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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 8

Gene

Map3k8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-389357 CD28 dependent PI3K/Akt signaling
R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 8Imported
Gene namesi
Name:Map3k8Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi620969 Map3k8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiG3V840

Expressioni

Gene expression databases

BgeeiENSRNOG00000016378

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 486Protein kinaseInterPro annotationAdd BLAST251

Phylogenomic databases

eggNOGiKOG0201 Eukaryota
ENOG410XP9G LUCA
GeneTreeiENSGT00800000124036
OMAiDVLLFPW
OrthoDBiEOG091G0682
TreeFamiTF105117

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

G3V840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGSHSETE RASHQGTLGW PAARRYSWKA PCSGPREVWT RGSSPFLLLP
60 70 80 90 100
GFRVTSQCRS GLRWWTGAHA LTASPAGDAA WTAAFWLLSL DSPAGTTVME
110 120 130 140 150
YMSTGSDEKE EIDLLINHLN VSEVLDIMEN LYASEEPAVY EPSLMTMCPD
160 170 180 190 200
SNQNKEHSES LLRSGQEVPW LSSVRYGTVE DLLAFANHIS NTTKHFYGCR
210 220 230 240 250
PQESGILLNM VISPQNGRYQ IDSDVLLVPW KLTYRSIGSG FVPRGAFGKV
260 270 280 290 300
YLAQDMKTKK RMACKLIPVD QFKPSDVEIQ ACFRHENIAE LYGAVLWGDT
310 320 330 340 350
VHLFMEAGEG GSVLEKLESC GPMREFEIIW VTKHVLKGLD FLHSKKVIHH
360 370 380 390 400
DIKPSNIVFM STKAVLVDFG LSVQMTEDVY LPKDLRGTEI YMSPEVILCR
410 420 430 440 450
GHSTKADIYS LGATLIHMQT GTPPWVKRYP RSAYPSYLYI IHKQAPPLED
460 470 480 490 500
IAGDCSPGMR ELIEAALERN PNHRPKAADL LKHEALNPPR EDQPRCQSLD
510 520 530 540 550
SALFDRKRLL SRKELELPEN IADSSCTGST EESEVLRRQR SLYIDLGALA
560
GYFNIVRGPP TLEYG
Length:565
Mass (Da):63,216
Last modified:July 22, 2015 - v2
Checksum:i69FD16D82E64748D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07028081 Genomic DNA No translation available.
RefSeqiXP_006254110.1, XM_006254048.2
UniGeneiRn.9939

Genome annotation databases

EnsembliENSRNOT00000022190; ENSRNOP00000022190; ENSRNOG00000016378
GeneIDi116596

Similar proteinsi

Entry informationi

Entry nameiG3V840_RAT
AccessioniPrimary (citable) accession number: G3V840
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: March 28, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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