UniProtKB - G3V798 (G3V798_RAT)
Protein
Submitted name:
Serine and arginine-rich-splicing factor 4
Gene
Srsf4
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- mRNA binding Source: GO_Central
- RNA binding Source: GO_Central
- sequence-specific mRNA binding Source: RGD
GO - Biological processi
- hematopoietic progenitor cell differentiation Source: RGD
- mRNA cis splicing, via spliceosome Source: GO_Central
- negative regulation of mRNA splicing, via spliceosome Source: RGD
- regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
- response to insulin Source: RGD
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | mRNA processing, mRNA splicingARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-RNO-72163, mRNA Splicing - Major Pathway R-RNO-72187, mRNA 3'-end processing R-RNO-73856, RNA Polymerase II Transcription Termination |
Names & Taxonomyi
Protein namesi | Submitted name: Serine and arginine-rich-splicing factor 4ImportedSubmitted name: Similar to Sfrs4 protein (Predicted)Imported |
Gene namesi | ORF Names:rCG_31003Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1561347, Srsf4 |
Subcellular locationi
Nucleus
- nuclear speck Source: GO_Central
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000010007, Expressed in thymus and 20 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | G3V798, 1 interactor |
STRINGi | 10116.ENSRNOP00000013301 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 72 | RRMInterPro annotationAdd BLAST | 71 | |
Domaini | 104 – 177 | RRMInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 95 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 169 – 488 | DisorderedSequence analysisAdd BLAST | 320 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 182 – 242 | BasicSequence analysisAdd BLAST | 61 | |
Compositional biasi | 243 – 330 | PolyampholyteSequence analysisAdd BLAST | 88 | |
Compositional biasi | 331 – 353 | BasicSequence analysisAdd BLAST | 23 | |
Compositional biasi | 374 – 433 | PolyampholyteSequence analysisAdd BLAST | 60 | |
Compositional biasi | 434 – 455 | PolarSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the splicing factor SR family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG0106, Eukaryota |
GeneTreei | ENSGT00940000156213 |
HOGENOMi | CLU_012062_34_2_1 |
OMAi | NPPTESR |
OrthoDBi | 1315388at2759 |
Family and domain databases
CDDi | cd12337, RRM1_SRSF4_like, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR035585, RRM1_SRSF4-like IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
i Sequence
Sequence statusi: Complete.
G3V798-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD
60 70 80 90 100
AVYELNGKDL CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT
110 120 130 140 150
RTEYRLIVEN LSSRCSWQDL KDYMRQAGEV TYADAHKGRK NEGVIEFVSY
160 170 180 190 200
SDMKRALEKL DGTEVNGRKI RLVEDKPGSR RRRSYSRSRS HSRSRSRSRH
210 220 230 240 250
SRKSRSRSGS SKSSHSKSRS RSRSGSHSRS KSRSRSQSRS RSKKEKSRSP
260 270 280 290 300
SKDNKSRSRS RSPDKSRSKS KDHAEDKLQN NDSAGKAKSH SPSRHDSKSR
310 320 330 340 350
SRSQERRAEE ERRSSTSRGH SQEKSLLKSR SRSRSKVGSR SRSRSKSKDK
360 370 380 390 400
RKGRKRSREE SRSRSRSKSE RSRKHSSKRD SKVSSSSSKK KKGDTDHSRS
410 420 430 440 450
PSRSVSKERE HATAEPGQRE SRAEGESEGP NPEPRARSRS TSKSKPSLPA
460 470 480
ESRSRSKSAS KTRSRSKSPS RSASRSPSRS RSRSHSRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07050069 Genomic DNA No translation available. CH473968 Genomic DNA Translation: EDL80612.1 |
RefSeqi | NP_001102155.1, NM_001108685.2 |
Genome annotation databases
Ensembli | ENSRNOT00000013301; ENSRNOP00000013301; ENSRNOG00000010007 |
GeneIDi | 362612 |
KEGGi | rno:362612 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07050069 Genomic DNA No translation available. CH473968 Genomic DNA Translation: EDL80612.1 |
RefSeqi | NP_001102155.1, NM_001108685.2 |
3D structure databases
SMRi | G3V798 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | G3V798, 1 interactor |
STRINGi | 10116.ENSRNOP00000013301 |
Proteomic databases
PRIDEi | G3V798 |
Genome annotation databases
Ensembli | ENSRNOT00000013301; ENSRNOP00000013301; ENSRNOG00000010007 |
GeneIDi | 362612 |
KEGGi | rno:362612 |
Organism-specific databases
CTDi | 6429 |
RGDi | 1561347, Srsf4 |
Phylogenomic databases
eggNOGi | KOG0106, Eukaryota |
GeneTreei | ENSGT00940000156213 |
HOGENOMi | CLU_012062_34_2_1 |
OMAi | NPPTESR |
OrthoDBi | 1315388at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-RNO-72163, mRNA Splicing - Major Pathway R-RNO-72187, mRNA 3'-end processing R-RNO-73856, RNA Polymerase II Transcription Termination |
Gene expression databases
Bgeei | ENSRNOG00000010007, Expressed in thymus and 20 other tissues |
Family and domain databases
CDDi | cd12337, RRM1_SRSF4_like, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR035585, RRM1_SRSF4-like IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V798_RAT | |
Accessioni | G3V798Primary (citable) accession number: G3V798 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |