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Entry version 64 (12 Aug 2020)
Sequence version 1 (16 Nov 2011)
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Protein

C-Jun-amino-terminal kinase-interacting protein 2

Gene

Mapk8ip2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 2
Short name:
JIP-2
Short name:
JNK-interacting protein 2
Alternative name(s):
Islet-brain-2
Short name:
IB-2
JNK MAP kinase scaffold protein 2
Mitogen-activated protein kinase 8-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mapk8ip2
Synonyms:Ib2, Jip2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7
  • UP000234681 Componentsi: Chromosome 7, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1309727, Mapk8ip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004448731 – 835C-Jun-amino-terminal kinase-interacting protein 2Add BLAST835

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G3V9M2

PRoteomics IDEntifications database

More...
PRIDEi
G3V9M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000032828, Expressed in frontal cortex and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the TPR motif-containing C-terminal of kinesin light chain. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin).

Interacts with DCLK2.

Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity.

Interacts with TIAM1 and TIAM2 (By similarity).

Interacts with SH3RF2 (PubMed:22128169).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G3V9M2, 1 interactor

Molecular INTeraction database

More...
MINTi
G3V9M2

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000052648

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3V9M2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini615 – 676SH3PROSITE-ProRule annotationAdd BLAST62
Domaini688 – 824PIDPROSITE-ProRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 278JNK-binding domain (JBD)By similarityAdd BLAST168
Regioni242 – 509Necessary for interaction with FGF13By similarityAdd BLAST268

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 36Asp/Glu-rich (acidic)7
Compositional biasi85 – 104Asp/Glu-rich (acidic)Add BLAST20
Compositional biasi154 – 156Poly-Asn3
Compositional biasi282 – 293Ser-richAdd BLAST12
Compositional biasi425 – 442Pro-richAdd BLAST18
Compositional biasi477 – 492Asp/Glu-rich (acidic)Add BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3775, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160461

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006711_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3V9M2

KEGG Orthology (KO)

More...
KOi
K04435

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEGNRPA

Database of Orthologous Groups

More...
OrthoDBi
372907at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G3V9M2

TreeFam database of animal gene trees

More...
TreeFami
TF325073

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11942, SH3_JIP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035637, JIP2_SH3
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00640, PID, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462, PTB, 1 hit
SM00326, SH3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179, PID, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3V9M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY
60 70 80 90 100
DSDHCEKDSL SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE EDEEEEEEEE
110 120 130 140 150
EEEDGDGDGR AGGGSGSQEL SGESLIPSPS IEESHKLRPT TLHLTTLGAQ
160 170 180 190 200
DSLNNNSNGG FTSAPPSSWQ ETVLRSPVQE PLKELPAPLL PAEEEHHEVQ
210 220 230 240 250
SLARPGCDCE GNQPPEPPAS GGASPSSDPG IEADLRSHSS GGHEGRRSSQ
260 270 280 290 300
ELSSPGSDSE EAGGARLGRM ISSISETELE LSSDSGSSSG RSSHLTNSIE
310 320 330 340 350
EASSPASEPE PEPEPEPLHE PPRRPAFLPV GQDDTNSEYE SGSESEPDLS
360 370 380 390 400
EDADSPWLLS NLVSRMISEG SSPIRCPGQC LSPPAPRPPE EAASQANPVP
410 420 430 440 450
QDCPDPEAVA GPHVELVDMD TLCGPPPPAP AAPRLGPAQS GPCLFLSNPT
460 470 480 490 500
RDTITPLWAP PGRTARPGRS CSAACSEEEE EDEEEDEEDE EDAEDSVIPP
510 520 530 540 550
GSRTTGSTAP LDASLVYDAV KYTLVVDEHT QLELVSLRRC AGLDNDSEED
560 570 580 590 600
SSCEASEEEA GATLLGSDQV PEDASPDSPD LTFSKKFLNV FVNSTSRSSS
610 620 630 640 650
TESFGLFSCV VNGEEREQTH RAVFRFIPRH PDELELDVDD PVLVEAEEDD
660 670 680 690 700
FWFRGFNMRT GERGVFPAFY AHAVPGPAKD LLGSKRSPCW VDRFDVQFLG
710 720 730 740 750
SVEVPCHQGN GILCAAMQKI ATARKLTVHL RPPASCDLEI SLRGVKLSLS
760 770 780 790 800
GGGPEFQRCS HFFQMKNISF CGCHPRNSCY FGFITKHPLL SRFACHVFVS
810 820 830
QESMRPVARS VGRAFLEYYQ EHLAFACPTE DIYLE
Length:835
Mass (Da):90,476
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD88871BA1FFB4398
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC125982 Genomic DNA No translation available.
CH474027 Genomic DNA Translation: EDL76573.1
BC105884 mRNA Translation: AAI05885.1

NCBI Reference Sequences

More...
RefSeqi
XP_001055248.1, XM_001055248.6
XP_235565.5, XM_235565.9

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000055792; ENSRNOP00000052648; ENSRNOG00000032828

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315220

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125982 Genomic DNA No translation available.
CH474027 Genomic DNA Translation: EDL76573.1
BC105884 mRNA Translation: AAI05885.1
RefSeqiXP_001055248.1, XM_001055248.6
XP_235565.5, XM_235565.9

3D structure databases

SMRiG3V9M2
ModBaseiSearch...

Protein-protein interaction databases

IntActiG3V9M2, 1 interactor
MINTiG3V9M2
STRINGi10116.ENSRNOP00000052648

Proteomic databases

PaxDbiG3V9M2
PRIDEiG3V9M2

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
G3V9M2, 1 sequenced antibody

Genome annotation databases

EnsembliENSRNOT00000055792; ENSRNOP00000052648; ENSRNOG00000032828
GeneIDi315220
KEGGirno:315220

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23542
RGDi1309727, Mapk8ip2

Phylogenomic databases

eggNOGiKOG3775, Eukaryota
GeneTreeiENSGT00940000160461
HOGENOMiCLU_006711_0_0_1
InParanoidiG3V9M2
KOiK04435
OMAiCEGNRPA
OrthoDBi372907at2759
PhylomeDBiG3V9M2
TreeFamiTF325073

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G3V9M2

Gene expression databases

BgeeiENSRNOG00000032828, Expressed in frontal cortex and 14 other tissues

Family and domain databases

CDDicd11942, SH3_JIP2, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035637, JIP2_SH3
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00640, PID, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 1 hit
SM00326, SH3, 1 hit
PROSITEiView protein in PROSITE
PS01179, PID, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJIP2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V9M2
Secondary accession number(s): Q3B8P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: November 16, 2011
Last modified: August 12, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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