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Entry version 86 (02 Jun 2021)
Sequence version 3 (22 Jul 2015)
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Protein

Utrophin

Gene

Utrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3051 – 3098ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UtrophinCurated
Alternative name(s):
Dystrophin-related protein 1
Short name:
DRP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UtrnImported
ORF Names:rCG_57340Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1
  • UP000234681 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
3947, Utrn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004528231 – 3419UtrophinAdd BLAST3419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphotyrosineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Modified residuei1998PhosphoserineBy similarity1
Modified residuei2201PhosphoserineBy similarity1
Modified residuei3284PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
G3V7L1

PRoteomics IDEntifications database

More...
PRIDEi
G3V7L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000011058, Expressed in lung and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G3V7L1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the syntrophins SNTA1; SNTB1 and SNTB2.

Interacts with SYNM.

Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1 (By similarity).

Interacts with DTNB (PubMed:10545507).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
G3V7L1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000016273

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3V7L1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 135Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini150 – 255Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati312 – 416Spectrin 1Sequence analysisAdd BLAST105
Repeati421 – 525Spectrin 2Sequence analysisAdd BLAST105
Repeati532 – 636Spectrin 3Sequence analysisAdd BLAST105
Repeati690 – 795Spectrin 4Sequence analysisAdd BLAST106
Repeati801 – 901Spectrin 5Sequence analysisAdd BLAST101
Repeati910 – 1012Spectrin 6Sequence analysisAdd BLAST103
Repeati1019 – 1121Spectrin 7Sequence analysisAdd BLAST103
Repeati1128 – 1229Spectrin 8Sequence analysisAdd BLAST102
Repeati1236 – 1333Spectrin 9Sequence analysisAdd BLAST98
Repeati1335 – 1436Spectrin 10Sequence analysisAdd BLAST102
Repeati1438 – 1540Spectrin 11Sequence analysisAdd BLAST103
Repeati1547 – 1648Spectrin 12Sequence analysisAdd BLAST102
Repeati1653 – 1747Spectrin 13Sequence analysisAdd BLAST95
Repeati1748 – 1840Spectrin 14Sequence analysisAdd BLAST93
Repeati1841 – 1958Spectrin 15Sequence analysisAdd BLAST118
Repeati1969 – 2070Spectrin 16Sequence analysisAdd BLAST102
Repeati2077 – 2176Spectrin 17Sequence analysisAdd BLAST100
Repeati2216 – 2319Spectrin 18Sequence analysisAdd BLAST104
Repeati2336 – 2426Spectrin 19Sequence analysisAdd BLAST91
Repeati2433 – 2542Spectrin 20Sequence analysisAdd BLAST110
Repeati2549 – 2674Spectrin 21Sequence analysisAdd BLAST126
Repeati2681 – 2783Spectrin 22Sequence analysisAdd BLAST103
Domaini2799 – 2832WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 246Actin-bindingBy similarityAdd BLAST246
Regioni268 – 905Interaction with SYNMBy similarityAdd BLAST638
Regioni1336 – 1761Interaction with SYNMBy similarityAdd BLAST426
Regioni2785 – 3152Interaction with SYNMBy similarityAdd BLAST368

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Actin binding affinity is primarily determined by CH domain 1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3051 – 3098ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4286, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153467

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000246_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3V7L1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035436, Dystrophin/utrophin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 8 hits
PF00397, WW, 1 hit
PF00569, ZZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002341, Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 20 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3V7L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKYGHLEAS PDDGQNQFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
60 70 80 90 100
PPINDMFSDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
110 120 130 140 150
HQNNVELVNI GGTDIVDGNP KLTLGLLWSI ILHWQVKDVM KDIMSDLQQT
160 170 180 190 200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD
210 220 230 240 250
RVVKMSPTER LEHAFSKAHT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL
260 270 280 290 300
FEVLPQQVTI DAIREVETLP RKYKKECEGE EINIQSAVLT EEGQSPRAET
310 320 330 340 350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEDVKEQFA
360 370 380 390 400
THETFMMELT AHQSSVGSVL QAGNQLMTQG TLSDEEEFEI QEQMTLLNAR
410 420 430 440 450
WEALRVESME RQSRLHDALM ELQKKQLQQL SGWLTLTEER IQKMESLPVG
460 470 480 490 500
DDLPSLQNLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAVLE
510 520 530 540 550
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LEAWLTEKEE
560 570 580 590 600
ALNKVQTGNF KDQKELGVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
610 620 630 640 650
LSNPKASEKM NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
660 670 680 690 700
DLLETVHVRE QGMIKKPKQE LPPPPPPKKR QIHVDVEAKK KFDATSAELQ
710 720 730 740 750
SWILRSKAAL QNTEMNEYKK SQETSGVRKK WKGLEKEQKE KIPQLDELNQ
760 770 780 790 800
TGQILQEQMG KEGLLAEEIN DVLERVLLEW KMISQQLEDL GRKIQLQEDI
810 820 830 840 850
NAYFRQLDAL EKTIRAKEEW LRDASFSESP QRSLPSLKDS CQRELTDLLG
860 870 880 890 900
LHPRIEILCA SCSALRSQPS VPGFVQQGFD DLRRHYQAVQ KALEEYQQQL
910 920 930 940 950
ENELKSQPEP AYLDTLNTLK KMLSESEKAA QASLSALNDP SAVEQALQEK
960 970 980 990 1000
KALDETLENQ KPTLHKLSEE TKALEKNMLP DVGKTYRQEF DDAQGKWNKV
1010 1020 1030 1040 1050
KTKVSRDLRS LEEIIPRLRD FKADSEVIEK WTNGVKDFLM KEQAAQGDTT
1060 1070 1080 1090 1100
ALQRQLDQCT TFANEIETIE SSLKNLRDIE TSLQRCPVTG VKTWVQTRLA
1110 1120 1130 1140 1150
DYQSQLEKFS QEIDIQKSRL SDSQEKAMNL KKDLAEMQEW MAQAEEDYLE
1160 1170 1180 1190 1200
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDSIK LVAARVPSGG
1210 1220 1230 1240 1250
QELTSEFNEV LESYQLLCNR IRGKCHTLEE VWSCWVELLH YLDLETSWLN
1260 1270 1280 1290 1300
TLEERMQSTE ALPERAEAVH DALESLESVL RHPADNRTQI RELGQTLIDG
1310 1320 1330 1340 1350
GILDDIISEK LEAFNSRYEE LSHLAESKQI SLEKQLQVLR ETDHMLQVLK
1360 1370 1380 1390 1400
ESLGELDKQL TTYLTDRIDA FQLPQEAQKI QAEISAHELT LEELKKNVRP
1410 1420 1430 1440 1450
QPPTSPEGRT TRGGSQMDLL QRKLREVSTK FQLFQKPANF EQRMLDCKRV
1460 1470 1480 1490 1500
LDGVKAELHV LSVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR
1510 1520 1530 1540 1550
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLSRKLK
1560 1570 1580 1590 1600
KEAAILSEWL STTEAELVQK STSEGVIGDL DTEISWAKNI LKDLERRKVD
1610 1620 1630 1640 1650
LNAITESSAA LQHLVVGSES VLEDTLCVLN AGWSRVRTWT EDWRNTLLNH
1660 1670 1680 1690 1700
QNQLEVFDGH VAHISTWLYQ AEALLDEIEK KPASKQEEIV KRLLSELSDA
1710 1720 1730 1740 1750
SIQVENVREQ AIVLVNARGS SSRELVEPKL AELSKNFEKV SQHINSAQML
1760 1770 1780 1790 1800
IGQDPAGTVE AVGPFSDLES LESDIENMLK VVEKHLDPSN DEKMDEERAQ
1810 1820 1830 1840 1850
IEEVLQRGEH LLHEPMEDSK KEKIRLQLLL LHTRYNKIKA IPQRKTIPLS
1860 1870 1880 1890 1900
SGIMSSALPA DYLVEINKIL LTLDDIELSL NIPELNTTVY EDFSFQEDSL
1910 1920 1930 1940 1950
KRIKDQLDRL GEQLAAVHEK QPDVILEASG PEAIQIRDML SQLNAKWDRV
1960 1970 1980 1990 2000
NRLYSDRRGS FARAVEEWKQ FHCDLDDLTQ WLSEAEDLLV GTCAPDGSLD
2010 2020 2030 2040 2050
LEKARTHQLE LEDGLSSHQP CLIDVNQKGE DIVQRLRPSD ASFLKDKLAS
2060 2070 2080 2090 2100
LNQRWSALVA EVKDLQPRLK GESKQVSGYR KRLDEVVCWL TKVENAVQKR
2110 2120 2130 2140 2150
STPDPEENPW ELTDLAQEMD AQAENIKWLN RAELEMLSDK NLSLCERDNL
2160 2170 2180 2190 2200
SESLRNVNTM WTKICREVPS LLKTRTQDPC SAPQTRIAAH PNVQKVALVS
2210 2220 2230 2240 2250
SASDAPLRGP EISVPADLDK TITELADWLV LIDQMLKSNI VTVGDVKEIN
2260 2270 2280 2290 2300
KTVSRMKITK ADLEQRHPQL DFVFTLAQNL KNKASSSDLR TAITEKLEKL
2310 2320 2330 2340 2350
KTQWESTQHG VELRRQQLED MVVDSLQWDD HREETEELMR KHEARFYMLQ
2360 2370 2380 2390 2400
QARRDPLSKQ VSDNQLLLQE LGSGDGVIMA FDNVLQKLLE EYSSDDTRNV
2410 2420 2430 2440 2450
EETTEYLKTS WINLKQSIAD RQSALEAELR TVQTSRRDLE NFVKWLQEAE
2460 2470 2480 2490 2500
TTANVLADAS QRENALQDSV LARQLRQQML DIQAEIDAHN DIFKSIDGNR
2510 2520 2530 2540 2550
QKMVKALGNS EEATMLQHRL DDMNQRWNDL KAKSASIRAH LEASAEKWNR
2560 2570 2580 2590 2600
LLASLEELIK WLNMKDEELK KQMPIGGDVP ALQLQYDHCK VLRRELKEKE
2610 2620 2630 2640 2650
YSVLNAVDQA RVFLADQPIE APEEPRRNPQ SKTELTPEER AQKIAKAMRK
2660 2670 2680 2690 2700
QSSEVREKWE SLNAVTSTWQ KQVGKALEKL RDLQGAVDDL DADMKEVEAV
2710 2720 2730 2740 2750
RNGWKPVGDL LIDSLQDHIE KTLAFREEIA PINLKVKTMN DLSSQLSPLD
2760 2770 2780 2790 2800
LHPSPKMSRQ LDDLNMRWKL LQVSVEDRLK QLQEAHRDFG PSSQHFLSTS
2810 2820 2830 2840 2850
VQLPWQRSIS HNKVPYYINH QTQTTCWDHP KMTELFQSLG DLNNVRFSAY
2860 2870 2880 2890 2900
RTAIKIRRLQ KALCLDLLEL NTTNEVFKQH KLNQNDQLLS VPDVINCLTT
2910 2920 2930 2940 2950
TYDGLEQLHK DLVNVPLCVD MCLNWLLNVY DTGRTGKIRV QSLKIGLMSL
2960 2970 2980 2990 3000
SKGLLEEKYR CLFKEVAGPT EMCDQRQLGL LLHDAIQIPR QLGEVAAFGG
3010 3020 3030 3040 3050
SNIEPSVRSC FQQNNNKPEI SVKEFIDWMR LEPQSMVWLP VLHRVAAAET
3060 3070 3080 3090 3100
AKHQAKCNIC KECPIVGFRY RSLKHFNYDV CQSCFFSGRT AKGHKLHYPM
3110 3120 3130 3140 3150
VEYCIPTTSG EDVRDFTKVL KNKFRSKKYF AKHPRLGYLP VQTVLEGDNL
3160 3170 3180 3190 3200
ETPITLISMW PEHYDPSQSP QLFHDDTHSR IEQYATRLAQ MERTNGSFLT
3210 3220 3230 3240 3250
DSSSTTGSVE DEHALIQQYC QTLGGESPVS QPQSPAQILK SVEKEERGEL
3260 3270 3280 3290 3300
ERIIADLEEE QRNLQVEYEQ LKEQHLRRGL PLGSPPDSIV SPYHTSEDSE
3310 3320 3330 3340 3350
LIAEAKLLRQ HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL EQPDSDSRIN
3360 3370 3380 3390 3400
GVSPWASPQH PSLSYSLDPD PGPQSHQAAS EDLLAPPHDT STDLTDVMEQ
3410
LNSTFPSCSP NVPSRPQAI
Length:3,419
Mass (Da):391,312
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A4F88AA71A6E4D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JW60A0A0G2JW60_RAT
Utrophin
Utrn
3,424Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07000248 Genomic DNA No translation available.
AABR07000249 Genomic DNA No translation available.
AABR07000250 Genomic DNA No translation available.
AABR07000251 Genomic DNA No translation available.
AABR07000252 Genomic DNA No translation available.
AABR07000253 Genomic DNA No translation available.
AABR07000254 Genomic DNA No translation available.
AABR07000255 Genomic DNA No translation available.
AABR07000256 Genomic DNA No translation available.
CH473994 Genomic DNA Translation: EDL93719.1

NCBI Reference Sequences

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RefSeqi
XP_008756815.1, XM_008758593.1
XP_008756816.1, XM_008758594.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000016273; ENSRNOP00000016273; ENSRNOG00000011058

Database of genes from NCBI RefSeq genomes

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GeneIDi
25600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07000248 Genomic DNA No translation available.
AABR07000249 Genomic DNA No translation available.
AABR07000250 Genomic DNA No translation available.
AABR07000251 Genomic DNA No translation available.
AABR07000252 Genomic DNA No translation available.
AABR07000253 Genomic DNA No translation available.
AABR07000254 Genomic DNA No translation available.
AABR07000255 Genomic DNA No translation available.
AABR07000256 Genomic DNA No translation available.
CH473994 Genomic DNA Translation: EDL93719.1
RefSeqiXP_008756815.1, XM_008758593.1
XP_008756816.1, XM_008758594.2

3D structure databases

SMRiG3V7L1
ModBaseiSearch...

Protein-protein interaction databases

IntActiG3V7L1, 1 interactor
STRINGi10116.ENSRNOP00000016273

Proteomic databases

PeptideAtlasiG3V7L1
PRIDEiG3V7L1

Genome annotation databases

EnsembliENSRNOT00000016273; ENSRNOP00000016273; ENSRNOG00000011058
GeneIDi25600

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7402
RGDi3947, Utrn

Phylogenomic databases

eggNOGiKOG4286, Eukaryota
GeneTreeiENSGT00940000153467
HOGENOMiCLU_000246_2_0_1
InParanoidiG3V7L1

Gene expression databases

BgeeiENSRNOG00000011058, Expressed in lung and 20 other tissues
ExpressionAtlasiG3V7L1, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
cd00201, WW, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035436, Dystrophin/utrophin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 8 hits
PF00397, WW, 1 hit
PF00569, ZZ, 1 hit
PIRSFiPIRSF002341, Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 20 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUTRN_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V7L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 2, 2021
Last sequence update: July 22, 2015
Last modified: June 2, 2021
This is version 86 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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