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Entry version 71 (31 Jul 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Complement factor H

Gene

Cfh

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Complement factor HImported
Submitted name:
RCG46221, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CfhImported
ORF Names:rCG_46221Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...
RGDi
620428 Cfh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509182319 – 1235Sequence analysisAdd BLAST1217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi114 ↔ 141PROSITE-ProRule annotation
Disulfide bondi178 ↔ 205PROSITE-ProRule annotation
Disulfide bondi629 ↔ 672PROSITE-ProRule annotation
Disulfide bondi995 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1054 ↔ 1097PROSITE-ProRule annotation
Disulfide bondi1115 ↔ 1158PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000030715 Expressed in 9 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000056859

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 82SushiInterPro annotationAdd BLAST64
Domaini83 – 143SushiInterPro annotationAdd BLAST61
Domaini144 – 207SushiInterPro annotationAdd BLAST64
Domaini208 – 264SushiInterPro annotationAdd BLAST57
Domaini265 – 322SushiInterPro annotationAdd BLAST58
Domaini387 – 444SushiInterPro annotationAdd BLAST58
Domaini446 – 505SushiInterPro annotationAdd BLAST60
Domaini507 – 566SushiInterPro annotationAdd BLAST60
Domaini567 – 624SushiInterPro annotationAdd BLAST58
Domaini627 – 685SushiInterPro annotationAdd BLAST59
Domaini688 – 745SushiInterPro annotationAdd BLAST58
Domaini750 – 804SushiInterPro annotationAdd BLAST55
Domaini808 – 865SushiInterPro annotationAdd BLAST58
Domaini867 – 934SushiInterPro annotationAdd BLAST68
Domaini935 – 992SushiInterPro annotationAdd BLAST58
Domaini993 – 1051SushiInterPro annotationAdd BLAST59
Domaini1052 – 1110SushiInterPro annotationAdd BLAST59
Domaini1113 – 1171SushiInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni869 – 892DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVQ9 Eukaryota
ENOG410YBAR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164315

KEGG Orthology (KO)

More...
KOi
K04004

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSQLEYR

Database of Orthologous Groups

More...
OrthoDBi
296899at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 18 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3V9R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSARIIWL ILWTVCVAED CKGPPPRENS EILSGSWSEQ LYSEGTQATY
60 70 80 90 100
KCRPGYRTLG TIVKVCKNGE WVPSNPSRIC RKRPCGHPGD TPFGSFRLAV
110 120 130 140 150
GSEFEFGAKV VYTCDEGYQL LGEIDYRECD ADGWTNDIPI CEVVKCLPVT
160 170 180 190 200
ELENGRIVSG AAEPDQEYYF GQVVRFECNS GFKIEGQKEM HCSENGLWSN
210 220 230 240 250
EKPQCVEISC LPPRVENGDG IYLKPVYKEN ERFQYKCKQG FVYKERGDAV
260 270 280 290 300
CTGSGWNPQP SCEEMTCLTP YIPNGIYTPH RIKHRIDDEI RYECKNGFYP
310 320 330 340 350
ATRSPVSKCT ITGWIPAPRC SLKPCDFPQF KHGRLYYEES RRPYFPVPIG
360 370 380 390 400
KEYSYYCDNG FTTPSQSYWD YLRCTVNGWE PEVPCLRQCI FHYVEYGESL
410 420 430 440 450
YWQRRYIEGQ SAKVQCHSGY SLPNGQDTIL CTENGWSPPP KCVRIKTCSV
460 470 480 490 500
SDIEIENGFF SESDYTYALN RKTRYRCKQG YVTNTGEISG IITCLQDGWS
510 520 530 540 550
PRPSCIKSCD MPVFENAMTK NNNTWFKLND KLDYECHIGY ENEYKHTKGS
560 570 580 590 600
ITCTYDGWSS TPSCYERECS IPLLHQDLVV FPREVKYKVG DSLSFSCRSG
610 620 630 640 650
HRVGADLVQC YHFGWSPNFP TCEGQVKSCD QPLEIPNGEI KGTKKVEYSH
660 670 680 690 700
GDVVEYDCKP RFLLKGPNKI QCVDGKWTTL PICVEYERTC GDLPALEHGS
710 720 730 740 750
VQLSVPPYHH GDSVEFTCAE TFTMIGHAVV FCISGRWTEL PQCVATDQLE
760 770 780 790 800
KCKAPKSTGI DAIHPNKNEF NHNFSVSYRC RQKQEYEHSI CINGRWDPEP
810 820 830 840 850
NCTRNEKRFC PPPPQIPNAQ VIETTVKYLD GEKVSVLCQD GYLTQGPEEM
860 870 880 890 900
VCKHGRWQSL PRCTEKIPCS QPPKIEHGSI KSPRSSEERD LIESSSYEHG
910 920 930 940 950
TTFSYVCDDG FRISEENRVT CNMGKWSSLP RCVGIPCGPP PSIPLGIVSH
960 970 980 990 1000
ELESYQYGEE VTYNCSEGFG IDGPAFIKCV GGQWSEPPKC IKTDCDNLPT
1010 1020 1030 1040 1050
FEIAKPTEKK KKSYRSGEQV TFRCPPPYRM DGSDIVTCVN TKWIGQPVCK
1060 1070 1080 1090 1100
DNSCVNPPHV PNATILTRHK TKYPSGDKVR YDCNKPFELF GEVEVMCQNG
1110 1120 1130 1140 1150
IWTEPPKCKD STGKCGPPPP IDNGDITSLS LPVYAPLSSV EYQCQNYYLL
1160 1170 1180 1190 1200
KGNKIVTCRN GKWSQPPTCL HACVIPEDIM EKHNIVLRWR ENAKIYSQSG
1210 1220 1230
ENIEFMCKPG YRKFRGSPPF RTKCIEGHIN YPTCV
Length:1,235
Mass (Da):140,231
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD49715E2880B282
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M983F1M983_RAT
Complement factor H
Cfh
1,234Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5XJW6Q5XJW6_RAT
Cfh protein
Cfh
689Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07072332 Genomic DNA No translation available.
AC112858 Genomic DNA No translation available.
CH473958 Genomic DNA Translation: EDM09615.1

NCBI Reference Sequences

More...
RefSeqi
NP_569093.2, NM_130409.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000060111; ENSRNOP00000056859; ENSRNOG00000030715

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
155012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:155012

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072332 Genomic DNA No translation available.
AC112858 Genomic DNA No translation available.
CH473958 Genomic DNA Translation: EDM09615.1
RefSeqiNP_569093.2, NM_130409.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056859

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000060111; ENSRNOP00000056859; ENSRNOG00000030715
GeneIDi155012
KEGGirno:155012

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3075
RGDi620428 Cfh

Phylogenomic databases

eggNOGiENOG410IVQ9 Eukaryota
ENOG410YBAR LUCA
GeneTreeiENSGT00940000164315
KOiK04004
OMAiDSQLEYR
OrthoDBi296899at2759
TreeFamiTF326157

Enzyme and pathway databases

ReactomeiR-RNO-977606 Regulation of Complement cascade

Gene expression databases

BgeeiENSRNOG00000030715 Expressed in 9 organ(s), highest expression level in liver

Family and domain databases

CDDicd00033 CCP, 16 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 18 hits
SMARTiView protein in SMART
SM00032 CCP, 20 hits
SUPFAMiSSF57535 SSF57535, 18 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V9R2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V9R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 31, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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