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Entry version 61 (08 May 2019)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Nuclear receptor coactivator 6

Gene

Ncoa6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear receptor coactivator 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncoa6Imported
ORF Names:rCG_37248Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
620111 Ncoa6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000018288 Expressed in 10 organ(s), highest expression level in lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
G3V8C9 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 189Nucleic_acid_bdInterPro annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili260 – 285Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK20 Eukaryota
ENOG410XW4F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111114

KEGG Orthology (KO)

More...
KOi
K14971

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMPNVGS

Database of Orthologous Groups

More...
OrthoDBi
35282at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332639

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026638 NCOA6
IPR032715 NCOA6_nucleic_acid-bd

The PANTHER Classification System

More...
PANTHERi
PTHR15690 PTHR15690, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13820 Nucleic_acid_bd, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3V8C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKSD SILEDSTIFV
60 70 80 90 100
AFKGNIDDKD FKWKLDTILQ SVPGLLHMES SKLKVQKVEP WNSVRVTFNI
110 120 130 140 150
PREAAERLRI LAQSNNQQLR DLGILSVQIE GEGAINLALG QNRSQDVRMN
160 170 180 190 200
GPVVSGNSVR MEAGFPMASG PGLIRMTSPA TVMMPQGGNA SSSMMAPGPN
210 220 230 240 250
PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH HPMQPVPVNR
260 270 280 290 300
QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QLQTRPLQQH QQQQPQGIRP
310 320 330 340 350
QFTAPTQVPV PPGWNQLPSG ALQPPPAQGS LGPMTTNQGW KKAPLPSPMQ
360 370 380 390 400
AQLQARPSLA TVQTPSHPPP PYPFGSQQAS QAHTNFPQMS NPGQFTAPQM
410 420 430 440 450
KSLQGGPSRV PTPLQQPHLT NKSPASSPSS FQQGSPASSP TVNQTQQQMG
460 470 480 490 500
PRPPQNNPLS QGFQQPVSSP GRNPMVQQGN VPPNFMVMQQ QPPSQGPPSL
510 520 530 540 550
HPGLGGMPKR LPPGFSAGQA NPNFMQGQVP STTAATPGNS GALQLQANQS
560 570 580 590 600
VQHAGGQGAG PPQNQMQVSH GPPNMMQPSL MGIHGNINNQ QAGSSGVPQV
610 620 630 640 650
TLGSMQGQPQ QGPPSQLMGM HQQIVPSQGQ MAQQQGTLNP QNPMILSRAQ
660 670 680 690 700
LMPQGQMMVN AQNQNLGPSP QRMTPPKQML PQQGPQMMAP HNQMMGPQGQ
710 720 730 740 750
VLLQQNPMIE QIMTNQMQGN KAQFNSQNQS NVMPGPAQIM RGPTPNMQGN
760 770 780 790 800
MVQFTGQMSG QMLPQQGPVS NSPSQVMGIQ GQVLRPPGPS PHMAQQHTDP
810 820 830 840 850
ATTANNDVNL SQMMPDVSMQ QTSMVPPHVQ SMQGNSASGS HFSGHGVSFN
860 870 880 890 900
APFGGAPNGT QMSCGQNPGF PVNKDVTLTS PLLVNLLQSD ISAGHFGVNN
910 920 930 940 950
KQNNTNANKQ KKKKPPRKKK NCHQDLNTPD SRPAGLEEVD QQSLPGEQGI
960 970 980 990 1000
NLDNTGPKLP DFSNRPPGYP TQPVEQRPLQ QMPPQLMQHV APPPQPPQQQ
1010 1020 1030 1040 1050
PQPQLPQQQP QPQPPPPSQP QSQQQQQQMM MMLMMQQDPK SIRLPVSQNV
1060 1070 1080 1090 1100
HPPRGPLNPD SQRVPMQQSG NVPVMVSLQG PASVPPSPDK QRMPMPVNTP
1110 1120 1130 1140 1150
LGSNSRKMVY QESPQNSSSP LGEMPSLPEA GGSEVPSVSG GPSNMPSHLV
1160 1170 1180 1190 1200
VSQNQLMMTG PKPGPSPLSA TQGATPQQPP VNSLPSSHGH HFPNVAAPTQ
1210 1220 1230 1240 1250
TSRPKTPNRA SPRPYYPQTP NNRPPSTEPS EISLSPERLN ASIAGLFPPQ
1260 1270 1280 1290 1300
INIPLPPRPN LNRGFDQQGL NPTTLKAIGQ APSNLTVSNP PNFAAPQAHK
1310 1320 1330 1340 1350
LDSVVVSSGK QSNPGTTKRA SPSNSRRSSP GSSRKTTPSP GRQNSKAPKL
1360 1370 1380 1390 1400
TLASQTSTTL LQNMELPRNV LVGPTPLANP PLSGSFPNNN GLNSQNPTVP
1410 1420 1430 1440 1450
APAVGTVVED NKESLNVPQD SDCQNSQGRK EQVNTELKAV PIQEAKMVVP
1460 1470 1480 1490 1500
EDQSKKDGQP LDPNKLPSVE ENKTLMSPAM REAPTSLSQL LDNSGAPNVT
1510 1520 1530 1540 1550
IKPPGLTDLE VTPPAVSGED LKKASVIPTL QDPSSKEPSN SLNLPHSNEP
1560 1570 1580 1590 1600
CSTLAHPELS EVSSNIAPSI PPVMSRPVSS SSISTPLPPN QITVFVTSNP
1610 1620 1630 1640 1650
ITTSSNTSAA LPTHLQSALM STVVTMPNVG NKVMVSEGQS AAQSNARPQF
1660 1670 1680 1690 1700
ITPVFINSSS IIQVMKGSQP STIPATPLTT NSGLMPPSVA VVGPLHIPQN
1710 1720 1730 1740 1750
IKFSSAPVTP NVPSSSPAPN IQTGRPLVLS SRATPVPLPS PPCTSSPVVA
1760 1770 1780 1790 1800
PNPSVQQVKE LNPDEASPQT NTSADQSTLP SSQPTTVVSP LLANSPGSSA
1810 1820 1830 1840 1850
NRRSPVSSSK GKGKVDKIGQ ILLTKACKKV TGSLEKGEEQ YGADGETEGP
1860 1870 1880 1890 1900
GLETTTPGLM GTEQCSTELD SKTPTPSAPT LLKMTSSPMG PSSTSTGPIL
1910 1920 1930 1940 1950
PGGALPTSVR SVVTTLVPSE LISTAPTTKG NHGGITSEPL AGGLVEEKVG
1960 1970 1980 1990 2000
SHPELLPSIA PSQTLVPKES PATALQGSVG RPELEANAAI ASGQSSEPKE
2010 2020 2030 2040 2050
TVEKSKTPSR RNSRTEEPTM ASENVENGHR KRSSRPASAS SSTKDITGAV

QSKRRKSK
Length:2,058
Mass (Da):218,188
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1A6B3AD6A00BD38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JLI4NCOA6_RAT
Nuclear receptor coactivator 6
Ncoa6 Aib3, Rap250, Trbp
418Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07072941 Genomic DNA No translation available.
CH474050 Genomic DNA Translation: EDL85918.1

NCBI Reference Sequences

More...
RefSeqi
NP_001263643.1, NM_001276714.1
XP_006235358.1, XM_006235296.3
XP_008760517.1, XM_008762295.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000024714; ENSRNOP00000024714; ENSRNOG00000018288

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:116464

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072941 Genomic DNA No translation available.
CH474050 Genomic DNA Translation: EDL85918.1
RefSeqiNP_001263643.1, NM_001276714.1
XP_006235358.1, XM_006235296.3
XP_008760517.1, XM_008762295.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024714; ENSRNOP00000024714; ENSRNOG00000018288
GeneIDi116464
KEGGirno:116464

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23054
RGDi620111 Ncoa6

Phylogenomic databases

eggNOGiENOG410IK20 Eukaryota
ENOG410XW4F LUCA
GeneTreeiENSGT00730000111114
KOiK14971
OMAiTMPNVGS
OrthoDBi35282at2759
TreeFamiTF332639

Gene expression databases

BgeeiENSRNOG00000018288 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiG3V8C9 RN

Family and domain databases

InterProiView protein in InterPro
IPR026638 NCOA6
IPR032715 NCOA6_nucleic_acid-bd
PANTHERiPTHR15690 PTHR15690, 2 hits
PfamiView protein in Pfam
PF13820 Nucleic_acid_bd, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V8C9_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V8C9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: May 8, 2019
This is version 61 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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