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Entry version 42 (07 Apr 2021)
Sequence version 2 (07 Apr 2021)
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Protein

Tub domain-containing protein

Gene

TULP4

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tub domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TULP4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007648 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9305.ENSSHAP00000007722

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2503, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_299339_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3VX17

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSERDHE

TreeFam database of animal gene trees

More...
TreeFami
TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025659, Tubby-like_C
IPR000007, Tubby_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01167, Tub, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54518, SSF54518, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

G3VX17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCHGRMLAH VLLHESDGIL SMSWNYPSFL VEDSSESDTD SDDYSPPQEV
60 70 80 90 100
VVQWCTQGDL LAVAGMEKQN QLVEIANGTF LKSALVKFYN VRGEHIFTLD
110 120 130 140 150
TPVQRPIISI CWGHRDSRLL MASGPALYVV RVEHRVSSLQ LLCQQAISSS
160 170 180 190 200
IRDDKDISKL TLPPRLCSYL TTAFIPTIKP PIPDPNNMRD FVSYPTAGNE
210 220 230 240 250
RLHCTMKRTE DDPEVGGPCY TLYLEYLGGL VPILKGRRIS KLRPEFVIMD
260 270 280 290 300
PKTDGKTDEI YGNSLLSTMI DSCNCSDSSD IELSDDWAAK KSPKISRASK
310 320 330 340 350
SPKLPRINIE ARKSPKLTRA AQEISRSPRL PIRKPSIGSP SLTRREFPLE
360 370 380 390 400
DITQHNYLAQ VTSNIWGTKF KIVGLATFLP TNLGAVIYKT SLLHLQPRQM
410 420 430 440 450
TIYLPEVRKI SMDYINLPVF NPNVFSEDED DLPVTGASGV PENNPPCTVN
460 470 480 490 500
IPIAPIHSSA QAMSPTQSIG LVQSLLANQN VQLDVLTNQT TSVGAADHAS
510 520 530 540 550
DSTLQYPVPN RYSSPGQVIF GGVEMGRMIQ APPQLSLPPQ GAIQLSMGDH
560 570 580 590 600
GDREHEHLQK ATKVLRPVQQ LAAEGDAVVF NTTQEIQMNK LNPPPPYPGT
610 620 630 640 650
IPAAPTTAAP PPPLPPPQPP VDVCLKKGDF SLFPSSGHYQ TPLGYERITT
660 670 680 690 700
FDSSGNVEEV CRPRTRMLCA QNTYTLPGPG SSATLRITAT QKKAPQPCSS
710 720 730 740 750
ATLNRLTVPR YSIPSGDPPP YPEITNQLAH GRGAAQRLDS TLIHATLRRN
760 770 780 790 800
NREVAQKMAQ LADSQRATLQ HPPKPKSSVV TAQYQPRPPA ALYTCSQCSG
810 820 830 840 850
SGANSGGGSV SGASANSGTS GLSGSVRPDL SSVGSSQHSS VIAHSVSTSP
860 870 880 890 900
LTSQSSYNLL SPPDNSRDRT DYVNSAFTED EALSQHCQVE KSVRHAALAE
910 920 930 940 950
ATLGVKRPPP YQWDPMLGED IWVPQERTAQ SSVPNPLKPP PLMIGQAQHL
960 970 980 990 1000
DVSRVPFVSP KSPTSPTATF QTGYGMGVPF PGSYNNPPLQ GMQAPCSPKE
1010 1020 1030 1040 1050
ALSSTQFAQQ EPTVVLQPGY SSNLSYCPLP PMYPGSSTCS SLQLPPIALH
1060 1070 1080 1090 1100
PWNSYSACPP VQNSQGTLPP KSHLVVEKPI VSPPPAEHQG HLGTEVMVET
1110 1120 1130 1140 1150
ADNFQEVLSL TESPIPQRTD KFGKKNRKHL DSRAEEGNVQ AITEGKGKKE
1160 1170 1180 1190 1200
ARTLSDFNSL ISSPRLGREK KKVKSQKDQL KSKKLNKTNE FQDSSESEPE
1210 1220 1230 1240 1250
LFISGDELMN QSQGSKKGWK TKRSLRTASE LEEFKCRKAN EKEDGRLGSQ
1260 1270 1280 1290 1300
GFVYVMANKQ PLWNEATQVY QLDFGGRVTQ ESAKNFQIEL EGRQVMQFGR
1310 1320 1330
IDGNAYILDF QYPFSAVQAF AVALANVTQR LK
Length:1,332
Mass (Da):145,646
Last modified:April 7, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i793BC50EA2501379
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7N4NPT0A0A7N4NPT0_SARHA
Uncharacterized protein
TULP4
1,570Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7N4NQ60A0A7N4NQ60_SARHA
Uncharacterized protein
TULP4
1,525Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7N4NQM2A0A7N4NQM2_SARHA
Uncharacterized protein
TULP4
1,550Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7N4V6P2A0A7N4V6P2_SARHA
Uncharacterized protein
TULP4
1,508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSHAT00000007785; ENSSHAP00000007722; ENSSHAG00000006707

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000007722

Genome annotation databases

EnsembliENSSHAT00000007785; ENSSHAP00000007722; ENSSHAG00000006707

Phylogenomic databases

eggNOGiKOG2503, Eukaryota
GeneTreeiENSGT00940000155913
HOGENOMiCLU_299339_0_0_1
InParanoidiG3VX17
OMAiRSERDHE
TreeFamiTF314076

Family and domain databases

Gene3Di3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR025659, Tubby-like_C
IPR000007, Tubby_C
PfamiView protein in Pfam
PF01167, Tub, 1 hit
SUPFAMiSSF54518, SSF54518, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3VX17_SARHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3VX17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: April 7, 2021
Last modified: April 7, 2021
This is version 42 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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