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Entry version 59 (08 May 2019)
Sequence version 1 (16 Nov 2011)
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Protein

Serine-protein kinase ATM

Gene

ATM

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
Biological processDNA damageUniRule annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine-protein kinase ATMUniRule annotation (EC:2.7.11.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicleUniRule annotation, NucleusUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9305.ENSSHAP00000012661

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1970 – 2576FATInterPro annotationAdd BLAST607
Domaini2722 – 3068PI3K/PI4KInterPro annotationAdd BLAST347
Domaini3036 – 3068FATCInterPro annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1621 – 1648Sequence analysisAdd BLAST28
Coiled coili3015 – 3035Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0892 Eukaryota
ENOG410XNPY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00670000098061

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3WB56

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDPFPDH

TreeFam database of animal gene trees

More...
TreeFami
TF101182

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR015519 ATM/Tel1
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR021668 TAN

The PANTHER Classification System

More...
PANTHERi
PTHR11139:SF72 PTHR11139:SF72, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF11640 TAN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM01342 TAN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3WB56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLDLHDLLL CCRQLENDRA TERRKEVEKF KHLIRDPETV KHLDRNSDSR
60 70 80 90 100
QGKYLNWDAV FRFLQKYIQK ETECLRTAKP NVSASTQASR QKKMQEITSL
110 120 130 140 150
VKYFIKCANK RAPRLKCQEL LNYVMDTVKD SSSGTTYGAD YSNILLKDIL
160 170 180 190 200
SVRKYWCEIS QHHWSELLAL YCTLYLKQSK DINRVLVARI IQTVTRGCCS
210 220 230 240 250
QTDGINLKFF DFFSKAMQCA RQEKSSAGLN HILAALNIFL KVFAVNYRIR
260 270 280 290 300
VCKLGEEILP TVLYIWSQQR PNDSLKDVII ELFHLQVRFH HPKGAKTQEK
310 320 330 340 350
GAYESAKWQS ILYNLYDLLL NEISHIGSRG KYSSGCRNIA VKENLVELMA
360 370 380 390 400
DVCHQVFSED TRVLEISQSY VTSPRDICSG STPSKRRKIE LGWEVIKDYL
410 420 430 440 450
QKSHNDFDLV PWLQITTQLI AKYPESLPNS ELTPLLTILH QLLSQQRRGE
460 470 480 490 500
RIPYVLRCLV KLALCQGKKL DLETSHKSDL LKLWNKIWSI TFRSISSEQI
510 520 530 540 550
QAENFGLLGA IIEGNLVGVD RELWKIFTGS ACRPSCPAVC CLSLALMSCI
560 570 580 590 600
VPEMSKVGMD QSVCEINQGY SLKELIMKWL LFYQLEDDIE ESTELPPVLC
610 620 630 640 650
SDFPHLTLES ILVSLTMKNC KGAMDFFQSV TESEQQQKGK VEATFLEVEE
660 670 680 690 700
LYLQTTFDQM DFCTNMMYSA SEKIQTSAGL SFHQNLKETL DRYLLGLSEQ
710 720 730 740 750
LLNNYSLETV RSEALVRCSS LLVGVLGCYC HAGILSEEDA YKSKLFQNAK
760 770 780 790 800
SLMQYAGKSI TLFKSKINEE SRICSLRTMM LLCTNYLYNC TKNKLNKIIS
810 820 830 840 850
GLFLRLLTSK LMNDIVDICT NLASLTKRPF DSGEVELMED DVDVKLMEVE
860 870 880 890 900
DQSTMNLFES DDTNINNANE SGEVQNTFGS ISPLAEEHLT KQDLLLLDML
910 920 930 940 950
KFLCICVTTA QSHTVSFRAC DIRRELLKLI EPSILDTSKS LHLHMYLVLL
960 970 980 990 1000
KELPVEEYPL PMEEVSELLK PLSHVCSLYR RDQDVCRAIL SHILPIITNL
1010 1020 1030 1040 1050
GQHSSDVENT RNAQGQFLTV IGAFWHLTKE GKCVASVRMA LVNCLKALLE
1060 1070 1080 1090 1100
TDPYSKWAVL SIMEKDLPVT EVLPQFLADN HHQVRMLAAK SINRKKKRLF
1110 1120 1130 1140 1150
QETKQVAISR SSRAFPLKLQ QKAFENAYLK VQEGMKEMPL KSRSPVTAGE
1160 1170 1180 1190 1200
LLDEPYNRKA TLLMTVSMIL YCSPVCEKQA LFAICQSVKE NGLETQLVKK
1210 1220 1230 1240 1250
VLKRVSEIFD YKHLEDFMNS HLDYLVLEWL KLQNIGYNLS SFPFILLNYT
1260 1270 1280 1290 1300
NITDFYSSCY KALIPLLVMR GQFEDVKSIA DQIQKDWKNL LTDCFPKILV
1310 1320 1330 1340 1350
NILPYFAFES TGNNDMSERR DTATKVYDML KDENILGKQI DHLLNSNLAE
1360 1370 1380 1390 1400
IIVELLMTLH EPADTETSES TDLSPFSGDL DPAPNPPYFP SHVIKATLAY
1410 1420 1430 1440 1450
ISNCHKTKFK SIVDILSKSP DSFQKILLAI CEQAAETNNV YKKNRILKVY
1460 1470 1480 1490 1500
HLFVNLLLRE IKSGLGGAWA FVLRDIIYTL IHYINNSVRP SHFMDVSLRS
1510 1520 1530 1540 1550
FSICCDLLSK VCRTAVTYCK DALESHLHVI VGTIIPLVGD QLEIQEQVLD
1560 1570 1580 1590 1600
LLKYLVIENK DNENLYHTIR LLDPFPDHEA FKDLRITQQK IKYSKGPFSL
1610 1620 1630 1640 1650
LEEIHHFLSV SICDSLPLTR LEGLKELRKQ LEQHKDQMKD LLKESQDNPQ
1660 1670 1680 1690 1700
DGIMVKLIVS LLQLSKMAIN HTGEKEVLEA IGNCLGEVGP IDFSTIAIQH
1710 1720 1730 1740 1750
GKDASYSKAI DLFEDKELQW TFIMLKYLNN ALVEDCVKVR SAAVACLKNI
1760 1770 1780 1790 1800
LATKTGHEFW EIYKKTTDPM LIYLQPFRTS RKKFLEVPRI DKENPLENLD
1810 1820 1830 1840 1850
DPNLWVPQEE NHDSWIKTLT CTLLKSGGIK SEILLLLKPL CEVKPSFCQY
1860 1870 1880 1890 1900
VLPYLIHDIL LHDTNESWRN LLSVHIQGFF TNCFRHSSQS NRSTTPANLD
1910 1920 1930 1940 1950
SESEFLFRGS LNKKSRRTML AVVDYMRRQR RPFSGTVFDD TFWLELNYLE
1960 1970 1980 1990 2000
VAMVAQSCAA HFTALLYAEI YADRKNSDDQ QKRSLTFEDG SQCTTISSLS
2010 2020 2030 2040 2050
EKSKEETGIS LQDLLMKIYR SIGEPDSLYG CGGGKMLQPL IRIRTYEHEA
2060 2070 2080 2090 2100
MWGKALVTYD LETTLSPTTR QAGIIEALQN FGLCHTLSTY LKGLDYEHSE
2110 2120 2130 2140 2150
WCAEQQELCY QAAWRNMQWE YCPSHRKRTE GPGYHESLYN ALQSLRDKEF
2160 2170 2180 2190 2200
STFYGTLKYA RLKEVEELCK GSLESVYSLY PALSRLQAIG ELENIGKLFS
2210 2220 2230 2240 2250
RSITDRELTE VYGKWQRQSQ LLKDSDFGFQ EPIMALRTVI LETLMKKETE
2260 2270 2280 2290 2300
DSQREGIKNI LIKHLVELSV LARTARNTQL PERAMFQIKQ YTSARCGISE
2310 2320 2330 2340 2350
WQLEEAQVFW AKKEQSLALS ILKQMIKKLD ENFSQNDSSL KLIYAECLRV
2360 2370 2380 2390 2400
CGNWLAETCL ENPTVIMQTY LEKAVEIAGS FDGECSDKLR SGKMKAFLSL
2410 2420 2430 2440 2450
ARFSDIQYQR IENYMKSSEF ENKQALLNKA KQEVGLLREH KVQTNRYTVK
2460 2470 2480 2490 2500
VQRELELDEC AIRALREDRK RFLCKAVENY ISCLLSGEEH DMWIFRLCSL
2510 2520 2530 2540 2550
WLENSAVSGV NSMMKKDGVK IPSYKFLPLM YQLAARMGTK MMGGLGFHEV
2560 2570 2580 2590 2600
LNNLIARISR DHPHHTLFII LALANANKDE LLTKSEAATR SRITKNAPKQ
2610 2620 2630 2640 2650
ISQLDEDRME AANNIISIIK DGKAKMVRNV KELCDAYITL ANMDANPWKT
2660 2670 2680 2690 2700
QRKGINIPAD QPIIRLKNLD DVVVPTMEIK IDPTGEYENV VTIRSFKQEF
2710 2720 2730 2740 2750
RLAGGLNLPK IIDCVGSDGK ERRQLVKKGR DDLRQDAVMQ QVFQMCNMLL
2760 2770 2780 2790 2800
QKNTDTRKRK LTICTYKVVP LSQRSGVLEW CTGTVPIGEF LVNNEDGAHK
2810 2820 2830 2840 2850
RYRPKDFSAY QCQKKMMDMQ KKSFEEKYEA FINVCQNFQP VFRYFCMEKF
2860 2870 2880 2890 2900
LDPAVWFEKR LAYTRSVATS SIVGYILGLG DRHVQNILIN EQSAELVHID
2910 2920 2930 2940 2950
LGVAFEQGKI LPTPETVPFR LTRDIVDGMG ITGVEGVFRR CCEKTMEVMR
2960 2970 2980 2990 3000
NSQETLLTIV EVLLYDPLFD WTMNPLKALY LQQRPEDETE LNSTLNTEDQ
3010 3020 3030 3040 3050
EYNRNLGSRI DQSFNKVAER VLMRLQEKLK GVEEGTVLSV DGQVNLLIQQ
3060
AMDPKNLSRL FPGWKAWV
Length:3,068
Mass (Da):351,894
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA525C2895D011CE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEFK01115011 Genomic DNA No translation available.
AEFK01115012 Genomic DNA No translation available.
AEFK01115013 Genomic DNA No translation available.
AEFK01115014 Genomic DNA No translation available.
AEFK01115015 Genomic DNA No translation available.
AEFK01115016 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSHAT00000012765; ENSSHAP00000012661; ENSSHAG00000010836

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01115011 Genomic DNA No translation available.
AEFK01115012 Genomic DNA No translation available.
AEFK01115013 Genomic DNA No translation available.
AEFK01115014 Genomic DNA No translation available.
AEFK01115015 Genomic DNA No translation available.
AEFK01115016 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000012661

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSHAT00000012765; ENSSHAP00000012661; ENSSHAG00000010836

Phylogenomic databases

eggNOGiKOG0892 Eukaryota
ENOG410XNPY LUCA
GeneTreeiENSGT00670000098061
InParanoidiG3WB56
OMAiLDPFPDH
TreeFamiTF101182

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR015519 ATM/Tel1
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR021668 TAN
PANTHERiPTHR11139:SF72 PTHR11139:SF72, 1 hit
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF11640 TAN, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM01342 TAN, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3WB56_SARHA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3WB56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 8, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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