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Entry version 72 (12 Aug 2020)
Sequence version 1 (16 Nov 2011)
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Protein

Cation-transporting ATPase

Gene

Atp13a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-transporting ATPaseUniRule annotation (EC:7.2.2.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atp13a1Imported
Synonyms:Atp13a1_predictedImported
ORF Names:rCG_38664Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
1306033, Atp13a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 84HelicalUniRule annotationAdd BLAST24
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei439 – 458HelicalUniRule annotationAdd BLAST20
Transmembranei1045 – 1066HelicalUniRule annotationAdd BLAST22
Transmembranei1096 – 1114HelicalUniRule annotationAdd BLAST19
Transmembranei1126 – 1144HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010776, Expressed in pancreas and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000015247

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni884 – 925DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi897 – 913PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0209, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075064

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001828_4_1_1

KEGG Orthology (KO)

More...
KOi
K14950

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFAPKQK

Database of Orthologous Groups

More...
OrthoDBi
172453at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300725

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 2 hits
TIGR01657, P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3V7I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVVGNAVPC GARPGGARGS GSPQPGRPGL AAGPALIASG DELVAAVWPY
60 70 80 90 100
RRLALLRRLT VLPFAGLLYP AWLGAAASGC WGWGNSWTQI PEAALLALAT
110 120 130 140 150
ICLAHALTIL SGHWSVHAHC ALTCTPEHDP NKVTFVKVVP TPNNGSTELV
160 170 180 190 200
ALHRDKGEDG LEVLSFEFQK IKYSYDALEK KQFLPVAFPV GNAFSYYQSN
210 220 230 240 250
RGFQEDSDIR AAEKKFGSNK AEMAVPDFSE LFKERATAPF FVFQVFCVGL
260 270 280 290 300
WCLDEYWYYS VFTLSMLVAF EASLVQQQMR NMSEIRKMGN KPHMIQVYRS
310 320 330 340 350
RKWRPIASDD IVPGDIVSIG RSPQENLVPC DVLLLRGRCI VDEAMLTGES
360 370 380 390 400
VPQMKEPIED LSPDRVLDLQ ADARLHVIFG GTKVVQHIPP QKATSGLKPV
410 420 430 440 450
DNGCVAFVLR TGFNTSQGKL LRTILFGVKR VTANNLETFI FILFLLVFAI
460 470 480 490 500
AAAAYVWIEG TKDPSRNRYK LFLECTLILT SVVPPELPIE LSLAVNTSLI
510 520 530 540 550
ALAKLYMYCT EPFRIPFAGK VEVCCFDKTG TLTSDSLVVR GVAGLRDGKE
560 570 580 590 600
VTPVSSIPIE THRALASCHS LMQLDDGTLV GDPLEKAMLT AVDWTLTKDE
610 620 630 640 650
KVFPRSIKTQ GLKIHQRFHF ASALKRMSVL ASYEKLGSTD LCYIAAVKGA
660 670 680 690 700
PETLHSMFSQ CPPDYHHIHT EISREGARVL ALGYKELGHL THQQAREVKR
710 720 730 740 750
EALECSLKFV GFIVVSCPLK ADSKAVIREI QNASHRVVMI TGDNPLTACH
760 770 780 790 800
VAQELHFIDK AHTLILHPPS EKGQPCEWRS IDNSIVLPLT LGSPKALALE
810 820 830 840 850
HALCLTGDGL AHLQAVDPQQ LLHLIPHVQV FARVAPKQKE FVITSLKELG
860 870 880 890 900
YVTLMCGDGT NDVGALKHAD VGVALLANAP ERVVERRRRP RDSPVLSNSG
910 920 930 940 950
PRVSRSTKQK SALLSPEEPP ASHRDRLSQV LRDLEDESTP IVKLGDASIA
960 970 980 990 1000
APFTSKLSSI QCICHVIKQG RCTLVTTLQM FKILALNALI LAYSQSVLYL
1010 1020 1030 1040 1050
EGVKFSDFQA TLQGLLLAGC FLFISRSKPL KTLSRERPLP NIFNLYTILT
1060 1070 1080 1090 1100
VMLQFSVHFL SLVYLYREAQ ARSPEKQEQF VDLYKEFEPS LVNSTVYIMA
1110 1120 1130 1140 1150
MAMQMATFAI NYKGPPFMES LPENKPLVWS LAVSLMAIMG LLLGSSPDFN
1160 1170 1180 1190
SQFGLVDIPV EFKLVIGQVL ALDFGLALLA DRVLQFFLGT PKLRVPS
Length:1,197
Mass (Da):131,916
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FC6EB2254ED8FC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07024882 Genomic DNA No translation available.
CH474031 Genomic DNA Translation: EDL90620.1

NCBI Reference Sequences

More...
RefSeqi
NP_001099549.2, NM_001106079.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000015247; ENSRNOP00000015247; ENSRNOG00000010776

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
290673

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:290673

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07024882 Genomic DNA No translation available.
CH474031 Genomic DNA Translation: EDL90620.1
RefSeqiNP_001099549.2, NM_001106079.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015247

Genome annotation databases

EnsembliENSRNOT00000015247; ENSRNOP00000015247; ENSRNOG00000010776
GeneIDi290673
KEGGirno:290673

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57130
RGDi1306033, Atp13a1

Phylogenomic databases

eggNOGiKOG0209, Eukaryota
GeneTreeiENSGT00550000075064
HOGENOMiCLU_001828_4_1_1
KOiK14950
OMAiRFAPKQK
OrthoDBi172453at2759
TreeFamiTF300725

Enzyme and pathway databases

ReactomeiR-RNO-936837, Ion transport by P-type ATPases

Gene expression databases

BgeeiENSRNOG00000010776, Expressed in pancreas and 20 other tissues

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 2 hits
TIGR01657, P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V7I3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V7I3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 12, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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