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Protein

Amino acid transporter

Gene

Slc1a3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:Slc1a3Imported
ORF Names:rCG_50959Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3698 Slc1a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 68HelicalUniRule annotationAdd BLAST25
Transmembranei88 – 111HelicalUniRule annotationAdd BLAST24
Transmembranei123 – 145HelicalUniRule annotationAdd BLAST23
Transmembranei241 – 260HelicalUniRule annotationAdd BLAST20
Transmembranei281 – 302HelicalUniRule annotationAdd BLAST22
Transmembranei314 – 339HelicalUniRule annotationAdd BLAST26
Transmembranei346 – 365HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiG3V846

Expressioni

Gene expression databases

BgeeiENSRNOG00000016163 Expressed in 9 organ(s), highest expression level in Ammon's horn

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
KOiK05614
OMAiTFAFSSR
OrthoDBiEOG091G0UCE
TreeFamiTF315206

Family and domain databases

Gene3Di1.10.3860.10, 2 hits
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 2 hits
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

G3V846-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKSNGEEPR MGSRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF
60 70 80 90 100
VLLTVSAVIV GTILGFALRP YKMSYREVKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG
160 170 180 190 200
TKENMYREGK IVQVTAADAF LDLIRNMFPP NLVEACFKQF KTSYEKRSFK
210 220 230 240 250
VPIQANETLL GAVINNVSEA METLTRIREE MVPVPGSVNG VNALGLVVFS
260 270 280 290 300
MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK
310 320 330 340 350
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG
360 370 380 390 400
GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRITRFV LPVGATINMD
410 420 430 440 450
GTALYEALAA IFIAQVNNFD LNFGQIITIS ITATAASIGA AGIPQAGLVT
460 470 480 490 500
MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH
510 520 530 540
ELKNRDVEMG NSVIEENEMK KPYQLIAQDN EPEKPVADSE TKM
Length:543
Mass (Da):59,683
Last modified:November 16, 2011 - v1
Checksum:iAB05E53CBB4BE090
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P24942EAA1_RAT
Excitatory amino acid transporter 1
Slc1a3 Eaat1
543Annotation score:
A0A0G2JSU1A0A0G2JSU1_RAT
Amino acid transporter
Slc1a3 rCG_50959
497Annotation score:
A0A0G2K611A0A0G2K611_RAT
Amino acid transporter
Slc1a3
431Annotation score:
A0A0G2KAS7A0A0G2KAS7_RAT
Amino acid transporter
Slc1a3
498Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008423 Genomic DNA No translation available.
AABR07008424 Genomic DNA No translation available.
CH474048 Genomic DNA Translation: EDL75679.1
RefSeqiNP_062098.1, NM_019225.2
XP_017446210.1, XM_017590721.1
UniGeneiRn.34134

Genome annotation databases

EnsembliENSRNOT00000022319; ENSRNOP00000022319; ENSRNOG00000016163
GeneIDi29483
KEGGirno:29483

Similar proteinsi

Entry informationi

Entry nameiG3V846_RAT
AccessioniPrimary (citable) accession number: G3V846
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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