Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - G3V6W5 (G3V6W5_RAT)

Entry version 70 (10 Feb 2021)
Sequence version 1 (16 Nov 2011)
Previous versions | rss
Add a publicationFeedback
Protein

RNA helicase

Gene

Ifih1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi909ZincPROSITE-ProRule annotation1
Metal bindingi912ZincPROSITE-ProRule annotation1
Metal bindingi964ZincPROSITE-ProRule annotation1
Metal bindingi966ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, RNA-bindingARBA annotation
Biological processAntiviral defenseARBA annotation, Immunity, Innate immunityARBA annotation
LigandATP-binding, Metal-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding, ZincPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-5689880, Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA helicaseARBA annotation (EC:3.6.4.13ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ifih1Imported
Synonyms:RGD1560496_predictedImported
ORF Names:rCG_27124Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...RGDi		1560496, Ifih1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		G3V6W5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000006227, Expressed in liver and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		G3V6W5, 3 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000009621

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		G3V6W5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini318 – 511Helicase ATP-bindingInterPro annotationAdd BLAST194
Domaini702 – 874Helicase C-terminalInterPro annotationAdd BLAST173
Domaini895 – 1022RLR CTRInterPro annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni243 – 262DisorderedSequence analysisAdd BLAST20
Regioni271 – 301DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi271 – 293PolarSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. RLR subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0354, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006888_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		CCLFSDE

Database of Orthologous Groups

More...OrthoDBi		1337630at2759

TreeFam database of animal gene trees

More...TreeFami		TF330258

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.170.150.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031964, CARD_dom
IPR011029, DEATH-like_dom_sf
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR041204, RIG-I_C
IPR038557, RLR_C_sf
IPR021673, RLR_CTR

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16739, CARD_2, 2 hits
PF00271, Helicase_C, 1 hit
PF04851, ResIII, 1 hit
PF18119, RIG-I_C, 1 hit
PF11648, RIG-I_C-RD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51789, RLR_CTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3V6W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTVCSAEDS FRNLISIFRP RVKMNIQVEP VLDYLVFLPA ETKEQILRKV 
        60         70         80         90        100
TTCGNTSAAE LLLSTLEQGQ WPLGWTQMFV EALEHSGNPL AARYVKPSLT 
       110        120        130        140        150
DLPSPSSETA HDECLHLLNL LQPTLVGKLL INDVLDTCSE KGLVTVEDRN 
       160        170        180        190        200
RISAAGNSGN ESGVRELLRR IVQKENWFST FLDVLRQTGN DALVQELTGV 
       210        220        230        240        250
SCPEESTDLD NASHKDRPAA NEPLLPAIDA LSLETEAWTI EDTSPEASFA 
       260        270        280        290        300
DSSVTTESDT SLAEGSVSCF DESLGHNSNM GRDSGTMGSD SDEDTIMGTK 
       310        320        330        340        350
RASPKPELQL RPYQMEVAQP ALDGKNIIIC LPTGSGKTRV AVYITKDHLD 
       360        370        380        390        400
KKKQACESGK VIVLVNKVML AEQLFRKEFN PFLKKWYRII GLSGDTQLKI 
       410        420        430        440        450
SFPEVVKSYD VIISTAQILE NSLLNLESGE DDGVQLSDFS LIIIDECHHT 
       460        470        480        490        500
NKEAVYNNIM RRYLKQKLKN HKLKKQNKPT IHLPQILGLT ASPGVGAAKK 
       510        520        530        540        550
QSEAEKHILN ICANLDAFTI KTVKENLSQL KHQIKEPCKK FVIADDTREN 
       560        570        580        590        600
PFKEKLLEIM ASIQTYCQKS PLSDFGTQHY EQWAIQMEKK AAKDGNRRDR 
       610        620        630        640        650
VCAEHLRKYN EALQINDTIR MIDAYSHLET FYTDEKEKKF AALNDSDESD 
       660        670        680        690        700
DDEASSCHDQ LKGNVKKSLK LDETDEFLMN LFFDNKKMLK KLAENPKYEN 
       710        720        730        740        750
EKLIKLRNTI LEQFTRSEES SRGIIFTKTR QSTYALSQWI MENEKFAEVG 
       760        770        780        790        800
VKAHHLIGAG HSSEVKPMTQ TEQKEVISKF RTGEINLLIA TTVAEEGLDI 
       810        820        830        840        850
KECNIVIRYG LVTNEIAMVQ ARGRARADES TYVLVTSSGS GVTEREIVND 
       860        870        880        890        900
FREKMMYKAI NRVQNMKPEE YAHKILELQV QSILEKKMKV KRSIARQYNS 
       910        920        930        940        950
DPSLITLLCK NCSTLVCSGE NIHVIEKMHH VNMTPEFKGL YIVRENKALQ 
       960        970        980        990       1000
MKFADYQTNG EIICKCGQAW GTMMVHKGLD LPCLKIRNFV VNFKNNSSKK 
      1010       1020 
QYKKWVELPI RFPDLDCSEY CLYSDED
Length:1,027
Mass (Da):116,068
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11C10C4C04997820
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07052347 Genomic DNA No translation available.
CH473949 Genomic DNA Translation: EDL79011.1

NCBI Reference Sequences

More...RefSeqi		NP_001102669.1, NM_001109199.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000009620; ENSRNOP00000009621; ENSRNOG00000006227

Database of genes from NCBI RefSeq genomes

More...GeneIDi		499801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:499801

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07052347 Genomic DNA No translation available.
CH473949 Genomic DNA Translation: EDL79011.1
RefSeqiNP_001102669.1, NM_001109199.1

3D structure databases

SMRiG3V6W5
ModBaseiSearch...

Protein-protein interaction databases

IntActiG3V6W5, 3 interactors
STRINGi10116.ENSRNOP00000009621

Proteomic databases

PRIDEiG3V6W5

Genome annotation databases

EnsembliENSRNOT00000009620; ENSRNOP00000009621; ENSRNOG00000006227
GeneIDi499801
KEGGirno:499801

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64135
RGDi1560496, Ifih1

Phylogenomic databases

eggNOGiKOG0354, Eukaryota
GeneTreeiENSGT00940000153173
HOGENOMiCLU_006888_0_0_1
OMAiCCLFSDE
OrthoDBi1337630at2759
TreeFamiTF330258

Enzyme and pathway databases

ReactomeiR-RNO-5689880, Ub-specific processing proteases

Gene expression databases

BgeeiENSRNOG00000006227, Expressed in liver and 21 other tissues

Family and domain databases

Gene3Di2.170.150.30, 1 hit
InterProiView protein in InterPro
IPR031964, CARD_dom
IPR011029, DEATH-like_dom_sf
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR041204, RIG-I_C
IPR038557, RLR_C_sf
IPR021673, RLR_CTR
PfamiView protein in Pfam
PF16739, CARD_2, 2 hits
PF00271, Helicase_C, 1 hit
PF04851, ResIII, 1 hit
PF18119, RIG-I_C, 1 hit
PF11648, RIG-I_C-RD, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51789, RLR_CTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V6W5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V6W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 10, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again