GLI family zinc finger 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGD
• DNA binding Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• metal ion binding Source: UniProtKB-KW
• microtubule binding Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
• transcription cis-regulatory region binding Source: RGD

GO - Biological processⁱ

• canonical Wnt signaling pathway Source: RGD
• cerebellar cortex morphogenesis Source: RGD
• dorsal/ventral pattern formation Source: RGD
• epidermal cell differentiation Source: RGD
• liver regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "The role of hedgehog signaling pathway in liver regeneration."
    Cai Y., Zheng H., Gong W., Che Y., Jiang B.
    Hepatogastroenterology 58:2071-2076(2011) [PubMed] [Europe PMC] [Abstract]
  • "Significance of sonic hedgehog signaling after massive hepatectomy in a rat."
    Hanaoka J., Shimada M., Utsunomiya T., Morine Y., Imura S., Ikemoto T., Mori H.
    Surg Today 43:300-307(2013) [PubMed] [Europe PMC] [Abstract]
• lung development Source: RGD
• negative regulation of canonical Wnt signaling pathway Source: RGD
• negative regulation of hh target transcription factor activity Source: Ensembl
• notochord regression Source: RGD
• osteoblast differentiation Source: RGD
• pituitary gland development Source: RGD
• positive regulation of cardiac muscle cell proliferation Source: RGD
• positive regulation of cell cycle G1/S phase transition Source: RGD
• positive regulation of cell population proliferation Source: RGD
• positive regulation of DNA replication Source: RGD
• positive regulation of smoothened signaling pathway Source: RGD
• positive regulation of transcription, DNA-templated Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• prostate gland development Source: RGDInferred from expression patternⁱ
  • "Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching."
    Pu Y., Huang L., Prins G.S.
    Dev Biol 273:257-275(2004) [PubMed] [Europe PMC] [Abstract]
• proximal/distal pattern formation Source: RGD
• regulation of hepatocyte proliferation Source: RGD
• regulation of osteoblast differentiation Source: RGD
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: RGD
• smoothened signaling pathway Source: RGD
• smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RGD
• spermatogenesis Source: RGD
• ventral midline development Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• microtubule binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFNPMTSPQV NSYGEPCCLR PLPSQGVPSM GTEGLSGLPF CHQANFMSGS 
        60         70         80         90        100
QGYGSARETS SCTEGSLFPP PRSSVKLTKK RALSISPLSD ASLDLQTVIR 
       110        120        130        140        150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPPQMS HQKGTSPPYG 
       160        170        180        190        200
VQPCVPHDST QGSMMLHPQS RGPRATCQLK SELDIMVGKC PEEPLEGDMS 
       210        220        230        240        250
SPNSTSTQDH LLGMLDGRED LEREEKPEPE SVYETDCRWD GCSQEFDSQE 
       260        270        280        290        300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 
       310        320        330        340        350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEQEGCSK AFSNASDRAK 
       360        370        380        390        400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD 
       410        420        430        440        450
GPLPRAQPLS TVEPKREREG GSGREESRLT VPEGTMPQQS PGAQSSCSSD 
       460        470        480        490        500
HSPAGSAANT DSGVEMAGNA GGSTEDLSSL DEGPCVAATG LSTLRRLENL 
       510        520        530        540        550
RLDQLHQLRP IGSRGLKLPS LTHAGAPVSR RLGPPVSLDR RSSSSSSISS 
       560        570        580        590        600
AYTVSRRSSL ASPFPPGSPP ENGASSLPGL TPAQHYMLRA RYASARGSGT 
       610        620        630        640        650
PPTAAHSLDR IGGLPAPPWR SRAEYPGYNP NAGVTRRASD PARAADHPAP 
       660        670        680        690        700
ARVQRFKSLG CVHTPPSVAT GRNFDPHLPT SVYSPQPPSI TENVAMDTRG 
       710        720        730        740        750
LQGELEVGTS MMGNDLNPYM DFSSADTLGY GGPEGTAAES YGSKGPGSLP 
       760        770        780        790        800
LGPGPPTNYG PGHCAQQVSY PDPTPETWGE FPSHAGVYPG TKALGTAYNQ 
       810        820        830        840        850
CPRLEHYGQV QVKPEQGCPV GSDSTGLAPC LNAHPSEGSP DPQPLFSHHS 
       860        870        880        890        900
QLPPPQYLQS GPYPQPPHDC LSLESRPGLN FNPSSHSTGQ LKAQLLCNYV 
       910        920        930        940        950
QSQQELLWEG RSRGGIPNQE LPYQSPKFLG GSQVSQSPTK VPAAAAAATF 
       960        970        980        990       1000
GSGFASPALA NHKSVSYPAP SPCHETFTMG VNRPPHRPAA PPRLLPPLPP 
      1010       1020       1030       1040       1050
CYGPLKVGDA NPSCGHPEVG RLGAGPALYP PPEGQVCNPL DSLDLDNTQL 
      1060       1070       1080       1090       1100
DFVAILDEAQ GLSPPPSHEQ GDSSKNTPPP SGPPNMAVGN MSVLLGSLPG 

ETQFLNSSA                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ