Hey2

Functionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
microsatellite binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II activating transcription factor binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior axis specification Source: Ensembl
arterial endothelial cell differentiation Source: Ensembl
ascending aorta morphogenesis Source: Ensembl
atrial septum morphogenesis Source: Ensembl
blood vessel development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cardiac left ventricle morphogenesis Source: Ensembl
cardiac muscle hypertrophy in response to stress Source: Ensembl
cardiac right ventricle morphogenesis Source: Ensembl
cardiac vascular smooth muscle cell development Source: Ensembl
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell fate commitment Source: Ensembl
cochlea development Source: Ensembl
coronary vasculature morphogenesis Source: Ensembl
dorsal aorta morphogenesis Source: Ensembl
endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
heart development
Source: RGD
Inferred from expression patternⁱ
- 10692439
heart trabecula formation Source: Ensembl
labyrinthine layer blood vessel development Source: Ensembl
mesenchymal cell development Source: Ensembl
muscular septum morphogenesis Source: Ensembl
negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
negative regulation of Notch signaling pathway Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
negative regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
negative regulation of transcription regulatory region DNA binding Source: Ensembl
Notch signaling pathway
Source: RGD
Inferred from direct assayⁱ
- 11741889
outflow tract morphogenesis Source: Ensembl
positive regulation of cardiac muscle cell proliferation Source: Ensembl
positive regulation of heart rate Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-DNA complex assembly Source: Ensembl
pulmonary artery morphogenesis Source: Ensembl
pulmonary valve morphogenesis Source: Ensembl
regulation of inner ear auditory receptor cell differentiation Source: Ensembl
regulation of neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of vasculogenesis Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule
tricuspid valve formation Source: Ensembl
umbilical cord morphogenesis Source: Ensembl
vasculogenesis Source: Ensembl
ventricular cardiac muscle cell development Source: Ensembl
ventricular trabecula myocardium morphogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Biological process

Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Hairy/enhancer-of-split related with YRPW motif 2Imported Submitted name: Hes-related family bHLH transcription factor with YRPW motif 2Imported
Gene namesⁱ	Name:Hey2Imported ORF Names:rCG_41985Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	621405 Hey2

RGDⁱ

621405 Hey2

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	G3V7S6

PRIDEⁱ

G3V7S6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000013364 Expressed in 9 organ(s), highest expression level in heart

Bgeeⁱ

ENSRNOG00000013364 Expressed in 9 organ(s), highest expression level in heart

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000018718

STRINGⁱ

10116.ENSRNOP00000018718

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	48 – 103	BHLHInterPro annotationAdd BLAST		56
Domainⁱ	122 – 157	OrangeInterPro annotationAdd BLAST		36

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130
KEGG Orthology (KO) More...KOⁱ	K09091
OMAⁱ	STCASQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HNC
TreeFamⁱ	TF323617

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00511 ORANGE, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

G3V7S6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRPCEETTS ESDLDETIDV GSENNYSGHS ASSVMRSNSP TTTSQIMARK 
        60         70         80         90        100
KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL 
       110        120        130        140        150
KMLQATGGKG YFDAHALATD FMSIGFRECL TEVARYLSSV EGLDPSDPLR 
       160        170        180        190        200
VRLVSHLSTC ASQREAAVMT SSMSHHHHPL HPHHWAAAFH HLPTSLLQPN 
       210        220        230        240        250
GLHTSESTPC RLSTSSEVPP AHGSALLTAT FAHADSALRM PSTGTVAPCV 
       260        270        280        290        300
PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA 
       310        320        330 
AATAISPPLS VSAASSPQQT SSGTNSKPYR PWGTEVGAF

Length:339

Mass (Da):35,922

Last modified:November 16, 2011 - v1

Checksum:ⁱ736D50C3043E14AF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07000940 Genomic DNA No translation available. CH474002 Genomic DNA Translation: EDL87708.1
NCBI Reference Sequences More...RefSeqⁱ	NP_569101.1, NM_130417.1
UniGeneⁱ	Rn.58672

Genome annotation databases

Ensemblⁱ	ENSRNOT00000018718; ENSRNOP00000018718; ENSRNOG00000013364
GeneIDⁱ	155430
KEGGⁱ	rno:155430

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
G3V7S6	Hairy/enhancer-of-split related with YRPW motif protein 2		MOUSE		339	UniRef90_Q9QUS4
Uncharacterized protein		NEOLE		368
hairy/enhancer-of-split related with YRPW motif protein 2		LIPVE		352
Uncharacterized protein		MONDO		341
Hes related family bHLH transcription factor with YRPW motif 2		SARHA		340
+41

Protein	Similar proteins		Species	Score	Length	Source
G3V7S6	Hairy/enhancer-of-split related with YRPW motif protein 2		MOUSE		339	UniRef50_Q9QUS4
Hairy/enhancer-of-split related with YRPW motif protein 1		XENTR		300
Hairy/enhancer-of-split related with YRPW motif protein 1		XENLA		294
Hairy/enhancer-of-split related with YRPW motif protein 2		DANRE		324
Uncharacterized protein		NEOLE		368
+176

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07000940 Genomic DNA No translation available. CH474002 Genomic DNA Translation: EDL87708.1
RefSeqⁱ	NP_569101.1, NM_130417.1
UniGeneⁱ	Rn.58672

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000018718

STRINGⁱ

10116.ENSRNOP00000018718

Proteomic databases

PRIDEⁱ	G3V7S6

PRIDEⁱ

G3V7S6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000018718; ENSRNOP00000018718; ENSRNOG00000013364
GeneIDⁱ	155430
KEGGⁱ	rno:155430

Organism-specific databases

CTDⁱ	23493
RGDⁱ	621405 Hey2

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
GeneTreeⁱ	ENSGT00700000104130
KOⁱ	K09091
OMAⁱ	STCASQR
OrthoDBⁱ	EOG091G0HNC
TreeFamⁱ	TF323617

Gene expression databases

Bgeeⁱ	ENSRNOG00000013364 Expressed in 9 organ(s), highest expression level in heart

Bgeeⁱ

ENSRNOG00000013364 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00511 ORANGE, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3V7S6_RAT
Accessionⁱ	G3V7S6Primary (citable) accession number: G3V7S6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	November 7, 2018
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3V7S6 (G3V7S6_RAT)

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Hairy/enhancer-of-split related with YRPW motif 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ