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Entry version 86 (07 Apr 2021)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Ribonuclease L

Gene

Rnasel

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-8983711, OAS antiviral response
R-RNO-909733, Interferon alpha/beta signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ribonuclease LImported
Submitted name:
Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RnaselImported
ORF Names:rCG_46078Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...
RGDi
727933, Rnasel

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
G3V915

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000027017, Expressed in jejunum and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000032975

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3V915

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 308ANK_REP_REGIONInterPro annotationAdd BLAST285
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 90ANKPROSITE-ProRule annotationAdd BLAST33
Repeati91 – 123ANKPROSITE-ProRule annotationAdd BLAST33
Repeati124 – 156ANKPROSITE-ProRule annotationAdd BLAST33
Repeati167 – 189ANKPROSITE-ProRule annotationAdd BLAST23
Repeati276 – 308ANKPROSITE-ProRule annotationAdd BLAST33
Domaini369 – 589Protein kinaseInterPro annotationAdd BLAST221
Domaini592 – 725KENInterPro annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni717 – 738DisorderedSequence analysisAdd BLAST22

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1027, Eukaryota
KOG4177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022542_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLYVVRK

Database of Orthologous Groups

More...
OrthoDBi
222916at2759

TreeFam database of animal gene trees

More...
TreeFami
TF344032

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10423, RNase_RNase-L, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.180, 1 hit
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR010513, KEN_dom
IPR038357, KEN_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR042745, RNase-L_RNase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF13606, Ank_3, 1 hit
PF00069, Pkinase, 1 hit
PF06479, Ribonuc_2-5A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 8 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS51392, KEN, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3V915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METTDHSTPQ CGSASAGGQK TVGKDDYLLI EAVNKGDADR VQQLLEQGAD
60 70 80 90 100
ANVCEESGGW TPLHNAVQSG RVDIVNLLLR YGADPHRRKK NGATPFIIAG
110 120 130 140 150
ICGDVSLLQI FLSRGANINE RDMHGFTAFM EAAEYGNVEA LKFLFAEGAD
160 170 180 190 200
VNLRRETTED RRRLKQGGAT ALMSAAENGH PEVVRILLDE MKAEADARDN
210 220 230 240 250
MGRNALIRSL LNRDCENVEI HVEEITSVLI QYGADINVRG EGEKTPLISA
260 270 280 290 300
VERKHTGLVQ MLLSQEGIKV NDRDSEGKTA LQIAVELKLK EIVRLLLEKG
310 320 330 340 350
ADTKCGDLVW IAKRNYDHGL VKLLLSYEAN HDTNPPAKDW LPHSARWGED
360 370 380 390 400
LKRLHSVSRP MIGKLKIFMN DAYKIASTSE GGIYLGIYDN REVAVKVFCE
410 420 430 440 450
NSSRGRKEVA CLRDCGDHSN LLTFYGSEEH KGNLYVCVSL CESTLEKFLN
460 470 480 490 500
VPREEPMEKG EDKFALSVLL SIFKGVQKLH MHGYSHQNLQ PPNILIDSEK
510 520 530 540 550
AVRLADFDES IQWMRESQTV QRDLEDLGRL VLYVVNKGEI PFETLKGQND
560 570 580 590 600
EELLTIAPNE ETKDLVHCLF SPGENVKNCL MDLLGHPFFW TWENRYRTLR
610 620 630 640 650
DVGNESDIKV RNNKSKLLKL LQPQTHAPSR SFDRWTSKID KRVMSDMNGF
660 670 680 690 700
YKSRKGYRDT VGDLLKFIRN IGEHINEEKN RQMKEILGDP SRYFQETFPD
710 720 730
LVIYIYKKLK ETEFRKHFPQ PPPSLSVPEA AGPGGVQS
Length:738
Mass (Da):83,222
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC4217C5385EC2BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07021420 Genomic DNA No translation available.
CH473958 Genomic DNA Translation: EDM09538.1

NCBI Reference Sequences

More...
RefSeqi
XP_006250060.1, XM_006249998.3
XP_006250061.1, XM_006249999.3
XP_006250062.1, XM_006250000.3
XP_006250063.1, XM_006250001.3
XP_006250064.1, XM_006250002.3
XP_017454330.1, XM_017598841.1
XP_017454331.1, XM_017598842.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000032157; ENSRNOP00000032975; ENSRNOG00000027017

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
359726

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021420 Genomic DNA No translation available.
CH473958 Genomic DNA Translation: EDM09538.1
RefSeqiXP_006250060.1, XM_006249998.3
XP_006250061.1, XM_006249999.3
XP_006250062.1, XM_006250000.3
XP_006250063.1, XM_006250001.3
XP_006250064.1, XM_006250002.3
XP_017454330.1, XM_017598841.1
XP_017454331.1, XM_017598842.1

3D structure databases

SMRiG3V915
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032975

Proteomic databases

PRIDEiG3V915

Genome annotation databases

EnsembliENSRNOT00000032157; ENSRNOP00000032975; ENSRNOG00000027017
GeneIDi359726

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6041
RGDi727933, Rnasel

Phylogenomic databases

eggNOGiKOG1027, Eukaryota
KOG4177, Eukaryota
GeneTreeiENSGT00940000161114
HOGENOMiCLU_022542_0_0_1
OMAiVLYVVRK
OrthoDBi222916at2759
TreeFamiTF344032

Enzyme and pathway databases

ReactomeiR-RNO-8983711, OAS antiviral response
R-RNO-909733, Interferon alpha/beta signaling

Gene expression databases

BgeeiENSRNOG00000027017, Expressed in jejunum and 21 other tissues

Family and domain databases

CDDicd10423, RNase_RNase-L, 1 hit
Gene3Di1.20.1440.180, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR010513, KEN_dom
IPR038357, KEN_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR042745, RNase-L_RNase
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF13606, Ank_3, 1 hit
PF00069, Pkinase, 1 hit
PF06479, Ribonuc_2-5A, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 8 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS51392, KEN, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V915_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V915
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 7, 2021
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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