UniProtKB - G3V8R2 (G3V8R2_RAT)
Protein
Submitted name:
Neurocan core protein
Gene
Ncan
Organism
Rattus norvegicus (Rat)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- carbohydrate binding Source: UniProtKB-KW
- hyaluronic acid binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: InterPro
Keywordsi
Ligand | Hyaluronic acidARBA annotation, LectinARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Neurocan core proteinImportedSubmitted name: RCG38677Imported |
Gene namesi | Name:NcanImported ORF Names:rCG_38677Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619941, Ncan |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014091905 | 23 – 1263 | Sequence analysisAdd BLAST | 1241 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 205 ↔ 226 | PROSITE-ProRule annotation | ||
Disulfide bondi | 303 ↔ 324 | PROSITE-ProRule annotation | ||
Disulfide bondi | 981 ↔ 990 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1019 ↔ 1028 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1162 ↔ 1205 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1191 ↔ 1218 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, Glycoprotein, ProteoglycanARBA annotationProteomic databases
PRIDEi | G3V8R2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000048036, Expressed in frontal cortex and 12 other tissues |
ExpressionAtlasi | G3V8R2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 157 | Ig-likeInterPro annotationAdd BLAST | 104 | |
Domaini | 159 – 254 | LinkInterPro annotationAdd BLAST | 96 | |
Domaini | 258 – 356 | LinkInterPro annotationAdd BLAST | 99 | |
Domaini | 955 – 991 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 993 – 1029 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1042 – 1156 | C-type lectinInterPro annotationAdd BLAST | 115 | |
Domaini | 1160 – 1220 | SushiInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 361 – 391 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 420 – 483 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 556 – 605 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 670 – 714 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 1221 – 1263 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 420 – 437 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 446 – 480 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 563 – 585 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1221 – 1248 | BasicSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1249 – 1263 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the aggrecan/versican proteoglycan family.ARBA annotation
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalSequence analysis, SushiPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158649 |
HOGENOMi | CLU_000303_0_1_1 |
OMAi | YPRRRAN |
OrthoDBi | 174823at2759 |
TreeFami | TF332134 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 3 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00059, Lectin_C, 1 hit PF00084, Sushi, 1 hit PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00034, CLECT, 1 hit SM00181, EGF, 2 hits SM00179, EGF_CA, 2 hits SM00409, IG, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 3 hits SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 3 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 1 hit PS50963, LINK_2, 2 hits PS50923, SUSHI, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G3V8R2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAESVWASG LLVLWLLLLV SGDQDTQDTT TTEKGLHMLK SGSGPIQAAL
60 70 80 90 100
AELVALPCFF TLQPRQSPLG DIPRIKWTKV QTASGQRQDL PILVAKDNVV
110 120 130 140 150
RVAKGWQGRV SLPAYPRHRA NATLLLGPLR ASDSGLYRCQ VVKGIEDEQD
160 170 180 190 200
LVTLEVTGVV FHYRAARDRY ALTFAEAQEA CHLSSATIAA PRHLQAAFED
210 220 230 240 250
GFDNCDAGWL SDRTVRYPIT QSRPGCYGDR SSLPGVRSYG RRDPQELYDV
260 270 280 290 300
YCFARELGGE VFYVGPARRL TLAGARALCQ RQGAALASVG QLHLAWHEGL
310 320 330 340 350
DQCDPGWLAD GSVRYPIQTP RRRCGGSAPG VRTVYRFANR TGFPAPGARF
360 370 380 390 400
DAYCFRAHHH TPQRGDSEIP SSGDEGEIVS AEGPPAPELK PRLGEQEVIT
410 420 430 440 450
PDFQEPLVSS GEDEPLDLTR TQASQETLAS TPGGPTLASW PSREKWLLTG
460 470 480 490 500
VTSSTGVPSP SSLGVDMEET TPSGTQVAPT PTMRRGRFKG LNGRHFQQQG
510 520 530 540 550
PEDQLLEAAE ASAQPPTLEV TADHMGPSAA TEALESDQSH SPWAILTNEV
560 570 580 590 600
DVPGAGSLGS RSLPESRKWS PSLISPSTVP STDSTPGLKP GADEAPGVKS
610 620 630 640 650
AIHHPPWLPS EPAVPSSIPS EALSAVSLQA SPGDGSPDFP IVAMLRAPKL
660 670 680 690 700
WLLPHSTLVP NVSPIPLSPA SPLPSSVPEE QAVRPVSFGA EDPETPFQTT
710 720 730 740 750
MAAPGEASHG SPEADSIEIE GISSMQATKH PISGPWASLD SSNVTVNPVP
760 770 780 790 800
SDAGILGTES GVLDLPGSPT SDGQATVDKV LATWLPLPGH GLDTGSQSTP
810 820 830 840 850
MEAHGVTMSV EPTVALEGGA TKDPMEATMD VVPSTVDATS GSEPKSSISS
860 870 880 890 900
THVVVTAAGD QGTPTLTPTS SEGQVVAQES LGTLTSLPSH PWSSLASSMD
910 920 930 940 950
EVASVSSGEP TGLWDIPSTL IPVSLGLDES DLKVVAESPG LEGFWEEVAS
960 970 980 990 1000
GQEDPTDPCE NNPCLHGGTC RTNGTMYGCS CDQGYAGENC EIDIDDCLCS
1010 1020 1030 1040 1050
PCENGGTCID EVNGFICLCL PSYGGNLCEK DTEGCDRGWH KFQGHCYRYF
1060 1070 1080 1090 1100
AHRRAWEDAE RDCRRRAGHL TSVHSPEEHK FINSFGHENS WIGLNDRTVE
1110 1120 1130 1140 1150
RDFQWTDNTG LQYENWREKQ PDNFFAGGED CVVMVAHENG RWNDVPCNYN
1160 1170 1180 1190 1200
LPYVCKKGTV LCGPPPAVEN ASLVGVRKVK YNVHATVRYQ CDEGFSQHHV
1210 1220 1230 1240 1250
ATIRCRNNGK WDRPQIVCTK PRRSHRMRRH HHHPHRHHKP RKEHRKHKRH
1260
PAEDWEKDEG DFC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP55067 | NCAN_RAT | Neurocan core protein | Ncan Cspg3 | 1,257 | Annotation score: | ||
A0A0G2K4R4 | A0A0G2K4R4_RAT | Neurocan core protein | Ncan | 834 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134063 Genomic DNA No translation available. CH474031 Genomic DNA Translation: EDL90647.1 |
RefSeqi | NP_113841.2, NM_031653.2 |
Genome annotation databases
Ensembli | ENSRNOT00000064308; ENSRNOP00000062123; ENSRNOG00000048036 |
GeneIDi | 58982 |
KEGGi | rno:58982 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134063 Genomic DNA No translation available. CH474031 Genomic DNA Translation: EDL90647.1 |
RefSeqi | NP_113841.2, NM_031653.2 |
3D structure databases
SMRi | G3V8R2 |
ModBasei | Search... |
Proteomic databases
PRIDEi | G3V8R2 |
Genome annotation databases
Ensembli | ENSRNOT00000064308; ENSRNOP00000062123; ENSRNOG00000048036 |
GeneIDi | 58982 |
KEGGi | rno:58982 |
Organism-specific databases
CTDi | 1463 |
RGDi | 619941, Ncan |
Phylogenomic databases
GeneTreei | ENSGT00940000158649 |
HOGENOMi | CLU_000303_0_1_1 |
OMAi | YPRRRAN |
OrthoDBi | 174823at2759 |
TreeFami | TF332134 |
Gene expression databases
Bgeei | ENSRNOG00000048036, Expressed in frontal cortex and 12 other tissues |
ExpressionAtlasi | G3V8R2, baseline and differential |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 3 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00059, Lectin_C, 1 hit PF00084, Sushi, 1 hit PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00034, CLECT, 1 hit SM00181, EGF, 2 hits SM00179, EGF_CA, 2 hits SM00409, IG, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 3 hits SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 3 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 1 hit PS50963, LINK_2, 2 hits PS50923, SUSHI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V8R2_RAT | |
Accessioni | G3V8R2Primary (citable) accession number: G3V8R2 Secondary accession number(s): F1LNN7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |