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UniProtKB - G3V6X8 (G3V6X8_RAT)
Protein
Submitted name:
GLI family zinc finger 1
Gene
Gli1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- metal ion binding Source: UniProtKB-KW
- microtubule binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- canonical Wnt signaling pathway Source: RGD
- cerebellar cortex morphogenesis Source: RGD
- dorsal/ventral pattern formation Source: RGD
- epidermal cell differentiation Source: RGD
- liver regeneration Source: RGD
- lung development Source: RGD
- negative regulation of canonical Wnt signaling pathway Source: RGD
- negative regulation of hh target transcription factor activity Source: Ensembl
- notochord regression Source: RGD
- osteoblast differentiation Source: RGD
- pituitary gland development Source: RGD
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of cell cycle G1/S phase transition Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of DNA replication Source: RGD
- positive regulation of smoothened signaling pathway Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- prostate gland development Source: RGD
- proximal/distal pattern formation Source: RGD
- regulation of hepatocyte proliferation Source: RGD
- regulation of osteoblast differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to wounding Source: RGD
- smoothened signaling pathway Source: RGD
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RGD
- spermatogenesis Source: RGD
- ventral midline development Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-5610780, Degradation of GLI1 by the proteasome R-RNO-5610787, Hedgehog 'off' state R-RNO-5632684, Hedgehog 'on' state |
Names & Taxonomyi
Protein namesi | Submitted name: GLI family zinc finger 1ImportedSubmitted name: GLI-Kruppel family member GLI1Imported |
Gene namesi | Name:Gli1Imported ORF Names:rCG_59661Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621673, Gli1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytoskeleton
- axoneme Source: RGD
Cytosol
- GLI-SUFU complex Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000025120, Expressed in female gonad and 19 other tissues |
Interactioni
GO - Molecular functioni
- microtubule binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009803 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 235 – 267 | C2H2-typeInterPro annotationAdd BLAST | 33 | |
Domaini | 268 – 300 | C2H2-typeInterPro annotationAdd BLAST | 33 | |
Domaini | 301 – 330 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 331 – 361 | C2H2-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 362 – 392 | C2H2-typeInterPro annotationAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 375 – 482 | DisorderedSequence analysisAdd BLAST | 108 | |
Regioni | 525 – 580 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 595 – 647 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 670 – 689 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 829 – 886 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 1060 – 1109 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 375 – 402 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 411 – 426 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 432 – 476 | Polar residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 538 – 562 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160235 |
HOGENOMi | CLU_003666_0_0_1 |
OMAi | HENFAVG |
OrthoDBi | 135929at2759 |
TreeFami | TF350216 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032850, GLI1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 2 hits PTHR45718:SF2, PTHR45718:SF2, 2 hits |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
G3V6X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNPMTSPQV NSYGEPCCLR PLPSQGVPSM GTEGLSGLPF CHQANFMSGS
60 70 80 90 100
QGYGSARETS SCTEGSLFPP PRSSVKLTKK RALSISPLSD ASLDLQTVIR
110 120 130 140 150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPPQMS HQKGTSPPYG
160 170 180 190 200
VQPCVPHDST QGSMMLHPQS RGPRATCQLK SELDIMVGKC PEEPLEGDMS
210 220 230 240 250
SPNSTSTQDH LLGMLDGRED LEREEKPEPE SVYETDCRWD GCSQEFDSQE
260 270 280 290 300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP
310 320 330 340 350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEQEGCSK AFSNASDRAK
360 370 380 390 400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD
410 420 430 440 450
GPLPRAQPLS TVEPKREREG GSGREESRLT VPEGTMPQQS PGAQSSCSSD
460 470 480 490 500
HSPAGSAANT DSGVEMAGNA GGSTEDLSSL DEGPCVAATG LSTLRRLENL
510 520 530 540 550
RLDQLHQLRP IGSRGLKLPS LTHAGAPVSR RLGPPVSLDR RSSSSSSISS
560 570 580 590 600
AYTVSRRSSL ASPFPPGSPP ENGASSLPGL TPAQHYMLRA RYASARGSGT
610 620 630 640 650
PPTAAHSLDR IGGLPAPPWR SRAEYPGYNP NAGVTRRASD PARAADHPAP
660 670 680 690 700
ARVQRFKSLG CVHTPPSVAT GRNFDPHLPT SVYSPQPPSI TENVAMDTRG
710 720 730 740 750
LQGELEVGTS MMGNDLNPYM DFSSADTLGY GGPEGTAAES YGSKGPGSLP
760 770 780 790 800
LGPGPPTNYG PGHCAQQVSY PDPTPETWGE FPSHAGVYPG TKALGTAYNQ
810 820 830 840 850
CPRLEHYGQV QVKPEQGCPV GSDSTGLAPC LNAHPSEGSP DPQPLFSHHS
860 870 880 890 900
QLPPPQYLQS GPYPQPPHDC LSLESRPGLN FNPSSHSTGQ LKAQLLCNYV
910 920 930 940 950
QSQQELLWEG RSRGGIPNQE LPYQSPKFLG GSQVSQSPTK VPAAAAAATF
960 970 980 990 1000
GSGFASPALA NHKSVSYPAP SPCHETFTMG VNRPPHRPAA PPRLLPPLPP
1010 1020 1030 1040 1050
CYGPLKVGDA NPSCGHPEVG RLGAGPALYP PPEGQVCNPL DSLDLDNTQL
1060 1070 1080 1090 1100
DFVAILDEAQ GLSPPPSHEQ GDSSKNTPPP SGPPNMAVGN MSVLLGSLPG
ETQFLNSSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114111 Genomic DNA No translation available. CH473950 Genomic DNA Translation: EDM16470.1 |
RefSeqi | NP_001178839.1, NM_001191910.1 XP_006241504.1, XM_006241442.3 XP_006241505.1, XM_006241443.3 XP_008763597.1, XM_008765375.2 XP_017450120.1, XM_017594631.1 |
Genome annotation databases
Ensembli | ENSRNOT00000009803; ENSRNOP00000009803; ENSRNOG00000025120 |
GeneIDi | 140589 |
KEGGi | rno:140589 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114111 Genomic DNA No translation available. CH473950 Genomic DNA Translation: EDM16470.1 |
RefSeqi | NP_001178839.1, NM_001191910.1 XP_006241504.1, XM_006241442.3 XP_006241505.1, XM_006241443.3 XP_008763597.1, XM_008765375.2 XP_017450120.1, XM_017594631.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009803 |
Genome annotation databases
Ensembli | ENSRNOT00000009803; ENSRNOP00000009803; ENSRNOG00000025120 |
GeneIDi | 140589 |
KEGGi | rno:140589 |
Organism-specific databases
CTDi | 2735 |
RGDi | 621673, Gli1 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160235 |
HOGENOMi | CLU_003666_0_0_1 |
OMAi | HENFAVG |
OrthoDBi | 135929at2759 |
TreeFami | TF350216 |
Enzyme and pathway databases
Reactomei | R-RNO-5610780, Degradation of GLI1 by the proteasome R-RNO-5610787, Hedgehog 'off' state R-RNO-5632684, Hedgehog 'on' state |
Gene expression databases
Bgeei | ENSRNOG00000025120, Expressed in female gonad and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032850, GLI1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 2 hits PTHR45718:SF2, PTHR45718:SF2, 2 hits |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V6X8_RAT | |
Accessioni | G3V6X8Primary (citable) accession number: G3V6X8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | January 19, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |