The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - G3V7T4 (G3V7T4_RAT)
Protein
Submitted name:
MYCL proto-oncogene, bHLH transcription factor
Gene
Mycl
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of inner ear auditory receptor cell differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MYCL proto-oncogene, bHLH transcription factor |
Gene namesi | |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1588591, Mycl |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- chromosome Source: Ensembl
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014259, Expressed in duodenum and 21 other tissues |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
UniRule annotationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019101 |
Structurei
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QWSU, Eukaryota |
GeneTreei | ENSGT00940000158613 |
HOGENOMi | CLU_052560_0_0_1 |
OMAi | CHPRPVS |
OrthoDBi | 877891at2759 |
TreeFami | TF106001 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR002418, Tscrpt_reg_Myc IPR012682, Tscrpt_reg_Myc_N |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF01056, Myc_N, 2 hits |
PIRSFi | PIRSF001705, Myc_protein, 2 hits |
PRINTSi | PR00044, LEUZIPPRMYC |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V7T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCVCAGCRAS PSRRGAAPLQ VAGGGSEGAD MDFDSYQHYF YDYDCGEDFY
60 70 80 90 100
RSTAPSEDIW KKFELVPSPP TSPPWGSGPG AVDPASGISP GEPWPGGGAG
110 120 130 140 150
DEAESRGHSK AWGRNYASII RRDCMWSGFS ARERLERVVS DRLAPGVPRG
160 170 180 190 200
NPPKAPATPD GTPSLEASNP APATQCQLGE PKTQACSGSE SPSDSEGEEI
210 220 230 240 250
DVVTVEKRRS LDIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP
260 270 280 290 300
ESCSQEGDPE PGAQEEALEI EAPKEKEEEE EEEEEEEEIV SPPPVENEAP
310 320 330 340 350
QSCHPKPVSS DTEDVTKRKN HNFLERKRRN DLRSRFLALR DQVPTLASCS
360 370 380 390
KAPKVVILSK ALEYLQALVG AEKKMATEKR QLRCRQQQLQ KRIAYLSGY
Sequence databases
RefSeqi | NP_001178692.1, NM_001191763.1 XP_006238857.1, XM_006238795.3 XP_008762224.1, XM_008764002.2 |
Genome annotation databases
Ensembli | ENSRNOT00000019101.6; ENSRNOP00000019101.4; ENSRNOG00000014259.6 |
GeneIDi | 298506 |
KEGGi | rno:298506 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001178692.1, NM_001191763.1 XP_006238857.1, XM_006238795.3 XP_008762224.1, XM_008764002.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019101 |
Genome annotation databases
Ensembli | ENSRNOT00000019101.6; ENSRNOP00000019101.4; ENSRNOG00000014259.6 |
GeneIDi | 298506 |
KEGGi | rno:298506 |
Organism-specific databases
CTDi | 4610 |
RGDi | 1588591, Mycl |
Phylogenomic databases
eggNOGi | ENOG502QWSU, Eukaryota |
GeneTreei | ENSGT00940000158613 |
HOGENOMi | CLU_052560_0_0_1 |
OMAi | CHPRPVS |
OrthoDBi | 877891at2759 |
TreeFami | TF106001 |
Gene expression databases
Bgeei | ENSRNOG00000014259, Expressed in duodenum and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR002418, Tscrpt_reg_Myc IPR012682, Tscrpt_reg_Myc_N |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF01056, Myc_N, 2 hits |
PIRSFi | PIRSF001705, Myc_protein, 2 hits |
PRINTSi | PR00044, LEUZIPPRMYC |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V7T4_RAT | |
Accessioni | G3V7T4Primary (citable) accession number: G3V7T4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |