UniProtKB - G3V846 (G3V846_RAT)
Protein
Amino acid transporter
Gene
Slc1a3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- glutamate binding Source: Ensembl
- high-affinity glutamate transmembrane transporter activity Source: Ensembl
GO - Biological processi
- auditory behavior Source: Ensembl
- cell morphogenesis involved in neuron differentiation Source: Ensembl
- cellular sodium ion homeostasis Source: Ensembl
- cranial nerve development Source: Ensembl
- D-aspartate import across plasma membrane Source: Ensembl
- gamma-aminobutyric acid biosynthetic process Source: Ensembl
- L-glutamate import across plasma membrane Source: Ensembl
- neuromuscular process controlling balance Source: Ensembl
- positive regulation of synaptic transmission Source: Ensembl
- response to antibiotic Source: Ensembl
- response to drug Source: Ensembl
- response to light stimulus Source: Ensembl
- response to wounding Source: Ensembl
- sensory perception of sound Source: Ensembl
Keywordsi
Biological process | SymportUniRule annotationARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Amino acid transporterUniRule annotation |
Gene namesi | Name:Slc1a3Imported ORF Names:rCG_50959Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3698, Slc1a3 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- neuron projection Source: Ensembl
- neuronal cell body Source: Ensembl
- synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 44 – 68 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 88 – 111 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 123 – 145 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 241 – 260 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 281 – 302 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 314 – 339 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 346 – 365 | HelicalUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSRNOG00000016163, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | G3V846, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 522 – 543 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155464 |
OMAi | GIMFVVH |
OrthoDBi | 1184392at2759 |
TreeFami | TF315206 |
Family and domain databases
Gene3Di | 1.10.3860.10, 2 hits |
InterProi | View protein in InterPro IPR001991, Na-dicarboxylate_symporter IPR018107, Na-dicarboxylate_symporter_CS IPR036458, Na:dicarbo_symporter_sf |
Pfami | View protein in Pfam PF00375, SDF, 1 hit |
SUPFAMi | SSF118215, SSF118215, 1 hit |
PROSITEi | View protein in PROSITE PS00713, NA_DICARBOXYL_SYMP_1, 1 hit PS00714, NA_DICARBOXYL_SYMP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
G3V846-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKSNGEEPR MGSRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF
60 70 80 90 100
VLLTVSAVIV GTILGFALRP YKMSYREVKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG
160 170 180 190 200
TKENMYREGK IVQVTAADAF LDLIRNMFPP NLVEACFKQF KTSYEKRSFK
210 220 230 240 250
VPIQANETLL GAVINNVSEA METLTRIREE MVPVPGSVNG VNALGLVVFS
260 270 280 290 300
MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK
310 320 330 340 350
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG
360 370 380 390 400
GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRITRFV LPVGATINMD
410 420 430 440 450
GTALYEALAA IFIAQVNNFD LNFGQIITIS ITATAASIGA AGIPQAGLVT
460 470 480 490 500
MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH
510 520 530 540
ELKNRDVEMG NSVIEENEMK KPYQLIAQDN EPEKPVADSE TKM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP24942 | EAA1_RAT | Excitatory amino acid transporter 1 | Slc1a3 Eaat1 | 543 | Annotation score: | ||
A0A0G2JSU1 | A0A0G2JSU1_RAT | Amino acid transporter | Slc1a3 rCG_50959 | 497 | Annotation score: | ||
A0A0G2KAS7 | A0A0G2KAS7_RAT | Amino acid transporter | Slc1a3 | 498 | Annotation score: | ||
A0A0G2K611 | A0A0G2K611_RAT | Amino acid transporter | Slc1a3 | 431 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07008423 Genomic DNA No translation available. AABR07008424 Genomic DNA No translation available. CH474048 Genomic DNA Translation: EDL75679.1 |
RefSeqi | NP_062098.1, NM_019225.2 XP_017446210.1, XM_017590721.1 |
Genome annotation databases
Ensembli | ENSRNOT00000022319; ENSRNOP00000022319; ENSRNOG00000016163 |
GeneIDi | 29483 |
KEGGi | rno:29483 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07008423 Genomic DNA No translation available. AABR07008424 Genomic DNA No translation available. CH474048 Genomic DNA Translation: EDL75679.1 |
RefSeqi | NP_062098.1, NM_019225.2 XP_017446210.1, XM_017590721.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | G3V846 |
Genome annotation databases
Ensembli | ENSRNOT00000022319; ENSRNOP00000022319; ENSRNOG00000016163 |
GeneIDi | 29483 |
KEGGi | rno:29483 |
Organism-specific databases
CTDi | 6507 |
RGDi | 3698, Slc1a3 |
Phylogenomic databases
GeneTreei | ENSGT00940000155464 |
OMAi | GIMFVVH |
OrthoDBi | 1184392at2759 |
TreeFami | TF315206 |
Gene expression databases
Bgeei | ENSRNOG00000016163, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | G3V846, baseline and differential |
Family and domain databases
Gene3Di | 1.10.3860.10, 2 hits |
InterProi | View protein in InterPro IPR001991, Na-dicarboxylate_symporter IPR018107, Na-dicarboxylate_symporter_CS IPR036458, Na:dicarbo_symporter_sf |
Pfami | View protein in Pfam PF00375, SDF, 1 hit |
SUPFAMi | SSF118215, SSF118215, 1 hit |
PROSITEi | View protein in PROSITE PS00713, NA_DICARBOXYL_SYMP_1, 1 hit PS00714, NA_DICARBOXYL_SYMP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V846_RAT | |
Accessioni | G3V846Primary (citable) accession number: G3V846 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | April 7, 2021 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |