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Entry version 82 (07 Oct 2020)
Sequence version 1 (16 Nov 2011)
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Protein

Integrin beta

Gene

Itgb7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationARBA annotation
Biological processCell adhesionUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-216083, Integrin cell surface interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itgb7Imported
ORF Names:rCG_50718Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
2929, Itgb7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei726 – 746HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509175620 – 807Integrin betaSequence analysisAdd BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 61UniRule annotation
Disulfide bondi54 ↔ 91UniRule annotation
Disulfide bondi64 ↔ 80UniRule annotation
Disulfide bondi216 ↔ 223UniRule annotation
Disulfide bondi271 ↔ 311UniRule annotation
Disulfide bondi449 ↔ 689UniRule annotation
Disulfide bondi475 ↔ 479UniRule annotation
Disulfide bondi489 ↔ 501UniRule annotation
Disulfide bondi498 ↔ 538UniRule annotation
Disulfide bondi503 ↔ 512UniRule annotation
Disulfide bondi514 ↔ 528UniRule annotation
Disulfide bondi544 ↔ 549UniRule annotation
Disulfide bondi546 ↔ 575UniRule annotation
Disulfide bondi551 ↔ 560UniRule annotation
Disulfide bondi562 ↔ 567UniRule annotation
Disulfide bondi581 ↔ 586UniRule annotation
Disulfide bondi583 ↔ 614UniRule annotation
Disulfide bondi588 ↔ 597UniRule annotation
Disulfide bondi599 ↔ 606UniRule annotation
Disulfide bondi620 ↔ 625UniRule annotation
Disulfide bondi622 ↔ 667UniRule annotation
Disulfide bondi627 ↔ 636UniRule annotation
Disulfide bondi639 ↔ 642UniRule annotation
Disulfide bondi646 ↔ 655UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation, GlycoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
G3V7M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012208, Expressed in thymus and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000016642

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3V7M2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 92PSIInterPro annotationAdd BLAST49
Domaini50 – 477INBInterPro annotationAdd BLAST428
Domaini646 – 722Integrin_B_tailInterPro annotationAdd BLAST77
Domaini747 – 793Integrin_b_cytInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 42DisorderedSequence analysisAdd BLAST22
Regioni91 – 124DisorderedSequence analysisAdd BLAST34
Regioni788 – 807DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi91 – 111PolyampholyteSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1226, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198506

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011772_2_1_1

KEGG Orthology (KO)

More...
KOi
K06590

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLAANCS

Database of Orthologous Groups

More...
OrthoDBi
473040at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105392

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR015437, Integrin_bsu-7
IPR014836, Integrin_bsu_cyt_dom
IPR012896, Integrin_bsu_tail
IPR036349, Integrin_bsu_tail_dom_sf
IPR002369, Integrin_bsu_VWA
IPR032695, Integrin_dom_sf
IPR016201, PSI
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10082, PTHR10082, 1 hit
PTHR10082:SF36, PTHR10082:SF36, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08725, Integrin_b_cyt, 1 hit
PF00362, Integrin_beta, 1 hit
PF17205, PSI_integrin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002512, Integrin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01186, INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00187, INB, 1 hit
SM01241, Integrin_b_cyt, 1 hit
SM01242, Integrin_B_tail, 1 hit
SM00423, PSI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 1 hit
SSF69687, SSF69687, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00243, INTEGRIN_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3V7M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDSSTVLIF LLVLGGGQSE LDTKITSSGE TTEWEDPDLS PQGSCQPAPS
60 70 80 90 100
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPEQELEEPR
110 120 130 140 150
GHQEVLQDRP LSQGDRGEGA TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY
160 170 180 190 200
PVDLYYLMDL SYSMKDDLER VRQLGQALLL RLREVTHSVR IGFGSFVDKT
210 220 230 240 250
VLPFVSTVPS KLNHPCPSRL ERCQAPFSYH HVLPLTRDAQ AFEREVGRQN
260 270 280 290 300
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
310 320 330 340 350
GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG
360 370 380 390 400
ATLPVYQELS QLIPKSAVGE LSEDSSNVVQ LIMDAYDNLS STVTLEHSSL
410 420 430 440 450
PPGVSISFES HCRSPEKSEG EAGDRRGQCN HVRVNQMVDF WVTLQASHCL
460 470 480 490 500
PEAHVLRLWA LGFSEELTVE LHTLCDCNCS DAQPRAPYCS DGQGDLQCGI
510 520 530 540 550
CSCAPGRLGQ LCECSEADLS SPDLESGCRA PNGTGPLCSG KGRCQCGRCS
560 570 580 590 600
CSGQSSGRLC ECDDASCERH EGILCGGFGH CQCGVCHCHA NRTGRACECS
610 620 630 640 650
ESVDSCVSPE GGLCSGHGDC KCNRCQCLDG YYGALCDQCL GCKSPCEQYR
660 670 680 690 700
DCAECGAFGT GPLAANCSAA CADVNVTLAL APNLDDGWCK ERTLDNQLFF
710 720 730 740 750
FLVENSARGV ILRVRPQEKG ADHTRAIILG CVGGIVAVGL GLVLAYRLSV
760 770 780 790 800
EVYDRLEYSR FEKERQQLNW KQDSNPLYKS AVTTTVNPRF QGGNKQSLSL

PLTQEAD
Length:807
Mass (Da):87,629
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27FEA31C5EFB5AEE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC110347 Genomic DNA No translation available.
CH474035 Genomic DNA Translation: EDL86853.1

NCBI Reference Sequences

More...
RefSeqi
NP_037303.1, NM_013171.1
XP_006242445.1, XM_006242383.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000016642; ENSRNOP00000016642; ENSRNOG00000012208

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25713

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25713

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110347 Genomic DNA No translation available.
CH474035 Genomic DNA Translation: EDL86853.1
RefSeqiNP_037303.1, NM_013171.1
XP_006242445.1, XM_006242383.3

3D structure databases

SMRiG3V7M2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016642

Proteomic databases

PRIDEiG3V7M2

Genome annotation databases

EnsembliENSRNOT00000016642; ENSRNOP00000016642; ENSRNOG00000012208
GeneIDi25713
KEGGirno:25713

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3695
RGDi2929, Itgb7

Phylogenomic databases

eggNOGiKOG1226, Eukaryota
GeneTreeiENSGT00980000198506
HOGENOMiCLU_011772_2_1_1
KOiK06590
OMAiPLAANCS
OrthoDBi473040at2759
TreeFamiTF105392

Enzyme and pathway databases

ReactomeiR-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-216083, Integrin cell surface interactions

Gene expression databases

BgeeiENSRNOG00000012208, Expressed in thymus and 21 other tissues

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR015437, Integrin_bsu-7
IPR014836, Integrin_bsu_cyt_dom
IPR012896, Integrin_bsu_tail
IPR036349, Integrin_bsu_tail_dom_sf
IPR002369, Integrin_bsu_VWA
IPR032695, Integrin_dom_sf
IPR016201, PSI
IPR036465, vWFA_dom_sf
PANTHERiPTHR10082, PTHR10082, 1 hit
PTHR10082:SF36, PTHR10082:SF36, 1 hit
PfamiView protein in Pfam
PF08725, Integrin_b_cyt, 1 hit
PF00362, Integrin_beta, 1 hit
PF17205, PSI_integrin, 1 hit
PIRSFiPIRSF002512, Integrin_B, 1 hit
PRINTSiPR01186, INTEGRINB
SMARTiView protein in SMART
SM00187, INB, 1 hit
SM01241, Integrin_b_cyt, 1 hit
SM01242, Integrin_B_tail, 1 hit
SM00423, PSI, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 1 hit
SSF69687, SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00243, INTEGRIN_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V7M2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V7M2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 7, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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