Hairy/enhancer-of-split related with YRPW motif 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
• histone deacetylase binding Source: RGD
• identical protein binding Source: RGD
• protein dimerization activity Source: InterPro
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
• sequence-specific DNA binding Source: RGD
• sequence-specific double-stranded DNA binding Source: RGD

GO - Biological processⁱ

• anterior/posterior axis specification Source: RGD
• anterior/posterior pattern specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• aortic valve morphogenesis Source: RGD
• arterial endothelial cell differentiation Source: RGD
• artery development Source: RGD
• ascending aorta morphogenesis Source: RGD
• atrial septum morphogenesis Source: RGD
• atrioventricular valve development Source: RGD
• blood vessel development Source: RGD
• cardiac epithelial to mesenchymal transition Source: RGD
• cardiac left ventricle morphogenesis Source: RGD
• cardiac muscle hypertrophy Source: RGD
• cardiac muscle hypertrophy in response to stress Source: RGD
• cardiac right ventricle morphogenesis Source: RGD
• cardiac septum morphogenesis Source: RGD
• cardiac vascular smooth muscle cell development Source: RGD
• cardiac ventricle morphogenesis Source: RGD
• cell fate commitment Source: RGD
• circulatory system development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cochlea development Source: RGD
• coronary vasculature morphogenesis Source: RGD
• dorsal aorta morphogenesis Source: RGD
• endocardial cushion to mesenchymal transition involved in heart valve formation Source: RGD
• heart development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
    Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E.
    J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
• heart trabecula formation Source: RGD
• labyrinthine layer blood vessel development Source: RGD
• mesenchymal cell development Source: RGD
• muscular septum morphogenesis Source: RGD
• negative regulation of biomineral tissue development Source: RGD
• negative regulation of cardiac muscle cell apoptotic process Source: RGD
• negative regulation of gene expression Source: RGD
• negative regulation of Notch signaling pathway Source: RGD
• negative regulation of transcription, DNA-templated Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: RGD
• negative regulation of transcription initiation from RNA polymerase II promoter Source: RGD
• negative regulation of transcription regulatory region DNA binding Source: RGD
• Notch signaling pathway Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "HERP1 is a cell type-specific primary target of Notch."
    Iso T., Chung G., Hamamori Y., Kedes L.
    J. Biol. Chem. 277:6598-6607(2002) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: RGD
• pattern specification process Source: RGD
• positive regulation of cardiac muscle cell proliferation Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of heart rate Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• protein-DNA complex assembly Source: RGD
• pulmonary artery morphogenesis Source: RGD
• pulmonary valve morphogenesis Source: RGD
• regulation of gene expression Source: RGD
• regulation of inner ear auditory receptor cell differentiation Source: RGD
• regulation of neurogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of vasculogenesis Source: RGD
• tricuspid valve formation Source: RGD
• tricuspid valve morphogenesis Source: RGD
• umbilical cord morphogenesis Source: RGD
• vascular associated smooth muscle cell development Source: RGD
• vasculogenesis Source: RGD
• ventricular cardiac muscle cell development Source: RGD
• ventricular septum morphogenesis Source: RGD
• ventricular trabecula myocardium morphogenesis Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: RGD
• identical protein binding Source: RGD
• protein dimerization activity Source: InterPro
• RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKRPCEETTS ESDLDETIDV GSENNYSGHS ASSVMRSNSP TTTSQIMARK 
        60         70         80         90        100
KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL 
       110        120        130        140        150
KMLQATGGKG YFDAHALATD FMSIGFRECL TEVARYLSSV EGLDPSDPLR 
       160        170        180        190        200
VRLVSHLSTC ASQREAAVMT SSMSHHHHPL HPHHWAAAFH HLPTSLLQPN 
       210        220        230        240        250
GLHTSESTPC RLSTSSEVPP AHGSALLTAT FAHADSALRM PSTGTVAPCV 
       260        270        280        290        300
PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA 
       310        320        330 
AATAISPPLS VSAASSPQQT SSGTNSKPYR PWGTEVGAF             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ