UniProtKB - G3V6W5 (G3V6W5_RAT)
Protein
RNA helicase
Gene
Ifih1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:3.6.4.13ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 909 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 912 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 964 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 966 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: InterPro
- double-stranded RNA binding Source: RGD
- identical protein binding Source: RGD
- ribonucleoprotein complex binding Source: RGD
- RNA helicase activity Source: UniProtKB-EC
- single-stranded RNA binding Source: RGD
- zinc ion binding Source: RGD
GO - Biological processi
- cellular response to exogenous dsRNA Source: RGD
- defense response to virus Source: RGD
- innate immune response Source: RGD
- MDA-5 signaling pathway Source: RGD
- positive regulation of interferon-alpha production Source: RGD
- positive regulation of interferon-beta production Source: RGD
- positive regulation of interleukin-6 production Source: RGD
- positive regulation of response to cytokine stimulus Source: RGD
- positive regulation of tumor necrosis factor production Source: Ensembl
- protein sumoylation Source: RGD
- response to virus Source: RGD
Keywordsi
Molecular function | HelicaseARBA annotation, Hydrolase, RNA-bindingARBA annotation |
Biological process | Antiviral defenseARBA annotation, Immunity, Innate immunityARBA annotation |
Ligand | ATP-binding, Metal-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding, ZincPROSITE-ProRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-5689880, Ub-specific processing proteases |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:rCG_27124Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1560496, Ifih1 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000006227, Expressed in liver and 21 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
IntActi | G3V6W5, 3 interactors |
STRINGi | 10116.ENSRNOP00000009621 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 318 – 511 | Helicase ATP-bindingInterPro annotationAdd BLAST | 194 | |
Domaini | 702 – 874 | Helicase C-terminalInterPro annotationAdd BLAST | 173 | |
Domaini | 895 – 1022 | RLR CTRInterPro annotationAdd BLAST | 128 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 243 – 262 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 271 – 301 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 271 – 293 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0354, Eukaryota |
GeneTreei | ENSGT00940000153173 |
HOGENOMi | CLU_006888_0_0_1 |
OMAi | CCLFSDE |
OrthoDBi | 1337630at2759 |
TreeFami | TF330258 |
Family and domain databases
Gene3Di | 2.170.150.30, 1 hit |
InterProi | View protein in InterPro IPR031964, CARD_dom IPR011029, DEATH-like_dom_sf IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR041204, RIG-I_C IPR038557, RLR_C_sf IPR021673, RLR_CTR |
Pfami | View protein in Pfam PF16739, CARD_2, 2 hits PF00271, Helicase_C, 1 hit PF04851, ResIII, 1 hit PF18119, RIG-I_C, 1 hit PF11648, RIG-I_C-RD, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51789, RLR_CTR, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V6W5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTVCSAEDS FRNLISIFRP RVKMNIQVEP VLDYLVFLPA ETKEQILRKV
60 70 80 90 100
TTCGNTSAAE LLLSTLEQGQ WPLGWTQMFV EALEHSGNPL AARYVKPSLT
110 120 130 140 150
DLPSPSSETA HDECLHLLNL LQPTLVGKLL INDVLDTCSE KGLVTVEDRN
160 170 180 190 200
RISAAGNSGN ESGVRELLRR IVQKENWFST FLDVLRQTGN DALVQELTGV
210 220 230 240 250
SCPEESTDLD NASHKDRPAA NEPLLPAIDA LSLETEAWTI EDTSPEASFA
260 270 280 290 300
DSSVTTESDT SLAEGSVSCF DESLGHNSNM GRDSGTMGSD SDEDTIMGTK
310 320 330 340 350
RASPKPELQL RPYQMEVAQP ALDGKNIIIC LPTGSGKTRV AVYITKDHLD
360 370 380 390 400
KKKQACESGK VIVLVNKVML AEQLFRKEFN PFLKKWYRII GLSGDTQLKI
410 420 430 440 450
SFPEVVKSYD VIISTAQILE NSLLNLESGE DDGVQLSDFS LIIIDECHHT
460 470 480 490 500
NKEAVYNNIM RRYLKQKLKN HKLKKQNKPT IHLPQILGLT ASPGVGAAKK
510 520 530 540 550
QSEAEKHILN ICANLDAFTI KTVKENLSQL KHQIKEPCKK FVIADDTREN
560 570 580 590 600
PFKEKLLEIM ASIQTYCQKS PLSDFGTQHY EQWAIQMEKK AAKDGNRRDR
610 620 630 640 650
VCAEHLRKYN EALQINDTIR MIDAYSHLET FYTDEKEKKF AALNDSDESD
660 670 680 690 700
DDEASSCHDQ LKGNVKKSLK LDETDEFLMN LFFDNKKMLK KLAENPKYEN
710 720 730 740 750
EKLIKLRNTI LEQFTRSEES SRGIIFTKTR QSTYALSQWI MENEKFAEVG
760 770 780 790 800
VKAHHLIGAG HSSEVKPMTQ TEQKEVISKF RTGEINLLIA TTVAEEGLDI
810 820 830 840 850
KECNIVIRYG LVTNEIAMVQ ARGRARADES TYVLVTSSGS GVTEREIVND
860 870 880 890 900
FREKMMYKAI NRVQNMKPEE YAHKILELQV QSILEKKMKV KRSIARQYNS
910 920 930 940 950
DPSLITLLCK NCSTLVCSGE NIHVIEKMHH VNMTPEFKGL YIVRENKALQ
960 970 980 990 1000
MKFADYQTNG EIICKCGQAW GTMMVHKGLD LPCLKIRNFV VNFKNNSSKK
1010 1020
QYKKWVELPI RFPDLDCSEY CLYSDED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07052347 Genomic DNA No translation available. CH473949 Genomic DNA Translation: EDL79011.1 |
RefSeqi | NP_001102669.1, NM_001109199.1 |
Genome annotation databases
Ensembli | ENSRNOT00000009620; ENSRNOP00000009621; ENSRNOG00000006227 |
GeneIDi | 499801 |
KEGGi | rno:499801 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07052347 Genomic DNA No translation available. CH473949 Genomic DNA Translation: EDL79011.1 |
RefSeqi | NP_001102669.1, NM_001109199.1 |
3D structure databases
SMRi | G3V6W5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | G3V6W5, 3 interactors |
STRINGi | 10116.ENSRNOP00000009621 |
Proteomic databases
PRIDEi | G3V6W5 |
Genome annotation databases
Ensembli | ENSRNOT00000009620; ENSRNOP00000009621; ENSRNOG00000006227 |
GeneIDi | 499801 |
KEGGi | rno:499801 |
Organism-specific databases
CTDi | 64135 |
RGDi | 1560496, Ifih1 |
Phylogenomic databases
eggNOGi | KOG0354, Eukaryota |
GeneTreei | ENSGT00940000153173 |
HOGENOMi | CLU_006888_0_0_1 |
OMAi | CCLFSDE |
OrthoDBi | 1337630at2759 |
TreeFami | TF330258 |
Enzyme and pathway databases
Reactomei | R-RNO-5689880, Ub-specific processing proteases |
Gene expression databases
Bgeei | ENSRNOG00000006227, Expressed in liver and 21 other tissues |
Family and domain databases
Gene3Di | 2.170.150.30, 1 hit |
InterProi | View protein in InterPro IPR031964, CARD_dom IPR011029, DEATH-like_dom_sf IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR041204, RIG-I_C IPR038557, RLR_C_sf IPR021673, RLR_CTR |
Pfami | View protein in Pfam PF16739, CARD_2, 2 hits PF00271, Helicase_C, 1 hit PF04851, ResIII, 1 hit PF18119, RIG-I_C, 1 hit PF11648, RIG-I_C-RD, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51789, RLR_CTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V6W5_RAT | |
Accessioni | G3V6W5Primary (citable) accession number: G3V6W5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |