Gli1

Functionⁱ

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
microtubule binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

canonical Wnt signaling pathway Source: Ensembl
cerebellar cortex morphogenesis Source: Ensembl
dorsal/ventral pattern formation Source: Ensembl
epidermal cell differentiation Source: Ensembl
liver regeneration
Source: RGD
Inferred from expression patternⁱ
- 22024090
- 22790641
lung development Source: Ensembl
negative regulation of canonical Wnt signaling pathway Source: Ensembl
notochord regression Source: Ensembl
osteoblast differentiation Source: Ensembl
pituitary gland development Source: Ensembl
positive regulation of cardiac muscle cell proliferation Source: Ensembl
positive regulation of cell cycle G1/S phase transition Source: Ensembl
positive regulation of DNA replication Source: Ensembl
positive regulation of smoothened signaling pathway Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
prostate gland development
Source: RGD
Inferred from expression patternⁱ
- 15328011
proximal/distal pattern formation Source: Ensembl
regulation of hepatocyte proliferation Source: Ensembl
regulation of osteoblast differentiation Source: Ensembl
response to wounding Source: Ensembl
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
spermatogenesis Source: Ensembl
ventral midline development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-5610780 Degradation of GLI1 by the proteasome R-RNO-5610787 Hedgehog 'off' state R-RNO-5632684 Hedgehog 'on' state

Reactomeⁱ

R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: GLI family zinc finger 1Imported Submitted name: GLI-Kruppel family member GLI1Imported
Gene namesⁱ	Name:Gli1Imported ORF Names:rCG_59661Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	621673 Gli1

RGDⁱ

621673 Gli1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	G3V6X8

PRIDEⁱ

G3V6X8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000025120 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000025120 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

GO - Molecular functionⁱ

microtubule binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000009803

STRINGⁱ

10116.ENSRNOP00000009803

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	235 – 267	C2H2-typeInterPro annotationAdd BLAST	33
Domainⁱ	268 – 300	C2H2-typeInterPro annotationAdd BLAST	33
Domainⁱ	301 – 330	C2H2-typeInterPro annotationAdd BLAST	30
Domainⁱ	331 – 361	C2H2-typeInterPro annotationAdd BLAST	31
Domainⁱ	362 – 392	C2H2-typeInterPro annotationAdd BLAST	31

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140802
KEGG Orthology (KO) More...KOⁱ	K16797
OMAⁱ	FCHQANL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01XS
TreeFamⁱ	TF350216

Family and domain databases

InterProⁱ	View protein in InterPro IPR032850 GLI1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR19818:SF2 PTHR19818:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

G3V6X8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFNPMTSPQV NSYGEPCCLR PLPSQGVPSM GTEGLSGLPF CHQANFMSGS 
        60         70         80         90        100
QGYGSARETS SCTEGSLFPP PRSSVKLTKK RALSISPLSD ASLDLQTVIR 
       110        120        130        140        150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPPQMS HQKGTSPPYG 
       160        170        180        190        200
VQPCVPHDST QGSMMLHPQS RGPRATCQLK SELDIMVGKC PEEPLEGDMS 
       210        220        230        240        250
SPNSTSTQDH LLGMLDGRED LEREEKPEPE SVYETDCRWD GCSQEFDSQE 
       260        270        280        290        300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 
       310        320        330        340        350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEQEGCSK AFSNASDRAK 
       360        370        380        390        400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD 
       410        420        430        440        450
GPLPRAQPLS TVEPKREREG GSGREESRLT VPEGTMPQQS PGAQSSCSSD 
       460        470        480        490        500
HSPAGSAANT DSGVEMAGNA GGSTEDLSSL DEGPCVAATG LSTLRRLENL 
       510        520        530        540        550
RLDQLHQLRP IGSRGLKLPS LTHAGAPVSR RLGPPVSLDR RSSSSSSISS 
       560        570        580        590        600
AYTVSRRSSL ASPFPPGSPP ENGASSLPGL TPAQHYMLRA RYASARGSGT 
       610        620        630        640        650
PPTAAHSLDR IGGLPAPPWR SRAEYPGYNP NAGVTRRASD PARAADHPAP 
       660        670        680        690        700
ARVQRFKSLG CVHTPPSVAT GRNFDPHLPT SVYSPQPPSI TENVAMDTRG 
       710        720        730        740        750
LQGELEVGTS MMGNDLNPYM DFSSADTLGY GGPEGTAAES YGSKGPGSLP 
       760        770        780        790        800
LGPGPPTNYG PGHCAQQVSY PDPTPETWGE FPSHAGVYPG TKALGTAYNQ 
       810        820        830        840        850
CPRLEHYGQV QVKPEQGCPV GSDSTGLAPC LNAHPSEGSP DPQPLFSHHS 
       860        870        880        890        900
QLPPPQYLQS GPYPQPPHDC LSLESRPGLN FNPSSHSTGQ LKAQLLCNYV 
       910        920        930        940        950
QSQQELLWEG RSRGGIPNQE LPYQSPKFLG GSQVSQSPTK VPAAAAAATF 
       960        970        980        990       1000
GSGFASPALA NHKSVSYPAP SPCHETFTMG VNRPPHRPAA PPRLLPPLPP 
      1010       1020       1030       1040       1050
CYGPLKVGDA NPSCGHPEVG RLGAGPALYP PPEGQVCNPL DSLDLDNTQL 
      1060       1070       1080       1090       1100
DFVAILDEAQ GLSPPPSHEQ GDSSKNTPPP SGPPNMAVGN MSVLLGSLPG 

ETQFLNSSA

Length:1,109

Mass (Da):118,219

Last modified:November 16, 2011 - v1

Checksum:ⁱ15EED030C411999F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC114111 Genomic DNA No translation available. CH473950 Genomic DNA Translation: EDM16470.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001178839.1, NM_001191910.1 XP_006241504.1, XM_006241442.3 XP_006241505.1, XM_006241443.3 XP_008763597.1, XM_008765375.2 XP_017450120.1, XM_017594631.1
UniGeneⁱ	Rn.219157

Genome annotation databases

Ensemblⁱ	ENSRNOT00000009803; ENSRNOP00000009803; ENSRNOG00000025120
GeneIDⁱ	140589
KEGGⁱ	rno:140589

Protein	Similar proteins		Species	Score	Length	Source
G3V6X8	Zinc finger transcription factor GLI (Fragment)		RAT		104	UniRef100_G3V6X8

Protein	Similar proteins		Species	Score	Length	Source
G3V6X8	Zinc finger protein GLI1		MOUSE		1111	UniRef90_P47806
Zinc finger transcription factor GLI (Fragment)		RAT		104
UPI000A31AF72		MUSCR		1112
UPI000A3086A7		MUSPA		1110
Gli1 protein		MOUSE		980
+1

Protein	Similar proteins		Species	Score	Length	Source
G3V6X8	Zinc finger protein GLI1	)	HUMAN		1106	UniRef50_P08151
Zinc finger protein GLI1		MOUSE		1111
GLI1 isoform 8 (Fragment)		PANTR		129
zinc finger protein GLI1		URSMA		1112
Uncharacterized protein		OTOGA		1108
+270

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC114111 Genomic DNA No translation available. CH473950 Genomic DNA Translation: EDM16470.1
RefSeqⁱ	NP_001178839.1, NM_001191910.1 XP_006241504.1, XM_006241442.3 XP_006241505.1, XM_006241443.3 XP_008763597.1, XM_008765375.2 XP_017450120.1, XM_017594631.1
UniGeneⁱ	Rn.219157

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000009803

STRINGⁱ

10116.ENSRNOP00000009803

Proteomic databases

PRIDEⁱ	G3V6X8

PRIDEⁱ

G3V6X8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000009803; ENSRNOP00000009803; ENSRNOG00000025120
GeneIDⁱ	140589
KEGGⁱ	rno:140589

Organism-specific databases

CTDⁱ	2735
RGDⁱ	621673 Gli1

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00900000140802
KOⁱ	K16797
OMAⁱ	FCHQANL
OrthoDBⁱ	EOG091G01XS
TreeFamⁱ	TF350216

Enzyme and pathway databases

Reactomeⁱ	R-RNO-5610780 Degradation of GLI1 by the proteasome R-RNO-5610787 Hedgehog 'off' state R-RNO-5632684 Hedgehog 'on' state

Reactomeⁱ

R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Gene expression databases

Bgeeⁱ	ENSRNOG00000025120 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000025120 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProⁱ	View protein in InterPro IPR032850 GLI1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR19818:SF2 PTHR19818:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3V6X8_RAT
Accessionⁱ	G3V6X8Primary (citable) accession number: G3V6X8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	November 7, 2018
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3V6X8 (G3V6X8_RAT)

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GLI family zinc finger 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ