The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - G3V7S6 (G3V7S6_RAT)
Protein
Submitted name:
Hairy/enhancer-of-split related with YRPW motif 2
Gene
Hey2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anterior/posterior axis specification Source: RGD
- anterior/posterior pattern specification Source: GO_Central
- aortic valve morphogenesis Source: RGD
- arterial endothelial cell differentiation Source: RGD
- artery development Source: RGD
- ascending aorta morphogenesis Source: RGD
- atrial septum morphogenesis Source: RGD
- atrioventricular valve development Source: RGD
- blood vessel development Source: RGD
- cardiac epithelial to mesenchymal transition Source: RGD
- cardiac left ventricle morphogenesis Source: RGD
- cardiac muscle hypertrophy Source: RGD
- cardiac muscle hypertrophy in response to stress Source: RGD
- cardiac right ventricle morphogenesis Source: RGD
- cardiac septum morphogenesis Source: RGD
- cardiac vascular smooth muscle cell development Source: RGD
- cardiac ventricle morphogenesis Source: RGD
- cell fate commitment Source: RGD
- circulatory system development Source: GO_Central
- cochlea development Source: RGD
- coronary vasculature morphogenesis Source: RGD
- dorsal aorta morphogenesis Source: RGD
- endocardial cushion to mesenchymal transition involved in heart valve formation Source: RGD
- heart development Source: RGD
- heart trabecula formation Source: RGD
- labyrinthine layer blood vessel development Source: RGD
- mesenchymal cell development Source: RGD
- muscular septum morphogenesis Source: RGD
- negative regulation of biomineral tissue development Source: RGD
- negative regulation of cardiac muscle cell apoptotic process Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of Notch signaling pathway Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: RGD
- negative regulation of transcription initiation from RNA polymerase II promoter Source: RGD
- negative regulation of transcription regulatory region DNA binding Source: RGD
- Notch signaling pathway Source: RGD
- outflow tract morphogenesis Source: RGD
- pattern specification process Source: RGD
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of heart rate Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- protein-DNA complex assembly Source: RGD
- pulmonary artery morphogenesis Source: RGD
- pulmonary valve morphogenesis Source: RGD
- regulation of gene expression Source: RGD
- regulation of inner ear auditory receptor cell differentiation Source: RGD
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of vasculogenesis Source: RGD
- tricuspid valve formation Source: RGD
- tricuspid valve morphogenesis Source: RGD
- umbilical cord morphogenesis Source: RGD
- vascular associated smooth muscle cell development Source: RGD
- vasculogenesis Source: RGD
- ventricular cardiac muscle cell development Source: RGD
- ventricular septum morphogenesis Source: RGD
- ventricular trabecula myocardium morphogenesis Source: RGD
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Hairy/enhancer-of-split related with YRPW motif 2ImportedSubmitted name: Hes-related family bHLH transcription factor with YRPW motif 2 |
Gene namesi | Name:Hey2Imported ORF Names:rCG_41985Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621405, Hey2 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- transcription repressor complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000013364, Expressed in heart and 21 other tissues |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018718 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 103 | BHLHInterPro annotationAdd BLAST | 56 | |
Domaini | 125 – 157 | OrangeInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 310 – 339 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 48 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 310 – 329 | Polar residuesSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000160636 |
HOGENOMi | CLU_048294_1_0_1 |
OMAi | HWTAAFH |
OrthoDBi | 1201152at2759 |
TreeFami | TF323617 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V7S6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRPCEETTS ESDLDETIDV GSENNYSGHS ASSVMRSNSP TTTSQIMARK
60 70 80 90 100
KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL
110 120 130 140 150
KMLQATGGKG YFDAHALATD FMSIGFRECL TEVARYLSSV EGLDPSDPLR
160 170 180 190 200
VRLVSHLSTC ASQREAAVMT SSMSHHHHPL HPHHWAAAFH HLPTSLLQPN
210 220 230 240 250
GLHTSESTPC RLSTSSEVPP AHGSALLTAT FAHADSALRM PSTGTVAPCV
260 270 280 290 300
PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA
310 320 330
AATAISPPLS VSAASSPQQT SSGTNSKPYR PWGTEVGAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474002 Genomic DNA Translation: EDL87708.1 |
RefSeqi | NP_569101.1, NM_130417.1 |
Genome annotation databases
Ensembli | ENSRNOT00000018718.7; ENSRNOP00000018718.3; ENSRNOG00000013364.7 |
GeneIDi | 155430 |
KEGGi | rno:155430 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474002 Genomic DNA Translation: EDL87708.1 |
RefSeqi | NP_569101.1, NM_130417.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018718 |
Genome annotation databases
Ensembli | ENSRNOT00000018718.7; ENSRNOP00000018718.3; ENSRNOG00000013364.7 |
GeneIDi | 155430 |
KEGGi | rno:155430 |
Organism-specific databases
CTDi | 23493 |
RGDi | 621405, Hey2 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000160636 |
HOGENOMi | CLU_048294_1_0_1 |
OMAi | HWTAAFH |
OrthoDBi | 1201152at2759 |
TreeFami | TF323617 |
Gene expression databases
Bgeei | ENSRNOG00000013364, Expressed in heart and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V7S6_RAT | |
Accessioni | G3V7S6Primary (citable) accession number: G3V7S6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |