannose receptor C-type 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1317 – 1339HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi102 ↔ 128PROSITE-ProRule annotation
Disulfide bondi116 ↔ 143PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 76Ricin B-type lectinInterPro annotationAdd BLAST76
Domaini97 – 145Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini159 – 275C-type lectinInterPro annotationAdd BLAST117
Domaini303 – 420C-type lectinInterPro annotationAdd BLAST118
Domaini443 – 558C-type lectinInterPro annotationAdd BLAST116
Domaini587 – 709C-type lectinInterPro annotationAdd BLAST123
Domaini738 – 854C-type lectinInterPro annotationAdd BLAST117
Domaini882 – 1010C-type lectinInterPro annotationAdd BLAST129
Domaini1031 – 1142C-type lectinInterPro annotationAdd BLAST112
Domaini1170 – 1286C-type lectinInterPro annotationAdd BLAST117

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234657

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYAGNCY

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062, FN2, 1 hit
cd00161, RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 5 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3WGQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISLKLCLG VSSKTDWVQV TLFPCDSKSD LQKWECKNDT LFGILGEDLY
60 70 80 90 100
FNYGNKQEKN IMLYKGSGLW SRWKIHGTSD DLCSRGYEEI YTLLGNSNGA
110 120 130 140 150
PCVFPFKFEN KWYADCTSAG RSDGWLWCGT TTDYEVTRLF GFCPRKFAGS
160 170 180 190 200
ESLWTKDPLT GISYQINSKS ALTWHQARKS CQQQQSELLS ITEVSEQTYL
210 220 230 240 250
TGLTNSLTTG LWIGLNSLSF NSGWQWAGYS PFRYLNWLPG SPALEPGKSC
260 270 280 290 300
VLLNPAKNAK WENVECSQKL GYICKKGNSS LNQFIIPSES DVPISCPSQW
310 320 330 340 350
WPYAGHCYKI SREPKIQKDA KTTCRKEGGD LASIHSIEEF DFIFSQLGYE
360 370 380 390 400
DTDTLWIGLN DLKHQMFFEW SDDTPVTFTK WLPGEPSHAN NRQEDCVVMK
410 420 430 440 450
GKNGYWADHP CEGHHGYVCK SKPLSTPPVV EVDTGCKKGW KRHGPYCYMI
460 470 480 490 500
GQTLSTFEVA NHTCINQNAY LVTVEDRYEQ AFLTSLVGLR PEKYFWIGLS
510 520 530 540 550
DVQNKGTFKW TIDENVQFSH WNSLMPGRKT GCVAMKTGIA GGLWDVLKCE
560 570 580 590 600
EKAKFVCKHW AEGVTPPPIP TTTPAPKCPD GWISSSKTNL CFKVFGKSKY
610 620 630 640 650
SKKTWFDARD FCRAIGGDLA RITNKEDQST IWQNIGTSNY HDVFWLGLTI
660 670 680 690 700
ANTDEGFTWS DGSPVTYENW SYGEPNNYGN IEFCGELKAD PSMRWNDINC
710 720 730 740 750
ELLRKWICHI KKGDELKPEP TPSPESNPPV TEDGWVIYKD YQYYFSKEKS
760 770 780 790 800
TMENARAFCK KNFGDIVTIS GESEKKFLWK YISALDLEAT YFIGLLISLD
810 820 830 840 850
KKFSWMDGSK VDYVAWAPGE PNFANDDENC VVLYTSSGLW NDINCGFPNA
860 870 880 890 900
FICQRHNSSI NTTASPTPLP PLGGCRWGWK LFQNKCYKIF GAKEEERKNW
910 920 930 940 950
QAARKDCQGY GGNLVSIHSR KEQAFLTTEL LESTYDSWIG MNDINSENKF
960 970 980 990 1000
LWTDGRGVQY TNWAKGFPAG RRSFLSYEDV DCVVIVGGPS LEAGKWIDEI
1010 1020 1030 1040 1050
CENEKGYICQ TDSDPAQPHP STPTSGNFIR FGDSSYSVVT SKMKWKDAKE
1060 1070 1080 1090 1100
YCEGSSSQIA SILDPYVNSF VWLEMQKHNE PMWIGLNSNL TQGEYAWIDR
1110 1120 1130 1140 1150
WRMRYTNWGP GEPQVKSGCV YMDLEGFWKT APCNESYQFL CKKSDVSPAT
1160 1170 1180 1190 1200
EPPQLPGRCP DSEQSSWIPF SGHCYYIESS STRSWGQALL ECSRMGASLV
1210 1220 1230 1240 1250
SIESAVESTF LTYKVEPLKS KTNFWIGMFK NVEGNWLWID NTAVSFVNWK
1260 1270 1280 1290 1300
TGEPSNDRNE DCVELYSSSG FWNNLYCSSY KGYICKREKI IDAKATEAIK
1310 1320 1330 1340 1350
PNDGPETRKA PKSHNSAGII VVVVLLILTG VGAAAYFFYK KRQVQIPQEG
1360 1370 1380
NFDNTLYFNT GSISGVSDTK DLMGNIEQNE HALI
Length:1,384
Mass (Da):156,747
Last modified:April 7, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43CEFE9D1D66A473
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3WGQ2G3WGQ2_SARHA
Mannose receptor C-type 1
MRC1
1,450Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSHAT00000014730; ENSSHAP00000014608; ENSSHAG00000012471

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSHAT00000014730; ENSSHAP00000014608; ENSSHAG00000012471

Phylogenomic databases

GeneTreeiENSGT01030000234657
OMAiPYAGNCY

Family and domain databases

CDDicd00062, FN2, 1 hit
cd00161, RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SUPFAMiSSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
SSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 5 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3WGQ3_SARHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3WGQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: April 7, 2021
Last modified: June 2, 2021
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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