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Entry version 63 (02 Jun 2021)
Sequence version 2 (07 Apr 2021)
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Protein
Submitted name:

Zinc finger protein 665-like

Gene

LOC100928888

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 665-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100928888Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 121KRABInterPro annotationAdd BLAST72
Domaini587 – 614C2H2-typeInterPro annotationAdd BLAST28
Domaini615 – 642C2H2-typeInterPro annotationAdd BLAST28
Domaini643 – 670C2H2-typeInterPro annotationAdd BLAST28
Domaini671 – 698C2H2-typeInterPro annotationAdd BLAST28
Domaini699 – 726C2H2-typeInterPro annotationAdd BLAST28
Domaini727 – 754C2H2-typeInterPro annotationAdd BLAST28
Domaini755 – 782C2H2-typeInterPro annotationAdd BLAST28
Domaini783 – 810C2H2-typeInterPro annotationAdd BLAST28
Domaini811 – 838C2H2-typeInterPro annotationAdd BLAST28
Domaini839 – 866C2H2-typeInterPro annotationAdd BLAST28
Domaini867 – 894C2H2-typeInterPro annotationAdd BLAST28
Domaini895 – 922C2H2-typeInterPro annotationAdd BLAST28
Domaini923 – 950C2H2-typeInterPro annotationAdd BLAST28
Domaini951 – 978C2H2-typeInterPro annotationAdd BLAST28
Domaini979 – 1006C2H2-typeInterPro annotationAdd BLAST28
Domaini1007 – 1031C2H2-typeInterPro annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni107 – 133DisorderedSequence analysisAdd BLAST27
Regioni152 – 493DisorderedSequence analysisAdd BLAST342
Regioni529 – 580DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 28Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi115 – 130Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi152 – 432Basic and acidic residuesSequence analysisAdd BLAST281
Compositional biasi440 – 467Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi468 – 493Polar residuesSequence analysisAdd BLAST26
Compositional biasi529 – 544Polar residuesSequence analysisAdd BLAST16
Compositional biasi545 – 580Basic and acidic residuesSequence analysisAdd BLAST36

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_12_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3W6L6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVCDSQD

TreeFam database of animal gene trees

More...
TreeFami
TF350822

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3W6L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKGAKRAK THTEKVPPSQ DQTMKEDHKR RSHKKRASIA VHLAKFQGLV
60 70 80 90 100
TFKDVSVDFS RSEWKQLKPA QKELYRDVML ENYKNLVSLG LQSFKPDVIT
110 120 130 140 150
RLEQGEVPWT PTDHNPKDSF HHKTDHGTKV STPKQDICVR VSSKIKFAKD
160 170 180 190 200
DSQDSKLRKV DDSQDSKLRK VYNSKDSKLR KLDDSQDSKL RKVDDSQDSK
210 220 230 240 250
IRKAYDSQDS KHRKVCDSQD SKLRKVCDPQ DSKLRKVYDS QDSKHRKVYD
260 270 280 290 300
SQDSKHRKVC DSQDSKHRKV CDSQDSKLKK VYDSQDSKLK KVYDSPDSKL
310 320 330 340 350
RKVCDSQDSK HRKVYDSQDS KLRKVYDSQD SKHRKVHDSP DSKLRKVHDS
360 370 380 390 400
PDSKIRKVHD SPDPKLRKVH DSPDPKLRKV HDSPDPKLRK VHDSPDPKLR
410 420 430 440 450
KVYDSPDSKL RKVHDSPDSK LRKVHDSPDS KLRKISGGNN SKPEIKKEKL
460 470 480 490 500
EKQIKKEVLD HDNNFNEPKA HSNNTSEKKC TPVSVSTSRQ SNTVPVRKSV
510 520 530 540 550
HKCDISRESF FKQLSELIKH SKISFGKNIN KYNNDKQTLS NHTDSTQNHE
560 570 580 590 600
RRNEEKLGKD NKCGKDDNVP RKPQTELQRS YIKDKRNRCN ECGKTFTRST
610 620 630 640 650
GLSEHKKIHK GEKPFECDEC GRTFTAKGRL NEHQKVHTGK KPYKCHECGK
660 670 680 690 700
AFTGRGRLNE HQKVHTGDKP YECNECGKAF IQKGTLLEHQ NVHTGEKPYE
710 720 730 740 750
CKQCGKAFRQ RGQLREHQKI HTGEKPYKCH ECGKAFSGKG RLTDHKKIHS
760 770 780 790 800
ADKPHKCSEC GKGFIQKSHL IDHLKVHTGE KPYKCNQCGK AFIKKALLNG
810 820 830 840 850
HQKIHTGVKP YECDHCGKAF TLKGRLNEHL KIHTGERPYE CVQCGKGFIV
860 870 880 890 900
KARLTEHLKI HTGEKPHKCA ECGKSFTQSG QLTEHMRIHS GLKPFKCSHC
910 920 930 940 950
GKAFTHKGRL GEHQKIHTGE KPFECSQCGK AFTQSGQLNE HMKIHTGEKP
960 970 980 990 1000
FECKQCGKAF TRKERLSEHQ RIHTGVIPYE CNECGKAFTR KERLSEHQRI
1010 1020 1030
HTGAKPFECN ECGKTFSRRT SFFYHQKTHT I
Length:1,031
Mass (Da):118,802
Last modified:April 7, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD468C642371F154E
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSHAT00000011165; ENSSHAP00000011071; ENSSHAG00000009534

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSHAT00000011165; ENSSHAP00000011071; ENSSHAG00000009534

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00950000182890
HOGENOMiCLU_002678_0_12_1
InParanoidiG3W6L6
OMAiKVCDSQD
TreeFamiTF350822

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3W6L6_SARHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3W6L6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: April 7, 2021
Last modified: June 2, 2021
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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