GLI family zinc finger 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis."
    Hu M.C., Mo R., Bhella S., Wilson C.W., Chuang P.T., Hui C.C., Rosenblum N.D.
    Development 133:569-578(2006) [PubMed] [Europe PMC] [Abstract]
  • "Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning."
    Vokes S.A., Ji H., McCuine S., Tenzen T., Giles S., Zhong S., Longabaugh W.J., Davidson E.H., Wong W.H., McMahon A.P.
    Development 134:1977-1989(2007) [PubMed] [Europe PMC] [Abstract]
  • "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."
    Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F.
    Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain."
    Saitsu H., Komada M., Suzuki M., Nakayama R., Motoyama J., Shiota K., Ishibashi M.
    Dev. Dyn. 232:282-292(2005) [PubMed] [Europe PMC] [Abstract]
  • "A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro."
    Sasaki H., Hui C., Nakafuku M., Kondoh H.
    Development 124:1313-1322(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning."
    Vokes S.A., Ji H., McCuine S., Tenzen T., Giles S., Zhong S., Longabaugh W.J., Davidson E.H., Wong W.H., McMahon A.P.
    Development 134:1977-1989(2007) [PubMed] [Europe PMC] [Abstract]
• microtubule binding Source: RGDInferred from sequence orthologyⁱ
  • "GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene."
    Kroft T.L., Patterson J., Won Yoon J., Doglio L., Walterhouse D.O., Iannaccone P.M., Goldberg E.
    Biol. Reprod. 65:1663-1671(2001) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration."
    Nakamura I., Fernandez-Barrena M.G., Ortiz-Ruiz M.C., Almada L.L., Hu C., Elsawa S.F., Mills L.D., Romecin P.A., Gulaid K.H., Moser C.D., Han J.J., Vrabel A., Hanse E.A., Akogyeram N.A., Albrecht J.H., Monga S.P., Sanderson S.O., Prieto J., Roberts L.R., Fernandez-Zapico M.E.
    J. Biol. Chem. 288:21389-21398(2013) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA."
    Sakai-Kato K., Ishiguro A., Mikoshiba K., Aruga J., Utsunomiya-Tate N.
    Biochim. Biophys. Acta 1784:1011-1019(2008) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."
    Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F.
    Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Suppressing Wnt signaling by the hedgehog pathway through sFRP-1."
    He J., Sheng T., Stelter A.A., Li C., Zhang X., Sinha M., Luxon B.A., Xie J.
    J. Biol. Chem. 281:35598-35602(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• canonical Wnt signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration."
    Nakamura I., Fernandez-Barrena M.G., Ortiz-Ruiz M.C., Almada L.L., Hu C., Elsawa S.F., Mills L.D., Romecin P.A., Gulaid K.H., Moser C.D., Han J.J., Vrabel A., Hanse E.A., Akogyeram N.A., Albrecht J.H., Monga S.P., Sanderson S.O., Prieto J., Roberts L.R., Fernandez-Zapico M.E.
    J. Biol. Chem. 288:21389-21398(2013) [PubMed] [Europe PMC] [Abstract]
• cerebellar cortex morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation."
    Corrales J.D., Blaess S., Mahoney E.M., Joyner A.L.
    Development 133:1811-1821(2006) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral pattern formation Source: RGDInferred from sequence orthologyⁱ
  • "Complementary Gli activity mediates early patterning of the mouse visual system."
    Furimsky M., Wallace V.A.
    Dev. Dyn. 235:594-605(2006) [PubMed] [Europe PMC] [Abstract]
• epidermal cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
• liver regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "The role of hedgehog signaling pathway in liver regeneration."
    Cai Y., Zheng H., Gong W., Che Y., Jiang B.
    Hepatogastroenterology 58:2071-2076(2011) [PubMed] [Europe PMC] [Abstract]
  • "Significance of sonic hedgehog signaling after massive hepatectomy in a rat."
    Hanaoka J., Shimada M., Utsunomiya T., Morine Y., Imura S., Ikemoto T., Mori H.
    Surg. Today 43:300-307(2013) [PubMed] [Europe PMC] [Abstract]
• lung development Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Suppressing Wnt signaling by the hedgehog pathway through sFRP-1."
    He J., Sheng T., Stelter A.A., Li C., Zhang X., Sinha M., Luxon B.A., Xie J.
    J. Biol. Chem. 281:35598-35602(2006) [PubMed] [Europe PMC] [Abstract]
• notochord regression Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
• pituitary gland development Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1."
    Zhang J.S., Zhao Y., Lv Y., Liu P.Y., Ruan J.X., Sun Y.L., Gong T.X., Wan N., Qiu G.R.
    Gene 626:426-432(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle G1/S phase transition Source: RGDInferred from sequence orthologyⁱ
  • "miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1."
    Zhang J.S., Zhao Y., Lv Y., Liu P.Y., Ruan J.X., Sun Y.L., Gong T.X., Wan N., Qiu G.R.
    Gene 626:426-432(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: RGDInferred from sequence orthologyⁱ
  • "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."
    Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F.
    Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA replication Source: RGDInferred from sequence orthologyⁱ
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of smoothened signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Suppressing Wnt signaling by the hedgehog pathway through sFRP-1."
    He J., Sheng T., Stelter A.A., Li C., Zhang X., Sinha M., Luxon B.A., Xie J.
    J. Biol. Chem. 281:35598-35602(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Physical and functional interactions between Zic and Gli proteins."
    Koyabu Y., Nakata K., Mizugishi K., Aruga J., Mikoshiba K.
    J. Biol. Chem. 276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract]
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
  • "Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain."
    Saitsu H., Komada M., Suzuki M., Nakayama R., Motoyama J., Shiota K., Ishibashi M.
    Dev. Dyn. 232:282-292(2005) [PubMed] [Europe PMC] [Abstract]
  • "Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function."
    Haycraft C.J., Banizs B., Aydin-Son Y., Zhang Q., Michaud E.J., Yoder B.K.
    PLoS Genet. 1:e53-e53(2005) [PubMed] [Europe PMC] [Abstract]
  • "The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis."
    Borello U., Berarducci B., Murphy P., Bajard L., Buffa V., Piccolo S., Buckingham M., Cossu G.
    Development 133:3723-3732(2006) [PubMed] [Europe PMC] [Abstract]
  • "Suppressing Wnt signaling by the hedgehog pathway through sFRP-1."
    He J., Sheng T., Stelter A.A., Li C., Zhang X., Sinha M., Luxon B.A., Xie J.
    J. Biol. Chem. 281:35598-35602(2006) [PubMed] [Europe PMC] [Abstract]
  • "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."
    Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F.
    Cancer Res. 69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb."
    Wang B., Fallon J.F., Beachy P.A.
    Cell 100:423-434(2000) [PubMed] [Europe PMC] [Abstract]
  • "Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma."
    Regl G., Neill G.W., Eichberger T., Kasper M., Ikram M.S., Koller J., Hintner H., Quinn A.G., Frischauf A.M., Aberger F.
    Oncogene 21:5529-5539(2002) [PubMed] [Europe PMC] [Abstract]
  • "Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation."
    Pan Y., Bai C.B., Joyner A.L., Wang B.
    Mol. Cell. Biol. 26:3365-3377(2006) [PubMed] [Europe PMC] [Abstract]
  • "Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning."
    Vokes S.A., Ji H., McCuine S., Tenzen T., Giles S., Zhong S., Longabaugh W.J., Davidson E.H., Wong W.H., McMahon A.P.
    Development 134:1977-1989(2007) [PubMed] [Europe PMC] [Abstract]
  • "Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration."
    Nakamura I., Fernandez-Barrena M.G., Ortiz-Ruiz M.C., Almada L.L., Hu C., Elsawa S.F., Mills L.D., Romecin P.A., Gulaid K.H., Moser C.D., Han J.J., Vrabel A., Hanse E.A., Akogyeram N.A., Albrecht J.H., Monga S.P., Sanderson S.O., Prieto J., Roberts L.R., Fernandez-Zapico M.E.
    J. Biol. Chem. 288:21389-21398(2013) [PubMed] [Europe PMC] [Abstract]
  • "A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro."
    Sasaki H., Hui C., Nakafuku M., Kondoh H.
    Development 124:1313-1322(1997) [PubMed] [Europe PMC] [Abstract]
• prostate gland development Source: RGDInferred from expression patternⁱ
  • "Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching."
    Pu Y., Huang L., Prins G.S.
    Dev. Biol. 273:257-275(2004) [PubMed] [Europe PMC] [Abstract]
• proximal/distal pattern formation Source: RGDInferred from sequence orthologyⁱ
  • "Complementary Gli activity mediates early patterning of the mouse visual system."
    Furimsky M., Wallace V.A.
    Dev. Dyn. 235:594-605(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of hepatocyte proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration."
    Nakamura I., Fernandez-Barrena M.G., Ortiz-Ruiz M.C., Almada L.L., Hu C., Elsawa S.F., Mills L.D., Romecin P.A., Gulaid K.H., Moser C.D., Han J.J., Vrabel A., Hanse E.A., Akogyeram N.A., Albrecht J.H., Monga S.P., Sanderson S.O., Prieto J., Roberts L.R., Fernandez-Zapico M.E.
    J. Biol. Chem. 288:21389-21398(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification."
    Hojo H., Ohba S., Yano F., Saito T., Ikeda T., Nakajima K., Komiyama Y., Nakagata N., Suzuki K., Takato T., Kawaguchi H., Chung U.I.
    J. Biol. Chem. 287:17860-17869(2012) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration."
    Nakamura I., Fernandez-Barrena M.G., Ortiz-Ruiz M.C., Almada L.L., Hu C., Elsawa S.F., Mills L.D., Romecin P.A., Gulaid K.H., Moser C.D., Han J.J., Vrabel A., Hanse E.A., Akogyeram N.A., Albrecht J.H., Monga S.P., Sanderson S.O., Prieto J., Roberts L.R., Fernandez-Zapico M.E.
    J. Biol. Chem. 288:21389-21398(2013) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning."
    Mariani F.V., Ahn C.P., Martin G.R.
    Nature 453:401-405(2008) [PubMed] [Europe PMC] [Abstract]
  • "Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity."
    Wall D.S., Mears A.J., McNeill B., Mazerolle C., Thurig S., Wang Y., Kageyama R., Wallace V.A.
    J. Cell Biol. 184:101-112(2009) [PubMed] [Europe PMC] [Abstract]
  • "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."
    Maloverjan A., Piirsoo M., Michelson P., Kogerman P., Osterlund T.
    Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
  • "Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth."
    Dassule H.R., McMahon A.P.
    Dev. Biol. 202:215-227(1998) [PubMed] [Europe PMC] [Abstract]
• smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation."
    Corrales J.D., Blaess S., Mahoney E.M., Joyner A.L.
    Development 133:1811-1821(2006) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: RGDInferred from sequence orthologyⁱ
  • "GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene."
    Kroft T.L., Patterson J., Won Yoon J., Doglio L., Walterhouse D.O., Iannaccone P.M., Goldberg E.
    Biol. Reprod. 65:1663-1671(2001) [PubMed] [Europe PMC] [Abstract]
• ventral midline development Source: RGDInferred from sequence orthologyⁱ
  • "Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation."
    Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L.
    Development 127:1593-1605(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• microtubule binding Source: RGDInferred from sequence orthologyⁱ
  • "GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene."
    Kroft T.L., Patterson J., Won Yoon J., Doglio L., Walterhouse D.O., Iannaccone P.M., Goldberg E.
    Biol. Reprod. 65:1663-1671(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFNPMTSPQV NSYGEPCCLR PLPSQGVPSM GTEGLSGLPF CHQANFMSGS 
        60         70         80         90        100
QGYGSARETS SCTEGSLFPP PRSSVKLTKK RALSISPLSD ASLDLQTVIR 
       110        120        130        140        150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPPQMS HQKGTSPPYG 
       160        170        180        190        200
VQPCVPHDST QGSMMLHPQS RGPRATCQLK SELDIMVGKC PEEPLEGDMS 
       210        220        230        240        250
SPNSTSTQDH LLGMLDGRED LEREEKPEPE SVYETDCRWD GCSQEFDSQE 
       260        270        280        290        300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 
       310        320        330        340        350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEQEGCSK AFSNASDRAK 
       360        370        380        390        400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD 
       410        420        430        440        450
GPLPRAQPLS TVEPKREREG GSGREESRLT VPEGTMPQQS PGAQSSCSSD 
       460        470        480        490        500
HSPAGSAANT DSGVEMAGNA GGSTEDLSSL DEGPCVAATG LSTLRRLENL 
       510        520        530        540        550
RLDQLHQLRP IGSRGLKLPS LTHAGAPVSR RLGPPVSLDR RSSSSSSISS 
       560        570        580        590        600
AYTVSRRSSL ASPFPPGSPP ENGASSLPGL TPAQHYMLRA RYASARGSGT 
       610        620        630        640        650
PPTAAHSLDR IGGLPAPPWR SRAEYPGYNP NAGVTRRASD PARAADHPAP 
       660        670        680        690        700
ARVQRFKSLG CVHTPPSVAT GRNFDPHLPT SVYSPQPPSI TENVAMDTRG 
       710        720        730        740        750
LQGELEVGTS MMGNDLNPYM DFSSADTLGY GGPEGTAAES YGSKGPGSLP 
       760        770        780        790        800
LGPGPPTNYG PGHCAQQVSY PDPTPETWGE FPSHAGVYPG TKALGTAYNQ 
       810        820        830        840        850
CPRLEHYGQV QVKPEQGCPV GSDSTGLAPC LNAHPSEGSP DPQPLFSHHS 
       860        870        880        890        900
QLPPPQYLQS GPYPQPPHDC LSLESRPGLN FNPSSHSTGQ LKAQLLCNYV 
       910        920        930        940        950
QSQQELLWEG RSRGGIPNQE LPYQSPKFLG GSQVSQSPTK VPAAAAAATF 
       960        970        980        990       1000
GSGFASPALA NHKSVSYPAP SPCHETFTMG VNRPPHRPAA PPRLLPPLPP 
      1010       1020       1030       1040       1050
CYGPLKVGDA NPSCGHPEVG RLGAGPALYP PPEGQVCNPL DSLDLDNTQL 
      1060       1070       1080       1090       1100
DFVAILDEAQ GLSPPPSHEQ GDSSKNTPPP SGPPNMAVGN MSVLLGSLPG 

ETQFLNSSA                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ