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Protein
Submitted name:

GLI family zinc finger 1

Gene

Gli1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Names & Taxonomyi

Protein namesi
Submitted name:
GLI family zinc finger 1Imported
Submitted name:
GLI-Kruppel family member GLI1Imported
Gene namesi
Name:Gli1Imported
ORF Names:rCG_59661Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621673 Gli1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiG3V6X8

Expressioni

Gene expression databases

BgeeiENSRNOG00000025120 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009803

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 267C2H2-typeInterPro annotationAdd BLAST33
Domaini268 – 300C2H2-typeInterPro annotationAdd BLAST33
Domaini301 – 330C2H2-typeInterPro annotationAdd BLAST30
Domaini331 – 361C2H2-typeInterPro annotationAdd BLAST31
Domaini362 – 392C2H2-typeInterPro annotationAdd BLAST31

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
KOiK16797
OMAiFCHQANL
OrthoDBiEOG091G01XS
TreeFamiTF350216

Family and domain databases

InterProiView protein in InterPro
IPR032850 GLI1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF2 PTHR19818:SF2, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

G3V6X8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNPMTSPQV NSYGEPCCLR PLPSQGVPSM GTEGLSGLPF CHQANFMSGS
60 70 80 90 100
QGYGSARETS SCTEGSLFPP PRSSVKLTKK RALSISPLSD ASLDLQTVIR
110 120 130 140 150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPPQMS HQKGTSPPYG
160 170 180 190 200
VQPCVPHDST QGSMMLHPQS RGPRATCQLK SELDIMVGKC PEEPLEGDMS
210 220 230 240 250
SPNSTSTQDH LLGMLDGRED LEREEKPEPE SVYETDCRWD GCSQEFDSQE
260 270 280 290 300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP
310 320 330 340 350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEQEGCSK AFSNASDRAK
360 370 380 390 400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD
410 420 430 440 450
GPLPRAQPLS TVEPKREREG GSGREESRLT VPEGTMPQQS PGAQSSCSSD
460 470 480 490 500
HSPAGSAANT DSGVEMAGNA GGSTEDLSSL DEGPCVAATG LSTLRRLENL
510 520 530 540 550
RLDQLHQLRP IGSRGLKLPS LTHAGAPVSR RLGPPVSLDR RSSSSSSISS
560 570 580 590 600
AYTVSRRSSL ASPFPPGSPP ENGASSLPGL TPAQHYMLRA RYASARGSGT
610 620 630 640 650
PPTAAHSLDR IGGLPAPPWR SRAEYPGYNP NAGVTRRASD PARAADHPAP
660 670 680 690 700
ARVQRFKSLG CVHTPPSVAT GRNFDPHLPT SVYSPQPPSI TENVAMDTRG
710 720 730 740 750
LQGELEVGTS MMGNDLNPYM DFSSADTLGY GGPEGTAAES YGSKGPGSLP
760 770 780 790 800
LGPGPPTNYG PGHCAQQVSY PDPTPETWGE FPSHAGVYPG TKALGTAYNQ
810 820 830 840 850
CPRLEHYGQV QVKPEQGCPV GSDSTGLAPC LNAHPSEGSP DPQPLFSHHS
860 870 880 890 900
QLPPPQYLQS GPYPQPPHDC LSLESRPGLN FNPSSHSTGQ LKAQLLCNYV
910 920 930 940 950
QSQQELLWEG RSRGGIPNQE LPYQSPKFLG GSQVSQSPTK VPAAAAAATF
960 970 980 990 1000
GSGFASPALA NHKSVSYPAP SPCHETFTMG VNRPPHRPAA PPRLLPPLPP
1010 1020 1030 1040 1050
CYGPLKVGDA NPSCGHPEVG RLGAGPALYP PPEGQVCNPL DSLDLDNTQL
1060 1070 1080 1090 1100
DFVAILDEAQ GLSPPPSHEQ GDSSKNTPPP SGPPNMAVGN MSVLLGSLPG

ETQFLNSSA
Length:1,109
Mass (Da):118,219
Last modified:November 16, 2011 - v1
Checksum:i15EED030C411999F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114111 Genomic DNA No translation available.
CH473950 Genomic DNA Translation: EDM16470.1
RefSeqiNP_001178839.1, NM_001191910.1
XP_006241504.1, XM_006241442.3
XP_006241505.1, XM_006241443.3
XP_008763597.1, XM_008765375.2
XP_017450120.1, XM_017594631.1
UniGeneiRn.219157

Genome annotation databases

EnsembliENSRNOT00000009803; ENSRNOP00000009803; ENSRNOG00000025120
GeneIDi140589
KEGGirno:140589

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114111 Genomic DNA No translation available.
CH473950 Genomic DNA Translation: EDM16470.1
RefSeqiNP_001178839.1, NM_001191910.1
XP_006241504.1, XM_006241442.3
XP_006241505.1, XM_006241443.3
XP_008763597.1, XM_008765375.2
XP_017450120.1, XM_017594631.1
UniGeneiRn.219157

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009803

Proteomic databases

PRIDEiG3V6X8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009803; ENSRNOP00000009803; ENSRNOG00000025120
GeneIDi140589
KEGGirno:140589

Organism-specific databases

CTDi2735
RGDi621673 Gli1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
KOiK16797
OMAiFCHQANL
OrthoDBiEOG091G01XS
TreeFamiTF350216

Enzyme and pathway databases

ReactomeiR-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Gene expression databases

BgeeiENSRNOG00000025120 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR032850 GLI1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF2 PTHR19818:SF2, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiG3V6X8_RAT
AccessioniPrimary (citable) accession number: G3V6X8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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