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UniProtKB - G3V8X3 (G3V8X3_RAT)
Protein
Submitted name:
RCG59756
Gene
Scx
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- bHLH transcription factor binding Source: RGD
- cis-regulatory region sequence-specific DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- E-box binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
GO - Biological processi
- BMP signaling pathway Source: RGD
- cell differentiation Source: RGD
- cellular response to BMP stimulus Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cellular response to transforming growth factor beta stimulus Source: RGD
- chondrocyte differentiation Source: RGD
- collagen fibril organization Source: RGD
- deltoid tuberosity development Source: RGD
- developmental process Source: GO_Central
- embryonic skeletal system development Source: RGD
- endochondral ossification Source: RGD
- face morphogenesis Source: RGD
- heart valve formation Source: RGD
- heart valve morphogenesis Source: RGD
- mesoderm formation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- positive regulation of cartilage development Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of collagen biosynthetic process Source: RGD
- positive regulation of gastrulation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of cartilage development Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- sclerotome development Source: RGD
- skeletal muscle cell differentiation Source: RGD
- tendon cell differentiation Source: RGD
- tendon development Source: RGD
- tendon formation Source: RGD
- tissue homeostasis Source: RGD
- transcription, DNA-templated Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: RCG59756ImportedSubmitted name: Scleraxis bHLH transcription factor |
Gene namesi | Name:ScxImported ORF Names:rCG_59756Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1588254, Scx |
Subcellular locationi
Nucleus
- nucleus Source: RGD
Other locations
- transcription regulator complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000021812, Expressed in female gonad and 21 other tissues |
Interactioni
GO - Molecular functioni
- bHLH transcription factor binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000029792 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 130 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 91 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 151 – 185 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 44 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 74 – 88 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 159 – 174 | Pro residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161897 |
HOGENOMi | CLU_115077_0_0_1 |
OMAi | PPKEYRQ |
OrthoDBi | 1511100at2759 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V8X3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFAMLRSAP PPGRYLYPEV SPLSEDEDRG SESSGSDEKP CRVHAARCGL
60 70 80 90 100
QGARRRAGGR RAAGSGPGPG GRPGREPRQR HTANARERDR TNSVNTAFTA
110 120 130 140 150
LRTLIPTEPA DRKLSKIETL RLASSYISHL GNVLLVGEAC GDGQPCHSGP
160 170 180 190 200
AFFHSGRAGS PLPPPPPPPP LPLARDGGEN TQPKQICTFC LSNQRKLSKD
RDRKTAIRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473950 Genomic DNA Translation: EDM15974.1 |
RefSeqi | NP_001123980.1, NM_001130508.1 |
Genome annotation databases
Ensembli | ENSRNOT00000029768.3; ENSRNOP00000029792.2; ENSRNOG00000021812.5 |
GeneIDi | 680712 |
KEGGi | rno:680712 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473950 Genomic DNA Translation: EDM15974.1 |
RefSeqi | NP_001123980.1, NM_001130508.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000029792 |
Genome annotation databases
Ensembli | ENSRNOT00000029768.3; ENSRNOP00000029792.2; ENSRNOG00000021812.5 |
GeneIDi | 680712 |
KEGGi | rno:680712 |
Organism-specific databases
CTDi | 642658 |
RGDi | 1588254, Scx |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161897 |
HOGENOMi | CLU_115077_0_0_1 |
OMAi | PPKEYRQ |
OrthoDBi | 1511100at2759 |
TreeFami | TF315153 |
Gene expression databases
Bgeei | ENSRNOG00000021812, Expressed in female gonad and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V8X3_RAT | |
Accessioni | G3V8X3Primary (citable) accession number: G3V8X3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |