D(1A) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine binding Source: Ensembl
• dopamine neurotransmitter receptor activity, coupled via Gs Source: Ensembl
• G protein-coupled receptor activity Source: UniProtKB-KW

GO - Biological processⁱ

• activation of adenylate cyclase activity Source: Ensembl
• adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
• adult walking behavior Source: Ensembl
• astrocyte development Source: Ensembl
• behavioral fear response Source: Ensembl
• behavioral response to cocaine Source: Ensembl
• cerebral cortex GABAergic interneuron migration Source: Ensembl
• conditioned taste aversion Source: Ensembl
• dentate gyrus development Source: Ensembl
• dopamine transport Source: Ensembl
• glucose import Source: Ensembl
• grooming behavior Source: Ensembl
• habituation Source: Ensembl
• histone H3-S10 phosphorylation Source: Ensembl
• long-term synaptic depression Source: Ensembl
• long-term synaptic potentiation Source: Ensembl
• maternal behavior Source: Ensembl
• mating behavior Source: Ensembl
• memory Source: Ensembl
• neuronal action potential Source: Ensembl
• operant conditioning Source: Ensembl
• peristalsis Source: Ensembl
• phospholipase C-activating dopamine receptor signaling pathway Source: Ensembl
• positive regulation of cell migration Source: Ensembl
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: Ensembl
• positive regulation of gene expression Source: Ensembl
• positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
• positive regulation of synaptic transmission, glutamatergic Source: Ensembl
• protein import into nucleus Source: Ensembl
• regulation of dopamine metabolic process Source: Ensembl
• regulation of protein phosphorylation Source: Ensembl
• regulation of synaptic vesicle exocytosis Source: Ensembl
• response to amphetamine Source: Ensembl
• response to drug Source: Ensembl
• sensitization Source: Ensembl
• striatum development Source: Ensembl
• temperature homeostasis Source: Ensembl
• vasodilation Source: InterPro
• visual learning Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF 
        60         70         80         90        100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGSFCNIWVA 
       110        120        130        140        150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS 
       160        170        180        190        200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL 
       210        220        230        240        250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP 
       260        270        280        290        300
VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 
       310        320        330        340        350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL 
       360        370        380        390        400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED 
       410        420        430        440 
LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ